ＧＳ‐３９７８３
GS-39783
出典: フリー百科事典『ウィキペディア（Wikipedia）』 (2025/08/31 02:31 UTC 版)
| |
|
| IUPAC命名法による物質名 | |
|---|---|
|
|
| データベースID | |
| CAS番号 |
39069-52-8 |
| ATCコード | None |
| PubChem | CID: 6604928 |
| IUPHAR/BPS | 5446 |
| ChemSpider | 5037184 |
| UNII | HD3T22A5DM |
| 化学的データ | |
| 化学式 | |
| 分子量 | 337.44 g·mol−1 |
|
|
|
|
GS-39783は、科学研究に使用される化合物で、GABAB受容体において陽性アロステリック調節因子として作用する[1][2]。動物実験では抗不安作用を示し[3][4][5]、アルコール[6][7]、コカイン[8][9][10]、、ニコチン[11]の自己投与を減少させることが示されている。
出典
- ^ “N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function”. The Journal of Pharmacology and Experimental Therapeutics 307 (1): 322–30. (October 2003). doi:10.1124/jpet.103.053074. PMID 129548166
- ^ “Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors”. Bioorganic & Medicinal Chemistry Letters 17 (22): 6206–11. (November 2007). doi:10.1016/j.bmcl.2007.09.023. PMC 2278029. PMID 17884493.
- ^ “Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior”. Neuropsychopharmacology 29 (6): 1050–62. (June 2004). doi:10.1038/sj.npp.1300413. PMID 15039762.
- ^ “Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines”. The Journal of Pharmacology and Experimental Therapeutics 310 (3): 952–63. (September 2004). doi:10.1124/jpet.104.066753. PMID 151138486
- ^ “Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents”. Neuropharmacology 54 (5): 854–62. (April 2008). doi:10.1016/j.neuropharm.2008.01.004. PMID 18328507.
- ^ “Reducing effect of the positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats”. European Journal of Pharmacology 525 (1–3): 105–11. (November 2005). doi:10.1016/j.ejphar.2005.10.005. PMID 162894526
- ^ “Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats”. Psychopharmacology 193 (2): 171–8. (August 2007). doi:10.1007/s00213-007-0776-1. PMID 17393141.
- ^ “Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats”. Psychopharmacology 173 (1–2): 105–11. (April 2004). doi:10.1007/s00213-003-1706-5. PMID 14712341.
- ^ “The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat”. Neuropsychopharmacology 30 (11): 2065–72. (November 2005). doi:10.1038/sj.npp.1300734. PMID 15841108.
- ^ “GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine”. Neuropsychopharmacology 32 (2): 388–98. (February 2007). doi:10.1038/sj.npp.1301102. PMC 1774586. PMID 16710312.
- ^ “Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats”. The Journal of Pharmacology and Experimental Therapeutics 326 (1): 306–14. (July 2008). doi:10.1124/jpet.108.139204. PMC 2574924. PMID 18445779.
- GS-39783のページへのリンク