JPH0813734B2 - Cosmetic composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to a cosmetic composition in which irritation to the skin and mucous membranes is suppressed by incorporating a mixture of α-, β- and γ-cyclodextrin.

[Prior Art and its Problems] Perfume is an important component that gives cosmetics a good feeling of use and influences the commercial value. In addition, the action of covering the base odor of other components, a slight bacteriostatic effect, It also has a preservative effect, and its formulation is essential for cosmetics. Further, the surfactant is necessary when emulsifying cosmetics.

When using cosmetics, there is no problem as long as the compounded fragrance or surfactant (hereinafter referred to as fragrance) simply adheres to the skin or mucous membranes, but if absorbed into the skin, it will be acute due to its irritation. It causes side effects such as chronic primary irritant dermatitis, phototoxicity, allergic or photoallergic dermatitis, and pigment abnormalities. Therefore, the fragrance and the like to be added to cosmetics must be carefully studied for their safety, but there are large individual differences in the properties of the skin, and skin irritation may occur depending on the user.

To solve this problem, Japanese Patent Publication No. 59-10323 discloses
Β-cyclodextrin is blended with cosmetics, and the perfume ingredients are combined with skin cells before they are stimulated by reacting with them,
Cosmetics in which a reaction between a fragrance ingredient and skin cells is prevented are disclosed. However, β-cyclodextrin has low solubility in cosmetics and its irritation-relieving effect is not sufficient. Separately, it has also been proposed to use methylated cyclodextrin in cosmetics (Japanese Patent Laid-Open No. 62-62-62).
No. 62897) is very expensive because it is chemically modified.

An object of the present invention is to provide a cosmetic composition which is less irritating to the skin and has high safety.

The present inventors have made various studies on such problems, and surprisingly, a mixture of α, β and γ-cyclodextrin (mixed dextrin) is unexpectedly dissolved in cosmetics at a higher concentration than in the case of β-cyclodextrin alone. The present invention has been completed based on the finding that it is possible.

[Means for Solving the Problems] The present invention provides a cosmetic containing a fragrance and a surfactant, wherein 50 to 80% by weight of α-cyclodextrin, 15 to 45% by weight of β-cyclodextrin and 5 to γ-cyclodextrin are contained. Α-, β- and γ- with a composition ratio of 20% by weight
Disclosed is a cosmetic composition containing 0.05 to 10% by weight of a cyclodextrin mixture, which suppresses skin and mucous membrane irritation.

The mixed cyclodextrin used in the present invention is 6
-8 glucose (glucose) molecules are non-reducing maltooligosaccharides in which α-1,4-glucoside bonds are linked in a ring, and a cyclodextrin-forming enzyme produced by a microorganism of the genus Bacillus sp. Cyclomylos Gluca
It is obtained by acting notransferase) on starch. As the mixed cyclodextrin, α-cyclodextrin 50 to 80% by weight, β-cyclodextrin 15 to
Those containing 45% by weight and 5 to 20% by weight of γ-cyclodextrin are particularly preferred. Such a mixed dextrin has a significantly higher solubility in cosmetics than conventionally-used β-cyclodextrin, and irritation of the cosmetics to the skin is greatly suppressed. If the blending ratio of α-, β-, and γ-dextrin in the mixed cyclodextrin is out of the above range, the solubility in cosmetics is low and the effect of suppressing skin irritation is reduced.

The results of examining the solubility of the cyclodextrin used in the present invention in water are shown in FIG. As is clear from FIG. 1, each cyclodextrin of α-cyclodextrin (α-CD), β-cyclodextrin (β-CD) and γ-cyclodextrin (γ-CD) in the practical temperature range of 10 to 30 ° C. The solubility of mixed dextrins (mixed CD; α: 60%, β: 30%, γ: 10%) is much higher than that of the single substances.

β-Cyclodextrin has low water solubility, and the benzene ring is stably included, but it is unstable when a fatty acid is included. However, by combining α, β, γ-cyclodextrin, the solubility is synergistically improved as compared with the case of alone, and as a result, it becomes possible to include a wider range of stimulants, It is estimated that the irritation suppression effect was significantly improved.

The cosmetics of the present invention include, for example, toothpaste, creams,
Known cosmetics such as lotions, soaps, shampoos and emulsions are included.

Cyclodextrin content in cosmetics is 0.05-10%
Is. If the blending amount is less than 0.05%, there is no irritation suppressing effect, and if the blending amount exceeds 10%, the effect is the same.

Various known components may be blended in the cosmetic of the present invention depending on the type.

In order to produce the cosmetic of the present invention, cyclodextrin is dissolved in water, a fragrance is added to this, a well-mixed solution is prepared, and other components are blended according to a conventional method.

Since the cosmetics of the present invention do not need to reduce the compounding ratio of a fragrance or a surfactant in order to suppress the irritation of the skin and mucous membranes as in the conventional case, the commercial value, the effect and the stability are not impaired, and the product character, It can be fully characterized and used, and its irritation-suppressing effect is high.

EXAMPLES Next, the present invention will be described more specifically based on Examples and Comparative Examples. In the examples and comparative examples, the blending amount is% by weight.

Example 1 (Facial cleansing cream (cleansing foam)) A facial cleansing cream was prepared according to a conventional method according to the following formulation.

Ingredients Amount Stearic acid 20.0 Palmitic acid 10.0 Myristic acid 12.0 Lauric acid 4.0 Oleyl alcohol 4.0 Polyoxyethylene reduced lanolin 2.0 Fragrance 0.8 Methyl paraoxybenzoate 0.2 Concentrated glycerin 18.0 Potassium hydroxide 7.0 α, β, γ-Cyclodextrin mixture (α : 60%, β: 30%, γ: 10%) 2.0 Purified water balance 100 A cleansing foam of Example 1 was subjected to an eye mucous membrane irritation test using each sample in which the fragrance was changed. The test was performed by using three Japanese white rabbit females each having an optometry and having a defect-free weight of 2,200 to 2,800 g, and 0.1 ml of the sample was injected into one eye so that the surface of the eyeball was sufficiently acted. The eyes of each rabbit without injection were used as controls, and the eyes were examined with a hand slit lamp one, two, and three days after injection, and the Draise [Draise,
JH "APPRISAL OF THE SAFETY OF CHEMICALS IN FOOD
S, DRUGS AND COSMETICS '', ASSOCIATION OF FDA OFFICI
ALS OF US, p. 51 (1959)] was used to evaluate the degree of irritation.

Highly stimulating cinnamic aldehyde and rose oil, which is usually irritating, were used as the fragrance. The results are shown in Table 1.

As shown in Table 1, it can be seen that the stimulus of the fragrance is completely suppressed by blending the cyclodextrin mixture.

Example 2 (Shampoo) Composition Blend amount Alkyl sulfate triethanolamine (35%) 40. Coconut oil fatty acid diethanolamide 6.0 Sodium benzoate 0.1 Methyl paraoxybenzoate 0.2 l-Menthol 0.4 Perfume 0.3 α, β, γ-cyclo Dextrin mixture (α: 60%, β: 30%, γ: 10%) 2.0 Purified water balance 100 Example 3 (cream) Component content Squalane 6.0 Liquid paraffin 5.0 Solid paraffin 2.0 Olive oil 3.0 Stearic acid 2.0 Parent Oil type glyceryl monostearate 2.5 Polyoxyethylene sorbitan monostearate (20E.
O.) 1.5 Triethanolamine 0.5 Polyethylene glycol 400 5.0 Methyl paraoxybenzoate 0.3 Propyl paraoxybenzoate 0.1 α, β, γ-Cyclodextrin mixture (α: 60%, β: 30%, γ: 10%) 2.0 Fragrance 0.2 Purified water Residual total 100 A human patch test was conducted using the obtained cream. The test was carried out by applying about 0.05 g of each sample to the lint cloth of the test plaster and applying the blockage to the inner part of the upper arm of 20 adult males for 48 hours. After removing the plaster, the residual sample on the epidermis is removed with 70% alcohol-impregnated absorbent cotton, and 30 minutes after the removal, the applied part is visually inspected to determine the degree of irritation according to the following criteria, and skin damage based on the following formula. An index (score) was calculated.

-: No change ±: Unclear erythema +: Clear erythema ++: Erythema and edema However, N-, N ±, N +, and N ++ are judgment −, ±, and
The numbers are + and ++.

As the fragrance, the same cinnamic aldehyde and rose oil as in Example 1 were used. The results are shown in Table 2.

As shown in Table 2, it can be seen that the cream containing the α, β, γ-cyclodextrin mixture (Sample Nos. 8 and 10) suppresses the stimulation of the fragrance.

Example 4 (Toner lotion) Composition Blend amount Denatured alcohol 11.0 Polyoxyethylene hydrogenated castor oil (40E.O.) 0.4 Perfume 0.2 Ethyl paraoxybenzoate 0.1 1,3-butylene glycol 5.0 α, β, γ-Cyclodextrin Mixture (α: 60%, β: 30%, γ: 10%) 1.0 Purified water balance 100 Example 5 (rinse) Component content Polyoxyethylene (20E.O.) oleyl ether 0.4 Stearyltrimethylammonium chloride 4.0 Cetanol 2.5 2-Octyldodecanol 1.0 1,3-butylene glycol 2.0 Methyl paraoxybenzoate 0.1 Citric acid 0.1 α, β, γ-Cyclodextrin mixture (α: 60%, β: 30%, γ: 10%) 1.0 Purified water Residual 100 Total Example 6 (Hairtonic) Component Content Polyoxyethylene hydrogenated castor oil (40E.O.) 0.5 Denatured alcohol 55.0 Benzyl nicotinate 0.005 Salicylic acid 0.2 para Methyl xybenzoate 0.1 Fragrance 0.4 l-Metol 0.1 1,3-butylene glycol 2.0 Dipotassium glycyrrhizinate 0.2 α, β, γ-Cyclodextrin mixture (α: 60%, β: 30%, γ: 10%) 2.5 Purification Water balance 100 Total The obtained hair tonic did not generate any precipitate or cloud even after left at -5 ° C for 1 month.

In addition, 7 types of hair tonics were prepared with the same composition except that the blending amounts of the α-, β-, and γ-cyclodextrin mixtures were changed to 0.01, 0.05, 0.1, 0.5, 1.0, 1.5, and 2.0% by weight, respectively. Similarly, when it was allowed to stand for 1 month at -5 ° C, 0.01 wt% of the product caused precipitation, and the skin irritation was also poorly evaluated.

Further, a cosmetic was prepared with the same composition except that the mixed cyclodextrin in Example 6 was changed to 100% of α-, β-, and γ-cyclodextrin, respectively. When evaluated by the above-mentioned evaluation methods, in all cases, clouding and precipitation occurred when left at -5 ° C, and the evaluation of skin irritation was also poor.

Example 7 (Peel-off pack) Component Blending amount Polyvinyl alcohol 14.0 Ethanol 13.0 Propylene glycol 5.0 Polyoxyethylene hydrogenated castor oil (60E.O.) 0.7 Fragrance 0.2 α, β, γ-cyclodextrin mixture (α: 60%, β: 30%, γ: 10%) 2.5 Purified water balance 100 [Effect of the invention] According to the present invention, a cosmetic which is less irritating to the skin without reducing the blending amount of the fragrance or the surfactant is provided. It is obtained and has high commercial value and excellent stability.

[Brief description of drawings]

FIG. 1 is a graph showing the solubility of cyclodextrin. FIG. 2 is a graph showing the difference between the cream base and the irritancy of each sample.

Claims (1)

[Claims] 1. In a cosmetic containing a fragrance and a surfactant, the composition ratio of α-cyclodextrin of 50 to 80% by weight, β-cyclodextrin of 15 to 45% by weight and γ-cyclodextrin of 5 to 20% by weight is used. A cosmetic composition which suppresses skin and mucous membrane irritation, characterized in that 0.05 to 10% by weight of the α-, β- and γ-cyclodextrin mixture is blended.