MEP37508A - Process for the preparation of mesylates of piperazine derivatives - Google Patents

Process for the preparation of mesylates of piperazine derivatives

Info

Publication number: MEP37508A
Authority: ME; Montenegro
Prior art keywords: mesylates; preparation; piperazine derivatives; relates; piperazine
Prior art date: 2001-02-16

Application number

MEP-375/08A

Other languages

Bosnian (bs)

English (en)

Croatian (hr)

Inventor

Marcel P M Van Aar

Stefanus J Schouten

Jan Zorgdrager

Michiel C Heslinga

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-16

Filing date

2002-02-14

Publication date

2011-02-10

2002-02-14 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2011-02-10 Publication of MEP37508A publication Critical patent/MEP37508A/xx

Links

AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
150000004885 piperazines Chemical class 0.000 title 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
125000004193 piperazinyl group Chemical group 0.000 abstract 2
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

MEP-375/08A 2001-02-16 2002-02-14 Process for the preparation of mesylates of piperazine derivatives MEP37508A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01200534		2001-02-16
PCT/EP2002/001666 WO2002066449A2 (en)	2001-02-16	2002-02-14	Process for the preparation of mesylates of piperazine derivatives

Publications (1)

Publication Number	Publication Date
MEP37508A true MEP37508A (en)	2011-02-10

Family

ID=8179894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-375/08A MEP37508A (en)	2001-02-16	2002-02-14	Process for the preparation of mesylates of piperazine derivatives

Country Status (34)

Country	Link
US (1)	US7030241B2 (sr)
EP (1)	EP1362040B1 (sr)
JP (1)	JP4328528B2 (sr)
KR (2)	KR100859106B1 (sr)
CN (1)	CN1176079C (sr)
AR (1)	AR034206A1 (sr)
AT (1)	ATE284875T1 (sr)
AU (1)	AU2002250962B2 (sr)
BG (1)	BG66101B1 (sr)
BR (1)	BR0205683A (sr)
CA (1)	CA2422703C (sr)
CZ (1)	CZ301780B6 (sr)
DE (1)	DE60202261T2 (sr)
DK (1)	DK1362040T3 (sr)
DZ (1)	DZ3489A1 (sr)
ES (1)	ES2230481T3 (sr)
HR (1)	HRP20030610B1 (sr)
HU (1)	HUP0400772A3 (sr)
IL (1)	IL153509A (sr)
IS (1)	IS2417B (sr)
ME (1)	MEP37508A (sr)
MX (1)	MXPA03002359A (sr)
MY (1)	MY130687A (sr)
NO (1)	NO324460B1 (sr)
NZ (1)	NZ524632A (sr)
PL (1)	PL208363B1 (sr)
PT (1)	PT1362040E (sr)
RS (1)	RS51126B (sr)
RU (1)	RU2272036C2 (sr)
SI (1)	SI1362040T1 (sr)
SK (1)	SK286143B6 (sr)
UA (1)	UA75390C2 (sr)
WO (1)	WO2002066449A2 (sr)
ZA (1)	ZA200301590B (sr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR045362A1 (es) *	2003-08-18	2005-10-26	Solvay Pharm Bv	Forma cristalina estable de mesilato de bifeprunox (monometansulfonato de 7-[4-([1,1- bifenil] -3- ilmetil) -1- piperazinil] - 2-(3h) -benzoxazolona
US7435738B2 (en)	2003-08-18	2008-10-14	Solvay Pharmaceuticals, Inc.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7405216B2 (en) *	2004-08-18	2008-07-29	Solvay Pharmaceuticals, B.V.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7964604B2 (en) *	2005-02-18	2011-06-21	Solvay Pharmaceuticals B.V.	Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7423040B2 (en) *	2005-02-18	2008-09-09	Irene Eijgendaal	Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US20070275977A1 (en) *	2006-05-02	2007-11-29	Van Aar Marcel P	N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
US7786126B2 (en) *	2006-06-16	2010-08-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising SLV308 and a dopamine agonist
US8106056B2 (en)	2006-06-16	2012-01-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising bifeprunox and a dopamine agonist
US20080132520A1 (en) *	2006-08-31	2008-06-05	Winsemius Antje A	Compositions, kits and methods for administering a titration schedule comprising bifeprunox compounds
CA2661120A1 (en)	2006-08-31	2008-03-06	Solvay Pharmaceuticals B.V.	Titration schedule for bifeprunox for treating schizophrenia and kits for use therein
US20090068290A1 (en) *	2006-08-31	2009-03-12	Michel Bourin	Bifeprunox doses for treating schizophrenia
WO2009100258A1 (en)	2008-02-05	2009-08-13	Hollis-Eden Pharmaceuticals, Inc.	Pharmaceutical solid state forms
WO2011023796A1 (en)	2009-08-31	2011-03-03	Abbott Healthcare Products B.V.	Bifeprunox for treating addiction
UY32935A (es)	2009-10-12	2011-05-31	Abbott Healthcare Products Bv	Polimorfos de pardoprunox

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0189612B1 (en)	1984-12-21	1992-11-04	Duphar International Research B.V	New pharmaceutical compositions having a psychotropic activity
EP0190472B1 (en) *	1984-12-21	1989-07-12	Duphar International Research B.V	New pharmaceutical compositions having anti-psychotic properties
JPH0344383A (ja) *	1989-07-12	1991-02-26	Ihara Chem Ind Co Ltd	５―トリフルオロメチル―２―ハロメチルベンゾチアゾール類の製造法
JP3044383B2 (ja) *	1990-05-22	2000-05-22	コニカ株式会社	含窒素６員環化合物の製造方法
GB9200293D0 (en) *	1992-01-08	1992-02-26	Wyeth John & Brother Ltd	Piperazine derivatives
JP3989554B2 (ja) *	1996-03-29	2007-10-10	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	ピペラジンおよびピペリジン化合物
SE9702799D0 (sv) *	1997-07-25	1997-07-25	Astra Ab	New compounds
UA71590C2 (en) *	1998-11-13	2004-12-15	Duphar Int Res	Piperazine and piperidine derivatives
US7435738B2 (en)	2003-08-18	2008-10-14	Solvay Pharmaceuticals, Inc.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)

2002
- 2002-02-12 AR ARP020100460A patent/AR034206A1/es active IP Right Grant
- 2002-02-14 ES ES02719858T patent/ES2230481T3/es not_active Expired - Lifetime
- 2002-02-14 RU RU2003105902/04A patent/RU2272036C2/ru not_active IP Right Cessation
- 2002-02-14 MY MYPI20020505A patent/MY130687A/en unknown
- 2002-02-14 BR BR0205683-6A patent/BR0205683A/pt not_active Application Discontinuation
- 2002-02-14 NZ NZ524632A patent/NZ524632A/en not_active IP Right Cessation
- 2002-02-14 PT PT02719858T patent/PT1362040E/pt unknown
- 2002-02-14 EP EP02719858A patent/EP1362040B1/en not_active Expired - Lifetime
- 2002-02-14 DZ DZ023489A patent/DZ3489A1/fr active
- 2002-02-14 PL PL369330A patent/PL208363B1/pl unknown
- 2002-02-14 ME MEP-375/08A patent/MEP37508A/xx unknown
- 2002-02-14 KR KR1020037000026A patent/KR100859106B1/ko not_active Expired - Fee Related
- 2002-02-14 UA UA2003098528A patent/UA75390C2/uk unknown
- 2002-02-14 DE DE60202261T patent/DE60202261T2/de not_active Expired - Lifetime
- 2002-02-14 AT AT02719858T patent/ATE284875T1/de active
- 2002-02-14 SI SI200230061T patent/SI1362040T1/xx unknown
- 2002-02-14 AU AU2002250962A patent/AU2002250962B2/en not_active Ceased
- 2002-02-14 IL IL153509A patent/IL153509A/en not_active IP Right Cessation
- 2002-02-14 RS YUP-644/03A patent/RS51126B/sr unknown
- 2002-02-14 CN CNB028016858A patent/CN1176079C/zh not_active Expired - Fee Related
- 2002-02-14 MX MXPA03002359A patent/MXPA03002359A/es active IP Right Grant
- 2002-02-14 KR KR1020087015071A patent/KR101000733B1/ko not_active Expired - Fee Related
- 2002-02-14 HR HR20030610A patent/HRP20030610B1/xx not_active IP Right Cessation
- 2002-02-14 JP JP2002565965A patent/JP4328528B2/ja not_active Expired - Fee Related
- 2002-02-14 DK DK02719858T patent/DK1362040T3/da active
- 2002-02-14 WO PCT/EP2002/001666 patent/WO2002066449A2/en not_active Ceased
- 2002-02-14 SK SK309-2003A patent/SK286143B6/sk not_active IP Right Cessation
- 2002-02-14 CZ CZ20030697A patent/CZ301780B6/cs not_active IP Right Cessation
- 2002-02-14 HU HU0400772A patent/HUP0400772A3/hu unknown
- 2002-02-14 US US10/468,098 patent/US7030241B2/en not_active Expired - Fee Related
- 2002-02-14 CA CA2422703A patent/CA2422703C/en not_active Expired - Fee Related
2003
- 2003-02-26 ZA ZA200301590A patent/ZA200301590B/en unknown
- 2003-04-15 NO NO20031754A patent/NO324460B1/no not_active IP Right Cessation
- 2003-07-17 IS IS6876A patent/IS2417B/is unknown
- 2003-08-13 BG BG108090A patent/BG66101B1/bg unknown

Also Published As

Publication number	Publication date
CN1176079C (zh)	2004-11-17
EP1362040B1 (en)	2004-12-15
IL153509A (en)	2007-12-03
NZ524632A (en)	2004-03-26
MXPA03002359A (es)	2003-06-30
JP4328528B2 (ja)	2009-09-09
DE60202261T2 (de)	2005-05-19
KR101000733B1 (ko)	2010-12-14
DZ3489A1 (fr)	2002-08-29
RS51126B (sr)	2010-10-31
PT1362040E (pt)	2005-05-31
CZ301780B6 (cs)	2010-06-23
CA2422703C (en)	2010-04-13
IS6876A (is)	2003-07-17
SK3092003A3 (en)	2003-09-11
AU2002250962B2 (en)	2006-08-24
KR100859106B1 (ko)	2008-09-18
IS2417B (is)	2008-10-15
CZ2003697A3 (cs)	2003-06-18
JP2004518741A (ja)	2004-06-24
US20040077631A1 (en)	2004-04-22
IL153509A0 (en)	2003-07-06
UA75390C2 (en)	2006-04-17
NO324460B1 (no)	2007-10-22
ES2230481T3 (es)	2005-05-01
ZA200301590B (en)	2004-02-05
SK286143B6 (sk)	2008-04-07
PL369330A1 (en)	2005-04-18
YU64403A (sh)	2006-05-25
HRP20030610A2 (en)	2005-06-30
EP1362040A2 (en)	2003-11-19
WO2002066449A2 (en)	2002-08-29
HK1059934A1 (en)	2004-07-23
CN1463268A (zh)	2003-12-24
KR20030077523A (ko)	2003-10-01
RU2272036C2 (ru)	2006-03-20
WO2002066449A3 (en)	2002-10-24
BR0205683A (pt)	2004-07-06
CA2422703A1 (en)	2002-08-29
NO20031754D0 (no)	2003-04-15
MY130687A (en)	2007-07-31
HUP0400772A2 (hu)	2004-08-30
DK1362040T3 (da)	2005-01-24
BG66101B1 (bg)	2011-04-29
PL208363B1 (pl)	2011-04-29
US7030241B2 (en)	2006-04-18
DE60202261D1 (de)	2005-01-20
NO20031754L (no)	2003-04-15
BG108090A (bg)	2004-12-30
ATE284875T1 (de)	2005-01-15
HUP0400772A3 (en)	2008-02-28
KR20080064206A (ko)	2008-07-08
HRP20030610B1 (en)	2006-02-28
SI1362040T1 (en)	2005-06-30
AR034206A1 (es)	2004-02-04

Publication	Publication Date	Title
MEP37508A (en)	2011-02-10	Process for the preparation of mesylates of piperazine derivatives
IL161559A0 (en)	2004-09-27	Dibenzylamine derivatives and pharmaceutical compositions containing the same
CO5611127A2 (es)	2006-02-28	Derivados de indolilmaleimida
NO20051826L (no)	2005-04-15	Heterosyklisk substituerte piperaziner for behandling av schizofreni
HUP0401982A2 (hu)	2005-01-28	Indolizinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
NO20060219L (no)	2006-04-28	Forbindelser
DE60130771D1 (de)	2007-11-15	Substituierte heterocyclische amide
WO2004103977A3 (en)	2005-01-06	Process for the preparation of pyrimidine derivatives
TNSN07006A1 (en)	2008-06-02	Novel heterocyclic compounds
AU2003249484A1 (en)	2004-02-09	Novel bio-active molecules
HUP9801072A2 (hu)	1999-02-01	Szubsztituált 6-és 7-amino-tetrahidro-izokinolin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
AU6785201A (en)	2002-01-14	Novel pyrazinone derivatives
NO934652D0 (no)	1993-12-16	Enzymatisk prosess for stereoselektiv fremstilling av heterobicyklisk alkoholenantiomer
MXPA04000978A (es)	2004-04-20	Procedimiento para la produccion de 4-amino-2,5-bisheterociclilquinazolinas.
WO2005000804A3 (en)	2005-08-04	Substituted indoles and a process for preparing substituted indoles
HRP20020440B1 (en)	2008-02-29	1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
GB0215392D0 (en)	2002-08-14	Chemical compounds
EA200400469A1 (ru)	2004-08-26	Замещенные производные алкиламинопиридазинона, способ их получения и содержащие их фармацевтические композиции
EA200101209A1 (ru)	2002-06-27	Новые производные бензола, способ их получения и фармацевтические композиции, содержащие их
MY139258A (en)	2009-09-30	Carbamoyl-type benzofuran derivatives
NO20063111L (no)	2006-09-05	Fremgangsmate for fremstilling av tiazolpyrimidiner
MXPA03012073A (es)	2004-03-26	Amidoderivados heterociclicos.
MY140442A (en)	2009-12-31	A new process for the preparation of epothilone derivatives
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NO955071D0 (no)	1995-12-14	abeo-Ergolin-derivater som 5HT1A-ligander