JPH0791179B2 - Whitening cosmetics - Google Patents

Description

TECHNICAL FIELD The present invention relates to a whitening cosmetic composition containing a component having a whitening effect on the skin.

[Conventional technology]

Heretofore, arbutin and the like have been known as cosmetic ingredients having a whitening effect and not adversely affecting the skin. However, there is a need for a whitening ingredient that has a greater whitening effect and has no side effects on the skin.

On the other hand, Koboku, which is a dried bark of magnolia bark, is a crude drug described in the Pharmacopoeia and has sedative, muscle relaxant, anticonvulsant, spinal reflex depressant actions, and magnolol and honokiol are reported to have central muscle relaxant action. , Used for medical conditions such as low back pain and colds.

However, there have been no reports of whitening effects for cosmetics.

[Problems to be Solved by the Invention]

An object of the present invention is to provide a whitening cosmetic which is safe for application to the skin and contains a component having a large whitening effect.

[Means for Solving the Problems]

As a result of intensive studies on various plants for a component having a whitening effect, the present inventors have found that magnolol and honokiol contained in the bark of magnolia bark have a tyrosinase activity inhibitory effect, and completed the present invention.

That is, the present invention is (1) a whitening cosmetic containing magnolol and / or honokiol, (2) a whitening cosmetic containing a liquid obtained by extracting bark of the magnolia family Honoki with an organic solvent, and (3) organic Solvents such as methanol, ethanol, ether,
(2) The whitening cosmetic composition according to (2), wherein at least one selected from the group consisting of acetone is used, and (4) the bark of Magnolia obovata is bark of Magnolia obovata. It is a whitening cosmetic.

Koboku, a dried bark of magnolia bark, is a herbal medicine that has been used for a long time and is listed in Shenno Herbal Herbs and Suchu products. It is also a raw material listed in the pharmacopoeia, and there is no problem with safety.

However, it is exclusively used orally and is only used for medical conditions such as abdominal pain and colds.

There are various extraction methods, but it is not necessary to isolate even magnolol or honokiol, and it is acceptable as long as these substances are contained.

The chemical structures of magnolol and honokiol are: [Examples] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

(Test method) 0.9 ml of Mcllvane buffer, 1.0 ml of 1.66 mM Tyrosine solution, and 1.0 ml of sample solution were placed in a screw vial and heated in a 37 ° C constant temperature water bath for 5 minutes or more. 0.1 ml of tyrosinase solution (manufactured by Sigma, mushroom-derived, 914 units / ml) was added, and the mixture was kept warm in a constant temperature water bath at 37 ° C, and after 10 minutes, the absorbance was measured at 475 nm.

As a control, pure water was added instead of the above sample solution, and the same measurement was performed.

〔a formula〕

Tyrosinase activity inhibition rate (%) = {B- (AP)} / B
× 100 However, A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) (Example 1) Lotion lotion ethanol 10% by weight 1,3 Butylene glycol 10% by weight Magnolol 1% by weight % Water 79% by weight (Example 2) A lotion in which magnolol of Example 1 was replaced with honokiol.

(Example 3) A lotion in which the magnolol of Example 1 was replaced with a methanol extract of honoki (dry matter).

(Comparative Example 1) A lotion in which the magnolol of Example 1 was replaced with water. Table 1 shows the tyrosinase activity inhibition rates (%) of magnolol itself, honokiol itself, and Examples 1 to 3 and Comparative Example 1 described above.

(Sensory test) The evaluation results were summarized by having 24 women and 12 men use the above lotion for 2 months.

The evaluation was a five-level evaluation and was described as follows.

The +5 example is much better.

The +4 embodiment is considerably better.

+3 Example is better.

+2 The embodiment is slightly better.

The +1 embodiment is slightly better.

 0 There is no difference.

-1 The comparative example is slightly better.

-2 The comparative example is slightly better.

-3 The comparative example is better.

-4 The comparative example is considerably better.

-5 The comparative example is very good.

All comparisons were made with Comparative Example-1.

The total score is shown in Table 2.

[Effects of the Invention] As is clear from the examples, it includes a liquid extracted with at least one solvent selected from solvents such as methanol, ethanol, ether, and acetone of bark of magnolol or honokiol or honoki of the magnoliaceae family. It has been clarified that the whitening cosmetic has a remarkable effect on the whitening of the skin.

Claims (4)

[Claims] 1. A whitening cosmetic containing magnolol and / or honokiol. 2. A whitening cosmetic containing a liquid obtained by extracting the bark of the magnolia family Honoki genus with an organic solvent. 3. The whitening cosmetic composition according to claim 2, wherein the organic solvent is at least one selected from the group consisting of methanol, ethanol, ether and acetone. 4. The bark of the magnolia family Honoki genus is magnolia (Ma
The whitening cosmetic composition according to claim 2, which is a bark of (gnolia obovata).