AU2015335036B2 - Powder for dental powder-jet cleansing - Google Patents
Powder for dental powder-jet cleansing Download PDFInfo
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- AU2015335036B2 AU2015335036B2 AU2015335036A AU2015335036A AU2015335036B2 AU 2015335036 B2 AU2015335036 B2 AU 2015335036B2 AU 2015335036 A AU2015335036 A AU 2015335036A AU 2015335036 A AU2015335036 A AU 2015335036A AU 2015335036 B2 AU2015335036 B2 AU 2015335036B2
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- AU
- Australia
- Prior art keywords
- powder
- jet
- disaccharide
- composition
- dental
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002016 disaccharides Chemical class 0.000 claims abstract description 60
- 239000000203 mixture Substances 0.000 claims abstract description 57
- 238000005498 polishing Methods 0.000 claims abstract description 16
- 239000002245 particle Substances 0.000 claims description 38
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- 239000000126 substance Substances 0.000 claims description 26
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- 238000009825 accumulation Methods 0.000 description 1
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
- 229950010221 alexidine Drugs 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium peroxydisulfate Substances [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 1
- VAZSKTXWXKYQJF-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)OOS([O-])=O VAZSKTXWXKYQJF-UHFFFAOYSA-N 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- HDTRYLNUVZCQOY-NCFXGAEVSA-N beta,beta-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-NCFXGAEVSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 1
- 235000019402 calcium peroxide Nutrition 0.000 description 1
- 229910000394 calcium triphosphate Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- NFCRBQADEGXVDL-UHFFFAOYSA-M cetylpyridinium chloride monohydrate Chemical compound O.[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NFCRBQADEGXVDL-UHFFFAOYSA-M 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 150000001879 copper Chemical class 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 229960004867 hexetidine Drugs 0.000 description 1
- DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 229960004995 magnesium peroxide Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229960001774 octenidine Drugs 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229940048084 pyrophosphate Drugs 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000012418 sodium perborate tetrahydrate Substances 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- IBDSNZLUHYKHQP-UHFFFAOYSA-N sodium;3-oxidodioxaborirane;tetrahydrate Chemical compound O.O.O.O.[Na+].[O-]B1OO1 IBDSNZLUHYKHQP-UHFFFAOYSA-N 0.000 description 1
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
- UHCGLDSRFKGERO-UHFFFAOYSA-N strontium peroxide Chemical compound [Sr+2].[O-][O-] UHCGLDSRFKGERO-UHFFFAOYSA-N 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- 229940105296 zinc peroxide Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to the use of disaccharides as abrasive and/or polishing bodies for producing a dental jet powder for the supra- and/or subgingival powder-jet cleansing of dental surfaces. The invention in particular relates also to compositions for use as dental jet powder, comprising one or more disaccharides as a first abrasive and/or polishing body.
Description
POWDER FOR DENTAL POWDER-JET CLEANSING
The present invention relates to the use of particulate substrates as abrasive and/or polishing bodies for producing a dental jet powder for supragingival and/or subgingival powder-jet cleaning.
Powder-jet cleaning is nowadays a common and widely used method for the professional cleaning of tooth or tooth-root surfaces. Stains, hard deposits and soft deposits can be removed therewith in a rapid, gentle and efficient manner, and powder-jet cleaning can thus replace or supplement mechanical scraping with hand instruments or ultrasound treatments.
Fundamentally, in the case of tooth-surface treatments using compressed air and fine powder particles, a distinction is made between so-called air abrasion (conventional powder-jet treatment) and air polishing (air/powder/water jet instruments) depending on the strength of abrasion. Both are based on the principle that the impact of a mixture of powder and compressed air on the tooth (root) surface makes it possible to remove deposits adhering thereon. In the case of air polishing, water is additionally added to the air/powder mixture at the same time.
In the case of said tooth-surface treatments, the powders used for this purpose are based on different substances, such as, for example, sodium bicarbonate, which has been used for over 20 years in powder-jet cleaning. Although sodium bicarbonate is distinguished by a good tolerability for the patients to be treated, significant substance removal has been found when cleaning exposed root or dentin surfaces.
Although powder-jet instruments using sodium bicarbonate as abrasive powder are an excellent means for the efficient cleaning of tooth surfaces, the use of sodium bicarbonate powders in the subgingival region is problematic owing to their high abrasiveness with respect to dentin and cementum.
Therefore, there has been research into mildly abrasive powders, especially with respect to subgingival tooth-surface cleaning, and sugar substitutes and crystalline amino acids have been tested here in particular, these now also being used with success.
For example, WO 97/04741 A1 discloses the usage of xylitol and calcium carbonate in powders having an average particle size of less than 20 pm. Furthermore, EP 1 468 659 A2 discloses the usage of calcium triphosphate as abrasive in powder-jet treatment.
Although a continuous improvement can be recognized for the powders known in the prior art, especially with respect to the abrasive effect thereof in conjunction with gentle usage in the case of dentin, many still have taste-related or physiological disadvantages, and cause in the patients an unpleasant mouthfeel due to dryness, bad taste, or act as a laxative.
It is therefore an object of the present invention to provide a new jet powder which can achieve an optimized abrasive effect, specifically both supragingivally and subgingivally, and can simultaneously overcome the disadvantages of the prior art with respect to patient acceptance.
According to the invention, this object is achieved by using at least one disaccharide as abrasive and/or polishing body for producing a dental jet powder for the supragingival and/or subgingival powder-jet cleaning of tooth surfaces.
According to the invention, this object is achieved by using at least one disaccharide as abrasive and/or polishing body for producing a dental jet powder for the supragingival and/or subgingival powder-jet cleaning of tooth surfaces, wherein the at least one disaccharide is selected from one or more of the followings: cellobiose, gentiobiose, isomaltulose (palatinose), isomaltose, lactose, lactulose, laminaribiose, maltose, maltulose, melibiose, rhamnose, neotrehalose, nigerose, rutinose sambubiose, sucrose, trehalose.
The object is further achieved by a composition for use as dental jet powder, comprising (i) from 70 to 99.9% by weight of one or more disaccharides as a first abrasive and/or polishing body, and (ii) from 0.1 to 30.0% by weight of an anticaking agent, the sum of all fractions yielding 100% by weight.
The object underlying the invention is thereby fully achieved. The new use or the new composition allows an efficient and patient-friendly cleaning of tooth (root) surfaces, which can overcome the disadvantages of the prior art, and which provides an outstanding alternative to the powders available to date.
According to the invention, a composition comprising at least one disaccharide is used. In the case of said composition, it is especially preferred when the disaccharide is selected from trehalose and/or palatinose or mixtures thereof. Compared to the powders known and used in the prior art, the disaccharides, especially trehalose and/or palatinose, or powders thereof have, inter alia, the surprising advantage that they exhibit a better solubility and that a more gentle treatment of tooth surfaces can be achieved therewith than with comparative powders, with tolerability being increased at the same time. Furthermore, the disaccharides are more acceptable than, for example, sodium bicarbonate as regards taste.
Here and in the relevant field, “disaccharides” are regularly understood to mean double sugars which, as a result of linking two monosaccharides (single sugars), are covalently bonded via a glycosidic bond. Common to all disaccharides is their sweet taste. In particular, preference is given here to acariogenic disaccharides. The disaccharides used according to the invention can be composed of alpha- or beta-linked monosaccharides and can comprise different stereoisomers. The monosaccharides which can be present in alpha- or beta-form and which are the building blocks for the disaccharides are generally glucose, fructose, galactose, which are linked together in different combinations and via different bonds (alpha- or beta-glycosidic).
Examples of known disaccharides are cellobiose, gentiobiose, isomaltulose (palatinose), isomaltose, lactose, lactulose, laminaribiose, maltose, maltulose, melibiose, rhamnose, neotrehalose, nigerose, rutinose sambubiose, sucrose, trehalose. Preference is given here to acariogenic disaccharides, especially palatinose and trehalose.
Trehalose is a disaccharide consisting of two glucose molecules linked by an α,α’-1,1-glycosidic bond. The systematic name of trehalose is a-D-glucopyranosyl-(1—>1)-a-D-glucopyranoside; the short name is Gic α(1—>1)a Gio.
Palatinose, also referred to as isomaltulose in the literature and in the relevant field, has the systematic name 6-O-a-D-glucopyranosyl-D-fructose and is, like trehalose, acariogenic and therefore tooth-friendly. Both sugars do not cause digestion problems or other tolerance complaints.
Both sugars have a low glycemic index, are of food-grade quality, and outstandingly suitable as regards taste.
Proceeding from the prior art, it was surprising that these disaccharides are suitable as jet powders.
According to the invention, the disaccharides are present as powders having a certain average particle size. In this connection, the powders are prepared in the desired particle-size distribution by grinding, screening, air classification, classification or other process steps known to a person skilled in the art. The abrasiveness of a jet powder substantially depends not only on the particle speed to be influenced by the relevant instrument, but also on factors such as the hardness and mass of the particles. For instance, large particles of a lower density have approximately the same abrasiveness as smaller particles of greater density when mass is the same.
Accordingly, in the case of the use according to the invention and in the case of the jet powder according to the invention, it is intended when the disaccharide - or the mixtures of two or more thereof - additionally has a density of less than or equal to 2.5 g/cm3, preferably less than or equal to 2.0 g/cm3. Palatinose has a density of 1.77 g/cm3, and trehalose has a density of 1.76 g/cm3.
It has been found that the use of disaccharides, especially of disaccharides of a density of less than or equal to 2.0 g/cm3 in powder form, leads to a jet powder which can overcome the disadvantages of the jet powders known in the prior art. The disaccharide powders also did not lead to clumping in the jet instrument in laboratory tests, and therefore offer an outstanding alternative to the jet powders used to date in the prior art, the production of which is frequently associated with high costs.
According to the invention, the disaccharide can be used subgingivally or supragingivally.
Here, subgingival usage or subgingival use is understood to mean the usage of the jet powder according to the invention for tooth surfaces below the gum line. A progressive inflammatory reaction caused by the accumulation of subgingival biofilms leads to the formation of gingival pockets. These practically cannot be cleaned by the usage of toothbrushes and dental floss. Since the subgingival tooth surfaces are softer and more sensitive than the supragingival tooth surfaces, it is important to keep the abrasiveness of the jet powder used as low as possible.
By contrast, in the case of supragingival usage, jet powders are used for those tooth surfaces above the gum line.
Especially when gingiva becomes inflamed and is untreated for a relatively long time, this can lead to the development of periodontitis, i.e., an inflammation of the periodentium.
This is regularly associated with bone degradation and gingival recession. Gingival recession in turn exposes the tooth necks, which leads to an increased sensitivity. These exposed tooth necks must, just like the regions usually situated subgingivally, especially the tooth roots, be treated with powders of lower abrasiveness than supragingival regions so as not to injure the more sensitive tooth tissue present here.
Therefore, it can thus be envisaged in the use according to the invention that, in the case of subgingival usage, the mean particle size of the jet powder according to the invention is smaller than in the case of usage of the powder for supragingival jet cleaning. A prominent role is played here especially by the interaction between the density of the disaccharides used and the particle size thereof, and it has been found that optimal cleaning results are obtained by a density of less than or equal to 2.0 g/cm3 for the disaccharides used for the powders, in conjunction with a certain disaccharide particle size or certain jet-powder particle size that is matched to the particular usage. In particular, it is preferred when, in this connection, the mean particle size is less than or equal to 50 pm (D50) for the subgingival region and is less than or equal to 80 pm (D50) for the supragingival region.
In general, a jet powder contains substances which act as polishing and/or abrasive bodies. Owing to the production process, the individual substance particles in the case of said jet powder do not all have exactly the same size, but vary within a certain range (particle-size distribution). In this connection, the D50 value specifies the mean particle size. Accordingly, further parameters are the D10, as a measure of the smallest particles, and D90, and possibly D95, D99 and D100, for the larger particles in the sample. The closer together D10 and D100, the narrower the particle-size distribution.
According to one embodiment of the use according to the invention, the jet powder further comprises at least one of the following ingredients: an anticaking agent, a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, Lactobacillus bacteria or fragments thereof, and/or bactericides, or mixtures of one or more thereof.
It is self-evident that, with respect to their particle size as regards the jet-powder composition, the aforementioned further ingredients are selected such that the mean particle size of the jet powder remains in the aforementioned preferred ranges, i.e., for example with a mean particle size (D50) of less than 50 pm in the case of subgingival applications, and of less than 80 pm (D50) in the case of supragingival applications.
Anticaking agents are known in the field of jet powders, and are separating agents added to crystalline substances to prevent clumping-together of the substances, which can thereby be used more efficiently and in an automated manner. In the case of jet powders, it may also be necessary to use one or more anticaking agents in order to avoid clogging of the nozzles of the jet instrument in the event of clumping of the powder substances.
According to a preferred embodiment, the anticaking agent is selected from silicon dioxide, calcium carbonate, aluminum silicates, and/or aluminum hydroxide.
These substances are known in the prior art, especially also for the usage of oral dental-care products.
According to one embodiment of the composition according to the invention or the use thereof, the alditol is selected from erythritol, sorbitol, xylitol, mannitol, isomalt, lactitol, threitol, or mixtures of one or more thereof.
Alditols are noncyclic polyols structurally derived from carbohydrates as reduction products and are therefore sugar alcohols. They have already been used for a long time in jet powders as sugar substitutes in order to improve taste, since alditols are not cariogenic. in addition, alditols have also been used as abrasive or polishing bodies in jet powders, the mean particle size used generally depending on whether the jet powder is to be used subgingivally or supragingivally. For subgingival applications, a mean particle size of less than or equal to approximately 50 pm (D50) is generally used; for supragingival applications, a mean particle size of less than or equal to approximately 80 pm (D50) is generally used.
The crystalline amino acid used can be, for example, glycine.
The taste substances to be used according to the invention are, for example, natural or nature-identical odor substances and/or taste substances. These are generally understood to mean flavors giving a particular odor or taste to products taken or used orally. “Natural” flavor-providing odor substances and taste substances are substances or substance mixtures obtained and possibly purified from natural sources, for example plants or plant parts. Alternatively, the taste substances to be used can also have been produced synthetically.
As bactericides or as substances acting antimicrobially in general, it is possible to use in particular triclosan, chlorhexidine, copper salts, zinc salts and tin(li) salts, such as zinc citrate, zinc sulfate, zinc glycinate, sodium zinc citrate and tin(ll) pyrophosphate; metronidazole, quaternary ammonium compounds; bisguanides, such as, for example, chlorhexidine digluconate, hexetidine, cetylpyridinium chloride, octenidine, alexidine. Suitable bleaching agents are, in particular or in general, peroxide compounds, potassium persulfate, ammonium persulfate, sodium persulfate and lithium persulfate, potassium perborate monohydrate, ammonium perborate monohydrate, sodium perborate monohydrate and lithium perborate monohydrate, potassium perborate tetrahydrate, ammonium perborate tetrahydrate, sodium perborate tetrahydrate and lithium perborate tetrahydrate, sodium pyrophosphate peroxyhydrate, and magnesium peroxide, calcium peroxide, strontium peroxide and zinc peroxide. On the other hand, it is also possible for natural substances or parts thereof, or substances or parts thereof that are derived from natural substances or microorganisms, to be used in the use/composition according to the invention, such as, for example, Lactobacillus bacteria or fragments thereof, which may or may not have been killed.
As already mentioned further above, the jet powder can have mean particle sizes differently matched for the different areas of application. For example, in the case of a subgingival application, mean particle sizes D50 of between 10 pm to 50 pm, in particular of less than 25 pm, are suitable, and, for the supragingival area, mean particle sizes of between 30 pm to 150 pm (D50), and in particular of between approximately 50 pm and 80 pm (D50), in particular 65 pm (D50), are suitable.
Furthermore, according to a preferred embodiment of the use, it is intended when the disaccharide is present in the jet powder at a fraction of between 70 to 99.9% by weight, in particular of between 95% to 99.9% by weight.
As elucidated further above, the composition can also comprise further ingredients such as taste substances, anticaking agents, etc., in addition to the disaccharide to be used according to the invention, and so the percentage fraction of the disaccharide can vary depending on the desired application.
According to the invention, the at least one disaccharide is used as abrasive and/or polishing body in a dental jet powder for the therapy and/or prophylaxis of tooth-root diseases or tooth diseases.
As elucidated at the start, the regular cleaning of tooth surfaces is essential for a healthy oral flora. In every mouth, a deposit called plaque or also biofilm forms on the teeth after one to two days. Said biofilm consists of billions of bacteria, the metabolic products of which can damage the teeth and the gingiva. Just like for the development of caries, deposits on the tooth surface, in the gaps between teeth and especially in the gingival pockets are also a major cause of inflammations of the gum line and of the periodentium (periodontal diseases).
Therefore, an important goal of all tooth-maintaining prophylactic measures for the prevention of caries and periodontitis is the prevention of the development of deposits and the removal of deposits by regular and thorough dental care. A successful prophylaxis and therapy can be achieved by means of the jet powder according to the invention or of the use of at least one disaccharide, especially trehalose and/or palatinose, in a jet powder.
Accordingly, the present invention also provides a composition for use as dental jet powder, wherein the composition comprises the following: from 70 to 99.9% by weight of one or more preferably acariogenic disaccharides as a first abrasive and/or polishing body, and from 0.1 to 30.0% by weight of an anticaking agent, the sum of all fractions yielding 100% by weight.
On the basis of the present disclosure, it will be clear to a person skilled in the art that different compositions can be used for different purposes, and here in particular the general state of the teeth and tooth surfaces is taken into consideration.
In the case of said compositions, the disaccharide can, for example, be present in anhydrous form or as a dihydrate.
Accordingly, the composition is preferably an anhydrous powder, “anhydrous” being understood here to mean that the composition does not comprise any further addition of water except for any hydrated ingredients.
As already outlined further above, in a preferred embodiment of the composition according to the invention, it is intended when the disaccharide is trehalose and/or palatinose and/or when the disaccharide in the composition has a mean particle size (D50) of between 10 pm and 80 pm.
Accordingly, the trehalose to be used can preferably be a trehalose selected from the following CAS (Chemical Abstract Services) numbers: 99-20-7 (α,α-D-trehalose), 585-91- 1 (α,β-D-trehalose), 6138-23-4 (α,β-D-trehalose dihydrate), 499-23-0 (β,β-D-trehalose), 25018-27-3 (trehalose octaacetate).
The palatinose (isomaltulose) to be used can be the disaccharide registered under the following CAS number: 13718-94-0.
As in the case of the above-outlined use according to the invention, one embodiment is preferred in the case of the composition according to the invention, when the composition further additionally comprises at least one of the following ingredients in addition to the disaccharide: an anticaking agent, a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, Lactobacillus bacteria, and/or bactericides, or mixtures of one or more thereof.
As likewise explained further above for the use according to the invention, it is preferred in the case of said composition according to the invention when the anticaking agent is selected from at least one of the following: silicon dioxide, calcium carbonate, aluminum silicates, and/or aluminum hydroxide.
According to a further embodiment of the composition according to the invention or the use thereof, when an alditol is additionally used, it is selected from erythritol, sorbitol, xylitol, mannitol, isomalt, lactitol, threitol, or mixtures of one or more thereof.
It is self-evident that, here, a person skilled in the art will, both for the use according to the invention and for the composition according to the invention, coordinate and appropriately adjust the respective particle sizes of the further ingredients, especially those of the alditol to be optionally used or of the crystalline amino acid, for example glycine, to the mean particle size of the disaccharide, meaning that the mean particle size of the jet powder corresponds to the values specified further above and is adapted to the particular usage (subgingivally or supragingivally).
According to a further preferred embodiment, the composition according to the invention further comprises a flavoring, preferably orange flavor or mint flavor. As explained in general further above for taste substances, these can be artificial or natural flavorings.
The present invention accordingly also generally provides for the use of the composition according to the invention as dental jet powder for the supragingival and subgingival powder-jet cleaning of tooth surfaces.
In the case of said use of the composition according to the invention, it is preferred according to one embodiment when the jet powder is applied by means of a jet-pressure instrument.
Jet-pressure instruments or, in general, powder-jet technology perse are known in the prior art. As mentioned at the start, it is possible using said technology or using jet-pressure instruments suitable therefor to apply the powders, mixed with water and/or air, at defined pressure to the tooth surfaces, making it possible for stains on top of the tooth and for microbial soft dental plaque to be gently removed.
Accordingly, the invention also provides a system or kit for the supragingival and subgingival powder-jet cleaning of tooth surfaces, comprising a jet-pressure instrument and the composition according to the invention.
It is self-evident that the features mentioned above and yet to be elucidated below are usable not only in the combination specified in each case, but also in isolation, without departing from the scope of the present invention.
Any discussion of documents, acts, materials, devices, articles or the like which has been included in the present specification is not to be taken as an admission that any or all of these matters form part of the prior art base or were common general knowledge in the field relevant to the present disclosure as it existed before the priority date of each of the appended claims.
Throughout this specification the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps.
Further advantages are revealed by the description below and by the experiments carried out in relation thereto, the figure and the exemplary embodiments. What is shown is:
Fig. 1 Fig. 1 shows a graph displaying abrasiveness versus time, specifically for one embodiment of the composition according to the invention (“inv. comp, supragingival”; bottommost curve) compared to two commercially available products A and B, also for supragingival use (product A: topmost curve; product B: middle curve).
Examples
Supragingival powder
In a first example of a composition according to the invention that is used for supragingival cleaning, or in a first example of a supragingival use according to the invention, firstly trehalose and secondly palatinose were selected as exemplary embodiments of a disaccharide according to the invention.
To this end, trehalose and palatinose powders were provided, the powders of the two disaccharides each having a mean particle size (D50) of approximately 65 pm; in each case, the D90 value was approximately 160 pm.
In general, the values D10, D50 and D90 are used to characterize a particle-size distribution. In this connection, as mentioned further above, the value of D50 is defined as “mean particle size”, and the values D10 and D90 are used to describe the width of a particle-size distribution (D10-D90).
Furthermore, different compositions were provided; these were, firstly, the disaccharide powders having the above-stated mean particle size of 65 pm with addition of an anticaking agent (Aerosil) and, secondly, the disaccharide powders having the abovestated mean particle size of 65 pm with addition of an anticaking agent (Aerosil) and flavor (mint or orange).
The specific compositions of the two jet powders were as follows:
Powder, trehalose, neutral
Powder, trehalose, orange
Powder, trehalose, mint:
Powder, palatinose, neutral:
Powder, palatinose, orange:
Powder, palatinose, mint:
All the jet powders exhibited a very good water-solubility. Furthermore, it was possible with said jet powders to achieve a constant output from the instrument used and also a uniform and constant removal of stains.
Thus, not only the dissolution behavior of the powders was comparatively better than those of competitor powders, as shown below:
The good or better solubility is important for the present purposes of powder-jet cleaning, since no residues are to remain in the mouth of the patient, especially in the case of subgingival cleaning, since said residues can lead to inflammations or other medical intolerances or complications.
Further test parameters were jet behavior on the surfaces of enamel and root element with respect to damage via detection using a scanning electron microscope, and cleaning behavior on stained bovine teeth.
With the compositions used above by way of example, it was possible by means of the scanning electron microscope to detect a lower degree of damage to enamel elements or
root elements compared to competitor powder, or to detect no damage at all (data not shown).
The better taste compared to conventional jet powders such as NaHCO3, the acariogenic properties and the food-grade quality of the disaccharides are also outstanding advantages in addition to the better solubility and lower degree of damage.
Subgingival powder
In a second example, for a composition according to the invention that is this time suitable for subgingival applications, trehalose and palatinose were again selected as exemplary embodiments of a disaccharide according to the invention.
Here, too, trehalose and palatinose powders were provided, the powders of the two disaccharides this time each having a mean particle size (D50) of approximately 25 pm, and a particle-size distribution D90 of approximately 90 pm.
Furthermore, different compositions were provided; these were, firstly, the disaccharide powders having the above-stated mean particle size (D50) of approximately 25 pm with addition of an anticaking agent (Aerosil) and, secondly, the disaccharide powders having the above-stated mean particle size (D50) of 25 pm with addition of an anticaking agent (Aerosil) and flavor (mint or orange).
Powder, trehalose
Powder, palatinose
These powder compositions, too, exhibited, like the supragingival compositions, an outstanding cleaning, solubility and tolerability compared to conventional powders.
Jet experiments with the different embodiments of the jet powders according to the invention on implant and ceramic models, and also on human tooth samples, additionally also showed, in comparison with four conventional jet powders and a control (untreated), that substance removal over time is improved compared to the conventional powders. (Data not shown).
Fig. 1 shows a graph showing the average abrasiveness, as measured on ivory plates, versus time, specifically for the composition according to the invention “inv. comp, supragingival” (embodiment: supragingival jet powder, see above) on the one hand (bottom curve in Fig. 1) and, on the other hand, for two comparative products that are commercially available and likewise intended for supragingival usage, one of them being based on sodium bicarbonate (product A: topmost, practically linear curve in Fig. 1) and the other being based on glycine (product B: middle curve cutting across the practical linear curve at 4 min).
It can be clearly seen from Fig. 1 that the composition according to the invention has a lower abrasiveness than two comparative products, and in particular an abrasiveness reduced by 25% compared to product A.
Claims (1)
- Claims The use of at least one disaccharide as abrasive and/or polishing body for producing a dental jet powder for the supragingival and/or subgingival powder-jet cleaning of tooth surfaces. The use of at least one disaccharide as abrasive and/or polishing body for producing a dental jet powder for the supragingival and/or subgingival powder-jet cleaning of tooth surfaces, wherein the at least one disaccharide is selected from one or more of the followings: cellobiose, gentiobiose, isomaltulose (palatinose), isomaltose, lactose, lactulose, laminaribiose, maltose, maltulose, melibiose, rhamnose, neotrehalose, nigerose, rutinose sambubiose, sucrose, trehalose. The use as claimed in claim 1 or 2, characterized in that the disaccharide is selected from trehalose and/or palatinose or mixtures thereof. The use as claimed in any of claims 1 to 3, characterized in that the jet powder further comprises at least one of the following: an anticaking agent, a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, Lactobacillus bacteria, and/or bactericides, or mixtures of one or more thereof. The use as claimed in claim 4, characterized in that the anticaking agent is selected from at least one of the following: silicon dioxide, calcium carbonate, aluminum silicates, aluminum hydroxide. The use as claimed in claim 4 or 5, characterized in that the alditol is selected from at least one of the following: xylitol, erythritol, sorbitol, mannitol. The use as claimed in any of the preceding claims, characterized in that the disaccharide has a mean particle size of between 10 pm and 80 pm. The use as claimed in any of the preceding claims, characterized in that the disaccharide is present in the jet powder at a fraction of between 70 to 99.9% by weight, in particular of between 95% to 99.9% by weight. The use of at least one disaccharide as abrasive and/or polishing body in a dental jet powder for the therapy and/or prophylaxis of tooth-root diseases or tooth diseases. . The use as claimed in claim 9, wherein the disaccharide is selected from trehalose and/or palatinose. . A composition for use as dental jet powder, comprising: from 70 to 99.9% by weight of one or more disaccharides as a first abrasive and/or polishing body, from 0.1 to 30.0% by weight of an anticaking agent, the sum of all fractions yielding 100% by weight. . The composition as claimed in claim 11, characterized in that the disaccharide is trehalose and/or palatinose. . The composition as claimed in claim 11 or 12, characterized in that the disaccharide has a mean particle size of between 10 pm and 80 pm. . The composition as claimed in any of claims 11 to 13, characterized in that it further comprises at least one of the following: a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, and/or bactericides, or mixtures of one or more thereof. . The composition as claimed in claim 14, characterized in that the anticaking agent is selected from the group comprising silicon dioxide, calcium carbonate, aluminum silicates, and/or aluminum hydroxide. . The composition as claimed in any of claims 11 to 15, characterized in that it further comprises a flavoring, preferably orange flavor or mint flavor. . The use of the composition as claimed in any of claims 11 to 16 as dental jet powder for the supragingival and/or subgingival powder-jet cleaning of tooth surfaces. . The use as claimed in claim 17, characterized in that the jet powder is applied by means of a jet-pressure instrument. . A kit for the supragingival and subgingival powder-jet cleaning of tooth surfaces, comprising a jet-pressure instrument and a composition as claimed in any of claims 11 to 16.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102014115412.6 | 2014-10-22 | ||
| DE102014115412.6A DE102014115412A1 (en) | 2014-10-22 | 2014-10-22 | Powder for dental powder jet cleaning |
| PCT/EP2015/074304 WO2016062742A1 (en) | 2014-10-22 | 2015-10-21 | Powder for dental powder-jet cleansing |
Publications (2)
| Publication Number | Publication Date |
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| AU2015335036A1 AU2015335036A1 (en) | 2017-05-18 |
| AU2015335036B2 true AU2015335036B2 (en) | 2018-11-29 |
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| AU2015335036A Active AU2015335036B2 (en) | 2014-10-22 | 2015-10-21 | Powder for dental powder-jet cleansing |
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| EP (1) | EP3209278A1 (en) |
| JP (1) | JP6501880B2 (en) |
| AU (1) | AU2015335036B2 (en) |
| DE (1) | DE102014115412A1 (en) |
| RU (1) | RU2717949C2 (en) |
| WO (1) | WO2016062742A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD825741S1 (en) | 2016-12-15 | 2018-08-14 | Water Pik, Inc. | Oral irrigator handle |
| CN119950331A (en) | 2017-02-02 | 2025-05-09 | 洁碧有限公司 | Tablets for cleaning teeth including abrasives |
| KR102625450B1 (en) | 2017-03-16 | 2024-01-16 | 워어터 피이크, 인코포레이티드 | Oral irrigator handle for use with oral agents |
| DE102017107124A1 (en) * | 2017-04-03 | 2018-10-04 | Ferton Holding S.A. | Powder for cleaning an internal body part and / or an implant, process for producing such a powder and suitable uses |
| ES2999379T3 (en) | 2017-10-04 | 2025-02-25 | PRISMAN GmbH | Use of a monosaccharide for sub and/or supragingival cleaning of teeth |
| USD868243S1 (en) | 2018-03-16 | 2019-11-26 | Water Pik, Inc. | Oral irrigator tip |
| EP3824873A1 (en) * | 2019-11-25 | 2021-05-26 | Ferton Holding S.A. | Use of rhamnose and arabinose for dental powder jet cleaning |
| US12478573B2 (en) | 2020-02-17 | 2025-11-25 | Ferton Holding S.A. | Cyclodextrins as dental cleaning powders |
| US20230414465A1 (en) * | 2020-12-11 | 2023-12-28 | Kabushiki Kaisha Shofu | Powder mixture for spraying into tooth surface or into gingival sulcus/periodontal pocket |
| WO2025205888A1 (en) * | 2024-03-26 | 2025-10-02 | 株式会社アパタイト | Tooth surface cleaning method |
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| JPH10330231A (en) * | 1997-05-29 | 1998-12-15 | Snow Brand Milk Prod Co Ltd | Agent for preventing formation of dental plaque and decomposition dental plaque |
| EP2228175A1 (en) * | 2009-03-12 | 2010-09-15 | Ferton Holding SA | Powder for powder streams, powder mixture and use for processing in particular dental surfaces |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60204709A (en) * | 1984-03-28 | 1985-10-16 | Lion Corp | Composition for oral cavity |
| FI104044B (en) | 1995-07-28 | 1999-11-15 | Neocare Oy | Preparation used for dental care |
| JP3335107B2 (en) * | 1997-07-22 | 2002-10-15 | 有限会社ディー・アン・ディー | Plaque remover |
| DE19804065A1 (en) * | 1998-02-04 | 1999-12-23 | Matthias Honl | Jet cutting method useful for cutting biological tissue, e.g. human connective and skeletal tissue |
| DE19910559A1 (en) * | 1999-03-10 | 2000-09-14 | Espe Dental Ag | Subgingival powder blasting |
| JP2004210722A (en) * | 2002-12-27 | 2004-07-29 | Kao Corp | Oral composition |
| KR101217382B1 (en) * | 2003-02-13 | 2012-12-31 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | EXTERNAL DERMATOLOGICAL FORMULATION COMPRISING SACCHARIDE DERIVATIVE OF α,α-TREHALOSE |
| US20040202980A1 (en) | 2003-04-14 | 2004-10-14 | Policicchio Piero A. | Dental prophylaxis and air appliance |
| JP2010053062A (en) * | 2008-08-28 | 2010-03-11 | Sunstar Inc | Oral cavity composition |
| EP2758024B1 (en) * | 2011-09-23 | 2015-09-09 | Tsu, Christopher Louis | Powder for dental powder blasting |
| EP2861202B1 (en) * | 2012-06-18 | 2018-07-18 | 3M Innovative Properties Company | Powder composition for air polishing the surface of hard dental tissue |
-
2014
- 2014-10-22 DE DE102014115412.6A patent/DE102014115412A1/en active Pending
-
2015
- 2015-10-21 EP EP15784025.7A patent/EP3209278A1/en active Pending
- 2015-10-21 JP JP2017522543A patent/JP6501880B2/en active Active
- 2015-10-21 AU AU2015335036A patent/AU2015335036B2/en active Active
- 2015-10-21 RU RU2017117496A patent/RU2717949C2/en active
- 2015-10-21 WO PCT/EP2015/074304 patent/WO2016062742A1/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10330231A (en) * | 1997-05-29 | 1998-12-15 | Snow Brand Milk Prod Co Ltd | Agent for preventing formation of dental plaque and decomposition dental plaque |
| EP2228175A1 (en) * | 2009-03-12 | 2010-09-15 | Ferton Holding SA | Powder for powder streams, powder mixture and use for processing in particular dental surfaces |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017117496A (en) | 2018-11-23 |
| AU2015335036A1 (en) | 2017-05-18 |
| EP3209278A1 (en) | 2017-08-30 |
| RU2017117496A3 (en) | 2018-11-23 |
| JP6501880B2 (en) | 2019-04-17 |
| DE102014115412A1 (en) | 2016-05-12 |
| RU2717949C2 (en) | 2020-03-27 |
| JP2017531690A (en) | 2017-10-26 |
| WO2016062742A1 (en) | 2016-04-28 |
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