JPH0753089B2 - Reishi-containing granules - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial field of application) The present invention is a particle containing concentrated Ganoderma lucidum or Ganoderma lucidum extract (hereinafter referred to as Ganoderma lucidum extract, etc.) and Vitamin C in layers. The present invention relates to health foods and pharmaceuticals having the form of agents.

(Prior Art) Health foods in which Ganoderma lucidum extract and the like are simply mixed with each other are known, but granules such as Ganoderma lucidum extract with vitamin C applied in layers are not known.

(Problems to be Solved by the Invention) Health foods such as Ganoderma lucidum extract simply mixed with vitamin C are
Vitamin C is sour and sour that it is difficult to take. In order to solve this difficulty, the present invention invented a dosage form in which the sour and sour taste of vitamin C is hardly felt,
Facilitated simultaneous intake of Ganoderma lucidum extract and vitamin C.

(Means and Actions for Solving Problems) In order to suppress the sour acidity of vitamin C, it was attempted to coat vitamin C with ganoderma lucidum extract or the like. , I have not found a method that can be manufactured within the range of practical cost.

Therefore, a method in which vitamin C is applied to the core portion having a composition of sugar or sugar and a binder using a sugar and a binder, and then Ganoderma lucidum extract or the like is also applied thereto using a sugar and a binder. I thought about it and examined it. As a result, this method produces granules of almost uniform size within a practical cost range.
The present invention has been completed by finding out that it is a method capable of producing a desired size.

The method of applying vitamin C and then Ganoderma lucidum extract or the like is a method according to a conventional method for forming multi-layered granules. Hereinafter, the present invention will be described in more detail.

First, the core portion, the first layer from the core portion (hereinafter referred to as the first layer).
Layer) and the second layer from the core (hereinafter referred to as the second layer).
The composition of the layer) will be described first, and then the method for producing the granule of the present invention will be described.

Sugars used to form the core portion and the first and second layers (hereinafter, both are referred to as multi-layers) include sucrose (sucrose), lactose, fructose, isomerized lactose, glucose, maltose, maltose, galactose, oligos. Sugar, D-xylose and D
-Sorbitol and the like, and these internal white sugar, lactose,
Glucose is preferable, and further, these internal white sugars are particularly preferable. The reason is that this sucrose has high water solubility, good adhesion, and excellent strength.

Further, instead of a part of sugar, excipients other than sugar, such as starch, dextrin, cyclodextrin, pullulan,
It is also possible to use crystalline cellulose and their sugar mixtures.

In order to form the core portion and the overlying layer into a spherical shape, it is preferable to add a binder, and examples of the binder include sucrose, starch, gelatin, alginic acid, gum arabic, guar gum, tara gum, tragacanth gum, roast bean gum, xanthan gum. , Karaya gum, pectin, carrageenan, pullulan, and other aqueous additives such as CMC-Na, propylene glycol alginate, methyl cellulose, sodium starch glycolate and sodium starch phosphate ester, etc. ,
Gum arabic, alginic acid and the like are preferable. Particularly preferred are sucrose, gelatin and the like.

When the above-mentioned sugar and binder are used, for example, a binder dissolved in water is added to and mixed with crushed sugar to produce the composition of the core part.

The weight mixing ratio of the binder to the sugar is in the range of `` 1: 0.05 to 0.6 '' when the sugar is sucrose, preferably `` 1: 0.1 to 0.
The range is 3 ".

The weight ratio of "sugar + binder" to vitamin C in the first layer is "vitamin C: (sugar + binder) = 1: 0.1 to 0.5".
However, the present invention is not limited thereto.

The weight ratio of "equal + binder" to Reishi extract etc. in the second layer is "Reishi extract etc .: (sugar + binder) = 1: 0.1-
0.5 "is preferable, but the present invention is not limited thereto.

The weight ratio of each component of the granules of the present invention is “Reishishiba extract etc .: Vitamin C: (sugar + binder) = 1: 0.5 to 2: 0.5 or less” in consideration of alteration of vitamin C due to contact with outside air. Is preferable, and the amount of (sugar + binder) is such that it is robust enough for practical use and is capable of forming the first layer and the second layer capable of achieving the effect of the granules of the present invention. It should be in the range of.

Three general methods for producing the core are described below.

Crystalline sucrose is crushed, and after sieving to a specified size, powdered sucrose and a dissolved sucrose solution are mixed with a crushed product to obtain a core.

After sieving the crystalline lactose to the specified size, use powdered sucrose and dissolved sucrose solution or gelatin, gum arabic mixture,
Mix with crystalline lactose by sieving to obtain a core.

Crystalline sucrose is crushed and sieved to a specified size, and then starch and a dissolved sucrose solution, gelatin or gum arabic mixture is used and mixed with the crushed product to obtain a core.

The thus-obtained core or commercially available core is coated with vitamin C as a first layer by a conventional method, and then the reishi extract is layered to obtain a target granule.

It is also possible to use a commercially available core that satisfies the composition conditions as the core. As an example of the core product on the market,
"Non-pareil" (made by Freund Sangyo Co., Ltd.) can be mentioned.

The first layer forms a multi-layer by a conventional method. That is, a small amount of a mixture of a sugar and a binder is added to the core portion under aeration in a rotating coating device to coat the core evenly, and then a small amount of vitamin C is added for uniform coating. Then, the first layer is formed by repeating the addition of a small amount of the mixture of sugar and the binder, a uniform coating, and the addition of a small amount of the mixture of the sugar and the binder, a uniform coating, a small amount of vitamin C, and a uniform coating.

Similarly to the first layer, the second layer is also laminated by adding a small amount of Ganoderma lucidum extract or the like to the mixture of sugar and the binder.

The use form of vitamin C used in the first layer is powder, and the average particle size of the powder is in the range of 10 to 100 microns, preferably 30 to 50 microns. When the particle size is in this range, the adhesion rate is good and the loss is small. In addition, it is easy to form a uniform spherical coating.

Examples of the Reishi extract and the like used in the second layer are as follows, but are not limited thereto.

Lingzhi is a Ganoderma l
eucidum) basidiomycete grows in the tree, 3-6 after germination
It matures in the lunar position to form a peculiar heart-shaped fruiting body, and the matured umbrella has a diameter of about 5 to 25 cm.

The umbrella and the handle of this fully matured fruit body of Ganoderma lucidum are repeatedly dried with warm air and air to such an extent that the inside is sufficiently dried, then extracted with hot water, and water is evaporated from the extract to concentrate Ganoderma lucidum. Or evaporate and scatter to obtain powdered Reishi extract.

The general composition of Ganoderma lucidum extract is shown in Table 1.

(Reference example) Manufacturing example of Reishi extract Extract of raw Reishi and its collection method: Basidiomycetes of Ganoderma lucidum, Ganoderma lucidum, are planted in a persimmon tree, and primary and secondary hyphae are grown to form fruit bodies. . When spores were sufficiently released from the back of the umbrella, the spores were collected and dried by warm air drying at 60 to 80 ° C. and air drying for several hours three times.

Method for producing Reishi extract: 1 kg of the dried fruiting body is crushed and extracted 3 times with 20 to 30 times the weight of hot water at a temperature close to 70 ° C to 100 ° C. The extracts were combined and evaporated to dryness to obtain about 80 g of Ganoderma lucidum extract. Its composition was as follows.

(Example) Hereinafter, a method for producing a granule from each composition will be specifically described. The method of the present invention is not limited to these.

In the following examples, the composition weight ratio of the granules was set to "Vitamin C: Reishi extract: (sugar + binder) ≈ 2: 2: 1".

Example 1 Core (consisting of 8 parts by weight of sucrose and 4 parts by weight of 50% sucrose)
After sieving about 0.2 mg by weight of one particle, the amount of 1.5 parts per 1 part by weight of the core part as the first layer was passed under aeration in a coating device.
~ 1.6% gum arabic solution: 50% white sugar solution ≒ 6.7: 19.6 (w / w)
5 parts by weight of a mixture of Vitamin C powder (80-100 μm)
8 parts by weight were alternately added in small amounts to form a layer according to a conventional method. As a second layer, 1 part by weight of the core portion was added to 1.5 parts by weight.
~ 1.6% gum arabic solution: 50% white sugar solution ≒ 6.7: 19.6 (w / w)
5 parts by weight of the mixture, 8 parts by weight of Reishi powder extract and 0.
8 parts by weight of the mixture was alternately added in small portions to form a layer by a conventional method and then dried (about 45 ° C.) to obtain a target granule.

The weight ratio of the composition of the obtained granule was "Vitamin C: Reishi extract: (sugar + binder) ≈ 2: 2: 1". The weight of 100 grains was 330 mg.

Example 2 Using a core (having the same composition as in Example 1), one particle is about 0.2 m
After sieving the g-weight product, a mixture of 1.5 to 1.6% gum arabic solution: 50% sucrose solution ≈ 6.7: 19.6 (w / w) to 1 part by weight of the core as the first layer under aeration in a coating apparatus 5 Parts by weight,
8 parts by weight of Vitamin C powder (50 to 100 μm) are added alternately in small portions to form a layer according to a conventional method. As a second layer, 1.5 to 1.6% gum arabic solution per 1 part by weight of the core portion: 5% by weight of a mixture of 50% white sugar solution ≈ 6.7: 19.6 (w / w),
A mixture of 8 parts by weight of Reishi powder extract and 0.8 part by weight of lactose,
After a small amount was added alternately in small portions to form a layer by a conventional method, the target granule was obtained by drying (about 40 to 45 ° C).

The weight ratio of the composition of the obtained granule was “Vitamin C: Reishi extract: (sugar + binder) ≈ 2: 2: 0.9”. The weight of 100 tablets was 325 mg.

Example 3 Using the core (composition: the same as in Example 1), particle size 24 to 32
After sieving into a mesh (about 0.2 mg / grain), 1.5 to 1.6 against 1 part by weight of the core as the first layer under aeration in a coating device
% Gum arabic solution: 50% sucrose solution ≒ 6.7: 19.6 (w / w) 5 parts by weight of mixture and 8 parts by weight of Vitamin C powder (30-60 μm) are added alternately in small portions, and according to a conventional method. A layer is formed, and 50% sucrose solution is used as the second layer for 1 part by weight of the core.
% Weak CMC-Na solution = 9.9: 5 (w / w) 5 parts by weight of mixture, 8 parts by weight of Reishi powder extract and 0.8 parts by weight of starch were added alternately in small portions to form a layer. After forming a layer by the method, the target granule was obtained by drying (about 50 ° C.).

The weight ratio of the composition of the obtained granule was "Vitamin C: Reishi extract: (sugar + binder) ≈ 1.9: 2: 0.9". Also, 100
The weight of the granule was 320 mg.

The target granules were easily obtained by the methods of Examples 1 to 3 above. The obtained granules had almost no sourness peculiar to vitamin C and were easy to take.

(Effects of the Invention) By selecting sugar as the composition of the core part, the production of the core part is facilitated.

・ Since the physical properties of sugar make it easy to process by crushing,
It is possible to obtain powder with an arbitrary mesh number.

・ Contains Vitamin C and Ganoderma lucidum extract, and Vitamin C
It became possible to manufacture the granules with suppressed sour and sour taste of practicable at a practical cost.

This form of granule provided the following effects.

・ Since it was possible to suppress the sour acidity of vitamin C, intake became easier.

・ By completely covering vitamin C with Reishi extract,
Vitamin C in the granule became difficult to absorb moisture. as a result,
Vitamin C was almost completely destroyed before ingestion.

Claims (2)

[Claims] 1. The composition of the core portion is sugar, or sugar and a binder, the composition of the first layer from the core portion is vitamin C, the sugar and a binder, and the composition of the second layer from the core portion. Reishi-containing granules whose layer composition is concentrated Reishi or Reishi extract, sugar and binder. 2. The Reishi-containing granule according to claim 1, wherein the sugar is a monosaccharide, disaccharide or polysaccharide.