NOTCH1とは？わかりやすく解説

NOTCH1
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA
識別子
記号	NOTCH1, Notch1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, AOS5, AOVD1, hN1, notch 1, notch receptor 1
外部ID	OMIM: 190198 MGI: 97363 HomoloGene: 32049 GeneCards: NOTCH1
遺伝子の位置 (ヒト)
染色体	9番染色体 (ヒト)
終点	136,546,048 bp
遺伝子の位置 (マウス)
染色体	2番染色体 (マウス)
終点	26,406,675 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• calcium ion binding; • DNA-binding transcription factor activity; • Notch binding; • enzyme inhibitor activity; • 金属イオン結合; • 酵素結合; • クロマチン結合; • 血漿タンパク結合; • sequence-specific DNA binding; • protein heterodimerization activity; • chromatin DNA binding; • 膜貫通シグナル伝達受容体活性; • シグナル伝達受容体活性; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA-binding transcription activator activity, RNA polymerase II-specific;
細胞の構成要素	• 細胞質; • 細胞質基質; • 膜; • 接着結合; • 細胞外領域; • 細胞核; • cell surface; • apical plasma membrane; • 小胞体; • integral component of membrane; • ゴルジ体; • receptor complex; • 細胞膜; • 核質; • MAML1-RBP-Jkappa- ICN1 complex; • 細胞周辺; • endoplasmic reticulum membrane; • ゴルジ膜; • 先体; • cytoplasmic vesicle;
生物学的プロセス	• cardiac vascular smooth muscle cell development; • 内胚葉の発生; • pulmonary valve morphogenesis; • positive regulation of endothelial cell differentiation; • regulation of somitogenesis; • cell differentiation in spinal cord; • negative regulation of neuron differentiation; • regulation of extracellular matrix assembly; • distal tubule development; • negative regulation of glial cell proliferation; • epithelial to mesenchymal transition involved in endocardial cushion formation; • regulation of transcription by RNA polymerase II; • aortic valve morphogenesis; • oligodendrocyte differentiation; • endocardium morphogenesis; • negative regulation of osteoblast differentiation; • negative regulation of stem cell differentiation; • negative regulation of ossification; • heart looping; • negative regulation of photoreceptor cell differentiation; • arterial endothelial cell differentiation; • atrioventricular valve morphogenesis; • Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; • humoral immune response; • foregut morphogenesis; • negative regulation of oligodendrocyte differentiation; • positive regulation of cardiac muscle cell proliferation; • regulation of developmental process; • mesenchymal cell development; • animal organ regeneration; • 血管新生; • 精子形成; • negative regulation of pro-B cell differentiation; • regulation of cardioblast proliferation; • hair follicle morphogenesis; • vasculogenesis involved in coronary vascular morphogenesis; • negative regulation of canonical Wnt signaling pathway; • regulation of neurogenesis; • negative regulation of cell population proliferation; • 集合管発生; • positive regulation of neuroblast proliferation; • cilium assembly; • heart trabecula morphogenesis; • atrioventricular node development; • negative regulation of myoblast differentiation; • cell fate commitment; • regulation of transcription, DNA-templated; • cellular response to follicle-stimulating hormone stimulus; • 肺発生; • negative regulation of inner ear auditory receptor cell differentiation; • cardiac septum morphogenesis; • ventricular septum morphogenesis; • negative regulation of cell differentiation; • coronary artery morphogenesis; • response to muramyl dipeptide; • cardiac left ventricle morphogenesis; • in utero embryonic development; • negative regulation of cell death; • endocardial cell differentiation; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • 心臓発生; • prostate gland epithelium morphogenesis; • embryonic limb morphogenesis; • growth involved in heart morphogenesis; • 神経管発生; • pericardium morphogenesis; • epidermis development; • cardiac atrium morphogenesis; • transcription initiation from RNA polymerase II promoter; • cardiac right atrium morphogenesis; • negative regulation of cell-substrate adhesion; • cell migration involved in endocardial cushion formation; • 細胞分化; • venous endothelial cell differentiation; • regulation of inner ear auditory receptor cell differentiation; • negative regulation of catalytic activity; • inflammatory response to antigenic stimulus; • positive regulation of astrocyte differentiation; • positive regulation of epithelial cell proliferation; • cardiac right ventricle formation; • endocardial cushion development; • cell fate specification; • positive regulation of keratinocyte differentiation; • positive regulation of glial cell differentiation; • negative regulation of neurogenesis; • glomerular mesangial cell development; • sprouting angiogenesis; • glial cell differentiation; • negative regulation of transcription by RNA polymerase II; • cardiac muscle cell proliferation; • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; • positive regulation of epithelial to mesenchymal transition; • ventricular trabecula myocardium morphogenesis; • neuronal stem cell population maintenance; • negative regulation of cell migration involved in sprouting angiogenesis; • リポ多糖への反応; • compartment pattern specification; • 免疫応答; • neuron differentiation; • 上皮間葉転換; • positive regulation of BMP signaling pathway; • skeletal muscle cell differentiation; • 遺伝子発現調節; • positive regulation of viral genome replication; • regulation of epithelial cell proliferation involved in prostate gland development; • negative regulation of transcription, DNA-templated; • cardiac ventricle morphogenesis; • branching morphogenesis of an epithelial tube; • positive regulation of receptor signaling pathway via JAK-STAT; • negative regulation of anoikis; • Notch signaling involved in heart development; • coronary vein morphogenesis; • apoptotic process involved in embryonic digit morphogenesis; • regulation of cell migration; • axonogenesis; • tissue regeneration; • positive regulation of cell migration; • somatic stem cell division; • cardiac muscle tissue morphogenesis; • negative regulation of endothelial cell chemotaxis; • keratinocyte differentiation; • negative regulation of BMP signaling pathway; • endocardial cushion morphogenesis; • endocardium development; • 多細胞個体の発生; • auditory receptor cell fate commitment; • コルチコステロイドへの反応; • tube formation; • determination of left/right symmetry; • astrocyte differentiation; • negative regulation of calcium ion-dependent exocytosis; • 脳発生; • regulation of cell population proliferation; • positive regulation of cell population proliferation; • negative regulation of myotube differentiation; • positive regulation of apoptotic process; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • mitral valve formation; • 肝臓発生; • cardiac chamber formation; • 前脳発生; • cellular response to vascular endothelial growth factor stimulus; • neuron fate commitment; • regulation of epithelial cell proliferation; • regulation of Notch signaling pathway; • left/right axis specification; • positive regulation of transcription by RNA polymerase II; • cardiac epithelial to mesenchymal transition; • embryonic hindlimb morphogenesis; • positive regulation of aorta morphogenesis; • venous blood vessel morphogenesis; • Notchシグナリング; • 遺伝子発現の負の調節; • negative regulation of growth rate; • positive regulation of Ras protein signal transduction; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of transcription of Notch receptor target; • positive regulation of Notch signaling pathway; • outflow tract morphogenesis; • coronary sinus valve morphogenesis; • negative regulation of cell proliferation involved in heart valve morphogenesis; • negative regulation of extracellular matrix constituent secretion; • negative regulation of cardiac muscle hypertrophy; • positive regulation of gene expression; • homeostasis of number of cells within a tissue; • negative regulation of biomineral tissue development; • positive regulation of apoptotic process involved in morphogenesis; • positive regulation of cardiac epithelial to mesenchymal transition; • negative regulation of cold-induced thermogenesis;
	出典:Amigo / QuickGO
オルソログ
	4851
	18128
	ENSG00000148400
	ENSMUSG00000026923
	P46531
	Q01705
	NM_017617
	NM_008714
	NP_060087
	NP_032740
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

NOTCH1（notch receptor 1）は、ヒトではNOTCH1遺伝子によってコードされているタンパク質であり^[5]、1回膜貫通受容体である。

機能

NOTCH1はNotchファミリーに属する。Notchファミリーに属するタンパク質は1型膜貫通タンパク質であり、共通して複数のEGF様リピートからなる細胞外ドメインを持ち、細胞内ドメインは複数の異なる種類のドメインから構成される。Notchシグナル伝達経路は進化的に保存された細胞間シグナル伝達経路であり、Notchファミリーの受容体はリガンドとの結合を介し、物理的に隣接する細胞間の相互作用を調節する。NOTCH1はプレプロタンパク質として産生され、トンラスゴルジ網においてタンパク質分解によるプロセシングを受けて2つのポリペプチド鎖からなるヘテロ二量体となることで、成熟した細胞表面受容体となる。この受容体は多くの細胞種や組織種の発生に関与している。NOTCH1遺伝子の変異は大動脈弁疾患（大動脈二尖弁（英語版）^[6]）、アダムズ・オリバー症候群（英語版）、T細胞急性リンパ芽球性白血病（英語版）、慢性リンパ性白血病、頭頸部扁平上皮がんと関連している^[7]。

NOTCH1やNOTCH3（英語版）の活性化は、神経前駆細胞のアストロサイトへの分化を促進する^[8]。NOTCH1は、出生前の段階で活性化された場合は放射状グリア細胞（英語版）への分化を誘導するが^[9]、出生後にはアストロサイトへの分化を誘導する^[10]。NOTCH1シグナル伝達カスケードは、その機構は未解明であるもの、リーリンによって活性化される^[11]。リーリンとNOTCH1は歯状回（英語版）の発生において協働的に機能する^[12]。

相互作用

NOTCH1は次に挙げる因子と相互作用することが示されている。

GSK3B^[13]
LCK（英語版）^[14]
MAML1（英語版）^[15]^[16]
SMAD3^[17]
NFKB1（英語版）^[18]^[19]
CCN3（英語版）^[20]
RBPJ（英語版）^[21]^[22]
SNW1（英語版）^[23]^[24]
UBC（英語版）^[25]
YY1^[26]
USP10（英語版）^[27]

出典

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148400 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026923 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “NOTCH1 - Neurogenic locus notch homolog protein 1 precursor - Homo sapiens (Human) - NOTCH1 gene & protein” (英語). www.uniprot.org. 2022年5月23日閲覧。
^ McKellar SH, Tester DJ, Yagubyan M, Majumdar R, Ackerman MJ, Sundt TM (August 2007). “Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms”. J Thorac Cardiovasc Surg 134 (2): 290–296. doi:10.1016/j.jtcvs.2007.02.041. PMID 17662764.
^ “Entrez Gene: NOTCH1 Notch homolog 1, translocation-associated (Drosophila)”. 2026年2月7日閲覧。
^ Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T (January 2001). “Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate”. Neuron 29 (1): 45–55. doi:10.1016/S0896-6273(01)00179-9. hdl:2433/150564. PMID 11182080.
^ Gaiano N, Nye JS, Fishell G (May 2000). “Radial glial identity is promoted by Notch1 signaling in the murine forebrain”. Neuron 26 (2): 395–404. doi:10.1016/S0896-6273(00)81172-1. PMID 10839358.
^ Chambers CB, Peng Y, Nguyen H, Gaiano N, Fishell G, Nye JS (March 2001). “Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors”. Development 128 (5): 689–702. doi:10.1242/dev.128.5.689. PMID 11171394.
^ Keilani S, Sugaya K (July 2008). “Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1”. BMC Dev. Biol. 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473.
^ Sibbe M, Förster E, Basak O, Taylor V, Frotscher M (July 2009). “Reelin and Notch1 cooperate in the development of the dentate gyrus”. J. Neurosci. 29 (26): 8578–85. doi:10.1523/JNEUROSCI.0958-09.2009. PMC 6665659. PMID 19571148.
^ Foltz DR, Santiago MC, Berechid BE, Nye JS (June 2002). “Glycogen synthase kinase-3beta modulates notch signaling and stability”. Curr. Biol. 12 (12): 1006–11. Bibcode: 2002CBio...12.1006F. doi:10.1016/s0960-9822(02)00888-6. PMID 12123574.
^ Sade H, Krishna S, Sarin A (January 2004). “The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells”. J. Biol. Chem. 279 (4): 2937–44. doi:10.1074/jbc.M309924200. PMID 14583609.
^ Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (December 2000). “MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors”. Nat. Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851.
^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (November 2002). “Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors”. Mol. Cell. Biol. 22 (21): 7688–700. doi:10.1128/mcb.22.21.7688-7700.2002. PMC 135662. PMID 12370315.
^ Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U, Ibáñez CF (November 2003). “Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3”. J. Cell Biol. 163 (4): 723–8. doi:10.1083/jcb.200305112. PMC 2173673. PMID 14638857.
^ Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T (May 1996). “T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells”. J. Exp. Med. 183 (5): 2025–32. doi:10.1084/jem.183.5.2025. PMC 2192574. PMID 8642313.
^ Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E (July 2001). “Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain”. J. Immunol. 167 (1): 289–95. doi:10.4049/jimmunol.167.1.289. PMID 11418662.
^ Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (August 2002). “The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway”. J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
^ Nam Y, Weng AP, Aster JC, Blacklow SC (June 2003). “Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex”. J. Biol. Chem. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
^ Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (April 1997). “Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription”. J. Biol. Chem. 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.
^ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). “The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity”. Mech. Dev. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
^ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). “SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function”. Mol. Cell. Biol. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
^ Chastagner P, Israël A, Brou C (2008). “AIP4/Itch regulates Notch receptor degradation in the absence of ligand”. PLOS ONE 3 (7). Bibcode: 2008PLoSO...3.2735C. doi:10.1371/journal.pone.0002735. PMC 2444042. PMID 18628966.
^ Yeh TS, Lin YM, Hsieh RH, Tseng MJ (October 2003). “Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch”. J. Biol. Chem. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.
^ Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JW, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M (April 2019). “Deubiquitinase USP10 regulates Notch signaling in the endothelium.”. Science 364 (6436): 188–193. Bibcode: 2019Sci...364..188L. doi:10.1126/science.aat0778. hdl:20.500.12105/9685. PMID 30975888.

外部リンク

NOTCH1 protein, human - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）
NOTCH1

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148400 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026923 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[uniprot-5] “NOTCH1 - Neurogenic locus notch homolog protein 1 precursor - Homo sapiens (Human) - NOTCH1 gene & protein” (英語). www.uniprot.org. 2022年5月23日閲覧。

[pmid17662764-6] McKellar SH, Tester DJ, Yagubyan M, Majumdar R, Ackerman MJ, Sundt TM (August 2007). “Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms”. J Thorac Cardiovasc Surg 134 (2): 290–296. doi:10.1016/j.jtcvs.2007.02.041. PMID 17662764.

[:0-7] “Entrez Gene: NOTCH1 Notch homolog 1, translocation-associated (Drosophila)”. 2026年2月7日閲覧。

[pmid11182080-8] Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T (January 2001). “Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate”. Neuron 29 (1): 45–55. doi:10.1016/S0896-6273(01)00179-9. hdl:2433/150564. PMID 11182080.

[pmid10839358-9] Gaiano N, Nye JS, Fishell G (May 2000). “Radial glial identity is promoted by Notch1 signaling in the murine forebrain”. Neuron 26 (2): 395–404. doi:10.1016/S0896-6273(00)81172-1. PMID 10839358.

[pmid11171394-10] Chambers CB, Peng Y, Nguyen H, Gaiano N, Fishell G, Nye JS (March 2001). “Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors”. Development 128 (5): 689–702. doi:10.1242/dev.128.5.689. PMID 11171394.

[pmid18593473-11] Keilani S, Sugaya K (July 2008). “Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1”. BMC Dev. Biol. 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473.

[pmid19571148-12] Sibbe M, Förster E, Basak O, Taylor V, Frotscher M (July 2009). “Reelin and Notch1 cooperate in the development of the dentate gyrus”. J. Neurosci. 29 (26): 8578–85. doi:10.1523/JNEUROSCI.0958-09.2009. PMC 6665659. PMID 19571148.

[pmid12123574-13] Foltz DR, Santiago MC, Berechid BE, Nye JS (June 2002). “Glycogen synthase kinase-3beta modulates notch signaling and stability”. Curr. Biol. 12 (12): 1006–11. Bibcode: 2002CBio...12.1006F. doi:10.1016/s0960-9822(02)00888-6. PMID 12123574.

[pmid14583609-14] Sade H, Krishna S, Sarin A (January 2004). “The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells”. J. Biol. Chem. 279 (4): 2937–44. doi:10.1074/jbc.M309924200. PMID 14583609.

[pmid11101851-15] Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (December 2000). “MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors”. Nat. Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851.

[pmid12370315-16] Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (November 2002). “Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors”. Mol. Cell. Biol. 22 (21): 7688–700. doi:10.1128/mcb.22.21.7688-7700.2002. PMC 135662. PMID 12370315.

[pmid14638857-17] Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U, Ibáñez CF (November 2003). “Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3”. J. Cell Biol. 163 (4): 723–8. doi:10.1083/jcb.200305112. PMC 2173673. PMID 14638857.

[pmid8642313-18] Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T (May 1996). “T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells”. J. Exp. Med. 183 (5): 2025–32. doi:10.1084/jem.183.5.2025. PMC 2192574. PMID 8642313.

[pmid11418662-19] Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E (July 2001). “Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain”. J. Immunol. 167 (1): 289–95. doi:10.4049/jimmunol.167.1.289. PMID 11418662.

[pmid12050162-20] Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (August 2002). “The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway”. J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.

[pmid12644465-21] Nam Y, Weng AP, Aster JC, Blacklow SC (June 2003). “Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex”. J. Biol. Chem. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.

[pmid9111040-22] Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (April 1997). “Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription”. J. Biol. Chem. 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.

[pmid11404076-23] Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). “The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity”. Mech. Dev. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.

[pmid10713164-24] Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). “SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function”. Mol. Cell. Biol. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.

[pmid18628966-25] Chastagner P, Israël A, Brou C (2008). “AIP4/Itch regulates Notch receptor degradation in the absence of ligand”. PLOS ONE 3 (7). Bibcode: 2008PLoSO...3.2735C. doi:10.1371/journal.pone.0002735. PMC 2444042. PMID 18628966.

[pmid12913000-26] Yeh TS, Lin YM, Hsieh RH, Tseng MJ (October 2003). “Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch”. J. Biol. Chem. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.

[pmid30975888-27] Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JW, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M (April 2019). “Deubiquitinase USP10 regulates Notch signaling in the endothelium.”. Science 364 (6436): 188–193. Bibcode: 2019Sci...364..188L. doi:10.1126/science.aat0778. hdl:20.500.12105/9685. PMID 30975888.

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NOTCH1とは？わかりやすく解説

NOTCH1

機能

相互作用

出典

関連文献

外部リンク

「NOTCH1」の関連用語

NOTCH1とは？ わかりやすく解説

NOTCH1

機能

相互作用

出典

関連文献

外部リンク

急上昇のことば

「NOTCH1」の関連用語

NOTCH1とは？わかりやすく解説