NO327004B1 - Nye faststoff-former av mesoprogestin 11<beta>-[4E-(hydroksyiminometyl)-fenyl]-17<alfa>-metoksymetyl-17<beta>-metoksyostra-4,9-dien-3-on - Google Patents

Nye faststoff-former av mesoprogestin 11<beta>-[4E-(hydroksyiminometyl)-fenyl]-17<alfa>-metoksymetyl-17<beta>-metoksyostra-4,9-dien-3-on Download PDF

Info

Publication number: NO327004B1
Authority: NO; Norway
Prior art keywords: solvate; methoxy; hydroxyiminomethyl; methoxymethyl; phenyl
Prior art date: 2000-05-23

Application number

NO20025613A

Other languages

English (en)

Norwegian (no)

Other versions

NO20025613L (no

NO20025613D0 (no

Inventor

Detlef Grawe

Peter Hosel

Uwe Mueller

Gabriele Winter

Original Assignee

Bayer Shering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-23

Filing date

2002-11-22

Publication date

2009-04-06

2002-11-22 Application filed by Bayer Shering Pharma Ag filed Critical Bayer Shering Pharma Ag

2002-11-22 Publication of NO20025613L publication Critical patent/NO20025613L/no

2002-11-22 Publication of NO20025613D0 publication Critical patent/NO20025613D0/no

2009-04-06 Publication of NO327004B1 publication Critical patent/NO327004B1/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Reproductive Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20025613A 2000-05-23 2002-11-22 Nye faststoff-former av mesoprogestin 11<beta>-[4E-(hydroksyiminometyl)-fenyl]-17<alfa>-metoksymetyl-17<beta>-metoksyostra-4,9-dien-3-on NO327004B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00110887A EP1157996A1 (de)	2000-05-23	2000-05-23	Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on
PCT/EP2001/005237 WO2001090137A2 (de)	2000-05-23	2001-05-09	NEUE FESTKÖRPERFORMEN DES MESOPROGESTINS 11β-[4E-(HYDROXYIMINOMETHYL)-PHENYL]-17α-METHOXYMETHYL-17β-METHOXY-ESTRA-4,9-DIEN-3-ON

Publications (3)

Publication Number	Publication Date
NO20025613L NO20025613L (no)	2002-11-22
NO20025613D0 NO20025613D0 (no)	2002-11-22
NO327004B1 true NO327004B1 (no)	2009-04-06

Family

ID=8168805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20025613A NO327004B1 (no)	2000-05-23	2002-11-22	Nye faststoff-former av mesoprogestin 11<beta>-[4E-(hydroksyiminometyl)-fenyl]-17<alfa>-metoksymetyl-17<beta>-metoksyostra-4,9-dien-3-on

Country Status (30)

Country	Link
US (1)	US7799770B2 (sr)
EP (3)	EP1157996A1 (sr)
JP (1)	JP2003534350A (sr)
KR (1)	KR100553292B1 (sr)
CN (1)	CN100384867C (sr)
AT (1)	ATE397617T1 (sr)
AU (2)	AU2001256344B2 (sr)
BG (1)	BG65968B1 (sr)
BR (1)	BR0111058A (sr)
CA (1)	CA2409869C (sr)
CZ (1)	CZ2003620A3 (sr)
DE (1)	DE50114012D1 (sr)
DK (1)	DK1292607T3 (sr)
EA (1)	EA005623B1 (sr)
EC (2)	ECSP024358A (sr)
ES (1)	ES2307613T3 (sr)
HR (2)	HRP20080423A2 (sr)
HU (1)	HUP0301956A3 (sr)
IL (2)	IL152868A0 (sr)
ME (1)	MEP15608A (sr)
MX (1)	MXPA02011524A (sr)
NO (1)	NO327004B1 (sr)
NZ (1)	NZ522768A (sr)
PL (1)	PL358789A1 (sr)
PT (1)	PT1292607E (sr)
RS (1)	RS50493B (sr)
SK (1)	SK2922003A3 (sr)
UA (1)	UA73988C2 (sr)
WO (1)	WO2001090137A2 (sr)
ZA (1)	ZA200209322B (sr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10218109A1 (de) *	2002-04-23	2003-11-20	Jenapharm Gmbh	Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
DE10218107A1 (de) *	2002-04-23	2003-11-20	Jenapharm Gmbh	Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
WO2006078731A2 (en) *	2005-01-18	2006-07-27	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
US20090054387A1 (en) *	2006-04-18	2009-02-26	Detlef Grawe	Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil)
DE102006018888A1 (de) *	2006-04-18	2007-10-25	Bayer Schering Pharma Ag	Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)
EP1862468A1 (de) *	2006-06-02	2007-12-05	Bayer Schering Pharma Aktiengesellschaft	Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on
DE102009034368A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de)	2009-07-21	2011-02-10	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de)	2009-07-21	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesteronrezeptorantagonisten
DE102010007719A1 (de)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesteronrezeptorantagonisten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4332283A1 (de) *	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19610667C2 (de) *	1996-03-08	1998-04-09	Schering Ag	(Z)-11ß-[4-(Dimethylamino)phenyl]17ß-hydroxy-17alpha-(3-hydroxy-1-propenyl)estr-4-en-3-on als kristallines Ansolvat
AU6335600A (en) *	1999-07-29	2001-02-19	Eli Lilly And Company	A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride

2000
- 2000-05-23 EP EP00110887A patent/EP1157996A1/de not_active Withdrawn
2001
- 2001-05-09 PT PT01929632T patent/PT1292607E/pt unknown
- 2001-05-09 SK SK292-2003A patent/SK2922003A3/sk not_active Application Discontinuation
- 2001-05-09 BR BR0111058-6A patent/BR0111058A/pt not_active IP Right Cessation
- 2001-05-09 US US10/296,463 patent/US7799770B2/en active Active
- 2001-05-09 EP EP07115136A patent/EP1862469A2/de not_active Withdrawn
- 2001-05-09 CN CNB018099394A patent/CN100384867C/zh not_active Expired - Fee Related
- 2001-05-09 EP EP01929632A patent/EP1292607B1/de not_active Expired - Lifetime
- 2001-05-09 HU HU0301956A patent/HUP0301956A3/hu unknown
- 2001-05-09 ME MEP-156/08A patent/MEP15608A/xx unknown
- 2001-05-09 CA CA002409869A patent/CA2409869C/en not_active Expired - Lifetime
- 2001-05-09 MX MXPA02011524A patent/MXPA02011524A/es active IP Right Grant
- 2001-05-09 AT AT01929632T patent/ATE397617T1/de not_active IP Right Cessation
- 2001-05-09 RS YUP-887/02A patent/RS50493B/sr unknown
- 2001-05-09 EA EA200201192A patent/EA005623B1/ru not_active IP Right Cessation
- 2001-05-09 IL IL15286801A patent/IL152868A0/xx unknown
- 2001-05-09 DK DK01929632T patent/DK1292607T3/da active
- 2001-05-09 HR HR20080423A patent/HRP20080423A2/xx not_active Application Discontinuation
- 2001-05-09 DE DE50114012T patent/DE50114012D1/de not_active Expired - Lifetime
- 2001-05-09 KR KR1020027015762A patent/KR100553292B1/ko not_active Expired - Fee Related
- 2001-05-09 AU AU2001256344A patent/AU2001256344B2/en not_active Ceased
- 2001-05-09 HR HR20021032A patent/HRP20021032B1/xx not_active IP Right Cessation
- 2001-05-09 WO PCT/EP2001/005237 patent/WO2001090137A2/de not_active Ceased
- 2001-05-09 ES ES01929632T patent/ES2307613T3/es not_active Expired - Lifetime
- 2001-05-09 NZ NZ522768A patent/NZ522768A/en unknown
- 2001-05-09 AU AU5634401A patent/AU5634401A/xx active Pending
- 2001-05-09 CZ CZ2003620A patent/CZ2003620A3/cs unknown
- 2001-05-09 JP JP2001586324A patent/JP2003534350A/ja active Pending
- 2001-05-09 PL PL01358789A patent/PL358789A1/xx not_active IP Right Cessation
- 2001-09-05 UA UA20021210147A patent/UA73988C2/uk unknown
2002
- 2002-11-14 IL IL152868A patent/IL152868A/en not_active IP Right Cessation
- 2002-11-15 ZA ZA200209322A patent/ZA200209322B/en unknown
- 2002-11-22 EC EC2002004358A patent/ECSP024358A/es unknown
- 2002-11-22 NO NO20025613A patent/NO327004B1/no not_active IP Right Cessation
2003
- 2003-02-14 BG BG107557A patent/BG65968B1/bg unknown
2008
- 2008-10-22 EC EC2008004358A patent/ECSP084358A/es unknown

Also Published As

Publication number	Publication date
US7799770B2 (en)	2010-09-21
RS50493B (sr)	2010-03-02
ECSP024358A (es)	2003-03-31
YU88702A (sh)	2006-01-16
EP1862469A2 (de)	2007-12-05
DK1292607T3 (da)	2008-10-13
BG65968B1 (bg)	2010-07-30
HUP0301956A3 (en)	2010-03-29
SK2922003A3 (en)	2003-08-05
EA200201192A1 (ru)	2003-06-26
NO20025613L (no)	2002-11-22
EP1292607B1 (de)	2008-06-04
ATE397617T1 (de)	2008-06-15
KR100553292B1 (ko)	2006-02-22
HRP20021032B1 (hr)	2008-09-30
PL358789A1 (en)	2004-08-23
CN100384867C (zh)	2008-04-30
ZA200209322B (en)	2005-03-10
MEP15608A (en)	2010-06-10
NZ522768A (en)	2005-03-24
JP2003534350A (ja)	2003-11-18
NO20025613D0 (no)	2002-11-22
ES2307613T3 (es)	2008-12-01
WO2001090137A3 (de)	2002-04-04
DE50114012D1 (en)	2008-07-17
CN1430624A (zh)	2003-07-16
CZ2003620A3 (cs)	2003-08-13
CA2409869A1 (en)	2002-11-20
AU5634401A (en)	2001-12-03
UA73988C2 (en)	2005-10-17
EP1292607A2 (de)	2003-03-19
MXPA02011524A (es)	2004-09-10
IL152868A0 (en)	2003-06-24
EA005623B1 (ru)	2005-04-28
PT1292607E (pt)	2008-09-15
HRP20021032A2 (en)	2005-02-28
US20040006241A1 (en)	2004-01-08
IL152868A (en)	2009-08-03
AU2001256344B8 (en)	2001-12-03
HUP0301956A2 (hu)	2003-09-29
KR20030028742A (ko)	2003-04-10
WO2001090137A2 (de)	2001-11-29
CA2409869C (en)	2009-02-03
ECSP084358A (es)	2008-11-27
BR0111058A (pt)	2003-04-15
EP1157996A1 (de)	2001-11-28
HRP20080423A2 (en)	2008-10-31
AU2001256344B2 (en)	2007-01-25
BG107557A (bg)	2004-01-30

Legal Events

Date	Code	Title	Description
2011-12-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO327004B1 (no)	2009-04-06	Nye faststoff-former av mesoprogestin 11<beta>-[4E-(hydroksyiminometyl)-fenyl]-17<alfa>-metoksymetyl-17<beta>-metoksyostra-4,9-dien-3-on
FI111844B (fi)	2003-09-30	Menetelmä terapeuttisesti käyttökelpoisten 11beta-aryyli-4-estreenijohdannaisten valmistamiseksi
CA2654126A1 (en)	2007-12-13	Crystalline forms of 11.beta.-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17.alpha.-pregna-4,9-dien-3-one
EP1709062B9 (en)	2013-02-13	Exemestane and its intermediates and methods of making the same
CA1305699C (en)	1992-07-28	17-substituted androsta-1,4-dien-3-one derivatives
CN102675395A (zh)	2012-09-19	醋酸乌利司他的多晶型及其制备方法
TWI354675B (en)	2011-12-21	Process for preparing aromatase inhibitors
WO2008014249A2 (en)	2008-01-31	Improved preparations of 2 -substituted pyrrolo [2, 3-b] pyrazine ( 4, 7 -diazaindole ) compounds
NO301003B1 (no)	1997-09-01	Fremgangsmåte for fremstilling av E-1-£4'-(2-dimetyl-aminoetoksy)-fenyl\|-1-(3'-hydroksyfenyl)-2-fenyl-1-buten
IL195650A (en)	2012-08-30	Crystalline forms of 11beta-(4-acetylphenyl)-20,2021,21,21-pentafluoro-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-one
JP2008527022A (ja)	2008-07-24	メドロゲストンの製造法
CA2193610A1 (en)	1997-06-23	17 .alpha.-cyanomethylestra-4, 9-dien derivative compounds, processes for making same and pharmaceutical compositions containing same
US20060178520A1 (en)	2006-08-10	Process for preparing medrogestone