JPH0731209B2 - Multi-item automatic analyzer - Google Patents

Description

TECHNICAL FIELD The present invention relates to a multi-item automatic analyzer for analyzing a plurality of components in a biological sample such as serum, plasma, urine of human or animal.

(B) Conventional technology A conventional multi-item automatic analyzer is placed in an area (area) on the sample erection table depending on the urgency of the test-for example, general sample (non-urgent sample) urgent sample standard sample quality control sample. It has been decided that when a real sample is analyzed, the item ID (analysis component) to be analyzed or the function / set test information combining these items is entered for each sample by a dedicated operator. Was going on.

In addition, when human (human) serum and urine analysis are processed by one automatic analyzer, there are some items that show orders of magnitude of concentration even in the same analysis item, and these are naturally different analysis items. It was analyzed under the conditions, and the sample ID operation was also performed separately. For example, when measuring total protein, urea nitrogen, and glucose in serum and urine, the analysis process was performed by changing the type of reagent even if the analysis items were the same.

(C) Problems to be Solved by the Invention However, in the conventional method, unless the method of sample ID is mastered, the automatic analyzer cannot be used. For example, in a general hospital, a test cannot be performed at night or on holidays when there is no dedicated operator. There were problems such as being unable to do so.

The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide an apparatus that automates a sample ID stage and can easily inspect a sample even when a dedicated operator is absent.

(D) Means for Solving the Problems In order to solve the above problems, the present invention provides a multi-item automatic analyzer that simultaneously analyzes many kinds of components, and inspects a plurality of samples for each kind or function / set inspection. A sample container erection table with an area display for each installation,
Storage means for storing a plurality of analysis items corresponding to the area display on the erection table, detection means for detecting whether or not a sample is arranged in the area on the erection table, and storage means based on the detection of the sample And analysis means for analyzing the analysis items stored in.

Here, the detection means for detecting whether or not the sample is placed in the area on the sample container erection table is a sample container erection table provided with a sample container detection mechanism (for example, reflected light, transmitted light sensor), Alternatively, a sample liquid level detection probe attached to the sample pipetter may be used to confirm the presence or absence of the sample.

(E) Operation The present invention is based on the type or function / function of the sample on the sample container erection table.
By arranging sample (specimen) containers corresponding to the area display for each set inspection, analysis of predetermined analysis items becomes possible.

(F) Example FIG. 1 is a diagram showing the construction of an example of the automatic analyzer of the present invention. In FIG. 1, 1 is a sample dispensing pump, 2 is a sample dispensing nozzle, 3 is a sample dispensing nozzle moving mechanism, 4 and 5 are standard sample containers and standard samples, respectively, and 6 is a sample container erection table (details will be described later). ), 7 and 8 are a sample container and a sample, 9 is a reaction disk, 10 (10 ', 10 ") is a reaction cell, and 1
1 is the first reagent dispensing pump, 12 is the first reagent dispensing nozzle, 13
Is a first reagent dispensing nozzle moving mechanism, 14 is a reagent storage, 15 and 16 are respectively a first reagent container and a first reagent, 17 is a spectroscope, and 18
Is a spectrometer moving mechanism, 19 is a control and data processing computer, 20 is a second reagent dispensing pump, 21 is a second reagent dispensing nozzle, 22 is a second reagent dispensing nozzle moving mechanism, and 23 and 24 are second respectively. Reagent container and second reagent, 25 is a cleaning pump, 26 is a cleaning nozzle up / down mechanism, 27 is a cleaning nozzle, 28 is analysis item information belonging to function / set inspection, and area information on the sample container erection table 6 for function / set inspection Storage unit, which stores
Is an instruction unit that gives an instruction to start analysis.

Next, the details of the sample mount 2 and the sample dispensing nozzle are described in the second section.
Shown in the figure.

As shown in FIG. 2, the sample container erection table 6 is provided with an area display (6-1 to 6-90,
However, in the figure, for convenience, they are indicated as 1 to 90), and the function / set inspection of Table 1 corresponds to such an area.

The analysis items corresponding to the function / set inspection are as shown in Table 2.

The information of Table 1 and Table 2 is stored in the storage unit 28 in advance.

A sample liquid level detection probe 30 preferentially searches the leading position of each area to confirm the presence or absence of the sample, and gives an analysis operation signal to the computer 19.

In the above configuration, the operation of the device is as follows.

First, arrange the sample containers 7 containing the target function / set inspection sample from the first area on the sample container erection table,
The instruction unit 29 gives an instruction to start analysis. At this time, the device is in an analysis standby state.

When the sample liquid level detection probe 30 searches the leading position of each area on the sample container erection table 6 to confirm the presence or absence of the sample, the analysis operation starts.

When the analysis operation is started, the sample dispensing nozzle 2 connected to the sample dispensing pump 1 is moved by the sample dispensing nozzle moving mechanism 3, and a predetermined amount of the sample container 7 is set on the sample container erection table 6. The sample 8 is sucked, and the sample 8 and the standard sample 5 are dispensed into the reaction cell 10 arranged in the reaction disk 9. The reaction cell 10 is driven at every step to move the reaction cell 10 to the first reagent dispensing position (position of the reaction cell 10 ').
The first reagent dispensing nozzle 12 connected to the first reagent dispensing pump 11 is moved by the first reagent dispensing nozzle moving mechanism 13 and set in the reagent storage 14 After aspirating a predetermined amount of the first reagent 16 from 15,
It moves to the first reagent dispensing position and dispenses into the reaction cell 10 '. During this time, the spectroscope 17 reciprocally rotates around the same axis as the reaction disk 9 by the spectroscope moving mechanism 18, while sequentially measuring the absorbance (Yt) of each measurement wavelength of each reaction cell, and controlling and data processing computer 19 Remember.

In addition, if it is necessary to dispense the second reagent, the reaction cell 10
Has reached the second reagent dispensing position (the position of the reaction cell 10 ″), the second reagent dispensing nozzle 21 connected to the second reagent dispensing pump 20 is moved by the second reagent dispensing nozzle moving mechanism 22, After sucking a predetermined amount of the second reagent 24 from the second reagent container 23 set in the reagent storage 14, it is moved to the second reagent dispensing position and dispensed into the reaction cell 10 ″. During each of these series of operations, the spectrometer reciprocates around the reaction disk each time the reaction cell is driven by one step, and the time series data of the absorbance of each reaction cell is measured. For the reaction cell outside the reciprocating rotation range of the spectroscope, the cleaning up / down nozzle mechanism 27
Then, the reaction solution is discarded and the cell is washed. The control and data processing computer 19 synchronously controls the operation of each part, and at the same time, according to the measurement mode from the time series data of the absorbance obtained for each analytical item (each reaction cell) set in advance, the absorbance or the absorbance per unit time. After being processed as a change, the concentration, activity value, etc. of each analysis item are calculated and output.

 Next, another embodiment of the present invention is shown in FIG.

In FIG. 3, the area display of the sample container erection table 6'is shown for each type of sample, and the areas 6'-1 to 6'-20 correspond to the arrangement of animal A (eg rat) serum. Area 6'-21 to 6'-30 contains animal A urine, and area 6'-31 to
Animal serum B (for example, rabbit) corresponds to 40.

Also in the present embodiment, the analysis conditions corresponding to the area display of the sample container erection table 6 ', that is, in the animal A serum area, the analysis conditions for the serum (for example, sample amount, analysis reagent type, analysis reagent injection amount) are used. However, in the urine sample area of animal A, the analysis conditions for urine are stored in the storage unit 28 of the apparatus shown in FIG.
Memorized in.

The following table shows specific examples of different analysis conditions (analytical reagents) depending on the type of sample even for the same analysis item.

The above table shows the commonality of the reagents to the serum and urine samples in the main analysis items, and the reagents are different although total protein, urea nitrogen, and glucose are the same analysis items.

As a countermeasure in such cases, change the type of reagent for total protein (for example, use Biuret reagent for serum samples and use pyrogallol red reagent for urine samples).
Analysis is performed, and urea nitrogen and glucose have the same reagent components, but the analysis is performed by changing the preparation concentration of the reagent.

Note that other analysis items are dealt with only by changing the liquid amount of the sample / reagent.

All of the above changes in the type of reagent are stored in the storage unit 28.

However, except for the storage contents of the analysis conditions in the sample container erection table 6'and the storage unit 28, the same operation is performed as in the above-described embodiment.

In the above description, the start of the analysis operation was performed based on the signal from the sample liquid level detection probe, but the present invention is not limited to this, and for example, when the sample container is set on the sample container erection table, Any analysis start instruction mechanism corresponding to each function / set inspection, such as a sample container detection mechanism for detecting transmitted / reflected light, can be used.

(G) Effect According to the present invention, the sample ID registration operation is simplified or unnecessary, and the labor of the operator is reduced. Therefore, even a person who is not familiar with the operation of the automatic analyzer can handle the automatic analyzer, and it becomes possible to perform inspections at night and on holidays.

Further, in the case where the analysis reagents are different depending on the type of sample even though they are the same analysis item, it is necessary to separate the analysis channel in the conventional method, but in the present invention, the same analysis is performed even if the type of sample is different. Since it can be input from the channel, sample ID input operation is easy.

[Brief description of drawings]

FIG. 1 is an overall view of an automatic analyzer according to the present invention, and FIG. 2 and FIG. 3 are enlarged views of a sample container erection table and a sample dispensing nozzle. 6 ... Sample container erection table

Claims (1)

[Claims] 1. A multi-item automatic analyzer for simultaneously analyzing many kinds of components, and a sample container erection table having an area display for setting a plurality of samples for each kind of sample or for each function / set inspection.
Storage means for storing a plurality of analysis items corresponding to the area display on the erection table, detection means for detecting whether or not a sample is arranged in the area on the erection table, and storage means based on the detection of the sample A multi-item automatic analysis device comprising an analysis means for analyzing the analysis items stored in.