JP6501880B2 - Powder for dental powder jet cleaning - Google Patents

Description

  The present invention relates to the use of a particulate substrate as cutting material and / or abrasive material for producing dental spray powders for powder spray cleaning above and / or below the gingival margin.

  Powder spray cleaning has recently been widely used as a method for professional cleaning of tooth surfaces or root surfaces. Powder jet cleaning can be an alternative or supplement to mechanical abrasion with hand instruments and sonication because it can remove stains, tartar and plaque quickly, gently and efficiently.

  Generally, tooth surface treatment using compressed air and fine powder particles is performed by so-called air ablation jet cutting (conventional powder jet treatment) and jet polishing by air polishing (air, powder and water jets) depending on the difference in cutting force. Treatment). All of these methods are based on the principle that a mixture of powder and compressed air can be applied to the tooth surface (root surface) to remove deposits deposited on the tooth surface (root surface). In air polishing, water is additionally added to the mixture of air and powder.

  The powders used in the dental treatment described above are composed of various substances, for example sodium bicarbonate etc., and sodium bicarbonate has been used for powder jet cleaning for over 20 years. Sodium bicarbonate is superior in that it is well-tolerated to the patient being treated, but it has the disadvantage that when cleaning exposed root and dentin surfaces, the surface is largely scraped off.

  Powder injection equipment using sodium bicarbonate as the cutting powder is very excellent as a method for efficiently cleaning the tooth surface, but when using sodium bicarbonate powder in the subgingival region, the machinability is high Therefore, there is a problem that dentin and cement quality are scraped off.

  Thus, research has been made on mild cutting powders that can be used, inter alia, for cleaning the subgingival tooth surface, and in particular for alternative sugars and crystalline amino acids, which are currently successfully used.

  For example, WO 97/04741 A1 discloses the use of xylitol and calcium carbonate in powders having an average particle size of less than 20 μm. Furthermore, EP 1 468 659 A2 discloses the use of calcium triphosphate as a cutting material in a powder jet treatment.

  In particular, with respect to cutting effects and mild treatment of dentin, improvements to conventionally known powders are continuously made, but there are still many defects associated with taste and physiological defects, and dry mouthfeel and taste Poorness can make the patient complain of discomfort or act as a laxative.

  Thus, the present invention provides a novel jet powder which can achieve an optimized cutting effect, in particular both above and below the gingival margin, and which can overcome the drawbacks of the prior art with regard to patient acceptance. The purpose is to

  According to the invention, this object is achieved by at least one cutting material and / or grinding for producing a dental spray powder for powder spray cleaning of the supragingival and / or subgingival surfaces. It is achieved by the use of disaccharides as wood.

  Furthermore, this object is a composition for use as a dental spray powder, wherein when the whole composition is 100% by weight, (i) one or more kinds as a first cutting material and / or abrasive material This composition is achieved by a composition comprising 70 to 99.9% by weight of the disaccharide of (1) and (ii) 0.1 to 30.0% by weight of the anti-caking agent.

  In this way, the object of the invention is completely achieved. The above new use or new composition enables efficient and patient-friendly cleaning of the tooth surface (root surface), which overcomes the drawbacks of the prior art, and is superior to currently used powders. An alternative can be provided.

  According to the invention, a composition comprising at least one disaccharide is used. In said composition it is particularly preferred that the disaccharide is selected from trehalose and / or palatinose or mixtures thereof. Compared to the conventionally used known powders, in particular the disaccharides such as trehalose and / or palatinose or their powders, surprisingly, in addition to the advantage of high solubility, treatment with conventional comparable powders It has the advantage of being able to treat the tooth surface more gently than it is and to be patient well tolerated. Furthermore, disaccharides are more patient-acceptable than sodium bicarbonate, for example in terms of taste.

  In the present specification and related fields, "disaccharide" is generally understood to mean a disaccharide resulting from the covalent attachment of two monosaccharides via glycosidic bonds. All disaccharides have sweetness. In particular, in the present invention, it is preferable to use non-cariogenic disaccharides. The disaccharide used in the present invention may be composed of a plurality of monosaccharides linked via an α bond or a β bond, and may contain various stereoisomers. Monosaccharides, which are components of disaccharides, exist in α or β form, typically glucose, fructose, galactose, and these monosaccharides have various bonds (α glycosidic bond or β glycosid And various combinations are coupled with each other via bonding.

  As known disaccharides, cellobiose, gentiobiose, isomaltulose (palatinose), isomaltose, lactose, lactulose, laminaribiose, maltose, maltose, melibiose, rhamnose, neotrehalose, neogelose, nigerose, rutinose, sambubiose, sucrose, trehalose It can be mentioned. In the present invention, non-cariogenic disaccharides are preferred, and palatinose and trehalose are particularly preferred.

  Trehalose is a disaccharide consisting of two glucose molecules linked by α, α'-1, 1-glycosidic bonds. The tissue name of trehalose is α-D-glucopyranosyl- (1 → 1) -α-D-glucopyranoside, and its abbreviation is Glcα (1 → 1) αGlc.

  The tissue name of palatinose, which is also referred to as isomaltulose in the present specification and related fields, is 6-O-α-D-glucopyranosyl-D-fructose and is tooth-friendly because it is non-cariogenic like trehalose. Both palatinose and trehalose cause no problems with digestion or other tolerability.

  Both palatinose and trehalose have a low glycemic index, are not a problem when taken orally, and are remarkably suitable in terms of taste.

  From the point of view of the prior art, it is surprising that these disaccharides are suitable as propellant powders.

  According to the invention, the disaccharide is present as a powder with a specific mean particle size. In this connection, the powder is prepared to the desired particle size distribution via grinding, sieving, air classification, classification or other preparation steps known to the person skilled in the art. The machinability of the jetted powder is substantially dependent not only on the particle velocity, which is affected by the relevant equipment, but also on factors such as the hardness and mass of the particles. For example, when the mass is the same, the cuttability of particles having a large particle diameter and a low density is similar to the cuttability of particles having a small particle diameter and a high density.

Thus, in the use and spray powder according to the invention, the density of the disaccharide, or a mixture of two or more thereof, is less than or equal to 2.5 g / cm ³ , preferably less than or equal to 2.0 g / cm ³ . Density of palatinose is 1.77 g / cm ^3, the density of trehalose is 1.76 g / cm ^3.

It has been found that by using disaccharides, in particular disaccharides in powder form with a density of 2.0 g / cm ³ or less, it is possible to obtain jet powders which can overcome the drawbacks of the previously known jet powders. The disaccharide powder of the present invention did not clump in pressurized jet equipment in laboratory testing. Thus, the disaccharide powder of the present invention is an excellent alternative to conventional propellant powders, which are often expensive to produce.

  According to the invention, the disaccharides of the invention can be used above or below the gingival margin.

  Here, subgingival use or subgingival use is taken to mean the use of the propellant powder according to the invention on the subgingival tooth surface. The progressive inflammatory response caused by the subgingival biofilm accumulation results in the formation of periodontal pockets. Even with toothbrushes and dental floss, cleaning of the periodontal pocket is nearly impossible. Since the subgingival tooth surface is softer and more sensitive than the tooth surface above the gingival edge, it is important to make the machinability of the jet powder used as low as possible.

  On the other hand, for use on the gingival margin, the propellant powder is used on the tooth surface above the gingival margin.

  In particular, if the gums become inflamed and have not been treated for a relatively long time, this can lead to the development of periodontitis, ie inflammation in periodontal tissues. Periodontitis usually involves bone degradation and gingival recession. Gingival recession means that the neck is gradually exposed, and the recession is exposed to the neck and becomes more responsive to irritation. A powder used for the area above the gingival margin so that the thus exposed tooth neck will not damage the tissues of the exposed more sensitive tooth, as well as the area normally located under the gingival margin (especially the tooth roots) It must be treated with a powder which has lower machinability.

Hence, in the use according to the invention, the mean particle size of the inventive jet powder in subgingival use is considered to be smaller than the particle size of the powder used for jet cleaning over the gingival margin. In the use according to the invention, in particular, the combination of the density of the disaccharide used and its particle size exerts a remarkable effect. Optimization by optimizing the density of the disaccharides used in the powder to 2.0 g / cm ³ or less, and by adapting the particle size of the specific disaccharides or the particle size of the specific propellant powder to the above specific application It was found that the cleaning results were obtained. Specifically, in connection with this, the average particle size (D50) is preferably 50 μm or less in the cleaning of the subgingival region, and the average particle size (D50) is 80 μm or less in the cleaning of the supragingival region Is preferred.

  In general, the propellant powder comprises a substance that acts as a cutting material and / or abrasive material. Depending on the manufacturing process, the particle size of each particle of the substance contained in the jet powder does not all have exactly the same particle size but varies within a specific range (particle size distribution). In this context, the D50 value defines the mean particle size. Thus, D10 is used as an additional parameter to measure the smallest particles in the sample, D90 is used as an additional parameter to measure the large particles in the sample, and also D95, D99 and D100. it can. The closer D10 and D100 are, the narrower the particle size distribution.

  According to one embodiment of the use according to the invention, the propellant powder according to the invention comprises an anti-caking agent, a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, a Lactobacillus or a fragment thereof, and / or a bactericidal agent Or at least one of mixtures of one or more thereof.

  As is apparent from the description herein, with regard to the particle size of the inventive spray powder composition, the aforementioned additional components are selected such that the average particle size of the spray powder falls within the aforementioned preferred range, and the spray powder The preferable range of the average particle size of the above is, for example, an average particle size (D50) of less than 50 .mu.m in the case of subgingival use, and an average particle size (D50) of 80 .mu.m in Less than.

  Anti-caking agents are known in the field of jet powders and are separating agents added to crystalline substances to prevent aggregation of crystalline substances, a more efficient automated method by adding anti-caking agents Crystalline material can be used. In the propellant powder it may also be necessary to use one or more anti-caking agents in order to avoid agglomeration of the powder substance and clogging of the nozzle of the propellant device.

  According to one preferred embodiment, the anti-caking agent is selected from silicon dioxide, calcium carbonate, aluminum silicate and / or aluminum hydroxide.

  These substances are known in the prior art and are known to be used in particular in dental care products of the oral cavity.

  According to one embodiment of the composition according to the invention, or the use thereof, the alditol is selected from erythritol, sorbitol, xylitol, mannitol, isomalt, lactitol, threitol or a mixture of one or more thereof.

  Alditol is an acyclic polyol that is structurally derived by reducing carbohydrates, and thus is a sugar alcohol. Since alditol is not cariogenic, it has already been used for many years in propellant powders as an alternative sugar to improve the taste. Furthermore, alditol is used as a cutting material or abrasive in blasting powders, and the average particle size generally used depends on whether the blasting powder is used subgingivally or on the gum border. For subgingival applications, an average particle size (D50) of about 50 μm or less is generally used, and for supragingival applications, an average particle size (D50) of about 80 μm or less is generally used.

  The crystalline amino acid used in the present invention may be, for example, glycine.

  The taste substances used in the present invention are, for example, natural odor substances or natural taste substances, or substances having the same odor or taste as natural substances. These odorants or taste substances are generally taken to mean flavors for imparting a specific odor or taste to the products to be taken or used in the oral cavity. "Natural" odorants and taste substances which impart a flavor are substances or mixtures of substances obtained from natural sources, such as plants or plant parts, which may be purified. Also, the taste substance used may be one produced synthetically.

  Specifically, as a bactericidal agent or a substance having an antimicrobial activity, specifically, triclosan; chlorhexidine; copper salts, zinc salts and tin (II) salts such as zinc citrate, zinc sulfate, zinc glycinate, and citric acid It is possible to use sodium zinc acid, tin (II) pyrophosphate, etc .; metronidazole; quaternary ammonium compounds; biguanides such as chlorhexidine digluconate etc .; hexetidine; cetyl pyridinium chloride; octenidine; Suitable bleaching agents are, specifically or generally, peroxide compounds; potassium peroxodisulfate, ammonium peroxodisulfate, sodium peroxodisulfate and lithium peroxodisulfate; potassium perborate monohydrate, ammonium perborate Monohydrate, sodium perborate monohydrate, and lithium perborate monohydrate; potassium perborate tetrahydrate, ammonium perborate tetrahydrate, sodium perborate tetrahydrate And lithium perborate tetrahydrate; sodium pyrophosphate hydrogen peroxide; magnesium peroxide, calcium peroxide, strontium peroxide, and zinc peroxide. It is also possible to use natural substances or parts thereof, or substances derived from natural substances or microorganisms or parts thereof in the use / composition according to the invention. For example, Lactobacillus bacteria or fragments thereof can be used, which may be viable.

  As already explained above, the mean particle size of the jetted powder according to the invention can be varied in different ways according to different application locations. For example, for subgingival applications the average particle size (D50) is suitably in the range 10 μm to 50 μm, in particular less than 25 μm, in the supragingival region the average particle size (D50) is in the range 30 μm to 150 μm In particular, the range of about 50 μm to 80 μm, in particular 65 μm, is suitable.

  Furthermore, according to a preferred embodiment of the use according to the invention, the content of disaccharides in the propellant powder according to the invention is intended to be 70 to 99.9% by weight, in particular 95 to 99.9% by weight. Ru.

  As explained above, the composition according to the invention can also comprise, in addition to the disaccharides used according to the invention, further ingredients such as taste substances, anti-caking agents etc. Thus, the content (%) of disaccharides can be varied according to the desired application.

  According to the invention, at least one disaccharide is used as a cutting material and / or abrasive in dental spray powders for treating and / or preventing dental or dental diseases.

  As explained at the outset, regular cleaning of the tooth surface is essential for maintaining the health of the oral flora. In the oral cavity, it is generally after 1 to 2 days that deposits, also called plaques or biofilms, form on the teeth. Biofilms consist of billions of bacteria, and metabolites of these bacteria can damage teeth and gums. Just like the formation of caries, deposits on tooth surfaces and between teeth, in particular in periodontal pockets, are also the main cause of gingival inflammation and inflammation of periodontal tissues (periodontal disease).

  Thus, preventive measures to maintain all the teeth, aimed at preventing caries and periodontitis, prevent the formation of deposits and remove deposits by means of regular and overall dental care To be an important goal.

  Prevention and treatment can be successfully achieved by using the propellant powder according to the invention or by using at least one disaccharide, in particular trehalose and / or palatinose, in the propellant powder.

  Therefore, the present invention is a composition for use as a dental spray powder, preferably 100% by weight as the first cutting material and / or abrasive, preferably 100% by weight, when the whole composition is 100% by weight. Also provided is a composition comprising 70 to 99.9% by weight of the original one or more disaccharides, as well as 0.1 to 30.0% by weight of the anti-caking agent.

  Those skilled in the art can readily understand that various compositions can be used for different purposes based on the disclosure of the present invention, and in the use of these compositions, in particular teeth and tooth surfaces. The overall status of is taken into account.

  The disaccharide contained in the composition may be, for example, an anhydride or a dihydrate.

  Accordingly, the composition is preferably an anhydrous powder, and "anhydrous" is understood to mean a composition that does not contain water other than the hydrate component.

  As already outlined above, in a preferred embodiment of the composition according to the invention, the disaccharide is trehalose and / or palatinose, and / or the average particle size (D50) of the disaccharides in the composition is 10 μm To 80 μm.

  Therefore, as trehalose, CAS (Chemical Abstracts Service) number: 99-20-7 (α, α-D-trehalose), 585-9-1 (α, β-D-trehalose), 6138-23-4 Preferably using trehalose selected from α, β-D-trehalose dihydrate), 499-23-0 (β, β-D-trehalose), and 25018-27-3 (trehalose octaacetate) Can.

  The palatinose (isomaltulose) used may be a disaccharide registered under CAS number: 13718-94-0.

  Similar to the use outlined above according to the invention, said composition according to the invention, as well as the use outlined above according to the invention, if it additionally comprises at least one of the following components in addition to the disaccharide: But in addition to the disaccharides, at least one of an anti-caking agent, a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, a Lactobacillus fungus, and / or a bactericidal agent, or a mixture of one or more thereof Preferred is an embodiment further comprising a component of

  As described above for the use according to the invention, in the composition according to the invention, the anti-caking agent is selected from at least one of silicon dioxide, calcium carbonate, aluminum silicate and / or aluminum hydroxide. Preferably.

  According to a further embodiment of the composition according to the invention or its use, when alditol is additionally used, the alditol is selected from erythritol, sorbitol, xylitol, mannitol, isomalt, lactitol, threitol or a mixture of one or more thereof .

  Here, in the use according to the invention and in the composition according to the invention, the particle sizes of the further components (in particular, optionally used alditol or crystalline amino acids (eg glycine)) are uniformed and the average particle size of the disaccharide is It is obvious for the person skilled in the art to adjust the particle sizes of the further components together as well, which means that the mean particle size of the jetted powder corresponds to the value specified above, and the specific application For use on the rim).

  According to a further preferred embodiment, the composition according to the invention further comprises a flavoring, preferably an orange flavoring or a mint flavoring. As outlined above for the taste substance, the flavoring may be an artificial flavoring or a natural flavoring.

  Thus, the present invention generally provides the use of the composition according to the invention as a dental spray powder for powder spray cleaning of the supragingival and lower gum tooth surfaces.

  According to one embodiment, in said use of the composition according to the invention, the propellant powder is preferably applied using a pressurized propellant device.

  Pressurized injection devices, ie generally powder injection techniques, are known per se in the prior art. As mentioned at the outset, applying powder mixed with water and / or air to the tooth surface at a given pressure using powder injection technology or using pressurized injection equipment suitable for powder injection technology It is possible to gently remove stains on the tips of teeth and soft dental plaques containing microorganisms.

  Thus, the present invention also provides a system or kit for powder jet cleaning of the subgingival tooth flank and the supragingival tooth flank comprising a pressurized jet device and a composition according to the present invention.

  It goes without saying that the features described above and the features described below can be used not only in the particular combination in the respective embodiment but also alone without departing from the scope of the present invention.

  Further advantages will become apparent by reference to the following description and experiments, drawings and exemplary embodiments related to the following description.

It is the graph which showed the machinability for every time. Specifically, one embodiment of the composition according to the invention ("inv. Comp. Supragingival"; bottom curve) and two commercially available products A and B used on the gingival margin Product A: top curve; Product B: middle curve) were compared.

In a first embodiment of the composition according to the invention used for the cleaning of the supragingival powder over the gingival margin, ie in the first embodiment of the use on the gingival margin according to the invention, Trehalose was chosen as the first exemplary embodiment of the saccharide and palatinose as the second exemplary embodiment.

  In order to carry out these experiments, trehalose powder and palatinose powder were prepared. The average particle size (D50) of each of these two disaccharide powders was about 65 μm, and the D90 value was about 160 μm.

  In general, the D10, D50 and D90 values are used to evaluate the particle size distribution. In this connection, as mentioned above, the D50 value is defined as "average particle size" and the D10 and D90 values (D10-D90) are used to explain the spread of the particle size distribution.

  In addition, various compositions were prepared. First, an anti-caking agent (Aerosil) is added to prepare a disaccharide powder having the above-mentioned average particle diameter of 65 μm, and then, the above-mentioned average particle diameter 65 μm to which the anti-caking agent (Aerosil) and a flavor agent (mint or orange) are added A disaccharide powder was prepared.

  The specific compositions of the above two types of jet powder were as follows.

  The above-mentioned jetted powders all showed very good water solubility. Furthermore, it was possible to carry out a constant jet from the used equipment using the jetted powder, and to carry out uniform and constant removal of stains.

  Thus, as shown below, the dissolution behavior of the propellant powder was relatively better than the other powders of the control.

  Residues of the powder may cause inflammation and other hypersensitivity or complications if remaining in the patient's oral cavity, so residual residues may remain in the patient's oral cavity, especially for subgingival cleaning. Therefore, it is important in powder jet cleaning for the purposes of the present invention that the solubility be high or that the solubility be better.

  As a further test parameter, the jetting behavior on the surface of the enamel and the root surface was evaluated for surface damage by detection using a scanning electron microscope, and the cleaning behavior for staining of bovine teeth was further evaluated.

  The above-mentioned composition used as an example showed that the degree of damage to the enamel portion or the root portion was smaller than that of the comparative powder, or no damage to the enamel portion or the root portion was observed by scanning electron microscope It could be detected (data not shown).

In addition to high solubility and low degree of damage, the disaccharides used in the present invention have a better taste than conventional jetted powders such as NaHCO ₃ and are non-cariogenic. And there is a remarkably excellent advantage that there is no problem even if it is taken orally.

Subgingival Powder In a second example, a composition according to the invention suitable for subgingival application was evaluated, again selecting trehalose and palatinose as embodiments of the disaccharide according to the invention.

  Again, trehalose powder and palatinose powder were prepared. In this example, the average particle size (D50) of these two disaccharide powders is about 25 μm each, and the particle size distribution D90 is about 90 μm each.

  In addition, various compositions were prepared. First, an anti-caking agent (Aerosil) is added to prepare a disaccharide powder having the above-mentioned average particle diameter of 25 μm, and then, the above-mentioned average particle diameter 25 μm to which the anti-caking agent (Aerosil) and a flavor agent (mint or orange) are added A disaccharide powder was prepared.

  Compared to the conventional powders, these powder compositions also showed excellent cleaning, solubility and tolerability similar to the composition applied on the previous gingival margin.

  In addition, injection experiments are performed on implant models and ceramic models and on human tooth samples using various embodiments of the injection powder according to the invention, and four conventional injection powders and control groups (without treatment) Compared with. As a result, the jetted powder of the present invention was superior to the conventional powder in removing deposits over time (data not shown).

  The graph which plotted the average machinability measured in the dentine section with respect to time is shown in FIG. Specifically, the composition according to the invention "inv. Comp. Supragingival" (see the above embodiment of the supragingival spray powder) (curve at the bottom of Fig. 1), 2 shows two commercial products as comparisons, which are intended for use on the gingival as well as compositions. Of the commercial products, one is based on sodium bicarbonate (Product A: substantially linear curve shown at the top of FIG. 1) and the other is based on glycine (Product B: A central curve intersecting the above substantially straight curve at a position of 4 minutes).

  It is apparent from FIG. 1 that the composition of the present invention has lower machinability compared to the two comparative products, in particular 25% lower machinability compared to product A.

Claims (20)

  Use of at least one disaccharide as cutting material and / or abrasive material for producing a dental spray powder for powder spray cleaning of supragingival and / or subgingival surfaces.   The use according to claim 1, characterized in that the disaccharide is selected from trehalose and / or palatinose or mixtures thereof.   The jet powder further comprises at least one of an anti-caking agent, a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, a Lactobacillus bacterium, and / or a bactericidal agent, or a mixture of one or more thereof. Use according to claim 1 or 2, characterized in that.   The use according to claim 3, characterized in that the anti-caking agent is selected from at least one of silicon dioxide, calcium carbonate, aluminum silicate, aluminum hydroxide.   The use according to claim 3 or 4, wherein the alditol is selected from at least one of xylitol, erythritol, sorbitol, mannitol. The average particle diameter of the disaccharide, use according to any one of 請 Motomeko 1-5 you being a 10Myuemu～80myuemu. The content of the disaccharide in the injection powder, use according to any one of 請 Motomeko 1-6 you characterized by a 70 to 99.9% by weight. The use according to any of the preceding claims, wherein the content of the disaccharide in the propellant powder is 95 to 99.9 wt%. A composition comprising at least one disaccharide as a cutting material and / or an abrasive material in a dental spray powder for treating and / or preventing a tooth root disease or a tooth disease. The composition according to claim 9 , wherein the disaccharide is selected from trehalose and / or palatinose. A composition for use as a dental spray powder,
When the whole composition is 100% by weight,
A composition comprising 70 to 99.9% by weight of one or more disaccharides as a first cutting material and / or abrasive and 0.1 to 30.0% by weight of an anti-caking agent. The composition according to claim 11 , wherein the disaccharide is trehalose and / or palatinose. The composition according to claim 11 or 12 , wherein an average particle size of the disaccharide is 10 μm to 80 μm. 12. The method according to claim 11 , further comprising at least one of an anticaking agent, a taste substance, a bleaching agent, an analgesic, a crystalline amino acid, an alditol, and / or a bactericidal agent, or a mixture of one or more thereof. The composition as described in any of 13 . 15. The composition according to claim 14 , wherein the anti-caking agent is selected from the group comprising silicon dioxide, calcium carbonate, aluminum silicate and / or aluminum hydroxide. A composition according to any one of claims 11 to 15, further comprising a flavoring charge. 17. A composition according to any of claims 11 to 16, further comprising an orange flavor or mint flavor. A composition according to any of claims 11 to 17 as a dental spray powder for powder spray cleaning of the supragingival tooth flanks and / or subgingival tooth flanks . The composition according to claim 18 , wherein the propellant powder is applied using a pressurized propellant device. Pressure injection device and a composition according to any one of claims 11 to 17, the kit for powder injection cleaning supragingival tooth surface and / or subgingival tooth surfaces.

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