glycosynthaseとは 意味・読み方・使い方

名詞

glycosynthase (複数形 glycosynthases)

1. (biochemistry) Any enzyme that catalyses the formation of a glycoside.
   • 2015 July 23, “Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, かつ A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities”, in PLOS ONE‎^[1], DOI:10.1371/journal.pone.0132848:

     To control Fc N-glycans, we performed a rearrangement of Fc N-glycans from a heterogeneous N-glycosylation pattern to homogeneous N-glycans using chemoenzymatic approaches with two types of endo-β-N-acetyl glucosaminidases (ENG’ases), one that works as a hydrolase to cleave all heterogeneous N-glycans, another that is used as a glycosynthase to generate homogeneous N-glycans.