JPH085776B2 - Method for producing enzyme-containing facial cleansing powder - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The present invention relates to a method for producing an enzyme-containing facial cleansing powder.

(B) Conventional technology Conventionally, as the enzyme of the facial cleansing powder containing the enzyme, a proteolytic enzyme of plant origin such as papain has been used alone.

(C) Problems to be solved by the invention However, such an enzyme alone has a weak proteolytic action, and the purpose of the enzyme is to sufficiently clean dirt such as proteins clogged in pores and keratinized skin. It was difficult.

Further, there is a problem that the face-washing powder itself is apt to take moisture, and this moisture hinders the stabilization of the enzyme, and the proteolytic action and the like decrease over time. In addition, since talc is used as the base material, it has a rough texture during use and is uncomfortable to use.

An object of the present invention is to provide a method for producing a face-washing powder that can solve such problems.

(D) Means for Solving the Problems In the present invention, when a surfactant, an enzyme of microbial origin as an enzyme component, and an enzyme of plant origin are mixed in the base of a facial cleansing powder, The present invention relates to a method for producing an enzyme-containing facial cleansing powder, which is characterized in that at least one of the above is granulated.

The enzymes of microbial origin are Bacillus subtilis, Aspergillus,
An enzyme having a proteolytic action and the like obtained from actinomycetes and the like.

The enzyme of plant origin refers to an enzyme having a proteolytic action, a lipolytic action, a starch decomposing action, etc. obtained from papain, bromelain, ficin, soybean, malt and the like.

In the present invention, at least one kind of each of the above-mentioned enzymes is granulated to prevent a significant decrease in enzyme activity due to a reaction between different kinds of enzymes in the base of the face-washing powder.

As the method for granulating the enzyme, various forms are conceivable, and there are extrusion granulation, tumbling granulation, briquetting, and the like, but from the viewpoint of granulation of the enzyme, the activity decrease due to the granulation step. An extrusion-type granulation method is desirable in consideration of prevention and compounding stability.

Mass production of granules in the extrusion granulation can be carried out by a wet granulation method which is carried out in the steps of powder → mixing → hydrogenation → granulation → drying → sieving.

In addition, both such microbial and plant-derived enzymes also have anti-inflammatory effects.

Furthermore, the base itself of the face-washing powder in the present invention is
It is well known as the base of facial cleansing powder,
Corn starch, talc, sodium lauryl sulfate, N
-A component such as sodium lauroyl-L-glutamate, allantoin, yochinin oil, and a fragrance is used in an appropriate combination.

Further, it is possible to mix sodium polyacrylate, mix vitamins such as vitamin C and vitamin E, or mix crude powders such as pearl syrup, senkyu, spruce, peony and crude drug extracts such as psyllium extract and various plant extracts. .

(E) Action and effect Since the enzyme of microbial origin and the enzyme of plant origin are different in the bands showing the highest values in the activity rates with respect to pH and temperature, respectively, the band showing the highest value is obtained by their cooperation. Therefore, it is possible to maintain a high cleaning action by the enzyme regardless of the difference in water quality and the difference in use temperature.

In addition, since at least one or more kinds of enzymes of microbial origin and plant origin are granulated, it is possible to prevent a decrease in enzyme activity due to a contact reaction between enzymes of different origins. The effect can be maintained for a long time.

Furthermore, by blending sodium polyacrylate, smooth foaming can be realized at the time of use, and the roughness due to talc or the like can be mitigated to improve the feeling of use.

(F) Example Hereinafter, a method for producing the enzyme-containing facial cleansing powder according to the present invention will be described in detail based on Comparative Examples and Examples.

[First Comparative Example] First, ASP protease (5
10,000 units / g) and the plant-derived enzyme papain (30,000 units / g) are mixed with the bases such as talc, corn starch, sodium lauryl sulfate, allantoin, and yochinin oil with stirring, and the mixture is used as a fragrance. To make Comparative Product 1.

[First Example] The face-washing powder according to this example is formed by granulating at least one of an enzyme of microbial origin and an enzyme of plant origin in order to stabilize the enzyme.

In Table 1 above, Comparative product 1 is a case where both the enzyme of microbial origin and the enzyme of plant origin are not granulated, and the invention product 1 is a case where only the enzyme of plant origin is granulated. The product 2 is a case where only the enzyme of microbial origin is granulated, and the invention product 3 is a case where both the enzyme of plant origin and the enzyme of microbial origin are granulated.

Such face-washing powder (Invention products 1 to 3 and Comparative product 1)
Also, it is manufactured by the same process as in the first embodiment.

In addition, the residual activity ratios of the enzymes contained in the invention products 1 to 3 and the comparative product 1 were examined when the room temperature (20 ° C to 27 ° C) and the storage temperature 40 ° C were used in a room that was not a thermostatic chamber, and the results were obtained. Is shown in the graphs of FIG. 1 and FIG.

As is clear from FIG. 1, after 100 days of storage at room temperature, the residual activity ratio of the facial cleansing powder (Comparative Product 1) in which neither the plant-derived enzyme nor the microbial-derived enzyme was granulated was 22. %, Whereas those granulated with either enzyme (invention products 1 and 2) had 72% and
The residual activity rate of 42% is shown, and the granulated product of both enzymes (Invention Product 3) shows a residual activity rate of 95%.

Further, as is clear from FIG. 2, the facial cleansing powder (Comparative Product 1) in which neither the plant-derived enzyme nor the microbial-derived enzyme had been granulated after storage at 40 ° C. remained after 70 days. Whereas the activity rate is zero, the facial cleansing powder (invention products 1 and 2) granulated with one of the enzymes
After 100 days, the residual activity rate was 34% and 17%, respectively.
%, And the facial cleansing powder (invention product 3) in which both enzymes were granulated showed a residual activity rate of 66% after 100 days. Thus, the product of the present invention, by granulating at least one of the enzyme,
The high activity of the enzyme can be retained at both room temperature and 40 ° C.

[Second Example and Second Comparative Example] A stabilization test of an enzyme by granulation similar to that of the first example was carried out by using bromelain (30,000 units / g) as an enzyme of plant origin.
Was performed on the face-washing powder (Invention Products 4 to 6 and Comparative Product 2) in which actinomycete protease (50,000 units / g) was mixed as an enzyme of microbial origin.

The composition of components of such face-washing powder is shown in Table 2, and the test results are shown in FIGS. 3 and 4. Comparative product 2 in Table 2 is a comparative product in which neither enzyme was granulated.

As is apparent from FIGS. 3 and 4, this embodiment also
It is shown that the high activity of the enzyme can be retained at both room temperature and 40 ° C. by granulating the enzyme of plant origin and / or microbial origin.

[Third Example and Third Comparative Example] Further, regarding the invention products 1 to 3 and the comparative product 1, the amount of the enzyme further contained was measured.

The tyrosin-fluorin method was used as the measuring method, and 1 μg of thyrozine equivalent amount of phosphorin per minute was defined as 1 protease unit.

 The results are shown in Table 3.

As is clear from Table 3, only the total titer of the comparative product 1 in which neither the plant-derived enzyme nor the microbial-derived enzyme was granulated, but the enzyme component was the same as the other components. Since it is a dosage form, pretreatment for activity measurement was not possible, and it was not possible to measure what kind of enzyme and what amount of activity was contained. That is, it was impossible to separate and quantify the comparative product 1.

On the other hand, with regard to Inventions 1 to 3, since at least one of the enzyme of plant origin and the enzyme of microbial origin was granulated, respectively, it is possible to accurately separate and quantify how much these enzymes are contained. it can.

This makes it possible to demonstrate that multiple enzymes are contained and how much their activity is,
It is possible to give the user a sense of security. [Fourth Example and Fourth Comparative Example] The amount of enzyme in the third example was also measured for Comparative Product 2 and Invention Products 4 to 6 in the second Example, and the results are shown in Table 4.

Also in this example, the face-washing powder according to the present invention can clearly show that a plurality of enzymes are contained and how much their active amount is, and give the user a sense of security. it can.

[Brief description of drawings]

FIG. 1 and FIG. 2 are graphs showing the residual activity rate of the enzyme in the face-washing powder at room temperature and 40 ° C. of the first example and the first comparative example, and FIGS. 3 and 4 are the second example. And the second
It is a graph which shows the residual activity rate of the enzyme in the face-washing powder at room temperature and 40 ° C of Comparative Example.

Claims (1)

[Claims] 1. When a surfactant, an enzyme of microbial origin as an enzyme component, and an enzyme of plant origin are mixed in a base of a facial cleansing powder, at least one or more of the enzyme components are granulated. A method for producing a facial cleansing powder containing an enzyme, which comprises: