AU608564B2 - Improvements in the inhibition of ectoparasites in domestic animals - Google Patents
Improvements in the inhibition of ectoparasites in domestic animals Download PDFInfo
- Publication number
- AU608564B2 AU608564B2 AU11221/88A AU1122188A AU608564B2 AU 608564 B2 AU608564 B2 AU 608564B2 AU 11221/88 A AU11221/88 A AU 11221/88A AU 1122188 A AU1122188 A AU 1122188A AU 608564 B2 AU608564 B2 AU 608564B2
- Authority
- AU
- Australia
- Prior art keywords
- parts
- acid
- pesticidal composition
- azadirachtin
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 244000078703 ectoparasite Species 0.000 title claims description 8
- 241001465754 Metazoa Species 0.000 title description 7
- 230000005764 inhibitory process Effects 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims description 19
- 239000005878 Azadirachtin Substances 0.000 claims description 14
- VEHPJKVTJQSSKL-UHFFFAOYSA-N azadirachtin Natural products O1C2(C)C(C3(C=COC3O3)O)CC3C21C1(C)C(O)C(OCC2(OC(C)=O)C(CC3OC(=O)C(C)=CC)OC(C)=O)C2C32COC(C(=O)OC)(O)C12 VEHPJKVTJQSSKL-UHFFFAOYSA-N 0.000 claims description 14
- FTNJWQUOZFUQQJ-IRYYUVNJSA-N azadirachtin A Natural products C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C/C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-IRYYUVNJSA-N 0.000 claims description 14
- FTNJWQUOZFUQQJ-NDAWSKJSSA-N azadirachtin A Chemical compound C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C\C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-NDAWSKJSSA-N 0.000 claims description 11
- 239000000284 extract Substances 0.000 claims description 8
- 230000000361 pesticidal effect Effects 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 150000007513 acids Chemical class 0.000 claims description 5
- 239000004166 Lanolin Substances 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- 235000019388 lanolin Nutrition 0.000 claims description 4
- 240000005343 Azadirachta indica Species 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 125000000917 azadirachtin group Chemical group 0.000 claims description 2
- 239000003599 detergent Substances 0.000 claims description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 8
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 3
- 229940087168 alpha tocopherol Drugs 0.000 claims 3
- 235000010323 ascorbic acid Nutrition 0.000 claims 3
- 239000011668 ascorbic acid Substances 0.000 claims 3
- 229960005070 ascorbic acid Drugs 0.000 claims 3
- 229960000984 tocofersolan Drugs 0.000 claims 3
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 claims 3
- 235000004835 α-tocopherol Nutrition 0.000 claims 3
- 239000002076 α-tocopherol Substances 0.000 claims 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 2
- 235000013500 Melia azadirachta Nutrition 0.000 claims 2
- XMHIUKTWLZUKEX-UHFFFAOYSA-N hexacosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O XMHIUKTWLZUKEX-UHFFFAOYSA-N 0.000 claims 2
- UTOPWMOLSKOLTQ-UHFFFAOYSA-N octacosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O UTOPWMOLSKOLTQ-UHFFFAOYSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 210000002268 wool Anatomy 0.000 claims 1
- 241001674048 Phthiraptera Species 0.000 description 8
- 241000238876 Acari Species 0.000 description 6
- 241000258242 Siphonaptera Species 0.000 description 6
- 210000004209 hair Anatomy 0.000 description 5
- 101100126955 Arabidopsis thaliana KCS2 gene Proteins 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 235000005633 Chrysanthemum balsamita Nutrition 0.000 description 2
- 244000260524 Chrysanthemum balsamita Species 0.000 description 2
- 241000258922 Ctenocephalides Species 0.000 description 2
- 241000509416 Sarcoptes Species 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 239000002018 neem oil Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 241000257161 Calliphoridae Species 0.000 description 1
- 241000359266 Chorioptes Species 0.000 description 1
- 206010014143 Ectoparasitic Infestations Diseases 0.000 description 1
- 241001302041 Heterodoxus Species 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 241001467800 Knemidokoptes Species 0.000 description 1
- 241000158728 Meliaceae Species 0.000 description 1
- 241000790250 Otodectes Species 0.000 description 1
- 241001482237 Pica Species 0.000 description 1
- 241001649229 Psoroptes Species 0.000 description 1
- 241000718000 Pulex irritans Species 0.000 description 1
- 230000001887 anti-feedant effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- BXNANOICGRISHX-UHFFFAOYSA-N coumaphos Chemical compound CC1=C(Cl)C(=O)OC2=CC(OP(=S)(OCC)OCC)=CC=C21 BXNANOICGRISHX-UHFFFAOYSA-N 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- OEBRKCOSUFCWJD-UHFFFAOYSA-N dichlorvos Chemical compound COP(=O)(OC)OC=C(Cl)Cl OEBRKCOSUFCWJD-UHFFFAOYSA-N 0.000 description 1
- 229950001327 dichlorvos Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000015250 liver sausages Nutrition 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000029380 parasitic ectoparasitic infectious disease Diseases 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- XYSQXZCMOLNHOI-UHFFFAOYSA-N s-[2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]phenyl] 5-pyridin-1-ium-1-ylpentanethioate;bromide Chemical compound [Br-].C1=CC(S(=O)(=O)NC(=O)C)=CC=C1NC(=O)C1=CC=CC=C1SC(=O)CCCC[N+]1=CC=CC=C1 XYSQXZCMOLNHOI-UHFFFAOYSA-N 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
I'll' .8 11111.25 11w1 1.4 1.6 O68L9g$ZL zAxMAn~sbdouwl 1!!H 64opDqo ZAkXMAflSNdONW1ArIH0s9a1HV 'Id 0 L,
''III
11.8 1.25 I- I I I I .1~j AUSR P/00/01lI Form PATENTS ACT 1952 COMPLETE SPECIFICATION
(ORIGINAL)
FOR OFFICE USE Short Title: mnt. CI: 2, Application Number: Lodged: a *Cc~rtplete Specification-Lodged: 0 Accepted: Lapsed: Published: iity: I T17T7M7
J.
Related Art: *4 0 f 1 :Namle of Applicant: VIiYCENT HENRY GUERRINI TO BE COMPLETED BY APPLICANT 'Address of Applicant: EI C 43CHATS WOOD ROAD, DAISY HILL 4128, QUEENSLAND, AUSTRALIA.
Actual Inventor: VINCENT HENRY GUERRINI .Address for Service: 773 CHATSWOOD ROAD, DAISY HILL 4128, QUEENSLAND, AUSTRALIA.
Complete Specification for the invention entitled: IMPROVEMENTS IN THE INHIBITION OF ECTOPARASITES IN DOMESTIC ANIMALS.
The following statement is a full description of this invention, including the best method of performing it known to me:-* Note: The description is to be typed in double spacing, pica ty 1 ,e face, in an area not exceeding 250 mm in depth and 160mm in width, on tough white paper of good quality and it is to be inserted inside this form.
1 4599/78a-L Printed by C. J. TnoNt'. flN. Commionwealti Go vcrntnnit P1rinter Cutbersa iI 14 4 -2- C I 1: C 41 41 4 41 4.
4r 0 (IiI I I.
IMPROVEMENTS IN THE INHIBITION OF ECTOPARASITES IN DOMESTIC ANIMALS This invention relates to pesticidal compositions and to methods of killing or repelling pests.
Infestations of animals by fleas (Ctenocephalides spp.), lice (Trichodectis and Heterodoxus spp.), mites (Otodectis and Sarcoptes spp.) are commonly found throughout the world and are the cause of irritation of the skin, scratchinig, rubbing and licking with consequential damage to the skin and hair coat, loss of appetite, weight gain and condition, and are also a health hazard to humans because the ectoparasites are able to transmit diseases.
Current methods of control include the application of mildly to highly toxic compounds such as dichlorvos, asuntol and the like.
The use of man-made insecticides with one mechanism of action such as the organophosphates, organochlorines and pyrethryns has induced resistance in ectoparasites.
From the above mentioned it should be appreciated that ectoparasitic infestations are a serious conditions in animals and that current methods of control are not satisfactory.
THE COMMISSIONER OF PATENTS.
(~gare of Declarant) (IMPORTANT Cross outi inapplicable words in the above Form.) C, J, THoMPSON, Commonwealth Government Printer .I e) -0 i-3- Azadirachtin-rich extracts of the seeds of the neem tree Azadirachta Tndica A. Juss (Meliaceae) contain a range of liminoid chemicals, such as the tetranortriterpernoid, azadirachtin, which are active as inSeCtL anti- feedants, growth disruptors and insecticides but effe':ts of azadi rachtLin against ectopal-asites h-ave niot been described except for Australian Patent Applications 43018/S, 75714/37 (Blowflies) and 11220/88 (Lice).
extrctsto prevent and inhibit the development of fleas e including Ctenocephalides spp., Pulex irritans, Leptosilla esegnis and Echinophagag,.illinacea, and mites, including Sarcopte caee Cnemidocoptes spp., Chorioptes spp., C 44 15 Notciendres spp. Otodectes spp. and Psoroptes spp.
C rrrtIt is a further objective of this invention to provide a composition to extend the presence of azadirachtin on a locus and to reduce the rate of degradation or oxidation of Azadirachtin.
The invention is a composition of azadirachtin or azadirachtin containing extracts or oils with wool wax with fatty acids with anti-oxidants and with acids.
Er.
PATE'T'OFFC,,
A
s~a; I Bg~ -4r r., l I1 E f' 10 r p In one embodiment the composition is further mixed with tween (Registered Trade Mark) or Span (Registered Trade Mark) and water to produce an emulsion which can be sprayed onto animals.
In another embodiment the composition is placed or impregnated into a device attached to an animal or person.
Further preferred embodiments of the invention shall become apparent from reference to the Examples:- Example 1 Table 1 shows the number of fleas, lice, mites and ticks counted on six dogs before and after treatment with a composition of 10 ml neem oil with 2% azadirachtin. The composition was spread manually onto the infested areas of the skin and hair coat.
TABLE 1 Time (Hours) Lice Fleas Mites Ticks 0 375 321 23 12 1 24 13 12 8 5 5 9 3 0 0 3 3 24 0 0 0 0 48 0 0 0 0 72 0 0 0 0 144 0 0 0 0 396 0 13 0 0 As ran be seen from Table 1 treatment of the hair and skin with the composition achieved a substancial reduction in the flea, lice, mite and tick population between 1 and 396 hours after treatment (treatment done at 0 hour).
"0 i ii Example 2 Table 2 shows the number of fleas, lice, mites and ticks counted on six dogs before and after treatment with a composition of 10 ml neem oil with 2% azadirachtin further blended with an oil, a detergent and water. The composition was sprayed onto the infested areas of the skin and hair coat.
TABLE 2 t 1 Time (Hours) Lice Fleas Mites Ticks 10 0 32 564 13 17 1 14 3 2 3 5 1 0 2 0 0 0 0 0 24 0 0 0 0 S 15 48 0 0 0 0 72 0 6 3 0 144 0 23 5 0 396 0 33 0 0 tt, As can be seen from Table 2 spray treatment of the t t 20 hair and skin with the composition achieved a substancial reduction in the flea, lice, mite and tick population C, between 1 and 396 hours after treatment (treatment done at 0 hour).
i, L_ L -j i LC I-
Claims (9)
1. A pesticidal composition comprising azadirachtin or azadirachtin containing extracts including neem extracts with wool wax or fatty acids or anti-oxidants or acids.
2. A pesticidal composition according to claim 1 wherein the fatty acids are oleic or linoleic or linolenic or palmitic or capric or lauric or myristic or palmitic or stearic or arachidic or beheric or cerotic, or montanic acid. o*
3. A pesticidal composition according to Claim 1 wherein a o the anti-oxidants are alpha-tocopherol or ascorbic acid a o oo (Vitamin C). o
4. A pesticidal composition according to claim 1 wherein the acids are boric acid or proprionic or salicilic acids.
A pesticidal composition of any of the preceding claims further comprising a detergent and water.
6. A pesticidal composition according to claim 1 comprising from 0.1 to 99 parts by weight azadirachtin containing extracts, 1 to 99.8 parts by weight wool wax, 1 to 99.8 parts by weight linoleic acid, 1 to 99.8 parts boric or salicilic acid, 1 to 99.8 parts alpha tocopherol or ascorbic acid. V \0 1 i L~ -I ill -7-
7. A pesticidal composition according to claim 1 comprising from 1 to 80 parts by weight azadirachtin containing extracts, 20 to 99 parts by weight wool wax, to 99 parts by weight linoleic acid, 20 to 99 parts boric or salicilic acid and 20 to 99 parts alpha tocopherol or ascorbic acid.
8. A method of inhibiting and preventing ectoparasites comprising applying a composition of azadirachtin or azadirachtin containing extracts including neem extracts with wool fat or fatty acids or anti-oxidants or acids to S Sthe pests or their surroundings or a locus. 0 0
9. A method according to claim 9 wherein ectoparasites a oa includes the eggs, larvae and adult forms of ectoparasites. 0 o VINCENT HENRY GUERRINI 'D TF 12th OF DECEMBER, 1990 i 1 i; i. .L -e
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPI493287 | 1987-10-19 | ||
| AUPI4932 | 1987-10-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1122188A AU1122188A (en) | 1989-04-20 |
| AU608564B2 true AU608564B2 (en) | 1991-04-11 |
Family
ID=3772500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU11221/88A Ceased AU608564B2 (en) | 1987-10-19 | 1988-10-19 | Improvements in the inhibition of ectoparasites in domestic animals |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU608564B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991008670A1 (en) * | 1989-12-11 | 1991-06-27 | Vincent Henry Guerrini | Pesticidal composition comprising azadirachtin, dialkyltoluamide and oil (geraniol and/or citronellal) |
| US6514951B1 (en) | 1989-12-15 | 2003-02-04 | American Cyanamid Company | Pour-on formulations effective for the control of internal and external parasites of homothermic animals |
| GB2252906B (en) * | 1991-02-23 | 1995-01-25 | Midland Biocides Limited | Biocidal use of naturally occurring oils |
| AUPS323002A0 (en) * | 2002-06-26 | 2002-07-18 | Virbac (Australia) Pty Limited | Worming formulation |
-
1988
- 1988-10-19 AU AU11221/88A patent/AU608564B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU1122188A (en) | 1989-04-20 |
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