Melendez et al., 2021 - Google Patents
TGFβ signalling acts as a molecular brake of myoblast fusionMelendez et al., 2021
View HTML- Document ID
- 14581776425338371179
- Author
- Melendez J
- Sieiro D
- Salgado D
- Morin V
- Dejardin M
- Zhou C
- Mullen A
- Marcelle C
- Publication year
- Publication venue
- Nature communications
External Links
Snippet
Fusion of nascent myoblasts to pre-existing myofibres is critical for skeletal muscle growth and repair. The vast majority of molecules known to regulate myoblast fusion are necessary in this process. Here, we uncover, through high-throughput in vitro assays and in vivo …
- 102000004887 Transforming Growth Factor beta 0 title abstract description 63
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Melendez et al. | TGFβ signalling acts as a molecular brake of myoblast fusion | |
| Drummond et al. | Hedgehog pathway drives fusion-negative rhabdomyosarcoma initiated from non-myogenic endothelial progenitors | |
| Zhang et al. | Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells | |
| Mehta et al. | Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway | |
| Schmahl et al. | Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination | |
| Asnani et al. | The zebrafish as a tool to identify novel therapies for human cardiovascular disease | |
| Jakobsson et al. | Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis | |
| Mueller et al. | Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis | |
| Eberhart et al. | MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis | |
| Langen et al. | Cell–matrix signals specify bone endothelial cells during developmental osteogenesis | |
| Park et al. | Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration | |
| Chen et al. | mir-17–92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts | |
| McCann et al. | Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development | |
| Suh et al. | Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory | |
| Yu et al. | The m6A readers YTHDF1 and YTHDF2 synergistically control cerebellar parallel fiber growth by regulating local translation of the key Wnt5a signaling components in axons | |
| Bornhorst et al. | Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions | |
| Jin et al. | Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport | |
| Camus et al. | Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish | |
| Kögler et al. | Extremely rapid and reversible optogenetic perturbation of nuclear proteins in living embryos | |
| Vicario et al. | Dendritic targeting of short and long 3′ UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins | |
| Yuan et al. | Analysis of integrin turnover in fly myotendinous junctions | |
| Luo et al. | N‐cadherin is not essential for limb mesenchymal chondrogenesis | |
| Cheng et al. | Characterization of the transcriptomes of Lgr5+ hair cell progenitors and Lgr5-supporting cells in the mouse cochlea | |
| Merz et al. | Evidence that Doublecortin is dispensable for the development of adult born neurons in mice | |
| Han et al. | Differential subcellular distributions and trafficking functions of hnRNP A2/B1 spliceoforms |