MA33589B1 - Dérivé d'hétérocycle condensé et son utilisation - Google Patents
Dérivé d'hétérocycle condensé et son utilisationInfo
- Publication number
- MA33589B1 MA33589B1 MA34695A MA34695A MA33589B1 MA 33589 B1 MA33589 B1 MA 33589B1 MA 34695 A MA34695 A MA 34695A MA 34695 A MA34695 A MA 34695A MA 33589 B1 MA33589 B1 MA 33589B1
- Authority
- MA
- Morocco
- Prior art keywords
- condensed heterocycle
- heterocycle derivative
- smo
- derivative
- condensed
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE UN DÉRIVÉ D'HÉTÉROCYCLE CONDENSÉ POSSÉDANT UNE PUISSANTE ACTIVITÉ D'INHIBITION DE SMO ; ET L'UTILISATION DU DÉRIVÉ D'HÉTÉROCYCLE CONDENSÉ. L'INVENTION CONCERNE SPÉCIFIQUEMENT UN COMPOSÉ REPRÉSENTÉ PAR LA FORMULE (CI) [DANS LAQUELLE CHAQUE SYMBOLE EST TEL QUE DÉFINI DANS LA DESCRIPTION] OU L'UN DE SES SELS ; ET UN MÉDICAMENT COMPRENANT LE COMPOSÉ OU L'UN DE SES PRÉCURSEURS, QUI PEUT ÊTRE UTILISÉ EN TANT QU'INHIBITEUR DE SMO OU EN TANT QU'AGENT PROPHYLACTIQUE OU THÉRAPEUTIQUE POUR LE CANCER.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009195770 | 2009-08-26 | ||
| JP2010015644 | 2010-01-27 | ||
| PCT/JP2010/064413 WO2011024872A1 (fr) | 2009-08-26 | 2010-08-25 | Dérivé d'hétérocycle condensé et son utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33589B1 true MA33589B1 (fr) | 2012-09-01 |
Family
ID=43627972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34695A MA33589B1 (fr) | 2009-08-26 | 2012-03-16 | Dérivé d'hétérocycle condensé et son utilisation |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8907089B2 (fr) |
| EP (1) | EP2471790B1 (fr) |
| JP (1) | JP5599802B2 (fr) |
| KR (1) | KR20120078703A (fr) |
| CN (1) | CN102574851A (fr) |
| AU (1) | AU2010287492A1 (fr) |
| BR (1) | BR112012004134A2 (fr) |
| CA (1) | CA2771833A1 (fr) |
| CL (1) | CL2012000461A1 (fr) |
| CR (1) | CR20120095A (fr) |
| DO (1) | DOP2012000048A (fr) |
| EA (1) | EA201270311A1 (fr) |
| EC (1) | ECSP12011747A (fr) |
| GE (1) | GEP20146075B (fr) |
| IL (1) | IL218323A0 (fr) |
| IN (1) | IN2012DN02069A (fr) |
| MA (1) | MA33589B1 (fr) |
| MX (1) | MX2012002419A (fr) |
| NZ (1) | NZ598749A (fr) |
| PE (1) | PE20121326A1 (fr) |
| SG (1) | SG178504A1 (fr) |
| TN (1) | TN2012000084A1 (fr) |
| WO (1) | WO2011024872A1 (fr) |
| ZA (1) | ZA201201795B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8614208B2 (en) * | 2009-08-26 | 2013-12-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring derivative and use thereof |
| US9670221B2 (en) | 2013-03-14 | 2017-06-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Furopyridines as bromodomain inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436965B1 (en) | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
| EP1310488A4 (fr) | 2000-08-09 | 2005-08-10 | Mitsubishi Pharma Corp | Composes amide bicycliques condenses et utilisations medicales associees |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| EP1465869B1 (fr) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulateurs de lxr |
| WO2004020599A2 (fr) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Antagonistes de la voie hedgehog, methodes et applications correspondantes |
| WO2005033288A2 (fr) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Antagonistes de la voie hedgehog |
| US20050203081A1 (en) | 2004-02-25 | 2005-09-15 | Jinbo Lee | Inhibitors of protein tyrosine phosphatase 1B |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| US20080194637A1 (en) | 2006-11-02 | 2008-08-14 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| US8273747B2 (en) | 2006-11-02 | 2012-09-25 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| GEP20125702B (en) | 2007-06-29 | 2012-12-10 | Pfizer | Benzimidazole derivatives |
| RU2364597C1 (ru) * | 2007-12-14 | 2009-08-20 | Андрей Александрович Иващенко | ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ Hh-СИГНАЛЬНОГО КАСКАДА, ЛЕКАРСТВЕННЫЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АББЕРАНТНОЙ АКТИВНОСТЬЮ Hh СИГНАЛЬНОЙ СИСТЕМЫ |
| JP4685891B2 (ja) | 2008-02-19 | 2011-05-18 | 株式会社ハネックス | 分離装置 |
| NZ587719A (en) * | 2008-02-26 | 2012-04-27 | Takeda Pharmaceutical | Fused heterocyclic derivative and use thereof |
| JP2010015644A (ja) | 2008-07-04 | 2010-01-21 | Fujitsu Ltd | スピンドル機構、電磁変換特性評価機、および情報記憶装置 |
| GB0900484D0 (en) | 2009-01-13 | 2009-02-11 | Angeletti P Ist Richerche Bio | Therapeutic agent |
-
2010
- 2010-08-25 KR KR1020127007793A patent/KR20120078703A/ko not_active Withdrawn
- 2010-08-25 EA EA201270311A patent/EA201270311A1/ru unknown
- 2010-08-25 CA CA2771833A patent/CA2771833A1/fr not_active Abandoned
- 2010-08-25 BR BR112012004134A patent/BR112012004134A2/pt not_active IP Right Cessation
- 2010-08-25 PE PE2012000255A patent/PE20121326A1/es not_active Application Discontinuation
- 2010-08-25 SG SG2012011599A patent/SG178504A1/en unknown
- 2010-08-25 WO PCT/JP2010/064413 patent/WO2011024872A1/fr not_active Ceased
- 2010-08-25 GE GEAP201012641A patent/GEP20146075B/en unknown
- 2010-08-25 NZ NZ598749A patent/NZ598749A/xx not_active IP Right Cessation
- 2010-08-25 JP JP2011528831A patent/JP5599802B2/ja active Active
- 2010-08-25 CN CN2010800469387A patent/CN102574851A/zh active Pending
- 2010-08-25 IN IN2069DEN2012 patent/IN2012DN02069A/en unknown
- 2010-08-25 EP EP10811921.5A patent/EP2471790B1/fr active Active
- 2010-08-25 AU AU2010287492A patent/AU2010287492A1/en not_active Abandoned
- 2010-08-25 MX MX2012002419A patent/MX2012002419A/es not_active Application Discontinuation
- 2010-08-25 US US13/391,791 patent/US8907089B2/en active Active
-
2012
- 2012-02-21 TN TNP2012000084A patent/TN2012000084A1/en unknown
- 2012-02-22 DO DO2012000048A patent/DOP2012000048A/es unknown
- 2012-02-23 CL CL2012000461A patent/CL2012000461A1/es unknown
- 2012-02-24 CR CR20120095A patent/CR20120095A/es not_active Application Discontinuation
- 2012-02-26 IL IL218323A patent/IL218323A0/en unknown
- 2012-03-12 ZA ZA2012/01795A patent/ZA201201795B/en unknown
- 2012-03-16 MA MA34695A patent/MA33589B1/fr unknown
- 2012-03-26 EC ECSP12011747 patent/ECSP12011747A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012002419A (es) | 2012-04-19 |
| US20120220570A1 (en) | 2012-08-30 |
| EP2471790A1 (fr) | 2012-07-04 |
| CN102574851A (zh) | 2012-07-11 |
| CR20120095A (es) | 2012-06-26 |
| EP2471790B1 (fr) | 2015-03-18 |
| IL218323A0 (en) | 2012-04-30 |
| ECSP12011747A (es) | 2012-05-30 |
| SG178504A1 (en) | 2012-04-27 |
| IN2012DN02069A (fr) | 2015-08-21 |
| GEP20146075B (en) | 2014-04-10 |
| NZ598749A (en) | 2013-01-25 |
| EA201270311A1 (ru) | 2012-09-28 |
| CL2012000461A1 (es) | 2012-10-05 |
| AU2010287492A1 (en) | 2012-03-29 |
| WO2011024872A1 (fr) | 2011-03-03 |
| ZA201201795B (en) | 2013-05-29 |
| TN2012000084A1 (en) | 2013-09-19 |
| BR112012004134A2 (pt) | 2017-06-20 |
| PE20121326A1 (es) | 2012-10-11 |
| KR20120078703A (ko) | 2012-07-10 |
| DOP2012000048A (es) | 2012-05-15 |
| EP2471790A4 (fr) | 2013-07-31 |
| CA2771833A1 (fr) | 2011-03-03 |
| JPWO2011024872A1 (ja) | 2013-01-31 |
| JP5599802B2 (ja) | 2014-10-01 |
| US8907089B2 (en) | 2014-12-09 |
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