AU608281B2 - Improvements in the inhibition of lice - Google Patents
Improvements in the inhibition of lice Download PDFInfo
- Publication number
- AU608281B2 AU608281B2 AU11220/88A AU1122088A AU608281B2 AU 608281 B2 AU608281 B2 AU 608281B2 AU 11220/88 A AU11220/88 A AU 11220/88A AU 1122088 A AU1122088 A AU 1122088A AU 608281 B2 AU608281 B2 AU 608281B2
- Authority
- AU
- Australia
- Prior art keywords
- parts
- lice
- azadirachtin
- acid
- pesticidal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 241001674048 Phthiraptera Species 0.000 title claims description 20
- 230000005764 inhibitory process Effects 0.000 title claims description 6
- 239000005878 Azadirachtin Substances 0.000 claims description 21
- VEHPJKVTJQSSKL-UHFFFAOYSA-N azadirachtin Natural products O1C2(C)C(C3(C=COC3O3)O)CC3C21C1(C)C(O)C(OCC2(OC(C)=O)C(CC3OC(=O)C(C)=CC)OC(C)=O)C2C32COC(C(=O)OC)(O)C12 VEHPJKVTJQSSKL-UHFFFAOYSA-N 0.000 claims description 21
- FTNJWQUOZFUQQJ-IRYYUVNJSA-N azadirachtin A Natural products C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C/C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-IRYYUVNJSA-N 0.000 claims description 21
- FTNJWQUOZFUQQJ-NDAWSKJSSA-N azadirachtin A Chemical compound C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C\C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-NDAWSKJSSA-N 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 15
- 239000000284 extract Substances 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000004166 Lanolin Substances 0.000 claims description 5
- 239000003963 antioxidant agent Substances 0.000 claims description 5
- 235000006708 antioxidants Nutrition 0.000 claims description 5
- 235000019388 lanolin Nutrition 0.000 claims description 5
- 240000005343 Azadirachta indica Species 0.000 claims description 4
- 235000013500 Melia azadirachta Nutrition 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
- 210000002268 wool Anatomy 0.000 claims description 4
- 125000000917 azadirachtin group Chemical group 0.000 claims description 3
- 239000003599 detergent Substances 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 230000000361 pesticidal effect Effects 0.000 claims 7
- 150000007513 acids Chemical class 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 3
- 229940087168 alpha tocopherol Drugs 0.000 claims 3
- 235000010323 ascorbic acid Nutrition 0.000 claims 3
- 239000011668 ascorbic acid Substances 0.000 claims 3
- 229960005070 ascorbic acid Drugs 0.000 claims 3
- 229960000984 tocofersolan Drugs 0.000 claims 3
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 claims 3
- 235000004835 α-tocopherol Nutrition 0.000 claims 3
- 239000002076 α-tocopherol Substances 0.000 claims 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 2
- XMHIUKTWLZUKEX-UHFFFAOYSA-N hexacosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O XMHIUKTWLZUKEX-UHFFFAOYSA-N 0.000 claims 2
- UTOPWMOLSKOLTQ-UHFFFAOYSA-N octacosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O UTOPWMOLSKOLTQ-UHFFFAOYSA-N 0.000 claims 2
- 241000607479 Yersinia pestis Species 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 241001494479 Pecora Species 0.000 description 7
- 239000002917 insecticide Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 208000028454 lice infestation Diseases 0.000 description 2
- 239000002018 neem oil Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 241001113967 Bovicola ovis Species 0.000 description 1
- 241000670113 Linognathus africanus Species 0.000 description 1
- 241000670112 Linognathus ovillus Species 0.000 description 1
- 244000309753 Linognathus pedalis Species 0.000 description 1
- 241000158728 Meliaceae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000001887 anti-feedant effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 150000002630 limonoids Chemical class 0.000 description 1
- 208000020442 loss of weight Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- -1 oleic Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003534 tetranortriterpenoids Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
D609?8 arry dUensmde de 1 I tcion 49 and is correct fol, Piflting.
t;~ C C
C
C~t
CC
VINCENT HENRY GUERRINI CC cC C C C cc CC
C
C C, C r C C CCC C, C C COMMONWEALTH OF AUSTRALIA The Patents Act 1952 1969 COMPLETE SPECIFICATION FOR THE INVENTION ENTITLED: IMPROVEMENTS IN THE INHIBITION OF LICE This invention is described in the following statement i.
-2- IMPROVEMENTS IN THE INHIBITION OF LICE THIS INVENTION relates to improved methods of prevention and inhibition of lice and preparations used in the method.
Lice infestations are common throughout the world and are the cause of irritation of the skin which stimulates scratching, rubbing, licking with consequential damage to fleece and hides, loss of weight ,t gain and meat production and in humans is a health t 10 hazard.
Conventional, current methods for the C t c et prevention and inhibition of lice.in sheep include the ecEe application of potentially toxic compounds or insecticides such as organophosphates and organochlorines, two or three or more times each year.
c C Although the above mentioned products
CCCC
SccC are effective in inhibiting lice in sheep for periods of up nr, to 3 or 4 months, none are effective beyond 4 to 5 months as applied by conventional jetting dipping or spraying, because the applications can be diluted by rain and leached out of the fleece and inactivated by the environment in the Sfleece and in the atmosphere The most common sheep lice are Damalinia ovis,a biting louse, Linognathus ovillus, a sucking louse, L. Africanus, L. pedalis and L. Stenopsis which are also sucking lice.
a Conventional lice insecticides are fairly to extremely toxic to persons and animals and their constant use has led to the development of insect resistance.
From the above mentioned it can be appreciated that lice infestations are a serious condition and that none of the current methods to control and/or inhibit lice are satisfactory.
Azadirachtin-rich extracts of the seeds of the ao« neem tree Azadiracta indica A. juss (Meliaceae) contain a o°°0Q range of limonoid chemicals, such as the oe oe tetranortriterpenoid, azadirachtin, which are active as O0 insect antifeedants, growth disruptors and insecticides but effects of azadirachtin against lice have not been described.
It is a preferred objective of this invention to C. Ve provide a preparation of azadirachtin and/or azadirachtin t containing extracts from the neem tree to prevent and inhibit the development of lice and a composition to extend the presence of azadirachtin in or on a locus.
9 'a0 It is a further objective of this invention to St, provide a method and a composition used in the method to inhibit the oxidation of azadirachtin and/or azadirachtin containing extracts.
The invention is a composition of azadirachtin or azadirachtin containing oils and/or extracts to inhibit lice: In one embodiment of the invention the composition of azadirachtin is blended with wool wax, an U ,acid, an anti-oxidant, a detergent and water.
4 I 4 A preferred preparation is azadirachtin and/or azadirachtin containing extracts blended with any combination of wool wax fatty acids, including oleic, linolenic, linoleic, palmitic, capric, lauric, myristic, palmitic, stearic, arachidic, beheric, lignoceric, cerotic, montanic, their iso series, their ante-iso series and/or sulphonic, acetic, hydrochloric, sulphuric, citric, e proprionic, salicilic or weak acid derivatives such as 0 t V e esters and anhydrides, antioxidants including 1Q butyl-hydroxy-anisole, vitamin C, vitamin E and vitamin A ,,tt a detergent and water.
Particular embodiments of the invention will now be described with reference to the following Tables in r which:- ECeC Table 1 Mean plus or minus standard ,EEO deviation number for lice found in 5 partings of wool on ~each side of a sheep. The sheep was treated on the left side with a composition of 2.5 millilitres neem oil containing azadirachtin. The right side was not treated. The composition was spread onto the skin and wool.
Days after treatment 0 3 20 60 110 200 Lice counted Treated 21+8 3+5 0 0 0 0 Not treated 16+S 21+12 14+5 35+9 22+3 17+3 Ii -t I
I
and where, Table 2 Mean plus or minus standard deviation for number of lice counted in 5 wool partings on each side of a sheep. The sheep was sprayed on the left side with a composition of 2.5 ml neem oil containing 10% azadirachtin.
The right side was not treated.
3,f Days after treatment 0 3 20 60 110 Lice counted Treated Not treated 200 0 12+4 11+6 0 17+5 21+8 0 14+3 0 25+2 2+2 31+4 4, 4,
S
4, 4>
Claims (9)
1. A pesticidal composition for the inhibition and prevention of lice comprising azadirachtin or azadirachtin containing extracts including neem extracts with wool wax or fatty acids or anti-oxidants or acids.
2. A pesticidal composition according to claim I wherein the fatty acids are oleic or linoleic or linolenic or palmitic or capric or lauric or myristic or palmitic or stearic or arachidic or beheric or cerotic, or montanic acid.
3. A pesticidal composition according to Claim 1 wherein the anti-oxidants are alpha-tocopherol or ascorbic acid (Vitamin C).
4. A pesticidal composition according to claim 1 wherein the acids are boric acid or proprionic or salicilic acids.
A pesticidal composition of any of the preceding claims further comprising diazinon or organophosphates or a detergent and water.
6. A pesticidal composition according to claim 1 comprising from 0.1 to 99 parts by weight azadirachtin containing extracts, 1 to 99.8 parts by weight wool wax, 1 to 99.8 parts by weight linoleic acid, 1 to 99.8 parts boric or salicilic acid, 1 to 99.8 parts alpha tocopherol or ascorbic acid. E I ItL44 AQ IO :-.r7 -7-
7. A pesticidal composition according to claim 1 comprising from 1 to 80 parts by weight azadirachtin containing extracts, 20 to 99 parts by weight wool wax, to 99 parts by weight linoleic acid, 20 to 99 parts boric or salicilic acid and 20 to 99 parts alpha tocopherol or ascorbic acid. e
8. A method of inhibiting and preventing lice comprising applying a composition of azadirachtin or azadirachtin containing extracts including neem extracts with wool fat or fatty acids or anti-oxidants or acids to the pests or S° their surroundings or locus.
9. A method according to claim 9 wherein lice 01 includes the eggs, larvae and adult forms of lice. 0 00 o a O 0 Dated this 12th day of December, 1990 o 0 0 I V NENT HENRY GUERRINI 'j 1 ff.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU11220/88A AU608281B2 (en) | 1987-07-14 | 1987-07-14 | Improvements in the inhibition of lice |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPI3083 | 1987-07-14 | ||
| AU11220/88A AU608281B2 (en) | 1987-07-14 | 1987-07-14 | Improvements in the inhibition of lice |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1122088A AU1122088A (en) | 1989-01-19 |
| AU608281B2 true AU608281B2 (en) | 1991-03-28 |
Family
ID=3702011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU11220/88A Ceased AU608281B2 (en) | 1987-07-14 | 1987-07-14 | Improvements in the inhibition of lice |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU608281B2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005561A1 (en) * | 1989-10-10 | 1991-05-02 | Peter Hugh Hull | Head lice treatment |
| WO1991008670A1 (en) * | 1989-12-11 | 1991-06-27 | Vincent Henry Guerrini | Pesticidal composition comprising azadirachtin, dialkyltoluamide and oil (geraniol and/or citronellal) |
| US5372817A (en) * | 1991-01-03 | 1994-12-13 | W. R. Grace & Co.-Conn. | Insecticidal compositions derived from neem oil and neem wax fractions |
| GB2252906B (en) * | 1991-02-23 | 1995-01-25 | Midland Biocides Limited | Biocidal use of naturally occurring oils |
| US5397571A (en) * | 1993-03-25 | 1995-03-14 | W. R. Grace & Co.-Conn. | Co-extraction of azadirachtin and neem oil |
| US6733802B1 (en) | 1997-12-17 | 2004-05-11 | Fortune Bio-Tech Limited | Natural azadirachtin composition |
-
1987
- 1987-07-14 AU AU11220/88A patent/AU608281B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU1122088A (en) | 1989-01-19 |
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