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MX350862B - Acidos de piperidinil naftilacetico. - Google Patents
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MX350862B - Acidos de piperidinil naftilacetico. - Google Patents

Acidos de piperidinil naftilacetico.

Info

Publication number
MX350862B
MX350862B MX2014006468A MX2014006468A MX350862B MX 350862 B MX350862 B MX 350862B MX 2014006468 A MX2014006468 A MX 2014006468A MX 2014006468 A MX2014006468 A MX 2014006468A MX 350862 B MX350862 B MX 350862B
Authority
MX
Mexico
Prior art keywords
compounds
formula
piperidinyl
naphthylacetic acids
receptor
Prior art date
Application number
MX2014006468A
Other languages
English (en)
Other versions
MX2014006468A (es
Inventor
So Sung-Sau
Lin Tai-An
Sidduri Achyutharao
Firooznia Fariborz
Mertz Eric
Wright Tilley Jefferson
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014006468A publication Critical patent/MX2014006468A/es
Publication of MX350862B publication Critical patent/MX350862B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a los compuestos de fórmula (I): y sales farmacéuticamente aceptables de los mismos, en la que R1, R2, R3 y X son definidos en la descripción detallada y las reivindicaciones. Además, la presente invención se refiere a métodos de fabricación y uso de los compuestos de fórmula (I), así como composiciones farmacéuticas que contienen tales compuestos. Los compuestos de fórmula (I) son antagonistas o agonistas parciales en el receptor CRTH2 y pueden ser útiles en el tratamiento de enfermedades y trastornos asociados con ese receptor, tales como asma.
MX2014006468A 2011-12-12 2012-12-10 Acidos de piperidinil naftilacetico. MX350862B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161569313P 2011-12-12 2011-12-12
PCT/EP2012/074882 WO2013087544A1 (en) 2011-12-12 2012-12-10 Piperidinyl naphthylacetic acids

Publications (2)

Publication Number Publication Date
MX2014006468A MX2014006468A (es) 2014-09-01
MX350862B true MX350862B (es) 2017-09-19

Family

ID=47427287

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006468A MX350862B (es) 2011-12-12 2012-12-10 Acidos de piperidinil naftilacetico.

Country Status (10)

Country Link
US (1) US8691993B2 (es)
EP (1) EP2791111B1 (es)
JP (1) JP6154397B2 (es)
KR (1) KR20140103319A (es)
CN (1) CN103958468B (es)
BR (1) BR112014013958A8 (es)
CA (1) CA2855940A1 (es)
MX (1) MX350862B (es)
RU (1) RU2628083C2 (es)
WO (1) WO2013087544A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201331179A (zh) 2011-12-21 2013-08-01 Actelion Pharmaceuticals Ltd 雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途
CA2876808A1 (en) 2012-07-05 2014-01-09 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
US9494035B2 (en) 2012-11-06 2016-11-15 Evolution Engineering Inc. Fluid pressure pulse generator and method of using same
US10753201B2 (en) 2012-12-17 2020-08-25 Evolution Engineering Inc. Mud pulse telemetry apparatus with a pressure transducer and method of operating same
US9714569B2 (en) 2012-12-17 2017-07-25 Evolution Engineering Inc. Mud pulse telemetry apparatus with a pressure transducer and method of operating same
US9574441B2 (en) 2012-12-17 2017-02-21 Evolution Engineering Inc. Downhole telemetry signal modulation using pressure pulses of multiple pulse heights
CA2895681A1 (en) 2014-06-27 2015-12-27 Evolution Engineering Inc. Fluid pressure pulse generator for a downhole telemetry tool
CA2895680A1 (en) 2014-06-27 2015-12-27 Evolution Engineering Inc. Fluid pressure pulse generator for a downhole telemetry tool
US9670774B2 (en) 2014-06-27 2017-06-06 Evolution Engineering Inc. Fluid pressure pulse generator for a downhole telemetry tool
US12060310B2 (en) * 2018-06-29 2024-08-13 Ergon Pharmaceuticals Llc Compositions and methods of using itaconic acid derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
WO2006091674A1 (en) * 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
EP2407459A1 (en) * 2005-09-27 2012-01-18 Shionogi & Co., Ltd. Synthetic intermediate in the production of a sulfonamide derivative having PGD2 receptor antagonistic activity
WO2007146838A2 (en) * 2006-06-09 2007-12-21 Icos Corporation Substituted phenyl acetic acids as dp-2 antagonists
US20110190336A1 (en) * 2008-10-16 2011-08-04 Cara Therapeutics, Inc. Azabenzimidazolones
US8621184B1 (en) 2008-10-31 2013-12-31 Netapp, Inc. Effective scheduling of producer-consumer processes in a multi-processor system
BRPI0921038A2 (pt) * 2008-11-17 2019-09-24 Hoffmann La Roche ácido naftilacéticos
CN102216273A (zh) * 2008-11-17 2011-10-12 霍夫曼-拉罗奇有限公司 用作crth2拮抗剂或部分激动剂的萘乙酸

Also Published As

Publication number Publication date
EP2791111B1 (en) 2017-01-18
EP2791111A1 (en) 2014-10-22
JP2015504863A (ja) 2015-02-16
HK1200453A1 (en) 2015-08-07
BR112014013958A2 (pt) 2017-06-13
WO2013087544A1 (en) 2013-06-20
KR20140103319A (ko) 2014-08-26
RU2014127143A (ru) 2016-02-10
CN103958468B (zh) 2017-03-01
US20130150407A1 (en) 2013-06-13
BR112014013958A8 (pt) 2017-06-13
JP6154397B2 (ja) 2017-06-28
US8691993B2 (en) 2014-04-08
CN103958468A (zh) 2014-07-30
RU2628083C2 (ru) 2017-08-14
CA2855940A1 (en) 2013-06-20
MX2014006468A (es) 2014-09-01

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