GB2182245A - Disinfectant composition - Google Patents
Disinfectant composition Download PDFInfo
- Publication number
- GB2182245A GB2182245A GB08623375A GB8623375A GB2182245A GB 2182245 A GB2182245 A GB 2182245A GB 08623375 A GB08623375 A GB 08623375A GB 8623375 A GB8623375 A GB 8623375A GB 2182245 A GB2182245 A GB 2182245A
- Authority
- GB
- United Kingdom
- Prior art keywords
- disinfectant
- surfactant
- emollient
- composition according
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 239000000645 desinfectant Substances 0.000 title claims abstract description 25
- 239000004094 surface-active agent Substances 0.000 claims abstract description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003974 emollient agent Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000011187 glycerol Nutrition 0.000 claims abstract description 7
- 230000000694 effects Effects 0.000 claims description 6
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims description 3
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical group CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract description 5
- 239000000600 sorbitol Substances 0.000 abstract description 5
- 241000283690 Bos taurus Species 0.000 abstract description 4
- 208000004396 mastitis Diseases 0.000 abstract description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 210000002445 nipple Anatomy 0.000 description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 230000003750 conditioning effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000010186 staining Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Chemical compound CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 2
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229940035535 iodophors Drugs 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000193985 Streptococcus agalactiae Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000012505 colouration Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000004120 green S Substances 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- AYOOGWWGECJQPI-NSHDSACASA-N n-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1h-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine Chemical compound N1C(OC(C)C)=CC(N2C3=NC(N[C@@H](C)C=4N=CC(F)=CN=4)=CC=C3N=C2)=N1 AYOOGWWGECJQPI-NSHDSACASA-N 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
The composition which is e.g. for use for the treatment of mastitis in cows comprises a disinfectant, an emollient, a surfactant and water. The disinfectant is polyhexamethylenediguanidehydrochloride having the general formula: <IMAGE> Suitable emollients are glycerin or sorbitol.
Description
SPECIFICATION
Disinfectant compositions
This invention relates two disinfectant compositions for application to the skin. The compositions ofthe invention are especially useful for veterinary purposes particularly as a teat dip or spray for the treatment of cow teats to control mastitis. However, the compositions of the invention may also be useful for other purposes.
lodophors, that is, solutions of iodine in aqueous surfactant, are highly effective disinfectant materials which are widely used for veterinary purposes. However, they have the disadvantage that they can cause unsightly staining particularly where plastics equipment, such as pipes and containers, is used.
Compositions based on chlorhexidine gluconate are used as an alternative to iodophors particularlyfor teat dips and such compositions do not cause staining. However, the disinfectant activity is lower and the material is relatively expensive. Moreover, known chlorhexidine teat dip com positions may contain relatively low levels of emollient which may not be satisfactory for good skin conditioning.
An object ofthe present invention is to provide a new disinfectant composition for application to the skin which has good activity and good skin conditioning properties yet which does not give rise to staining problems and which is a relatively inexpensive and convenientformulation.
According to the invention therefore there is provided a disinfectant composition comprising a mixture of a disinfectant, an emollient, a surfactant and water, characterised in that the disinfectant is polyhexamethylenediguanidehydrochloride having the formula
This disinfectant (hereinafter referred to as PHMDG) has known bactericidal properties and is sold by ICI Limited underthe trade mark Vantocil IB for use as an industrial bactericide for example for cleaning brewery equipment. The value of n in Vantocil IB is typically 5. Hitherto, it is believed that the material has not been used for application to the skin for any veterinary purpose nor has it been formulated with emollient and surfactant or any similar combination of substances.
In accordance with the present invention it has been found that a remarkably stable and effective skin disinfectant can be obtained by mixing the PHMDG with emollient and surfactant, without giving rise to any staining problems (since PHMDG is essentially a colourless liquid). The resulting composition can tolerate relatively high levels of emollient without loss of stability whereby excellent skin conditioning can be conveniently achieved. Moreover, PHMDG is relatively inexpensive and can be readily incorporated with the emollient and surfactant and also with other materials, such as dyestuffs which are commonly added to disinfectant preparations for identification purposes.With regard to the question of stability it is to be understood that it is required that a disinfectant composition such as a teat dip should be capable of retaining its disinfectant activity on storage and also should remain as a homogeneous mixture without appreciable precipitation or other separation of components. With known disinfectant compositions as discussed above stability problems can arise in that, for example, there can be loss of activity with made-up iodophors on storage, and precipitation can occur with the chlorhexidine gluconate compositions during formulation or on storage especially where dyestuffs are incorporated.The composition of the present invention is particularly stable and especially easy and convenientto prepare in that, for example, it can be possible to avoid precipitation or separation even where water is used which has not been specially de-ionised.
The composition of the invention may be prepared as a fully made-up ready-for-use disinfectant, since it is storage stable in this form. However, if desired, it may also be made up as a concentrate to be diluted by addition of water prior to use.
The proportion of PHMDG, at the ready-for-use dilution, may be about 5000 ppm. A lower limit would be say 2500 ppm, and an upper limitwould be about 7500 ppm by weight.
The emollient is preferably glycerin and/or Sorbitol although any other suitable substance orcombination of substances may be used. A preferred proportion of emollient, at the ready-for-use dilution, is about 7% by weight. A suitable range would be 4% to 12% by weight.
The surfactant may be any suitable substance although preferably,forcompatabiiity with otherin- gredients, a non-ionicsurfactant (e.g. having an HLB value in the range 12to 16 more preferably 13to 16) is used. A nonyl phenol 12 mole ethoxylate is particularly suitable. The proportion of surfactant at the ready-foruse dilution may by 0.1% to 0.5% preferably 0.2% byweight.
Other substances may be incorporated as desired such as colouring agents and/or isopropyl alcohol.
Examples
EXAMPLE 1 Thefollowing ingredients were mixed with stirring in the stated proportions (byweight): PHMDG (20% ww) 250 kg (5000 ppm)
Glycerin BP 80 700 kg (7%)
Nonyl phenol 12 mole ethoxylate surfactant 20 kg (0.2%)
Food Green4(E142) 200 g De-ionised water to 10000 litres
The resulting mixture was used in conventional manner as a teat dip to assess its effect on the conditioning ofteats. That is, the mixture was applied regularly to teats of milk cows after milking and the improvement in skin condition was monitored.
Staphylococcus aureus and Streptococcus agalactiae are the predominating mastitis pathogens spread principally during the milking process. The mixture of Example 1 was found to have a good bactericidal effect againstthese when tested on the teats of 16 lactating dairy cows.
Skin sores and skin cracking can occur on teats of milk cowls due to irritation orchafing caused bydisinfectant materials and milking equipment. The mixture of Example 1 was found to give good skin conditioning to the extent that sores and cracking could be prevented and healed.
The mixture of Example 1 was a storage stable homogeneous solution having a pleasing blue colouration (due to the dyestuff).
EXAMPLE2
The following ingredients were mixed with stirring in the stated proportions by weight:
PHMDG 5000 ppm
Glycerin 6%
Sorbitol 8.5%
Isopropyl Alcohol 3%
Surfactant 0.2%
Water to 100
EXAMPLE3
The following ingredients were mixed with stirring in the stated proportions by weight
PHMDG 5000 ppm Glycerin 5%
Surfactant 0.2%
Water to 100
EXAMPLE4
The following ingredients were mixed with stirring in the stated proportions byweight
PHMDG 5000 ppm
Glycerin 12%
Surfactant 0.2%
Water to 100
EXAMPLE5
The following ingredients were mixed with stirring in the stated proportions byweight
PHMDG 5000 ppm
Sorbitol 5%
Surfactant 0.2%
Water to 100
EXAMPLE6
The following ingredients were mixed with stirring in the stated proportions byweight
PHMDG 5000 ppm
Sorbitol 12%
Surfactant 0.2%
Water to 100
In the foregoing examples the water is preferably de-ionised water.
The mixtures of Examples 2 to 6 were found to demonstrate good storage stability and good bactericidal effect.
It is of course to be understood that the invention is not intended to be restricted to the details of the above examples.
Claims (1)
1. A disinfectant composition comprising a mixture of a disinfectant, an emollient, a surfactant and water, characterised in that the disinfectant is polyhexamethylenediguanidehydrochloride having theformula
2. A composition according to claim 1, wherein the disinfectant is present in a proportion between 2500 ppm and 7500 ppm.
3. A composition according to claim 1 or 2, wherein the emollient is glycerin and/orsorbitol.
4. A composition according to any one of claims 1 to 3, wherein the emollient is present in the range 4%to 12% by weight.
5. A composition according to any one of claims 1 to 4, wherein the surfactant is a non-ionicsurfactant.
6. A composition according to claim 5, wherein the surfactant has an HLB value in the range 13to 16.
7. A composition according to claim 6, wherein the surfactant is a nonyl phenol 12 mole ethoxylate.
8. A composition according to any one of claims 1 to7, wherein the surfactant is present in the proportion 0.1%to 0.5% by weight.
9. A composition substantially as herein before described in any of the examples.
Amendments to the claims have been filed, and have the following effect:a) Claim 1 only above has been textually amended.
1. A disinfectant composition comprising a mixture of an emollient, a surfactant, water and in addition thereto a sole disinfectant, characterised in that the sole disinfectant is polyhexamethylenediguanidehydrochloride having the formula
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8623375A GB2182245B (en) | 1985-09-28 | 1986-09-29 | Disinfectant compositions |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858523947A GB8523947D0 (en) | 1985-09-28 | 1985-09-28 | Disinfectant compositions |
| GB8623375A GB2182245B (en) | 1985-09-28 | 1986-09-29 | Disinfectant compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8623375D0 GB8623375D0 (en) | 1986-11-05 |
| GB2182245A true GB2182245A (en) | 1987-05-13 |
| GB2182245B GB2182245B (en) | 1989-10-18 |
Family
ID=26289815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8623375A Expired GB2182245B (en) | 1985-09-28 | 1986-09-29 | Disinfectant compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2182245B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002069954A1 (en) * | 2001-03-02 | 2002-09-12 | Mcj, Inc. | Composition and methods for the treatment and prevention of bovine mastitis |
| EP1218016A4 (en) * | 1999-09-27 | 2003-06-04 | David J Ricketts | COMPOSITION AND METHOD FOR MANUFACTURING LUBRICATING AND GERMICIDE FOAM |
| WO2005092358A1 (en) * | 2004-02-26 | 2005-10-06 | Tasker Products Ip Holdings Corp. | Oral health care drink and method for reducing malodors |
| US7845351B2 (en) * | 2005-08-31 | 2010-12-07 | Kimberly-Clark Worldwide Inc. | Germicidal face mask |
| CN102399419A (en) * | 2010-09-16 | 2012-04-04 | 中国石油化工股份有限公司 | Antibacterial polyethylene terephthalate composition and preparation method thereof |
| WO2018137497A1 (en) * | 2017-01-26 | 2018-08-02 | 上海富元塑胶科技有限公司 | Guanidine oligomer, method for preparing same, and application of guanidine oligomer for being bonded to molecular chain of universal polymer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1246841A (en) * | 1968-05-10 | 1971-09-22 | Ici Ltd | Bactericidal and detergent compositions |
| GB2171013A (en) * | 1985-02-19 | 1986-08-20 | Fibre Treatments Limited | Skin care composition |
-
1986
- 1986-09-29 GB GB8623375A patent/GB2182245B/en not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1246841A (en) * | 1968-05-10 | 1971-09-22 | Ici Ltd | Bactericidal and detergent compositions |
| GB2171013A (en) * | 1985-02-19 | 1986-08-20 | Fibre Treatments Limited | Skin care composition |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1218016A4 (en) * | 1999-09-27 | 2003-06-04 | David J Ricketts | COMPOSITION AND METHOD FOR MANUFACTURING LUBRICATING AND GERMICIDE FOAM |
| WO2002069954A1 (en) * | 2001-03-02 | 2002-09-12 | Mcj, Inc. | Composition and methods for the treatment and prevention of bovine mastitis |
| US6525071B2 (en) | 2001-03-02 | 2003-02-25 | Mcj, Inc. | Compositions and methods for the treatment and prevention of bovine mastitis |
| WO2005092358A1 (en) * | 2004-02-26 | 2005-10-06 | Tasker Products Ip Holdings Corp. | Oral health care drink and method for reducing malodors |
| US7845351B2 (en) * | 2005-08-31 | 2010-12-07 | Kimberly-Clark Worldwide Inc. | Germicidal face mask |
| CN102399419A (en) * | 2010-09-16 | 2012-04-04 | 中国石油化工股份有限公司 | Antibacterial polyethylene terephthalate composition and preparation method thereof |
| CN102399419B (en) * | 2010-09-16 | 2013-07-03 | 中国石油化工股份有限公司 | Antibiotic poly(ethylene terephthalate) composition and preparation method thereof |
| WO2018137497A1 (en) * | 2017-01-26 | 2018-08-02 | 上海富元塑胶科技有限公司 | Guanidine oligomer, method for preparing same, and application of guanidine oligomer for being bonded to molecular chain of universal polymer |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2182245B (en) | 1989-10-18 |
| GB8623375D0 (en) | 1986-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE20 | Patent expired after termination of 20 years |
Effective date: 20060928 |