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NZ742570B2 - Apparatus for conducting an assay - Google Patents
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NZ742570B2 - Apparatus for conducting an assay - Google Patents

Apparatus for conducting an assay Download PDF

Info

Publication number
NZ742570B2
NZ742570B2 NZ742570A NZ74257016A NZ742570B2 NZ 742570 B2 NZ742570 B2 NZ 742570B2 NZ 742570 A NZ742570 A NZ 742570A NZ 74257016 A NZ74257016 A NZ 74257016A NZ 742570 B2 NZ742570 B2 NZ 742570B2
Authority
NZ
New Zealand
Prior art keywords
turntable
assay
disc
heater
assay disc
Prior art date
Application number
NZ742570A
Other versions
NZ742570A (en
Inventor
Howard Rose
David Hugh Williams
Ken Jin Wong
Original Assignee
Mast Group Limited
Filing date
Publication date
Priority claimed from GBGB1520193.2A external-priority patent/GB201520193D0/en
Application filed by Mast Group Limited filed Critical Mast Group Limited
Publication of NZ742570A publication Critical patent/NZ742570A/en
Publication of NZ742570B2 publication Critical patent/NZ742570B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using Bluetooth®
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1811—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using electromagnetic induction heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/14—Measuring arrangements characterised by the use of optical techniques for measuring distance or clearance between spaced objects or spaced apertures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material

Abstract

The present invention discloses an apparatus for conducting an assay, wherein the apparatus comprises a turntable (1) for receiving an assay disc (100) and to control an assay on said assay disc by rotational movement of said turntable, wherein said turntable comprises: one or more heater modules (4) to apply heat to one or more specific locations forming part of said assay disc during rotation; a heater controller (54) to select a required heater and to control the temperature thereof, and an IR transceiver (30, 55) to allow instructions and/or heating parameters to be transferred to the heater controller wirelessly. More specifically, the present invention discloses, an apparatus for conducting an assay, wherein the heating location and rate of heating/cooling at a particular location on the assay disc may be controlled.

Claims (23)

1. Turntable for receiving an assay disc and to control an assay on said assay disc by rotational movement of said turntable, wherein said turntable comprises: one or more heater modules to apply heat to one or more specific locations forming part of said assay disc during rotation; a heater controller to select a required heater and to control the temperature thereof, an IR transceiver to allow instructions and/or heating parameters to be transferred to the heater controller wirelessly.
2. Turntable as claimed in claim 1 further comprising means to facilitate correct positioning of the assay disc relative to the turntable.
3. Turntable as claimed in claim 2 wherein said means comprise a central spindle on the turntable corresponding to a spindle hole in the assay disc, and wherein said spindle has a longitudinal groove to correspond with a longitudinal projection on a central hub of the assay disc; optionally, wherein the horizontal dimension of the groove of the spindle decreases in a longitudinally downward direction.
4. Turntable as claimed in claim 2 wherein said means comprise a locating projection on the turntable to mate with a corresponding locating recess on the assay disc, optionally at, adjacent to, or near the periphery of the assay disc.
5. Turntable as cla ime d in claim 3 wherein the means of locating the assay disc relative to the turntable further comprises a locating projection on the turntable to mate with a corresponding locating recess on the assay disc, optionally at, adjacent to, or near the periphery of the assay disc.
6. Turntable as claimed in claim 1 further comprising clamping means to secure the assay disc to the turntable; optionally wherein said clamping means comprise a mechanical ball bearing clamping mechanism to hold the assay disc to the turntable.
7. Turntable as claimed in claim 6 wherein the clamping means comprise magnetic means for holding the assay disc in a fixed position relative to the turntable and/or for aligning and/or guiding the disc to a correct position.
8. Turntable as claimed in claim 7 wherein said magnetic means comprise disc magnets arranged in opposite pole directions in the turntable corresponding to disc magnets arranged in opposite pole directions in the assay disc.
9. Turntable as claimed in any preceding claim further comprising wireless power transfer means to transfer power to heater modules in the turntable and/or to the heater controller.
10. Turntable as claimed in any preceding claim further wherein the IR transceiver comprises four IR emitters and one IR receiver; optionally wherein the four emitters are in equidistance surrounding the central hub of the turntable. arranged
11. Turntable as claimed in any preceding claim wherein there are two or more heater modules.
12. Turntable as claimed in any preceding claim wherein there are two heater modules.
13. Turntable as claimed in claim 11 or claim 12 wherein the heater modules are independently controlled.
14. Turntable as claimed in any of claims 11 to 13 wherein the turntable is configured to distributed to two or more heaters receive power and wherein power supplied may be operating at different power levels at the same time.
15. Turntable as claimed in any preceding claim comprising a primary coil assembly and a secondary coil assembly.
16. Assay unit comprising a turntable as claimed in any preceding claim.
Assay unit as claimed in claim 16 further comprising means for heating and/or cooling the ambient temperature of a chamber within which the assay disc is located during the assay.
18. Assay unit as claimed in claim 17 wherein said means for heating and/or cooling the ambient temperature of the chamber is a fan heater or cooler.
19. The combination of a turntable as claimed in any of claims 1 to 15 or an assay unit as claimed in any of claims 16 to 18, and an assay disc configured to be located on the turntable.
20. Use of an apparatus as claimed in any preceding claim to conduct an assay.
21. Turntable as claimed in claim 1, substantially as herein described with reference to any embodiment disclosed.
22. Assay unit as claimed in claim 16, substantially as herein described with reference to any embodiment disclosed.
23. Use as claimed in claim 20, substantially as herein described with reference to any embodiment disclosed.
NZ742570A 2016-11-15 Apparatus for conducting an assay NZ742570B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1520193.2A GB201520193D0 (en) 2015-11-16 2015-11-16 Apparatus for conducting an assay
PCT/GB2016/053568 WO2017085472A1 (en) 2015-11-16 2016-11-15 Apparatus for conducting an assay

Publications (2)

Publication Number Publication Date
NZ742570A NZ742570A (en) 2024-08-30
NZ742570B2 true NZ742570B2 (en) 2024-12-03

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