JPH0729913B2 - Aqueous lubricating composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The present invention relates to an aqueous lubricating composition for smoothly inserting or maintaining an object into a female vagina during sexual intercourse and insertion of a sanitary product.

(B) Conventional technology In recent years, in the age of 80 years of age, many families have lived together over the age of 60, and more than 80% of men over the age of 60 have a spouse. In addition, the age gap between men and women at the time of marriage has recently disappeared, and the remarriage rate of women after the loss of their spouse is increasing, so it is expected that the number of elderly people with married couples will increase at the end of this century.

In the past, remarriage was reluctant to worry about the world, but recently, both heterosexual morality and sexual awareness have changed drastically, and sexual behavior of men and women beyond just `` tea friends only '' since their 60s. There is a tendency for relationships with the number to increase.

However, sexual intercourse in the elderly is associated with sexual intercourse because of atrophy of the genitals and decreased sexual response. The main causes are erectile dysfunction in men and a lack of vaginal fluid in women. Also, women who have undergone uterine removal surgery for some reason often complain of pain during intercourse due to insufficient secretion.

A lot of consultations about such problems were brought to the obstetrician and gynecologist,
Currently, application of glycerin etc. is instructed.

On the other hand, sanitary products (e.g., tampon), which have rapidly spread in recent years, tend to be disliked by young people, especially those who have not had sex, but the main reason is considered to be discomfort during wearing and resistance such as pain.

Lubricants used for these actions have been marketed in Europe and the United States for quite some time, but most of them have a cellulose derivative (eg, methylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose) added to a glycerin base. It is a transparent gel (or paste) formulation. These preparations exhibit physical properties far from the properties of female secretions, have a strong stickiness after use, and are often found to give off white residue or stain clothes and cause discomfort.

(C) Structure of the present invention As a result of intensive research to solve these drawbacks,
It has been found that when unmodified mucin, hyaluronic acid and dextran are blended in appropriate proportions, the physical properties are closest to those of natural female secretion fluid, and the present invention was reached.

The present invention has been achieved based on such findings, and provides the following compositions (1) to (3).

(1) (a) mucin 0.6 to 5% by weight, (b) hyaluronic acid 0.02 to 2% by weight, (c) dextran 0.2 to 5% by weight, (d) aqueous medium 1 to 95% by weight, and, if necessary, An aqueous lubricating composition consisting essentially of (e) 1 to 35% by weight of glycerin and / or sorbitol and (f) 0.1 to 0.5% by weight of metal salts.

(2) (a) mucin 0.6 to 5% by weight, (b) hyaluronic acid 0.02 to 2% by weight, (c) dextran 0.2 to 5% by weight, (d) aqueous medium 1 to 95% by weight, (g) pasted Or gelling agent 0.05 to 3% by weight and optionally (e) glycerin and / or sorbitol 1 to 35% by weight, (f) metal salt 0.1 to 0.5% by weight in the form of paste or gel Aqueous lubricating composition.

(3) (i) (a) Mucin 0.3-5 wt%, (b) Hyaluronic acid 0.02-2 wt%, (c) Dextran 0.2-
5% by weight, (d) 1 to 95% by weight of an aqueous medium, and (e) glycerin and / or sorbitol 1 as required.
To 35 wt%, (f) 70 to 90 parts by weight of an aqueous solution consisting essentially of 0.1 to 0.5 wt% of metal salts, and (ii) a foaming property consisting essentially of 10 to 30 parts by weight of a foaming agent and a foam forming agent. Aqueous lubricating composition.

The (a) mucin used in the present invention is suitably a 1 to 4% liquid extracted from the submandibular membrane of a cow's head or a freeze-dried product thereof, and a 2 to 4% mucin liquid extracted from a gastric mucosa of a pig. . Mucin is preferably used in a proportion of 0.3 to 5% by weight per composition. (B) Hyaluronic acid, which has been extracted and purified from chicken mackerel and has a molecular weight of about 20,000 to 5,000,000, is suitably used in the range of 0.02 to 2% by weight based on the composition. As the dextran (c), those having a molecular weight of 30,000 to 100,000 produced by a fermentation method are suitable, and it is advantageous to add them at a ratio of 0.2 to 5% by weight based on the composition.

1 to 35% by weight of (e) glycerin or / and sorbitol in the aqueous lubricating composition of the present invention for the purpose of preventing drying,
(F) Sodium chloride, potassium chloride, magnesium chloride, calcium chloride in appropriate amount for physiological isotonicity, 0.1-0.5% by weight of sodium phosphate dibasic as PH buffer, sodium edetate for the purpose of antibacterial antiseptic effect, It is even better to add an appropriate amount of butylparaben and benzalkonium chloride, and an appropriate amount of perfume.

Further, the composition of the present invention can be used as an aqueous solution, but its dosage form can be a foam injection type (aerosol type) or a paste or gel type (paste tube type) for easier use. .

In the case of the foamy spray type, 10 to 30 parts by weight of a foaming agent and a foaming agent are added to 70 to 90 parts by weight of the aqueous solution composition. In this case, as the foam-forming agent, a usual one can be used, or preferably, polyoxyethylene cetyl ether and / or polyoxyethylene cetyl ester is used in an amount of 0.1 to 5% by weight based on the whole composition. Is desirable. As the foaming agent, those generally used may be used, and for example, fluoroethylene chloride, liquefied propane, etc. are used. Such a foam injection type formulation is
When sprayed, a foamy aqueous lubricating composition comes out, which is very simple to use.

Paste or gel type is the above aqueous solution (g)
A paste agent or gelling agent such as carrageenan, xanthan gum, pectin, and a cellulose derivative is added individually or in an appropriate combination in an amount of 0.05 to 3% by weight, and mixed uniformly and then filled in an appropriate container, for example, a tube.

Hereinafter, each dosage form will be described in more detail with reference to Examples.

Example 1 First, a solution-type composition, which is a basic dosage form, was mixed and dissolved according to the following formulation until it became uniform, to prepare a formulation 1.

Formulation 1 Mucin powder (abbreviated as BSM below bovine submandibular gland) 0.5 3.5% mucin solution (abbreviated as PGM below swine gastric mucosa) 30.00 Dextran (molecular weight 70,000) 1.0 Glycerin 2.0 0.1% Hyaluronic acid solution 10.0 Food salt 0.1 Potassium chloride 0.1 Magnesium Chloride 0.005 Calcium Chloride 0.005 Sodium Phosphate 0.4 EDTA-2Na 0.1 Butylparaben 0.08 Benzalkonium Chloride 0.005 Purified Water Residual 100.00 Next, examples of foam jet type compositions will be described.

Example 2 1. Mucin powder (BSM) 2.0 2. 3.5% mucin solution (PGM) 30 3. Dextran (molecular weight 40,000) 5 4. Glycerin 2 5.1 1% hyaluronic acid solution 15 6. Salt 0.1 7. Potassium chloride 0.1 8. Magnesium chloride 0.005 9. Calcium chloride 0.005 10. Sodium primary phosphate 0.30 11. Disodium edetate 0.10 12. Butylparaben 0.08 13. 10% benzalkonium chloride aqueous solution 0.005 14. Polyoxyethylene cetyl ether 0.4 15. Purified water Residue 100 ... Liquid The above formulation was mixed with stirring to obtain a liquid. After putting 35 parts by weight of liquid into an aerosol can, liquefied CFC
Foam jet type composition filled with 15 parts by weight (formulation 2)
Was prepared.

Example 3 1. Mucin powder (BSM) 2.0 2. Dextran (molecular weight 70,000) 5 3. Sorbitol 2 4.1 1% hyaluronic acid solution 20 5. Sodium chloride 0.1 6. Magnesium chloride 0.005 7. Potassium chloride 0.1 8. Calcium chloride 0.005 9. Monosodium phosphate 0.30 10. Disodium edetate 0.10 11. Butylparaben 0.08 12. 10% benzalkonium chloride aqueous solution 0.005 13. Polyoxyethylene cetyl ester 0.4 14. Purified water residual 100 ... Liquid Above formulation Was dissolved and mixed to obtain a liquid. 35 parts by weight of the liquid was filled to prepare a foam injection type composition (formulation 3).

Examples of paste or gel type compositions will be described.

Example 4 1. Mucin powder (BSM) 2.0 2. 3.5% mucin solution (PGM) 30 3. Dextran 2 4. Glycerin 2 5.1% Hyaluronic acid solution 10 6. Sodium chloride 0.1 7. Potassium chloride 0.1 8. Chloride Magnesium 0.005 9. Calcium chloride 0.005 10. Sodium primary phosphate 0.30 11. Disodium edetate 0.10 12. Butylparaben 0.08 13. 10% aqueous benzalkonium chloride solution 0.005 14. Xanthan gum (microorganism-producing polysaccharide) 2 15. Purification Water Residue 100 The above formulation was stirred, mixed and dissolved to obtain a transparent gel-like paste composition. This is formulation 4
And

Example 5 1. Mucin powder (BSM) 1.5 2. 3.5% mucin solution (PGM) 35 3. Dextran 3 4. Sorbitol 25.1 1% hyaluronic acid solution 12 6. Sodium chloride 0.1 7. Potassium chloride 0.1 8. Chloride Magnesium 0.005 9. Calcium chloride 0.005 10. Sodium monophosphate 0.30 11. Disodium edetate 0.10 12. Butylparaben 0.08 13. 10% benzalkonium chloride aqueous solution 0.005 14. Hydroxyethyl cellulose 2 15. Purified water residue 100 Above The blended formulation was stirred and mixed so as to be sufficiently uniform and dissolved to obtain a transparent viscous paste composition. This is designated as Formulation 5.

Example 6 1. Mucin powder (BSM) 2 2. 3.5% mucin solution (PGM) 25 3. Dextran 3 4. Glycerin 2 5.1% hyaluronic acid solution 12 6. Sodium chloride 0.1 7. Potassium chloride 0.1 8. Chloride Magnesium 0.005 9. Calcium chloride 0.005 10. Sodium monophosphate 0.30 11. Disodium edetate 0.10 12. Butylparaben 0.08 13. 10% benzalkonium chloride aqueous solution 0.005 14. Carrageenan 1.5 15. Fragrance 0.01 16. Purified water Appropriate amount 100 The above blended formulation was stirred and dissolved to be sufficiently uniform to obtain a transparent gel composition. This is designated as Formulation 6.

The formulations 1 to 6 were compared with water and saliva for lubricity and surface tension. The method is length 7.5 cm, width 2.5 c
0.01 cc of each sample was dropped on m glass pain with a micropipette, a 1 g weight was placed on it, and one of the glass plates was lifted to measure the tilt angle at which the weight started to move. Therefore, the smaller the angle, the better the lubricity.

Saliva is used here because it has physical properties very similar to the secretions from the female genitals.

The surface tension is also an important factor, and the smaller this force, the better the contactability (wettability).

Therefore, the surface tensions of Formulations 1 to 6 and 8 samples of saliva and water were compared and judged by the wettability to paraffin film. That is, 100 μm of each sample was taken with a microsyringe, dropped on a paraffin film, allowed to stand for 5 minutes, the maximum diameter and the minimum diameter thereof were measured with a caliper, and the average diameter was calculated. It can be determined that the larger this value is, the better the wettability (contact property) and the smaller the surface tension. The results were as follows.

Next, in order to measure the feeling when actually touching the mucous membrane,
0.5 cc of each sample was dropped on the palm of the hand, and the sample was rubbed with one forefinger in a circle with a diameter of 3 to 4 cm in a circular motion, and the smoothness and the wet feeling after rubbing were subjected to a sensory test by 10 people. The average of 10 people made the evaluation. The results were as follows.

From these results, Formulations 1 to 3 have almost the same lubricity and surface tension as saliva.
It turns out that all 6 are compositions which should be fully expected for use for this purpose.

Claims (3)

[Claims] 1. (a) Mucin 0.6-5% by weight, (b) Hyaluronic acid 0.02-2% by weight, (c) Dextran 0.2-5.
%, (D) 1 to 95% by weight of the aqueous medium, and (e) 1 to glycerin and / or sorbitol 1 to if necessary.
An aqueous lubricating composition consisting essentially of 35% by weight, (f) metal salts of 0.1 to 0.5% by weight. 2. (a) Mucin 0.6 to 5% by weight, (b) Hyaluronic acid 0.02 to 2% by weight, (c) Dextran 0.2 to 5
%, (D) 1 to 95% by weight of aqueous medium, (g) 0.05 to 3% by weight of pasting agent or gelling agent and optionally (e) 1 to 35% by weight of glycerin and / or sorbitol, (f ) A paste-like or gel-like aqueous lubricating composition consisting essentially of 0.1 to 0.5% by weight of metal salts. (1) (a) Mucin 0.3-5% by weight,
(B) Hyaluronic acid 0.02 to 2% by weight, (c) Dextran 0.2 to 5% by weight, (d) Aqueous medium 1 to 95% by weight, and optionally (e) Glycerin and / or sorbitol 1 to 35% by weight. , (F) 0.1-0.5% by weight of metal salts, 70-90 parts by weight of an aqueous solution which substantially consists, and (2) 10-30 parts by weight of a foaming agent and a foam-forming agent. .