AR245431A1 - Procedimiento para separar los enantiomeros de un derivado de benzopirano. - Google Patents
Procedimiento para separar los enantiomeros de un derivado de benzopirano.Info
- Publication number
- AR245431A1 AR245431A1 AR90316164A AR31616490A AR245431A1 AR 245431 A1 AR245431 A1 AR 245431A1 AR 90316164 A AR90316164 A AR 90316164A AR 31616490 A AR31616490 A AR 31616490A AR 245431 A1 AR245431 A1 AR 245431A1
- Authority
- AR
- Argentina
- Prior art keywords
- enantiomer
- enantiomers
- separation
- racemico
- inoculated
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 239000012442 inert solvent Substances 0.000 abstract 2
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA SEPARAR LOS ENATIOMEROS DE TRANS 3-HIDROXI-2,2-DIMETIL-4 (2-OXO-1,2-DIHIDROPIRIDIN-1-IL)-3,4-DIHIDRO-2H-1-BENZOP IRANO-6- CARBONITRILO (''I''), DONDE EN UN DISOLVENTE INERTE O EN UNA MEZCLA DE DISOLVENTES INERTES SE DISUELVE EL COMPUESTO ''I'' RACEMICO JUNTO CON UNA PEQUENA CANTIDAD DEL ENANTIOMERO (-)-''I'' O (+)-''I''; LA SOLUCION OBTENIDA SE INOCULA CON EL MISMO ENANTIOMERO, CON LO QUE PRECIPITA ESTE, QUE SE AISLA; EN EL FILTRADO SE DISUELVE MAS COMPUESTO ''I'' RACEMICO; LA SOLUCION SE INOCULA CON EL OTRO ENANTIOMERO, (+)-''I'' O (-)-''I'', RESPECTIVAMENTE, QUE ASI PRECIPITA Y SE AISLA, Y, SI SE DESEA, ESTE CICLO DE CRISTALIZACIONES SE REPITE UNA O VARIAS VECES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3904496A DE3904496A1 (de) | 1989-02-15 | 1989-02-15 | Verfahren zur enantiomerentrennung eines benzopyranderivats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR245431A1 true AR245431A1 (es) | 1994-01-31 |
Family
ID=6374110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR90316164A AR245431A1 (es) | 1989-02-15 | 1990-02-15 | Procedimiento para separar los enantiomeros de un derivado de benzopirano. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4952696A (es) |
| EP (1) | EP0383316B1 (es) |
| JP (1) | JP2847255B2 (es) |
| KR (1) | KR0144575B1 (es) |
| AR (1) | AR245431A1 (es) |
| AT (1) | ATE101109T1 (es) |
| AU (1) | AU623738B2 (es) |
| CA (1) | CA2009924A1 (es) |
| DE (2) | DE3904496A1 (es) |
| DK (1) | DK0383316T3 (es) |
| ES (1) | ES2048338T3 (es) |
| FI (1) | FI91756C (es) |
| HU (1) | HU208535B (es) |
| IE (1) | IE63050B1 (es) |
| IL (1) | IL93396A (es) |
| NO (1) | NO174747C (es) |
| NZ (1) | NZ232527A (es) |
| PT (1) | PT93145B (es) |
| ZA (1) | ZA901166B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU618007B2 (en) * | 1987-06-23 | 1991-12-12 | Sanofi | 2,2-dimethylchroman-3-ol derivatives, process for their preparation and pharmaceutical compositions in which they are present |
| DE3936616A1 (de) * | 1989-11-03 | 1991-05-08 | Merck Patent Gmbh | Verfahren zur enantiomerentrennung von benzopyranderivaten |
| CA2070243A1 (en) * | 1991-06-14 | 1992-12-15 | Akira Shiozawa | Chroman derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4916426B1 (es) * | 1968-09-30 | 1974-04-22 | ||
| FR2517677B1 (fr) * | 1981-12-09 | 1986-05-16 | Roussel Uclaf | Nouveaux ethers dont les restes organiques comportent des atomes chiraux, leur procede de preparation et leur application au dedoublement des alcools ou de certains composes de structure hemiacetalique. |
| DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
-
1989
- 1989-02-15 DE DE3904496A patent/DE3904496A1/de active Granted
-
1990
- 1990-02-10 KR KR1019900001619A patent/KR0144575B1/ko not_active Expired - Fee Related
- 1990-02-12 AU AU49391/90A patent/AU623738B2/en not_active Ceased
- 1990-02-13 JP JP2029756A patent/JP2847255B2/ja not_active Expired - Lifetime
- 1990-02-13 CA CA002009924A patent/CA2009924A1/en not_active Abandoned
- 1990-02-14 HU HU90798A patent/HU208535B/hu not_active IP Right Cessation
- 1990-02-14 PT PT93145A patent/PT93145B/pt not_active IP Right Cessation
- 1990-02-14 FI FI900725A patent/FI91756C/fi not_active IP Right Cessation
- 1990-02-14 IL IL9339690A patent/IL93396A/en not_active IP Right Cessation
- 1990-02-14 IE IE53690A patent/IE63050B1/en not_active IP Right Cessation
- 1990-02-14 US US07/479,893 patent/US4952696A/en not_active Expired - Lifetime
- 1990-02-14 NZ NZ232527A patent/NZ232527A/en unknown
- 1990-02-14 NO NO900716A patent/NO174747C/no unknown
- 1990-02-15 ZA ZA901166A patent/ZA901166B/xx unknown
- 1990-02-15 AR AR90316164A patent/AR245431A1/es active
- 1990-02-15 EP EP90102917A patent/EP0383316B1/de not_active Expired - Lifetime
- 1990-02-15 ES ES90102917T patent/ES2048338T3/es not_active Expired - Lifetime
- 1990-02-15 DK DK90102917.3T patent/DK0383316T3/da active
- 1990-02-15 AT AT90102917T patent/ATE101109T1/de not_active IP Right Cessation
- 1990-02-15 DE DE90102917T patent/DE59004452D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL93396A (en) | 1994-05-30 |
| NO174747B (no) | 1994-03-21 |
| HU900798D0 (en) | 1990-04-28 |
| EP0383316B1 (de) | 1994-02-02 |
| ZA901166B (en) | 1990-11-28 |
| KR900012930A (ko) | 1990-09-03 |
| DK0383316T3 (da) | 1994-03-07 |
| FI91756C (fi) | 1994-08-10 |
| PT93145A (pt) | 1990-08-31 |
| ATE101109T1 (de) | 1994-02-15 |
| US4952696A (en) | 1990-08-28 |
| IL93396A0 (en) | 1990-11-29 |
| AU4939190A (en) | 1990-08-23 |
| FI900725A0 (fi) | 1990-02-14 |
| AU623738B2 (en) | 1992-05-21 |
| EP0383316A2 (de) | 1990-08-22 |
| FI91756B (fi) | 1994-04-29 |
| NZ232527A (en) | 1991-03-26 |
| ES2048338T3 (es) | 1994-03-16 |
| JP2847255B2 (ja) | 1999-01-13 |
| NO900716D0 (no) | 1990-02-14 |
| PT93145B (pt) | 1996-04-30 |
| NO900716L (no) | 1990-08-16 |
| CA2009924A1 (en) | 1990-08-15 |
| IE63050B1 (en) | 1995-03-22 |
| NO174747C (no) | 1994-06-29 |
| EP0383316A3 (de) | 1991-01-16 |
| HU208535B (en) | 1993-11-29 |
| JPH02258781A (ja) | 1990-10-19 |
| HUT52772A (en) | 1990-08-28 |
| DE59004452D1 (de) | 1994-03-17 |
| KR0144575B1 (ko) | 1998-07-15 |
| DE3904496C2 (es) | 1990-12-06 |
| DE3904496A1 (de) | 1990-08-16 |
| IE900536L (en) | 1990-08-15 |
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