JPH0743360B2 - Ion exchange column manufacturing method - Google Patents
Ion exchange column manufacturing methodInfo
- Publication number
- JPH0743360B2 JPH0743360B2 JP1077876A JP7787689A JPH0743360B2 JP H0743360 B2 JPH0743360 B2 JP H0743360B2 JP 1077876 A JP1077876 A JP 1077876A JP 7787689 A JP7787689 A JP 7787689A JP H0743360 B2 JPH0743360 B2 JP H0743360B2
- Authority
- JP
- Japan
- Prior art keywords
- ion exchange
- exchange resin
- tube
- fibrous
- heat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Description
【発明の詳細な説明】 （産業上の利用分野） この発明は、各種イオンの定量分析や、液体クロマトグ
ラフィーや、イオン交換クロマトグラフィー等において
使用するのに適したイオン交換カラムを製造する方法に
関する。TECHNICAL FIELD The present invention relates to a method for producing an ion exchange column suitable for use in quantitative analysis of various ions, liquid chromatography, ion exchange chromatography and the like. .
（従来の技術） 従来、イオンを定量分析するときに、イオン交換カラム
を用いて目的とするイオンを濃縮することが行われてい
る。(Prior Art) Conventionally, when quantitatively analyzing ions, the target ions are concentrated using an ion exchange column.
かかる目的に使用するイオン交換カラムとしては、粒状
イオン交換樹脂を充填したものがあるが、粒状イオン交
換樹脂は単位体積当りのイオン交換容量が小さく、濃縮
に時間がかかったり、微量成分の濃縮が正確に行いにく
いといった問題があるため、たとえば特開昭54−158997
号公報に記載されるように、繊維状イオン交換樹脂を使
用することが多い。As an ion exchange column used for such a purpose, there is one packed with a granular ion exchange resin, but the granular ion exchange resin has a small ion exchange capacity per unit volume, and it takes a long time to concentrate, or a trace amount of components cannot be concentrated. Since there is a problem that it is difficult to perform accurately, for example, JP-A-54-158997
Fibrous ion exchange resins are often used, as described in the publication.
そのようなイオン交換カラムは、繊維状イオン交換樹脂
をカラムに充填することによって作られるが、繊維状で
あるために充填むらによる空隙ができやすく、充填量を
一定にするのが極めて難しい。また、繊維状イオン交換
樹脂の固定が難しいために、捕捉したイオンを溶離液で
溶出し、分析するようなときに、溶離液の圧力によって
繊維状イオン交換樹脂が移動し、圧力が変動して分析ピ
ークがシャープにならないといった問題がある。Such an ion exchange column is manufactured by packing a fibrous ion exchange resin in the column, but since it is fibrous, it is easy to form voids due to uneven packing, and it is extremely difficult to make the packing amount constant. Further, since it is difficult to fix the fibrous ion exchange resin, when the captured ions are eluted with an eluent and analyzed, the fibrous ion exchange resin moves due to the pressure of the eluent and the pressure fluctuates. There is a problem that the analysis peak does not become sharp.
（発明が解決しようとする課題） この発明の目的は、従来の方法の上述した問題点を解決
し、繊維状イオン交換樹脂に、密に、かつ、一定の充填
量で充填できるばかりか、その固定を良好に行うことが
できる、イオン交換カラムの製造方法を提供するにあ
る。(Problems to be Solved by the Invention) An object of the present invention is to solve the above-mentioned problems of the conventional method, and to allow the fibrous ion-exchange resin to be packed densely and at a constant filling amount. Another object of the present invention is to provide a method for producing an ion exchange column, which enables good fixation.
（課題を解決するための手段） 上記目的を達成するために、この発明は、熱収縮性チュ
ーブに、水を含浸させた所要量の繊維状イオン交換樹脂
を充填した後、上記チューブを加熱して収縮させること
を特徴とする、イオン交換カラムの製造方法を提供す
る。(Means for Solving the Problems) In order to achieve the above-mentioned object, the present invention is to heat a heat-shrinkable tube with a required amount of fibrous ion-exchange resin impregnated with water, and then heat the tube. Provided is a method for producing an ion exchange column, which is characterized in that it is contracted.
この発明を詳細に説明するに、この発明においては、ま
ず、チューブと、イオン交換樹脂とを用意する。To explain the present invention in detail, in the present invention, first, a tube and an ion exchange resin are prepared.
上記チューブは、100〜250℃程度に加熱すると収縮す
る、すなわち、熱収縮性の、たとえばポリエチレン、ポ
リ四フッ化エチレン、ポリ塩化ビニル、シリコンゴム等
のポリマーからなっている。なかでも、加熱時に、後述
するイオン交換樹脂を変性させたり、使用時に不要な成
分を溶出したりしにくいポリエチレンからなるものであ
るのが好ましい。The tube is made of a heat-shrinkable polymer, such as polyethylene, polytetrafluoroethylene, polyvinyl chloride, or silicone rubber, which shrinks when heated to about 100 to 250 ° C. Above all, it is preferably made of polyethylene which is difficult to denature the ion exchange resin described below during heating and to elute unnecessary components during use.
一方、イオン交換樹脂は、太さが１〜500μｍ、好まし
くは10〜100μｍ、長さが0.1〜100mm、好ましくは0.5〜
50mmの繊維状で、スチレンとジビニルベンゼンとの共重
合体に所望のイオン交換基を導入したようなものや、ア
クリル、ポリエチレン、ポリビニルアルコール等の樹脂
に所望のイオン交換基を導入したようなものや、補強用
ポリマー、たとえばポリエチレンを島成分とし、所望の
イオン交換基を導入したポリマー、たとえばポリスチレ
ンにイオン交換基を導入したポリマーを海成分とする、
いわゆる多芯海島型複合繊維からなるもの等を使用する
ことができる。イオン交換基としては、スルホン酸基、
カルボン酸基、４級アンモニウム基、１〜３級アミン等
がある。On the other hand, the ion exchange resin has a thickness of 1 to 500 μm, preferably 10 to 100 μm, and a length of 0.1 to 100 mm, preferably 0.5 to
50 mm fibrous material with desired ion-exchange groups introduced into the copolymer of styrene and divinylbenzene, or with desired ion-exchange groups introduced into resins such as acrylic, polyethylene and polyvinyl alcohol. Or a reinforcing polymer, for example, polyethylene as an island component, and a polymer having a desired ion exchange group introduced, for example, a polymer having an ion exchange group introduced on polystyrene as a sea component,
A so-called multicore sea-island type composite fiber or the like can be used. As the ion exchange group, a sulfonic acid group,
There are carboxylic acid groups, quaternary ammonium groups, primary to tertiary amines, and the like.
さて、この発明においては、上述したチューブに、一定
長さの上記繊維状イオン交換樹脂を充填する。このと
き、チューブの太さや長さは、充填する繊維状イオン交
換樹脂の量に基いて選定する。また、繊維状イオン交換
樹脂の量は、所望するイオン交換容量に基いて選定す
る。Now, in the present invention, the above-mentioned tube is filled with the fibrous ion exchange resin of a certain length. At this time, the thickness and length of the tube are selected based on the amount of fibrous ion exchange resin to be filled. The amount of fibrous ion exchange resin is selected based on the desired ion exchange capacity.
繊維状イオン交換樹脂は、チューブの長さ方向に引き揃
えて充填しても、ランダムな塊状で充填しても、いずれ
でもよい。なお、充填に際しては、繊維状イオン交換樹
脂に水を含浸させておく。これによって、繊維状イオン
交換樹脂の取扱いが容易となるばかりでなく、後の加
熱、収縮時に繊維状イオン交換樹脂に加わる熱を低減す
ることができる。The fibrous ion exchange resin may be packed in the tube in the lengthwise direction or packed, or packed in a random block. In addition, at the time of filling, water is impregnated in the fibrous ion exchange resin. This not only facilitates the handling of the fibrous ion exchange resin, but also reduces the heat applied to the fibrous ion exchange resin during subsequent heating and contraction.
次に、繊維状イオン交換樹脂を充填したチューブを加熱
し、熱収縮させる。この熱収縮によって繊維状イオン交
換樹脂間に取り込まれていた空気が追い出され、また、
熱収縮に伴う力によって繊維状イオン交換樹脂の充填密
度が高められるとともに、管内に良好に保持されるよう
になる。熱収縮後、チューブの各端部に連結管を取り付
ければ、分析機器等に装着し得る態様となるが、各端部
に、あらかじめ、多孔板、たとえばポリ四フッ化エチレ
ン製ポーラスフィルタを装着した連結管を内挿してお
き、それから加熱を行うようにすれば、チューブと連結
管との一体化を同時に行うことができるので好ましい。
多孔板の使用は、充填端における繊維状イオン交換樹脂
のくずれや移動をより確実に阻止するうえでも好まし
い。Next, the tube filled with the fibrous ion-exchange resin is heated to cause heat shrinkage. Due to this heat shrinkage, the air taken in between the fibrous ion exchange resins is expelled,
Due to the force associated with the heat shrinkage, the packing density of the fibrous ion exchange resin is increased, and the fibrous ion exchange resin is well retained in the tube. After heat shrinkage, if a connecting pipe is attached to each end of the tube, it becomes a mode that can be attached to an analytical instrument or the like, but a porous plate such as a polytetrafluoroethylene porous filter is attached to each end in advance. It is preferable to insert the connecting tube in advance and then heat the tube, since the tube and the connecting tube can be integrated at the same time.
The use of a perforated plate is also preferable for more reliably preventing the fibrous ion exchange resin from collapsing or moving at the filling end.
図面は、この方法によって得たイオン交換カラムの一例
を示すもので、熱収縮したチューブ１内に繊維状イオン
交換樹脂２が保持され、また、チューブ１の各端部に
は、フィルタ３（３′）を有する連結管４（４′）が、
管１の熱収縮と同時に一体化されている。The drawing shows an example of an ion exchange column obtained by this method, in which a fibrous ion exchange resin 2 is held in a heat-shrinkable tube 1, and a filter 3 (3 Connecting pipe 4 (4 ') having')
The tube 1 is integrated with the heat shrinkage at the same time.
（実 施 例） 繊維状イオン交換樹脂として、４級アンモニウム基を交
換基とする、太さ40μｍ、長さ1mmの、東レ株式会社繊
維状イオン交換樹脂TIN−200を用意した。(Example) As a fibrous ion exchange resin, Toray Industries, Inc. fibrous ion exchange resin TIN-200 having a thickness of 40 μm and a length of 1 mm and having a quaternary ammonium group as an exchange group was prepared.
次に、25gの上記繊維状イオン交換樹脂を水に浸した
後、内径3mm、長さ30mmのポリエチレン製チューブの中
央部に充填し、そのチューブの両端に、ポリ四フッ化エ
チレン製ポーラスフィルタを装着した、外径2mmの連結
管を挿入し、しかる後ドライヤで加熱して上記チューブ
を熱収縮させ、図面に示すようなイオン交換カラムを得
た。Next, after soaking the fibrous ion exchange resin of 25 g in water, the inner diameter of 3 mm, the central portion of a length 30 mm polyethylene tube is filled, and at both ends of the tube, a polytetrafluoroethylene porous filter. The attached connecting tube having an outer diameter of 2 mm was inserted, and then the tube was heat-shrinked by heating with a dryer to obtain an ion exchange column as shown in the drawing.
（発明の効果） この発明は、熱収縮チューブに、水を含浸させた所望量
の繊維状イオン交換樹脂を充填した後、上記チューブを
加熱して熱収縮させるので、熱収縮に伴う力によって、
繊維状イオン交換樹脂を、密に、かつ、一定の充填量で
充填することができるばかりか、その固定を良好に行な
うことができるようになる。しかも水を含浸させること
によって繊維状イオン交換樹脂の取扱いが容易となり、
後の加熱時に繊維状イオン交換樹脂に加わる熱を低減す
ることができる。(Effects of the Invention) The present invention fills a heat-shrinkable tube with a desired amount of fibrous ion-exchange resin impregnated with water, and heats the tube to heat-shrink it.
Not only can the fibrous ion-exchange resin be packed densely and at a fixed packing amount, but also the fixing can be carried out satisfactorily. Moreover, the impregnation with water makes it easy to handle the fibrous ion exchange resin,
It is possible to reduce heat applied to the fibrous ion exchange resin during the subsequent heating.
図面は、この発明の方法によって得たイオン交換カラム
の一例を示す概略縦断面図である。 1:熱収縮後のチューブ 2:繊維状イオン交換樹脂 ３、３′：フィルタ ４、４′：連結管The drawing is a schematic longitudinal sectional view showing an example of an ion exchange column obtained by the method of the present invention. 1: Tube after heat shrinking 2: Fibrous ion exchange resin 3, 3 ': Filter 4, 4': Connection tube
───────────────────────────────────────────────────── フロントページの続き (72)発明者 井垣 浩侑 滋賀県大津市北大路３丁目９番27号 審査官 柏崎 康司 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Hiroyuki Igaki 3-9-27 Kitaoji, Otsu, Shiga Examiner Koji Kashiwazaki
Claims (1)
量の繊維状イオン交換樹脂を充填した後、上記チューブ
を加熱して収縮させることを特徴とする、イオン交換カ
ラムの製造方法。1. A method for producing an ion exchange column, which comprises filling a heat-shrinkable tube with a desired amount of fibrous ion-exchange resin impregnated with water and then shrinking the tube by heating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1077876A JPH0743360B2 (en) | 1989-03-28 | 1989-03-28 | Ion exchange column manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1077876A JPH0743360B2 (en) | 1989-03-28 | 1989-03-28 | Ion exchange column manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02254359A JPH02254359A (en) | 1990-10-15 |
| JPH0743360B2 true JPH0743360B2 (en) | 1995-05-15 |
Family
ID=13646262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1077876A Expired - Lifetime JPH0743360B2 (en) | 1989-03-28 | 1989-03-28 | Ion exchange column manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0743360B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4520621B2 (en) * | 2000-11-01 | 2010-08-11 | 信和化工株式会社 | Chromatographic separation column, solid phase extraction medium, and chromatographic sample injection system |
| US7261813B2 (en) * | 2004-08-10 | 2007-08-28 | Clemson University | Monolithic structures comprising polymeric fibers for chemical separation by liquid chromatography |
| JP4728739B2 (en) * | 2004-08-30 | 2011-07-20 | ヘラマンタイトン株式会社 | Pipette tip manufacturing method |
| WO2025187798A1 (en) * | 2024-03-07 | 2025-09-12 | Jnc株式会社 | Chromatographic carrier using microfibers and method for producing same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54158997A (en) * | 1978-06-05 | 1979-12-15 | Mitsubishi Rayon Co | Ionnexchange chromatographic column and making method thereof |
| US4657742A (en) * | 1985-07-01 | 1987-04-14 | Ppg Industries, Inc. | Packed fiber glass reaction vessel |
-
1989
- 1989-03-28 JP JP1077876A patent/JPH0743360B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02254359A (en) | 1990-10-15 |
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