AR083338A1 - Formulaciones estabilizadas que contienen anticuerpos anti-receptor de interleucina-4 (il-4r) - Google Patents
Formulaciones estabilizadas que contienen anticuerpos anti-receptor de interleucina-4 (il-4r)Info
- Publication number
- AR083338A1 AR083338A1 ARP110103663A AR083338A1 AR 083338 A1 AR083338 A1 AR 083338A1 AR P110103663 A ARP110103663 A AR P110103663A AR 083338 A1 AR083338 A1 AR 083338A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- pharmaceutical formulation
- liquid pharmaceutical
- buffer
- concentration
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 108040006852 interleukin-4 receptor activity proteins Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 14
- 239000007788 liquid Substances 0.000 abstract 12
- 239000006184 cosolvent Substances 0.000 abstract 4
- 239000003638 chemical reducing agent Substances 0.000 abstract 3
- 239000003017 thermal stabilizer Substances 0.000 abstract 3
- 101001033312 Homo sapiens Interleukin-4 receptor subunit alpha Proteins 0.000 abstract 2
- 229920001213 Polysorbate 20 Polymers 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 102000054663 human IL4R Human genes 0.000 abstract 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 2
- 229940068977 polysorbate 20 Drugs 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 229920002508 Poloxamer 181 Polymers 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 229940085692 poloxamer 181 Drugs 0.000 abstract 1
- 229940050929 polyethylene glycol 3350 Drugs 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 125000000185 sucrose group Chemical group 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39028310P | 2010-10-06 | 2010-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR083338A1 true AR083338A1 (es) | 2013-02-21 |
Family
ID=45995014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110103663 AR083338A1 (es) | 2010-10-06 | 2011-10-03 | Formulaciones estabilizadas que contienen anticuerpos anti-receptor de interleucina-4 (il-4r) |
Country Status (13)
| Country | Link |
|---|---|
| AR (1) | AR083338A1 (sr) |
| DK (2) | DK3354280T3 (sr) |
| ES (2) | ES2820246T3 (sr) |
| HR (1) | HRP20181822T1 (sr) |
| HU (1) | HUE052089T2 (sr) |
| LT (1) | LT2624865T (sr) |
| PT (1) | PT3354280T (sr) |
| RS (1) | RS57850B1 (sr) |
| SI (1) | SI2624865T1 (sr) |
| SM (1) | SMT201800488T1 (sr) |
| TW (7) | TWI679988B (sr) |
| UA (1) | UA111731C2 (sr) |
| UY (1) | UY33652A (sr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9574004B2 (en) | 2012-08-21 | 2017-02-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| TWI707694B (zh) * | 2013-06-21 | 2020-10-21 | 法商賽諾菲生物技術公司 | Ｉｌ-４ｒ拮抗劑用於製造治療鼻息肉症的藥物之用途 |
| CN111437387B (zh) * | 2013-06-21 | 2024-10-01 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗鼻息肉症的方法 |
| AU2015346150B2 (en) | 2014-11-14 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| CA3079946A1 (en) | 2017-10-30 | 2019-05-09 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| BR112022000740A2 (pt) | 2019-07-16 | 2022-07-05 | Sanofi Biotechnology | Métodos para tratamento ou prevenção de asma por administração de um antagonista de il-4r |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| ES2332082B1 (es) * | 2008-07-24 | 2010-10-26 | Consejo Superior De Investigaciones Cientificas (Csic) 45% | Sistema de alineacion de patrones en un sustrato mediante litografia por estencil. |
| KR101593726B1 (ko) * | 2008-09-10 | 2016-02-18 | 니혼 엑스란 고교 (주) | 가교 아크릴레이트계 섬유 및 이의 제조방법 |
| AU2010221156A1 (en) * | 2009-03-06 | 2011-09-22 | Genentech, Inc. | Antibody formulation |
-
2011
- 2011-05-10 UA UAA201305598A patent/UA111731C2/uk unknown
- 2011-10-03 AR ARP110103663 patent/AR083338A1/es not_active Application Discontinuation
- 2011-10-05 TW TW105134483A patent/TWI679988B/zh active
- 2011-10-05 TW TW104123984A patent/TWI568445B/zh active
- 2011-10-05 TW TW111138434A patent/TWI856388B/zh active
- 2011-10-05 SI SI201131568T patent/SI2624865T1/sl unknown
- 2011-10-05 HU HUE18161288A patent/HUE052089T2/hu unknown
- 2011-10-05 LT LTEP11770625.9T patent/LT2624865T/lt unknown
- 2011-10-05 PT PT181612888T patent/PT3354280T/pt unknown
- 2011-10-05 RS RS20181308A patent/RS57850B1/sr unknown
- 2011-10-05 HR HRP20181822TT patent/HRP20181822T1/hr unknown
- 2011-10-05 TW TW109107375A patent/TWI718890B/zh active
- 2011-10-05 TW TW109131629A patent/TWI782325B/zh active
- 2011-10-05 DK DK18161288.8T patent/DK3354280T3/da active
- 2011-10-05 ES ES18161288T patent/ES2820246T3/es active Active
- 2011-10-05 TW TW108111631A patent/TWI690329B/zh active
- 2011-10-05 TW TW100135992A patent/TWI498121B/zh active
- 2011-10-05 ES ES11770625.9T patent/ES2687813T3/es active Active
- 2011-10-05 DK DK11770625.9T patent/DK2624865T3/en active
- 2011-10-05 SM SM20180488T patent/SMT201800488T1/it unknown
- 2011-10-06 UY UY33652A patent/UY33652A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1258305A1 (en) | 2019-11-08 |
| UY33652A (es) | 2012-04-30 |
| UA111731C2 (uk) | 2016-06-10 |
| LT2624865T (lt) | 2018-10-25 |
| HUE052089T2 (hu) | 2021-04-28 |
| TW201542229A (zh) | 2015-11-16 |
| TW201221141A (en) | 2012-06-01 |
| RS57850B1 (sr) | 2018-12-31 |
| TW202102262A (zh) | 2021-01-16 |
| SMT201800488T1 (it) | 2018-11-09 |
| TW202320851A (zh) | 2023-06-01 |
| DK2624865T3 (en) | 2018-10-22 |
| TWI718890B (zh) | 2021-02-11 |
| PT3354280T (pt) | 2020-09-01 |
| DK3354280T3 (da) | 2020-09-28 |
| TWI568445B (zh) | 2017-02-01 |
| ES2687813T3 (es) | 2018-10-29 |
| TWI679988B (zh) | 2019-12-21 |
| TW202026011A (zh) | 2020-07-16 |
| TWI782325B (zh) | 2022-11-01 |
| TW201716086A (zh) | 2017-05-16 |
| ES2820246T3 (es) | 2021-04-20 |
| TWI498121B (zh) | 2015-09-01 |
| HRP20181822T1 (hr) | 2018-12-28 |
| TWI690329B (zh) | 2020-04-11 |
| TWI856388B (zh) | 2024-09-21 |
| SI2624865T1 (sl) | 2018-10-30 |
| TW201924718A (zh) | 2019-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |