CA2117367A1 - 3-phenylureido-azepin-2-ones and benzazepin-2-ones useful as cholecystokinin antagonists - Google Patents

3-phenylureido-azepin-2-ones and benzazepin-2-ones useful as cholecystokinin antagonists

Info

Publication number: CA2117367A1
Authority: CA; Canada
Prior art keywords: oxo; phenyl; ureido; nmr; cdci3
Prior art date: 1992-01-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002117367A

Other languages

English (en)

French (fr)

Inventor

John A. Lowe, Iii

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Ltd Great Britain

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-27

Filing date

1992-12-16

Publication date

1993-08-05

1992-12-16 Application filed by Individual filed Critical Individual

1993-08-05 Publication of CA2117367A1 publication Critical patent/CA2117367A1/en

Status Abandoned legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002117367A 1992-01-27 1992-12-16 3-phenylureido-azepin-2-ones and benzazepin-2-ones useful as cholecystokinin antagonists Abandoned CA2117367A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US82567792A	1992-01-27	1992-01-27
US825,677		1992-01-27

Publications (1)

Publication Number	Publication Date
CA2117367A1 true CA2117367A1 (en)	1993-08-05

Family

ID=25244657

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002117367A Abandoned CA2117367A1 (en)	1992-01-27	1992-12-16	3-phenylureido-azepin-2-ones and benzazepin-2-ones useful as cholecystokinin antagonists

Country Status (19)

Country	Link
EP (1)	EP0625145A1 (sr)
JP (1)	JPH07503465A (sr)
KR (1)	KR950700257A (sr)
CN (1)	CN1074903A (sr)
AU (1)	AU3276193A (sr)
BR (1)	BR9207071A (sr)
CA (1)	CA2117367A1 (sr)
CZ (1)	CZ391092A3 (sr)
FI (1)	FI943513A0 (sr)
HU (1)	HUT70496A (sr)
IL (1)	IL104472A0 (sr)
MX (1)	MX9300409A (sr)
NO (1)	NO942775L (sr)
NZ (1)	NZ245759A (sr)
RU (1)	RU94038063A (sr)
TW (1)	TW213901B (sr)
WO (1)	WO1993015059A1 (sr)
YU (1)	YU4393A (sr)
ZA (1)	ZA93582B (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2097688A1 (es) *	1993-07-14	1997-04-01	Pfizer	Hexahidroazepinonas y tetrahidrobenzazepinonas sustituidas.
JP2862675B2 (ja) *	1993-07-26	1999-03-03	フアイザー・インコーポレイテツド	選択的コレシストキニン−ｂ受容体拮抗薬としてのテトラヒドロ−１ｈ−ベンゾアゼピノンおよびヘキサヒドロアゼピノン
CA2176019A1 (en) *	1993-11-22	1995-06-01	John J. Baldwin	3-acylaminobenzazepines
US5453424A (en) *	1993-11-22	1995-09-26	Merck & Co., Inc.	Furanodiazepines
WO1996010564A1 (en) *	1994-10-04	1996-04-11	Pfizer Inc.	Processes and intermediates for preparing 3-amino-benzo(b)azepinones
ES2171196T3 (es) *	1994-10-14	2002-09-01	Glaxosmithkline Spa	Uso de antagonistas del receptor cck-b para el tratamiento de trastornos del sueño.
DE10153348A1 (de) *	2001-10-29	2003-05-08	Gruenenthal Gmbh	Substituierte Benzo(b)azepin-2-on-Verbindungen
WO2007120160A2 (en) *	2005-06-16	2007-10-25	Novartis Ag	Lactam containing hcv inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
US4767756A (en) *	1987-07-17	1988-08-30	E. R. Squibb & Sons, Inc.	3-substituted benzazepines
EP0322779A3 (en) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolactam compounds and pharmaceutical uses thereof
US5206234A (en) *	1990-10-22	1993-04-27	Merck & Co., Inc.	Benzolactam analogs as antagonists of cck

1992
- 1992-12-15 TW TW081110044A patent/TW213901B/zh active
- 1992-12-16 WO PCT/US1992/010720 patent/WO1993015059A1/en not_active Ceased
- 1992-12-16 JP JP5513196A patent/JPH07503465A/ja active Pending
- 1992-12-16 RU RU94038063/04A patent/RU94038063A/ru unknown
- 1992-12-16 FI FI943513A patent/FI943513A0/fi unknown
- 1992-12-16 EP EP93901470A patent/EP0625145A1/en not_active Withdrawn
- 1992-12-16 HU HU9402195A patent/HUT70496A/hu unknown
- 1992-12-16 CA CA002117367A patent/CA2117367A1/en not_active Abandoned
- 1992-12-16 BR BR9207071A patent/BR9207071A/pt not_active Application Discontinuation
- 1992-12-16 KR KR1019940702565A patent/KR950700257A/ko not_active Ceased
- 1992-12-16 AU AU32761/93A patent/AU3276193A/en not_active Abandoned
- 1992-12-28 CZ CS923910A patent/CZ391092A3/cs unknown
1993
- 1993-01-21 CN CN93101158A patent/CN1074903A/zh active Pending
- 1993-01-21 IL IL104472A patent/IL104472A0/xx unknown
- 1993-01-26 MX MX9300409A patent/MX9300409A/es unknown
- 1993-01-26 YU YU4393A patent/YU4393A/sr unknown
- 1993-01-26 NZ NZ245759A patent/NZ245759A/en unknown
- 1993-01-27 ZA ZA93582A patent/ZA93582B/xx unknown
1994
- 1994-07-26 NO NO942775A patent/NO942775L/no unknown

Also Published As

Publication number	Publication date
CN1074903A (zh)	1993-08-04
NZ245759A (en)	1997-06-24
WO1993015059A1 (en)	1993-08-05
JPH07503465A (ja)	1995-04-13
CZ391092A3 (en)	1994-01-19
EP0625145A1 (en)	1994-11-23
TW213901B (sr)	1993-10-01
YU4393A (sr)	1996-01-09
NO942775D0 (no)	1994-07-26
KR950700257A (ko)	1995-01-16
IL104472A0 (en)	1993-05-13
RU94038063A (ru)	1996-05-27
FI943513A7 (fi)	1994-07-26
AU3276193A (en)	1993-09-01
FI943513L (fi)	1994-07-26
HUT70496A (en)	1995-10-30
FI943513A0 (fi)	1994-07-26
ZA93582B (en)	1994-07-27
HU9402195D0 (en)	1994-09-28
BR9207071A (pt)	1995-12-05
NO942775L (no)	1994-09-20
MX9300409A (es)	1993-07-01

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Legal Events

Date	Code	Title	Description
1994-07-07	EEER	Examination request
1998-10-15	FZDE	Discontinued