JPH0791173B2 - Liposomes containing skin cosmetics - Google Patents

Description

TECHNICAL FIELD The present invention relates to a novel liposome-containing skin cosmetic, and more specifically, the membrane component substance is composed of a specific hydrogenated phospholipid and a liquid hydrocarbon, and The present invention relates to a liposome-containing skin cosmetic which is characterized by mixing two components and water in a specific ratio, has good stability over time, and has an extremely excellent feeling in use.

[Prior Art] Liposomes are closed vesicles composed of bilayer membranes of phospholipids, which are the main constituents of biological membranes, and have been used for research as a biological membrane model, and have long been used as microcapsules of pharmaceuticals and cosmetics. It has been attempted to be used for such purposes (Japanese Patent Laid-Open Nos. 49-118826 and 52-6375). Particularly in the field of cosmetics, liposome is a valuable form as a microcapsule, and its constituent component, phospholipid itself, is a highly safe amphipathic substance derived from biological membrane, and also has a moisturizing effect. , Has been attracting attention.

However, since liposomes using natural phospholipids contain a large amount of unsaturated fatty acids, the membrane structure is weakened due to chemical changes such as oxidation, and the membrane is destroyed due to physical changes, resulting in retention of substances. There was a drawback that it was easy to leak. There is also a problem of discoloration and odor due to oxidation.

As described above, since natural phospholipids tend to oxidize lipids, a method of adding an antioxidant such as α-tocopherol to the bilayer membrane for the purpose of antioxidant, or a synthetic phospholipid / hydrogenated phospholipid Has been taken.

On the other hand, it is known to utilize cholesterol, which contributes to the stabilization of the membrane in the biological membrane, as a means for stabilizing the membrane and preventing the leakage of the drug, and adding a hydrophilic polymer or an oily substance. Attempts are being made. It is also known to use synthetic phospholipids or hydrogenated phospholipids having a higher phase transition temperature (Tc) than natural phospholipids in order to obtain liposomes that are stable on the one hand.

[Problems to be Solved by the Invention] As described above, various studies have hitherto been made to utilize liposomes for pharmaceuticals and cosmetics.

However, when used as a cosmetic product, it is difficult to stably mix liposomes because addition or addition of other cosmetic raw materials causes aggregation or precipitation, or liposomes are not formed. However, the sensual effect such as feeling of use is not sufficient by itself, and the actual situation is that a satisfactory result has not been obtained yet.

[Means for Solving Problems] In view of the above points, the present inventors have earnestly studied in order to obtain a liposome-containing skin cosmetic having an excellent feeling of use without impairing the stability of the liposome, and as a result, a film By adding liquid hydrocarbon as a component substance to a specific hydrogenated phospholipid so that the composition ratio is 1: 1 or less, and mixing these two components and water in a specific ratio, it is very excellent It was found that a liposome-containing skin cosmetic having a feeling of use can be obtained, and the present invention has been completed.

That is, in the present invention, the membrane component substance is (A) one or more selected from hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated phosphatidylcholine and hydrogenated phosphatidylserine, and (B) a liquid hydrocarbon. And the ratio of the component (B) to the component (A) is 1: 1 or less by weight, and the mixing ratio of these two components and water (C) is (A) component: (B). Component: (C) component = 0.
The liposome-containing skin cosmetic is characterized in that it is 1 to 9.5: 0.01 to 1.5: 90.5 to 99.89.

As the specific hydrogenated phospholipid in the liposome-containing skin cosmetics according to the present invention, iodine value is preferably 30 or less, soybean lecithin which is natural lecithin, other than those hydrogenated egg yolk lecithin according to a conventional method, phosphatidylcholine, Examples thereof include hydrogenated phosphatidylserine, and one or more selected from these may be used.

Further, the liquid hydrocarbon essential to the present invention may be a liquid hydrocarbon at room temperature, which is usually used as a raw material for cosmetics, for example, squalane, pristane,
Liquid paraffin, low viscosity polybutene (viscosity 5-1000cs
t) and the like. These are arbitrarily selected according to need and used alone or in combination. The ratio of liquid hydrocarbons to specific hydrogenated phospholipids is 1: 1 by weight.
It is the following. When the amount of the liquid hydrocarbon is larger than that of the specific hydrogenated phospholipid, it is difficult to form the bilayer membrane of the liposome, and the precipitation or aggregation occurs.

In the liposome-containing skin cosmetic of the present invention, as described above, the membrane component substance is one or more selected from (A) hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated phosphatidylcholine, and hydrogenated phosphatidylserine. , (B) are composed of liquid hydrocarbon, but in order for liposome to exist stably, these two components and (C)
As a result of various investigations, the blending ratio with water was, by weight ratio, (A) component: (B) component: (C) component = 0.1 to 9.5: 0.01.
It is preferable that it is -1.5: 90.5-99.89. In Figure 1,
Triangular coordinates of three components showing preferable compounding ratios for stable existence are shown. It has been confirmed that, in a preferable region indicated by a diagonal line, liposomes are formed and stability is good by measuring the retention rate by a conventional method. If the amount of the specific hydrogenated phospholipid and the liquid hydrocarbon exceeds the above range, the stability of the liposome is deteriorated and precipitation, aggregation, separation, etc. are likely to occur. When the amount of the specific hydrogenated phospholipid is less than the above range, the moisturizing effect and the like of the phospholipid cannot be obtained. Further, when the liquid hydrocarbon is not added, liposomes are obtained, but the cosmetic effect is reduced. That is, when the amount of the liquid hydrocarbon is less than the above range, there is no emollient effect, which is not preferable in achieving the object of the present invention.

The methods usually used for preparing liposomes are: i) removing the organic solvent from the lipid solution and adding water to the prepared lipid film to disperse it. Ii) injecting the lipid solution into water and then removing the organic solvent. iii) A method of simply dispersing a lipid in water and the like can be mentioned, but in obtaining the liposome of the present invention, any of the above-mentioned general methods may be used without any particular limitation.

The liposome-containing skin cosmetic of the present invention is composed of the above essential components and has a transparent to translucent appearance. Normal,
It is necessary to solubilize liquid hydrocarbons stably in an aqueous system by using a large amount of surfactant, or to emulsify when liquid hydrocarbons are large, but when using a surfactant Breaks the liposomes. However, according to the present invention, it has become possible to stably add a liquid hydrocarbon to an aqueous system without impairing the morphology of the liposome.

Furthermore, in the liposome-containing skin cosmetic of the present invention, in addition to the above essential components, moisturizers, ultraviolet absorbers, alcohols, chelating agents, pH adjusters, preservatives, thickeners, pigments that are usually used in cosmetics. , A fragrance, etc. may be appropriately blended within a range not impairing the object of the present invention.

EXAMPLES Next, the present invention will be further described with reference to examples. These do not limit the invention in any way.

Example [1] First, 9 kinds of samples whose formulations are shown in Table 1 were prepared,
The temporal stability was examined by measuring the transmittance and observing the appearance. In the table, the blending amount is parts by weight. The results are shown in Table 2.
Shown in.

(Manufacturing Method) A One kind selected from (1) to (3) and (5) to (13) is heated to 85 ° C. and mixed and dissolved.

Stir and mix while slowly adding (4) to BA.

Cool CB to room temperature.

(Measurement of Transmittance) Transmittance was measured by spectrophotometric UV-160 manufactured by Shimadzu Corporation immediately after the sample preparation and after being left at room temperature for 1 week. The measurement condition was 700 nm.

(Appearance) The state after one week of sample preparation was observed.

◯: Good without change ×: Precipitation / aggregation occurred As is clear from the results in Table 2, the liposome-containing skin cosmetics of the samples containing the liquid hydrocarbon (the present invention).
Has a high transmittance immediately after preparation and after 1 week, and has a transparent to translucent uniform appearance, and has a aging equivalent to or higher than that of cholesterol, which is generally known to stabilize the liposome membrane. The stability was good. On the other hand, samples containing liquid oils other than hydrocarbon oils (comparative products) were in a cloudy state with extremely low transmittance, and creaming, precipitation, aggregation, etc. occurred over time, and stable products could not be obtained. It was

Example [2] Thirteen kinds of samples whose formulations are shown in Table 3 were prepared, and stability with time was examined by the same method as described above.

In the table, the blending amount is parts by weight. The results are shown in Table 3.

(Manufacturing method) A (1) to (2) and (4) to (5) are each 85 ° C.
Heat to mix and dissolve.

Stir and mix while slowly adding (3) to BA.

Cool CB to room temperature.

As shown in Table 3, hydrogenated soybean lecithin, squalane,
As a result of investigating by changing the mixing ratio of water, high transmittance was obtained and stability over time was good only when the ratio of these three components was within the shaded region in FIG. .

Next, in order to confirm the sensory effect of the present invention, a conventional skin cosmetic having a transparent form similar to that of the sample of the present invention (product of the present invention) and the product of the present invention whose formulation is shown later. Using the comparative product, a use test was conducted on a panel of 10 women. The use test was conducted by sensory evaluation, and each of the four items shown in Table 4 was evaluated by 5 grades. The evaluation results are the average of the evaluation points of each panel.

Comparative product (Formulation) (% by weight) (1) Squalane 0.01 (2) Polyoxyethylene monooleate sorbitan (20E.O.) 0.5 (3) Polyoxyethylene hydrogenated castor oil 0.5 (4) Ethyl alcohol 5.0 (5) 1,3-Butylene glycol 15.0 (6) Glycerin 5.0 (7) Sodium alginate 10.0 (1% aqueous solution) (8) Carboxymethylcellulose 10.0 (1% aqueous solution) (9) Purified water residual amount (production method) A (1) to ( 4) is mixed and dissolved.

B (5) to (9) are mixed and dissolved.

Stir mix CA and B.

As is clear from the results in Table 4, the sample liposome-containing skin cosmetics (product of the present invention), when compared with the comparative product, spreads better at the time of use, was more familiar to the skin, and had a mellow yet refreshing feeling. However, it had an excellent feeling of use that remained moist after use and remained moist until the next day.

Further, in order to confirm the organoleptic effect of the liposome-containing skin cosmetic according to the present invention, a wide range of use tests were conducted using the samples. The usage test was conducted by a sensory test by a panel of 141 females, and the eight items shown in Table 5 were evaluated on a 5-point scale. Table 5 shows the evaluation results. The values in the table indicate the number of people evaluated in each rank.

As is clear from the results in Table 5, the liposome-containing skin cosmetic composition of the present invention has not only good stability over time, but also good spreadability and familiarity to the skin during use, no sticky feeling, and a good feeling after use. The moist feeling and moisturizing feeling remained, and the effect was long lasting, and the feeling of use was very excellent.

Example [3] Nutritional lotion (prescription) (% by weight) (1) Hydrogenated soybean lecithin 1.5 (2) Squalane 0.2 (3) Glycerin 5.0 (4) 1,3-butylene glycol 15.0 (5) Methylparaben 0.1 (6) ) Pyrrolidone carboxylic acid 0.01 (7) Sodium pyrrolidone carboxylic acid 0.1 (8) Collagen hydrolyzate 0.01 (9) Perfume 0.01 (10) Purified water residual amount (production method) A (1) to (5), (9) Heat to ℃ to mix and dissolve.

B (6) to (8) are dissolved in (10).

Stir mix while gradually adding CB to A.

Allow DC to cool to room temperature.

The nutritional lotion of Example [3] produced as described above is
Not only the stability over time was good, but also the spreadability and the familiarity with the skin were good, and the product had a moisturizing feeling.

[Effects of the Invention] As described in detail above, in the present invention, the membrane component substance is composed of a specific hydrogenated phospholipid and liquid hydrocarbon, and these 2
By mixing the components and water in a specific ratio, a remarkable effect which has never been obtained is exhibited.

That is, according to the present invention, it is possible to provide a novel liposome-containing skin cosmetic which has a good appearance of transparent to translucent and is extremely excellent in moisturizing and moisturizing feeling while stably blending liposomes. It has become.

[Brief description of drawings]

FIG. 1 shows the compounding ratio of the three components (A) a specific hydrogenated phospholipid, (B) a liquid hydrocarbon, and (C) water, which is preferable for the stable presence of the liposome-containing skin cosmetic according to the present invention. It is a drawing shown.

Claims (1)

[Claims] 1. A membrane component substance comprising (A) one or more selected from hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, hydrogenated phosphatidylcholine and hydrogenated phosphatidylserine, and (B) a liquid hydrocarbon, And the ratio of component (B) to component (A) is 1: 1 by weight.
The following are the mixing ratios of these two components and (C) water in terms of weight ratio: (A) component: (B) component: (C) component = 0.1 to 9.
A liposome-containing skin cosmetic, which is 5: 0.01 to 1.5: 90.5 to 99.89.