MD1716B2 - Utilizare a melatoninei pentru tratamentul pacientilor dependenti de benzodiazepine - Google Patents

Utilizare a melatoninei pentru tratamentul pacientilor dependenti de benzodiazepine Download PDF

Info

Publication number: MD1716B2
Authority: MD; Moldova
Prior art keywords: treatment; melatonin; benzodiazepine; benzodiazepinic; dependence
Prior art date: 1995-02-01

Application number

MD97-0254A

Other languages

English (en)

Other versions

MD1716C2 (ro

MD970254A (ro

Inventor

Nava Zisapel

Original Assignee

Neurim Pharma 1991

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-01

Filing date

1996-01-29

Publication date

2001-08-31

1995-02-01 Priority claimed from US08/381,535 external-priority patent/US6469044B1/en

1996-01-29 Application filed by Neurim Pharma 1991 filed Critical Neurim Pharma 1991

1999-05-31 Publication of MD970254A publication Critical patent/MD970254A/ro

2001-08-31 Publication of MD1716B2 publication Critical patent/MD1716B2/ro

2002-02-28 Publication of MD1716C2 publication Critical patent/MD1716C2/ro

Links

238000011282 treatment Methods 0.000 title abstract 3
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title abstract 2
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title abstract 2
229960003987 melatonin Drugs 0.000 title abstract 2
SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 title 1
229940049706 benzodiazepine Drugs 0.000 title 1
230000001419 dependent effect Effects 0.000 title 1
239000003814 drug Substances 0.000 abstract 3
229940079593 drug Drugs 0.000 abstract 2
208000024891 symptom Diseases 0.000 abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Toxicology (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MD97-0254A 1995-02-01 1996-01-29 Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine MD1716C2 (ro)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/381,535 US6469044B1 (en)	1995-02-01	1995-02-01	Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
EP95303853A EP0724878B1 (en)	1995-02-01	1995-06-06	Use of melatonin for treating patients suffering from drug dependencies
PCT/IB1996/000082 WO1996023496A1 (en)	1995-02-01	1996-01-29	Use of melatonin for treating patients suffering from drug addiction

Publications (3)

Publication Number	Publication Date
MD970254A MD970254A (ro)	1999-05-31
MD1716B2 true MD1716B2 (ro)	2001-08-31
MD1716C2 MD1716C2 (ro)	2002-02-28

Family

ID=26140195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MD97-0254A MD1716C2 (ro)	1995-02-01	1996-01-29	Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine

Country Status (22)

Country	Link
JP (1)	JP4516159B2 (ro)
CN (1)	CN1083263C (ro)
AT (1)	AT408188B (ro)
AU (1)	AU695366B2 (ro)
BG (1)	BG62876B1 (ro)
BR (1)	BR9607169A (ro)
CZ (1)	CZ291349B6 (ro)
DK (1)	DK176081B1 (ro)
EE (1)	EE03384B1 (ro)
FI (1)	FI119586B (ro)
IS (1)	IS1980B (ro)
LU (1)	LU90118B1 (ro)
LV (1)	LV11940B (ro)
MD (1)	MD1716C2 (ro)
NO (1)	NO312814B1 (ro)
NZ (1)	NZ298878A (ro)
PL (1)	PL183148B1 (ro)
SI (1)	SI9620022A (ro)
SK (1)	SK284521B6 (ro)
TR (1)	TR199700723T1 (ro)
TW (1)	TW483757B (ro)
WO (1)	WO1996023496A1 (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1272177E (pt)	2000-01-05	2007-07-11	Neurim Pharma 1991	Método e formulação para o tratamento da resistência aos antihipertensos e condições associadas.
IL149377A (en) *	2002-04-28	2012-10-31	Neurim Pharma 1991	Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds
IL155666A (en)	2003-04-29	2013-12-31	Neurim Pharma 1991	Insomnia treatment
US9119846B2 (en)	2003-04-29	2015-09-01	Neurim Pharmaceuticals (1991) Ltd.	Method and composition for enhancing cognition in alzheimer's patients
US11918557B2 (en)	2012-01-26	2024-03-05	Vanda Pharmaceuticals Inc.	Treatment of circadian rhythm disorders
KR102593047B1 (ko)	2012-01-26	2023-10-24	반다 파마슈티칼즈, 인코퍼레이티드.	일주기 리듬 장애의 치료
WO2014100292A1 (en)	2012-12-18	2014-06-26	Vanda Pharmaceuticals Inc.	Treatment of circadian rhythm disorders
US10376487B2 (en)	2013-11-12	2019-08-13	Vanda Pharmaceuticals Inc.	Method of treatment
US11090285B2 (en)	2013-11-12	2021-08-17	Vanda Pharmaceuticals Inc	Treatment of circadian rhythm disorders
SG11201903829PA (en) *	2016-10-31	2019-05-30	Neurim Pharma 1991	Melatonin mini-tablets and method of manufacturing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE181670T1 (de) *	1991-05-09	1999-07-15	Neurim Pharma 1991	Melatonin enthaltende arzneimittel
IT1251544B (it) *	1991-05-13	1995-05-17	Gabriele Biella	Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico

1996
- 1996-01-29 MD MD97-0254A patent/MD1716C2/ro not_active IP Right Cessation
- 1996-01-29 TR TR97/00723T patent/TR199700723T1/xx unknown
- 1996-01-29 EE EE9700166A patent/EE03384B1/xx not_active IP Right Cessation
- 1996-01-29 AT AT0901396A patent/AT408188B/de not_active IP Right Cessation
- 1996-01-29 SI SI9620022A patent/SI9620022A/sl not_active IP Right Cessation
- 1996-01-29 NZ NZ298878A patent/NZ298878A/xx not_active IP Right Cessation
- 1996-01-29 JP JP52338596A patent/JP4516159B2/ja not_active Expired - Lifetime
- 1996-01-29 BR BR9607169A patent/BR9607169A/pt not_active Application Discontinuation
- 1996-01-29 SK SK1030-97A patent/SK284521B6/sk unknown
- 1996-01-29 PL PL96321630A patent/PL183148B1/pl unknown
- 1996-01-29 CZ CZ19972405A patent/CZ291349B6/cs not_active IP Right Cessation
- 1996-01-29 CN CN96191750A patent/CN1083263C/zh not_active Expired - Lifetime
- 1996-01-29 WO PCT/IB1996/000082 patent/WO1996023496A1/en not_active Ceased
- 1996-01-29 AU AU44574/96A patent/AU695366B2/en not_active Expired
- 1996-04-12 TW TW085104319A patent/TW483757B/zh not_active IP Right Cessation
1997
- 1997-07-24 LV LVP-97-144A patent/LV11940B/en unknown
- 1997-07-25 IS IS4532A patent/IS1980B/is unknown
- 1997-07-30 DK DK199700896A patent/DK176081B1/da not_active IP Right Cessation
- 1997-07-30 BG BG101803A patent/BG62876B1/bg unknown
- 1997-07-31 NO NO19973531A patent/NO312814B1/no not_active IP Right Cessation
- 1997-07-31 FI FI973185A patent/FI119586B/fi not_active IP Right Cessation
- 1997-08-01 LU LU90118A patent/LU90118B1/fr active

Also Published As

Publication number	Publication date
NO312814B1 (no)	2002-07-08
AT408188B (de)	2001-09-25
FI973185L (fi)	1997-09-30
NZ298878A (en)	1999-05-28
DK176081B1 (da)	2006-04-18
IS1980B (is)	2005-01-14
MD1716C2 (ro)	2002-02-28
IS4532A (is)	1997-07-25
MX9705856A (es)	1998-07-31
FI119586B (fi)	2009-01-15
NO973531L (no)	1997-09-30
SI9620022A (sl)	1998-10-31
CZ291349B6 (cs)	2003-02-12
WO1996023496A1 (en)	1996-08-08
LU90118B1 (fr)	1997-11-13
SK284521B6 (sk)	2005-05-05
LV11940A (lv)	1998-01-20
BR9607169A (pt)	1997-11-11
JP4516159B2 (ja)	2010-08-04
PL183148B1 (pl)	2002-05-31
CN1083263C (zh)	2002-04-24
TR199700723T1 (xx)	1998-02-21
EE03384B1 (et)	2001-04-16
TW483757B (en)	2002-04-21
JPH10513177A (ja)	1998-12-15
SK103097A3 (en)	1998-01-14
LV11940B (en)	1998-05-20
CN1172431A (zh)	1998-02-04
AU695366B2 (en)	1998-08-13
FI973185A0 (fi)	1997-07-31
PL321630A1 (en)	1997-12-08
BG101803A (en)	1998-04-30
ATA901396A (de)	2001-02-15
EE9700166A (et)	1998-02-16
DK89697A (da)	1997-07-30
BG62876B1 (bg)	2000-10-31
AU4457496A (en)	1996-08-21
MD970254A (ro)	1999-05-31
CZ240597A3 (cs)	1998-01-14
NO973531D0 (no)	1997-07-31

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Legal Events

Date	Code	Title
1999-06-15	PD99	Pending application
2007-08-31	KA4A	Patent for invention lapsed due to non-payment of fees (with right of restoration)
2008-03-31	MM4A	Patent for invention definitely lapsed due to non-payment of fees