JPH0787757B2 - Highly stable liquid nutritional supplement - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a carbohydrate source and a fat for use in combination with a nutritional supplement containing a nitrogen source protein, amino acid, and low molecular weight peptide alone or in a mixture thereof. A liquid nutritional supplement containing a source.

Technical background Nutrients are widely used for preoperative and postoperative nutritional management. At that time, the nitrogen sources of nutrients are roughly divided into protein group and amino acid and low molecular weight peptides.

And, under normal pathological conditions, the nitrogen source is sufficient in the protein state, but if extreme digestive and absorption disorders occur, especially in the pathological state where pancreatic juice and the like are not secreted, amino acids and low-molecular peptides as nitrogen sources are It is preferable because of good absorption.

Thus, in the nutrients containing these nitrogen sources, when they are made into a liquid form, the deterioration of pitamines is observed, and when amino acids and low molecular weight peptides are nitrogen sources, they are reduced as sugar sources. A browning phenomenon (aminocarbonyl reaction or Maillard reaction) occurs in the presence of sugar, and problems such as instability of emulsion are observed.

The present inventor, as a result of studying the stability of the nutritional supplement during liquefaction, a nutritional supplement consisting of a nitrogen source,
Focusing on the fact that the above problem can be solved by mixing the two liquids at the time of administration with the two liquids of the components consisting of sugars and fats, regarding the nutritional supplement of the part consisting of sugars and fats, It has been found that a liquid form having high emulsion stability can be obtained by using a dextrin having a DE of a certain level or more as a carbohydrate, and containing dextrin and fat in an amount within a certain range, respectively. It arrived.

In general, as a sugar source, its digestibility is good,
Carbohydrates such as starch, monosaccharides, and disaccharides are used from the viewpoint of preventing high viscosity due to the use of a thin tube during administration, preventing diarrhea, and preventing hyperosmotic pressure due to a rapid increase in blood sugar concentration. It is known that dextrin obtained by hydrolyzing starch is superior to dextrin.

On the other hand, as a fat source, vegetable oils such as soybean oil, corn oil, coconut oil, and safflower oil, fish oils, or artificial oils from the viewpoint of supply and absorbability of linoleic acid which is an essential fatty acid or ω3 type highly unsaturated fatty acid. The medium-chain fatty acid triglyceride (MCT) prepared in 1. is said to be preferable. If necessary, fat-soluble and water-soluble vitamins such as vitamin B ₁ and minerals can be added to the nutritional supplement if the kind and amount thereof are limited.

Conventionally, intravenous fat emulsions used in medicine use soybean oil as a fat, which is emulsified using high-purity lecithin separated and purified from soybean or egg as an emulsifier, and concentrated glycerin as an isotonicity agent. Is homogenized by adding and is sterilized by retort and then used for administration.

However, in the above fat emulsion, when dextrin is used in place of concentrated glycerin, the emulsion stability is poor, and the emulsion is immediately separated by retort sterilization. Therefore, conventionally, a stable emulsifier from a liquid mixture of fat and dextrin is It was said that he could not get it.

DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention As described above, the present invention provides a liquid nutrition that exhibits high emulsion stability under sterilization and storage even when dextrin, which is excellent as a sugar source for nutritional supplements, is mixed with a fat source. It is an object to provide an agent.

The present invention will be described in detail below.

Structure of the Invention The structural feature of the present invention is that dextrin 10 having a DE of 25 or more is used.
~ 20% (W / V) and 2.5-10% fat (W / V), and the total amount of dextrin and fat is 15-25% (W / V), emulsify and sterilize It is a highly stable liquid nutritional supplement.

Means for Solving the Problems In order to stably maintain the emulsifiability of a liquid nutrient containing dextrin and fat under sterilization and storage thereof, it is important to select the concentration of dextrin and fat and the DE of dextrin.

That is, it is essential that the dextrin used in the present invention has a DE of 25 or more, and with a dextrin having a DE of less than 25, the emulsified state is separated during retort sterilization and storage for 1 month.

The concentration of dextrin and fat is in the range of 10 to 20% (W / V) for dextrin and 2.5 to 10% (W / V) for fat, and the total amount of dextrin and fat is 15 to 25%.
It is important to be in the range of% (W / V).

Next, DE-33 dextrin was used as the dextrin, and soybean oil was used as the fat.
28% (W / V), soybean oil at each concentration of 1.5-10% (W / V), combined so that the total amount becomes 15% -34.5% (W / V) Table 1 A liquid nutrient having the composition shown in (1) was prepared, and the emulsion stability after retort sterilization and after storage at 37 ° C. for 6 months was examined. The liquid nutrient was emulsified using an emulsifier and homogenized three times at 500 kg / cm ² with a homogenizer. Also, for retort sterilization, fill the glass bottle with the nutritional supplement and
I went for 5 minutes.

The results are shown in Table 1.

As seen in Table 1, dextrin is 10% to 20% (W /
V) concentration, soybean oil 2.5 to 10% (W / V) concentration, and total solid content of dextrin and soybean oil in the range of 15% to 25%, emulsion is stable even after storage for 6 months after retort sterilization. It is recognized that they are doing.

Next, the influence of various dextrin DEs on the stability of the nutritional supplement was investigated by the following.

As the dextrin, various DEs shown in Table 2 were used at a concentration of 15% (W / V), and soybean oil was used as a fat at 10% (W / V).
V) Concentrate, add an emulsifier and homogenize 3 times with a homogenizer at 500 kg / cm ² into a glass bottle, perform retort sterilization at a temperature of 121 ° C for 15 minutes, and then to 1 ° C at 37 ° C. Stored for a month.

The results are shown in Table 2.

As shown in Table 2, with dextrin having a DE of 25 or more, the emulsifiability was retained even after storage for 1 month after sterilization.
When DE is 19 or less, the emulsifying property is unstable and cannot be maintained.

As described above, by emulsifying dextrin and fat having a certain DE or more according to the present invention in a concentration in a specific range, a liquid nutrient with high emulsion stability even under retort sterilization and subsequent long-term storage. Since it can be provided, the present invention can be put to practical use as a sterile liquid nutritional supplement.

Hereinafter, the method for preparing the liquid nutritional supplement according to the present invention will be specifically described with reference to examples.

Example 1 To 140 kg of refined soybean oil, an emulsifier was added and dissolved by heating at a temperature of 70 ° C. This solution was added to a solution prepared by previously adding 700 kg of dextrin of DE33 to 2800 water and dissolving it, and further adding water to adjust the total amount to 3750, and preliminarily emulsified with a homomixer under heating at a temperature of 70 ° C. . Then, this emulsion was further emulsified three times at 500 kg / cm ² using a high-pressure homogenizer. The obtained homogeneous emulsion was filled in a glass bottle and retort sterilized at a temperature of 121 ° C. for 15 minutes to obtain a target liquid nutrient.

The obtained nutritional supplement was stored at 37 ° C for 6 months, but no water separation or oil separation was observed and the emulsion stability was good.

Example 2 An emulsifier was added to a mixed oil of 98 kg of medium chain fatty acid triglyceride and 42 kg of refined soybean oil, and the mixture was heated to 70 ° C. and dissolved. This solution was added to a solution prepared by adding 700 kg of DE44 dextrin to 2800 water in advance and further adding water to adjust the total amount to 3750.
Pre-emulsification was performed with a homomixer at a temperature of 70 ° C.

Then, this emulsion was further subjected to a high pressure homogenizer at 500 kg / cm.
^The emulsion was emulsified by repeating ² times 3 times. The obtained homogeneous emulsion was filled in a glass bottle and retort sterilized at 121 ° C. for 15 minutes to obtain a liquid nutrient.

The obtained nutrient was stored at 37 ° C. for 6 months, but no water separation or oil separation was observed and the emulsion stability was good.

Claims (1)

[Claims] 1. A liquid nutritional supplement containing dextrin and fat, wherein dextrin having a DE of 25 or more is 10 to 20% (W /
V) and 2.5 to 10% (W / V) fat, and the total amount of dextrin and fat is 15 to 25% (W / V), a highly stable product obtained by emulsifying and sterilizing a nutrient. Liquid nutritional supplement.