Petri et al., 2011 - Google Patents
Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effectsPetri et al., 2011
View PDF- Document ID
- 10478551003320704765
- Author
- Petri S
- Dueck A
- Lehmann G
- Putz N
- Rüdel S
- Kremmer E
- Meister G
- Publication year
- Publication venue
- Rna
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Snippet
Argonaute (Ago) proteins form the core of RNA-induced silencing complexes (RISCs) and mediate small RNA-guided gene silencing. In RNAi, short interfering RNAs (siRNAs) guide RISCs to complementary target RNAs, leading to cleavage by the endonuclease Ago2 …
- 239000002924 silencing RNA 0 title abstract description 196
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