JPH0812184B2 - Radioisotope automatic analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial field of application) The present invention relates to an RI automatic analyzer for use in an RI labeled compound analyzer such as an automatic RI (radioisotope) gas analyzer for respiration or an exhaust gas monitor. Regarding the analyzer
In particular, the present invention relates to an analyzer including a chromatograph such as a gas chromatograph or a liquid chromatograph for separating and detecting a sample containing RI, and a radiation detecting unit for detecting radiation in the outflow from this chromatograph.

(Prior Art) Respiratory RI gas containing a labeled compound is synthesized using RI generated by a cyclotron, and then sent to a patient respiratory RI gas supply system.

However, the synthesized RI gas cannot be immediately inhaled by the patient, and it is necessary to analyze whether or not the RI gas is safe to be inhaled by the human body. Therefore, the RI gas synthesized by the synthesizer is passed through the respiratory RI gas automatic analyzer before being sent to the patient respiratory RI gas supply system, and a part thereof is collected and analyzed.

Fig. 4 shows the outline of a conventional automatic RI gas analyzer for respiration equipped with a gas chromatograph and a radiation detector.

The respiratory RI gas automatic analyzer includes a gas chromatograph 2 that separates and detects the collected RI gas, and a radiation detection unit 4 that detects radiation in the outflow gas from the gas chromatograph 2.

In the gas chromatograph 2, the gas separated by the column is detected by, for example, TCD (thermal conductivity detector). That TCD
The detection signal from the computer 6 is cold data.
Sent to

The radiation detection unit 4 includes, for example, a scintillator, a photomultiplier tube, and a multichannel analyzer, and the signal from the multichannel analyzer is sent to the computer 8 as hot data.

As described above, the gas chromatograph 2 and the radiation detection unit 4 are provided with their own computers 6 and 8 for the respective data processing, and the data processing results of the cold data and the hot data are obtained by the printers 10 and 12, respectively. Displayed separately.

(Problems to be solved by the invention) With an automatic RI gas analyzer for breathing, cold data and hot data can be processed quickly, and it can be quickly judged whether or not it is safe to inhale the RI gas into the human body. Are needed.

However, in the conventional automatic RI gas analyzer for respiration, cold data and hot data are collected separately, so data matching is troublesome, and prompt judgment is required in spite of the need for quick judgment. There was the problem of wasting time. In addition, since the half-life of hot data was not corrected, there was a problem in the accuracy of quantitative determination of RI gas concentration.

Also, regarding the analyzer, the operator has to be on during the analysis operation because the operator judges the sampling timing of the sample and the timing of the end of the analysis and operates the buttons.

The present invention includes RI including an automatic RI gas analyzer for breathing.
It is an object of the present invention to make it possible to quickly and accurately determine the result of data processing and to automate the analysis operation in the analyzer handling the above.

(Means for Solving Problems) In the present invention, the control of analysis operation to the processing of cold data and hot data is performed by one computer, and the data processing results are those of cold data and hot data. The quality of the sample can be judged at a glance by displaying it on a printer etc. in a state where they are associated with each other.

That is, to explain with reference to FIG. 1 showing an embodiment, the automatic analyzer of the present invention comprises a chromatograph (2) for separating and detecting a sample containing RI and a effluent from the chromatograph (2). Radiation detector (4a, 4)
b) and an analytical device comprising: a chromatograph (2) for controlling analytical operation, data processing of cold data which is a detection signal of the chromatograph (2), and a radiation detector (4a, 4b). A computer (14) that performs data processing including half-life correction of hot data that is a detection signal is connected, and the radiation detection unit (4a, 4b) is provided with an interface (16).
The radiation detection unit (4
a, 4b) is controlled and the radiation detector (4a, 4b)
Of the data of the chromatograph (2) and the radiation detection section (4a, 4) are transferred to the computer (14).
The data processing result of b) is displayed correspondingly.

(Example) FIG. 1 shows an example in which the present invention is applied to an automatic RI gas analyzer for breathing.

Represented by the symbol 20 and surrounded by the one-dot chain line is for breathing
RI gas automatic analyzer, the equipment part surrounded by the chain double-dashed line
22 and a data processing unit 24 other than that.

The gas chromatograph 2 and the radiation detector 4a are provided in the equipment section 22.
And a sampler valve 26 is provided.

Helium gas is supplied from the gas cylinder 26 to the column 2a of the gas chromatograph 2 as a carrier gas. The RI gas synthesized by the labeling compound synthesizer 30 using the RI generated by the cyclotron 28 is sent to the patient breathing RI gas supply system 32 via the sampler valve 26. The sampler valve 26 is driven by the helium gas supplied from the gas cylinder 26 via the pressure regulating valve 34 as a power source, and the computer via the relay box 36.
It operates by the control signal from 14, and RI gas is sampled and supplied to the column 2a of the gas chromatograph 2.

In the gas chromatograph 2, the outflow gas from the column 2a is detected by the TCD 2b, and the detection signal is sent to the computer 14 via the relay box 36. When the column is changed in the gas chromatograph 2, the change of the analysis flow path is sent via the relay box 36 to the computer 14.
It is controlled by a control signal from.

Outflow gas emitted from the TCD 2b of the gas chromatograph 2 is guided to the radiation detection unit 4a. The radiation detector 4a is provided with a scintillator that receives RI radiation in the outflow gas, and a photomultiplier tube that detects the light emission of the scintillator,
The signal of the photomultiplier tube is a multi-channel analyzer.
Sent to 4b. The outflow gas that has passed through the radiation detection unit 4a is discharged.

The radiation detector 4a and the multi-channel analyzer 4b form a radiation detection unit.

The data processing unit 24 is provided with a computer 14, a multi-channel analyzer 4b and a relay box 36.

The computer 14 is connected with interfaces 14a and 14b for exchanging signals and data, and an interface 14c.
The printer 38 is connected via.

Interface 16 for multichannel analyzer 4b
Are connected, and control signals and data are exchanged with the computer 14 via the interface 16.

Computer 14 is a sampler valve associated with the start of analysis
26 drive control, multi-channel analyzer 4b control,
Change of analysis channel of gas chromatograph 2, processing of cold data from gas chromatograph 2, multi-channel /
Programs are provided to perform operations such as hot data processing from the analyzer 4b, matching of cold data processing results and hot data processing results, and output to the printer 38.

40 is an external computer, which supplies an analysis start timing signal to the computer 14 and
Enter and store 14 analysis results.

 The operation of this embodiment will be described with reference to FIG.

The entire apparatus is turned on and the computer 14 starts the automatic analysis program (steps S1 and S2).

The analysis condition and date are input to the computer 14 (step S3).

Computer 14 with multi-channel analyzer 4b
Is activated and the background of radioactivity is measured (step S4).

Gas chromatograph 2 is stabilized, external computer
When the analysis start signal is input from 40, the analysis is started (steps S5 and S6).

When the analysis is started, the following operations are automatically performed. First, the sampler valve 26 is driven to collect, for example, 2 cc of RI gas, and among the columns of the gas chromatograph 2,
The collected RI into the column corresponding to the input analysis conditions
Supply gas. At the same time as the RI gas is supplied to the gas chromatograph 2, the computer 14 starts collecting the data of the gas chromatograph 2 and stores it in real time. Further, the multi-channel analyzer 4b receives a start signal from the computer 14 at the same time as the start of analysis, clears old data, and then stores hot data in the multi-channel analyzer 4b in real time (step S7).

When the analysis time corresponding to the input analysis condition has elapsed, the collection of both cold data and hot data is stopped (steps S8, S9).

After that, the computer 14 processes the cold data of the gas chromatograph 2 by the existing program to calculate the peak integration and the area ratio (step S10).

Next, the hot data is sent to the multi-channel analyzer 4b.
To the computer 14 (step S11). The computer 14 subtracts the background from the hot data, performs half-life correction, and performs data processing such as peak integration and area ratio calculation (step S12).

When the hot data processing is completed, the cold data processing result and the hot data data processing result are associated and output by the printer 38 (step S13). At this time, raw data of cold data and hot data may be output together.

FIG. 3 shows the processing result of the cold data and the processing result of the hot data output by the printer 38. In the graph, C represents the result of cold data, H represents the result of hot data, and the horizontal axis represents time.

 Here, the half-life correction will be described.

The half-life is the time until the number of radioactive isotopes decays to halve. If the half-life is T, the number of radioisotopes initially present (t = 0) is N ₀ , and the number of radioisotopes after time t is N, then N = N ₀ (1/2) ^{t / T} It can be expressed as (1) (see “Detailed description of radiation handling technology (revised version)”, published by Japan Atomic Energy Industry Council (1983)).

Half-life correction is the correction of the number of radioisotopes reduced by decay to the number of radioisotopes if there was no decay, using half-life.

Specifically, in a radio gas chromatograph or a radio liquid chromatograph, the amount of radiation such as γ-rays is counted every fixed time (for example, every 10 seconds). Was detected a sample labeled with a radioactive isotope half-life T for a time t ₁ ~t _5, as shown in FIG. 5, the histogram is obtained detected intensity at each time is C ₁ -C ₅ Suppose

The integrated intensity I of this peak is the sum of the detected intensities C _{1 to} C ₅ at each time without half-life correction, Is represented.

The detection intensities C _{01 to} C ₀₅ at each time after half-life correction are
From equation (1), Ci = C ₀ i (1/2) ^{t / T} (3), so the integrated intensity I ′ of this peak after half-life correction
Is Becomes

(Effects of the Invention) In the device of the present invention, since the processing result of cold data and the processing result of hot data including half-life correction are displayed in correspondence with each other, there is no difficulty in matching the two data. The degree of impurities in the gas can be quickly and accurately determined.

Further, since the analyzer is automatically operated, it is not necessary for the operator to constantly monitor the device.

[Brief description of drawings]

FIG. 1 is a block diagram showing an embodiment, FIG. 2 is a flow chart showing the operation of the embodiment, FIG. 3 is a view showing an output example of the embodiment, and FIG. 4 is a conventional RI gas for breathing. It is a block diagram which shows the outline of an automatic analyzer. FIG. 5 schematically shows a chromatogram obtained by a radio gas chromatograph or a radio liquid chromatograph. 2 ... Gas chromatograph, 4a ... Radiation detector, 4b ...
… Multi-channel analyzer, 14… Computer,
16 …… Interface.

Claims (1)

[Claims] 1. An analyzer equipped with a chromatograph for separating and detecting a sample containing a radioisotope, and a radiation detecting section for detecting radiation in the effluent from this chromatograph, wherein the chromatograph is analyzed. A computer for performing operation control, data processing of the detection signal of the chromatograph, and data processing including half-life correction of the detection signal of the radiation detection unit is connected, and the radiation detection unit is provided with an interface. While controlling the radiation detection unit by the computer via the, the data of the radiation detection unit is transferred to the computer, the processing result of the data of the chromatograph and the processing result of the data of the radiation detection unit are made to correspond to each other. An automatic analyzer for radioisotopes characterized by displaying.