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AU607765B2 - Cyclic amine derivatives - Google Patents
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AU607765B2 - Cyclic amine derivatives - Google Patents

Cyclic amine derivatives

Info

Publication number
AU607765B2
AU607765B2 AU16562/88A AU1656288A AU607765B2 AU 607765 B2 AU607765 B2 AU 607765B2 AU 16562/88 A AU16562/88 A AU 16562/88A AU 1656288 A AU1656288 A AU 1656288A AU 607765 B2 AU607765 B2 AU 607765B2
Authority
AU
Australia
Prior art keywords
cyclic amine
amine derivatives
diastereomers
enantiomers
oxides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU16562/88A
Other versions
AU1656288A (en
Inventor
Andreas Bomhard
Jurgen Dammgen
Norbert Hauel
Joachim Heider
Walter Kobinger
Christian Lillie
Berthold Narr
Klaus Noll
Manfred Psiorz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of AU1656288A publication Critical patent/AU1656288A/en
Application granted granted Critical
Publication of AU607765B2 publication Critical patent/AU607765B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gears, Cams (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cyclic amine derivatives of the formula <IMAGE> in which A, B, E, G, R, R1, R2, m and n are as defined in Claim 1, their enantiomers, their diastereomers, their N-oxides and their acid addition salts have useful pharmacological properties, in particular a bradycardic action. The novel compounds can be prepared by processes known per se.
AU16562/88A 1987-05-25 1988-05-24 Cyclic amine derivatives Ceased AU607765B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3717561 1987-05-25
DE19873717561 DE3717561A1 (en) 1987-05-25 1987-05-25 INDOL, ISOCHINOLINE AND BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
AU1656288A AU1656288A (en) 1988-12-01
AU607765B2 true AU607765B2 (en) 1991-03-14

Family

ID=6328351

Family Applications (1)

Application Number Title Priority Date Filing Date
AU16562/88A Ceased AU607765B2 (en) 1987-05-25 1988-05-24 Cyclic amine derivatives

Country Status (21)

Country Link
EP (1) EP0292840B1 (en)
JP (1) JP2634190B2 (en)
KR (1) KR960009432B1 (en)
AT (1) ATE126225T1 (en)
AU (1) AU607765B2 (en)
CA (2) CA1330993C (en)
DD (1) DD284678A5 (en)
DE (2) DE3717561A1 (en)
DK (1) DK282188A (en)
ES (1) ES2076147T3 (en)
FI (1) FI94343C (en)
GR (1) GR3017550T3 (en)
HU (1) HU198201B (en)
IE (1) IE68842B1 (en)
IL (1) IL86477A (en)
IN (1) IN169514B (en)
NO (1) NO171017C (en)
NZ (1) NZ224756A (en)
PT (1) PT87567B (en)
SU (1) SU1561823A3 (en)
ZA (1) ZA883680B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU624280B2 (en) * 1989-11-20 1992-06-04 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and medicinal products containing them
AU625817B2 (en) * 1988-04-19 1992-07-16 Bayer Aktiengesellschaft 1,3-disubstituted pyrrolidines
AU655406B2 (en) * 1989-10-27 1994-12-22 Du Pont Merck Pharmaceutical Company, The (N-phthalimidoalkyl) piperidines

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3640641A1 (en) * 1986-11-28 1988-07-14 Thomae Gmbh Dr K NEW HETEROAROMATIC AMINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
EP0351283A1 (en) * 1988-07-12 1990-01-17 Synthelabo 2-[(4-Piperidinyl)methyl]-2,3-dihydro-1H-isoindole and 2,3,4,5-tetrahydro-1H-benzazepine derivatives, their preparation and therapeutical use
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
US4952692A (en) * 1989-04-04 1990-08-28 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
ZA908641B (en) * 1989-10-27 1992-06-24 Du Pont (n-phthalimidoalkyl)piperidines
US5356906A (en) * 1989-10-27 1994-10-18 The Du Pont Merck Pharmaceutical Company (N-phthalimidoalkyl) piperidines useful as treatments for psychosis
US7166617B2 (en) * 2000-02-29 2007-01-23 Mitsubishi Pharma Corporation Cyclic amide derivatives
KR100897642B1 (en) 2002-12-20 2009-05-14 글락소 그룹 리미티드 Benzazepine Derivatives for the Treatment of Neurological Disorders
FR2868776B1 (en) * 2004-04-13 2008-04-18 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
JP5031745B2 (en) * 2005-08-12 2012-09-26 アストラゼネカ アクチボラグ Metaindole glutamate receptor potentiating isoindolone
AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
SI2203439T1 (en) 2007-09-14 2011-05-31 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-y1, 4' bipyridinyl-2'-ones
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
JP5690277B2 (en) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
BRPI1010831A2 (en) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa 1,2,4-triazolo [4,3-a] pyridine derivatives and their as positive allosteric modulators of mglur2 receptors
CN102439008B (en) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-Triazolo[4,3-A]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2536433T3 (en) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
WO2013024036A1 (en) 2011-08-12 2013-02-21 Boehringer Ingelheim Vetmedica Gmbh Funny current (if) inhibitors for use in a method of treating and preventing heart failure in feline
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6, 7- dihydropyrazolu [5,1-a] pyrazine-4 (5 hands) -on compounds and their use as negative excretory regulators of Miglore 2 receptors.
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
MX386697B (en) 2014-01-21 2025-03-19 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
ME03518B (en) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv COMBINATIONS INCLUDING POSITIVE ALOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR APPLICATIONS
JP6931456B2 (en) * 2017-04-03 2021-09-08 川崎化成工業株式会社 Photopolymerization sensitizer containing 2-haloalkoxy-6-substituted oxynaphthalene compound and 2-haloalkoxy-6-substituted oxynaphthalene compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6576486A (en) * 1985-11-27 1987-06-04 Dr. Karl Thomae Gmbh Cyclic amine derivatives
AU2047588A (en) * 1987-08-07 1989-02-09 Synthelabo 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy
AU2961789A (en) * 1988-07-12 1990-01-18 Synthelabo Derivatives of 2-{(4-piperidinyl)methyl}-1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639718C2 (en) * 1976-09-03 1987-03-05 Dr. Karl Thomae Gmbh, 7950 Biberach 1-[6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane, its physiologically acceptable acid addition salts and medicaments containing these compounds
DE3119874A1 (en) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
DE3418271A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3418270A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW AMINOTETRAL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
FR2686339B1 (en) * 1992-01-22 1994-03-11 Adir Cie NOVEL NAPHTHALENIC AMIDES AND SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6576486A (en) * 1985-11-27 1987-06-04 Dr. Karl Thomae Gmbh Cyclic amine derivatives
AU2047588A (en) * 1987-08-07 1989-02-09 Synthelabo 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy
AU2961789A (en) * 1988-07-12 1990-01-18 Synthelabo Derivatives of 2-{(4-piperidinyl)methyl}-1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU625817B2 (en) * 1988-04-19 1992-07-16 Bayer Aktiengesellschaft 1,3-disubstituted pyrrolidines
AU655406B2 (en) * 1989-10-27 1994-12-22 Du Pont Merck Pharmaceutical Company, The (N-phthalimidoalkyl) piperidines
AU624280B2 (en) * 1989-11-20 1992-06-04 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and medicinal products containing them

Also Published As

Publication number Publication date
EP0292840A3 (en) 1990-04-11
CA1330993C (en) 1994-07-26
HU198201B (en) 1989-08-28
KR880013924A (en) 1988-12-22
FI882418A7 (en) 1988-11-26
NO882258L (en) 1988-11-28
ES2076147T3 (en) 1995-11-01
FI882418A0 (en) 1988-05-23
IL86477A0 (en) 1988-11-15
HUT46906A (en) 1988-12-28
CA1287226C (en) 1991-08-06
DK282188D0 (en) 1988-05-24
KR960009432B1 (en) 1996-07-19
FI94343B (en) 1995-05-15
EP0292840B1 (en) 1995-08-09
IE881559L (en) 1988-11-25
PT87567A (en) 1989-05-31
FI94343C (en) 1995-08-25
ATE126225T1 (en) 1995-08-15
SU1561823A3 (en) 1990-04-30
IN169514B (en) 1991-11-02
AU1656288A (en) 1988-12-01
NO171017B (en) 1992-10-05
PT87567B (en) 1992-09-30
ZA883680B (en) 1990-01-31
EP0292840A2 (en) 1988-11-30
JP2634190B2 (en) 1997-07-23
IE68842B1 (en) 1996-07-10
GR3017550T3 (en) 1995-12-31
DK282188A (en) 1988-11-26
DD284678A5 (en) 1990-11-21
IL86477A (en) 1992-07-15
NZ224756A (en) 1991-02-26
NO171017C (en) 1993-01-13
NO882258D0 (en) 1988-05-24
DE3717561A1 (en) 1988-12-08
DE3854280D1 (en) 1995-09-14
JPS6445381A (en) 1989-02-17

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