HK40102185A - Liquid oral composition - Google Patents

Description

Liquid oral composition

Technical Field

This invention relates to a liquid oral composition containing vitamin E that provides an excellent refreshing sensation in the mouth after use.

Background Technology

Vitamin E, as one of the fat-soluble vitamins, repairs gum tissue and strengthens the gum epithelium by promoting the activation of gum cells caused by improved blood circulation, thus preventing periodontal disease factors from invading the gums. It is expected to have a preventive or inhibitory effect on periodontal diseases such as gingivitis.

On the other hand, generally speaking, liquid oral compositions such as mouthwashes, as a basic function of oral purification, require a refreshing feeling in the mouth after use.

However, liquid oral compositions containing vitamin E often leave an oily aftertaste after application, compromising the refreshing sensation upon spitting. Furthermore, nonionic surfactants, commonly used as solubilizers, sometimes have bitter or unpleasant odors, making it particularly difficult to incorporate vitamin E into liquid oral compositions to ensure appearance stability and provide a refreshing sensation in the mouth.

Patent documents 1 and 2 (Japanese Patent Application Publication No. 2012-97057 and Japanese Patent Application Publication No. Hei 2-59512) disclose oral compositions containing vitamin E and related technologies. Patent document 3 (Japanese Patent Application Publication No. 2020-172467) discloses the addition of vitamin E to oral compositions containing condensed phosphate or its salts. However, none of these technologies ensure appearance stability and provide a refreshing feeling in the mouth with liquid oral compositions.

Existing technical documents

[Patent Literature]

Patent Document 1: Japanese Patent Application Publication No. 2012-97057;

Patent Document 2: Japanese Patent Application Publication No. 2-59512

Patent Document 3: Japanese Patent Application Publication No. 2020-172467

Patent Document 4: International Publication No. 2012/124533

Summary of the Invention

The technical problem that the invention aims to solve

The present invention was made in view of the above circumstances, and its object is to provide a liquid oral composition containing vitamin E that provides an excellent refreshing sensation in the oral cavity after use.

Technical solutions for solving technical problems

To achieve the above-mentioned objectives, the inventors conducted in-depth research and discovered that by incorporating a nonionic surfactant and a condensed phosphoric acid or its salt into a liquid oral composition containing tocopherol, tocopherol esters or their salts as vitamin E in a specific water content, appearance stability can be ensured, providing a refreshing feeling in the mouth after use. Furthermore, unpleasant friction is suppressed, significantly improving the user experience. Specifically, according to the present invention, it was discovered that by preparing a liquid oral composition containing (A) condensed phosphoric acid or its salt, (B) tocopherol, tocopherol esters or their salts, and (C) a nonionic surfactant with a water content of 65% to 98% by mass, a highly clear and uniform appearance stability is achieved even after high-temperature storage, and an excellent refreshing feeling in the mouth after use is also achieved, along with suppressed friction, resulting in an excellent user experience. Thus, the present invention was completed.

In this invention, in the liquid oral composition, by combining components (A), (B), and (C), the unique oily aftertaste of component (B) is suppressed by component (A). Moreover, even when component (C) is used in conjunction with component (B), the bitterness and off-flavors from component (C) are reduced by component (A). Thus, the oily aftertaste from component (B) does not worsen further, and no unpleasant taste is felt, resulting in a unique and significant refreshing sensation (a refreshing feeling without discomfort) in the mouth after use. In addition, the frictional sensation (the feeling of friction when teeth rub against each other) caused by component (A) is reduced by component (B), resulting in a significantly superior user experience.

Therefore, according to the present invention, it is possible to obtain a liquid oral composition containing component (B) that ensures appearance stability even when the mouthwash has a clear appearance, can stably maintain the appearance of the formulation even after high-temperature storage, and imparts a refreshing feeling to the oral cavity after use, and also provides a good user experience with almost no friction. In particular, it is a liquid oral composition that is a homogeneous system as a solubilizing system or a microemulsion system.

It should be noted that Patent Document 4 (International Publication No. 2012/124533) is a two-layered liquid oral composition that separates into an oil layer and a water layer when left to stand. As a formulation example, it shows a composition in which tocopherol acetate is incorporated into the oil layer. However, the improvement in tooth cleaning effect and oily feel (improvement in astringency) is achieved by using a specific oil agent in the oil layer and condensed phosphate or its salt in the water layer in a specific ratio. In contrast, the present invention ensures the appearance stability and improves the refreshing feel of a one-liquid liquid oral composition, such as a mouthwash, resulting from the combination of components (A), (B), and (C), which forms a homogeneous system.

Therefore, the present invention provides the following liquid oral composition.

[1]

A liquid oral composition, characterized in that it contains:

(A) Condensed phosphate or its salt.

(B) Tocopherols, esters of tocopherols with organic acids, or their salts, and

(C) Nonionic surfactants;

The water content is 65% to 98% by mass.

[2]

According to the liquid oral composition described in [1], (C) the nonionic surfactant is selected from one or more of polyoxyethylene fatty acid esters, polyoxyethylene alkyl ethers and polyoxyethylene polyoxypropylene copolymers.

[3]

The liquid oral composition according to [1] or [2] contains 0.01% to 2% by mass of component (A), 0.01% to 0.5% by mass of component (B), and 0.1% to 2% by mass of component (C).

[4]

The liquid oral composition according to any one of [1] to [3], wherein (A)/(B) is 0.1 to 200 by mass.

[5]

The liquid oral composition according to any one of [1] to [4], wherein (A)/(C) is 0.005 to 20 by mass.

[6]

The liquid oral composition according to any one of [1] to [5] further comprises, wherein the content of ethanol is 0% by mass to 20% by mass.

[7]

According to the liquid oral composition described in [6], the content of ethanol is 0% by mass to less than 1% by mass.

[8]

The liquid oral composition described in any one of [1] to [7] is a mouthwash.

Invention Effects

According to the present invention, a liquid oral composition containing component (B) is provided, which exhibits appearance stability even after high-temperature storage, provides an excellent refreshing sensation in the mouth after use, suppresses friction, and offers a pleasant user experience. In addition to the periodontal disease prevention or inhibition effects of component (B), the liquid oral composition of the present invention also exhibits the expected effects of component (A) in preventing or inhibiting tartar deposition, making it effective for the prevention or inhibition of periodontal disease.

Detailed Implementation

The present invention will now be described in further detail.

The liquid oral composition of the present invention contains (A) condensed phosphate or a salt thereof, (B) tocopherol, esters of tocopherol and organic acids or their salts, and (C) a nonionic surfactant.

(A) Condensed phosphate or its salts have the effect of removing stains such as tooth discoloration, and have the effect of preventing or inhibiting tartar deposition. When combined with ingredients (B) and (C), they can give a refreshing feeling.

Examples of condensed phosphoric acid or its salts include linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid, and tetrapolyphosphoric acid, cyclic polyphosphoric acids such as trimetaphosphoric acid, tetrapolyphosphoric acid, and hexametaphosphoric acid, and reticular hyperphosphoric acid or its salts. Water-soluble condensed phosphoric acid or its salts can be used. Examples of their salts include alkali metal salts such as sodium salts and potassium salts. Among these, linear polyphosphoric acids or their salts are preferred, and pyrophosphoric acid, tripolyphosphoric acid, or their sodium salts are particularly preferred.

These can be used individually or in combination of two or more, and commercially available products can also be used.

(A) The amount of condensed phosphate or its salt is preferably 0.01% to 2% (by mass), more preferably 0.1% to 1.5%, and even more preferably 0.2% to 1.0% of the total composition. When the amount is 0.01% or more, a sufficient refreshing feeling can be obtained while preventing or inhibiting tartar deposition. When the amount is 2% or less, it is suitable for inhibiting friction.

(B) Components are typically substances used as vitamin E, and can utilize tocopherol, tocopherol esters with organic acids, or their salts. They have the effects of promoting the activation of gingival cells caused by improved blood circulation, repairing gingival tissue, and strengthening the gingival epithelium, making them effective components for the prevention or inhibition of periodontal diseases such as gingivitis.

Examples of tocopherols include d-α-tocopherol, dl-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, and d-δ-tocopherol. Furthermore, esters of tocopherols with organic acids can be esters of the aforementioned tocopherols with organic acids such as acetic acid, nicotinic acid, succinic acid, and linolenic acid, or their salts. Specifically, examples include tocopherol acetates such as d-α-tocopherol acetate, dl-α-tocopherol acetate, dl-β-tocopherol acetate, dl-γ-tocopherol acetate, and dl-δ-tocopherol acetate; tocopherol nicotinic acid esters such as d-α-tocopherol nicotinic acid and dl-α-tocopherol nicotinic acid; tocopherol succinates such as d-α-tocopherol succinate and dl-α-tocopherol succinate; tocopherol linolenic acid esters such as d-α-tocopherol linolenic acid and dl-α-tocopherol linolenic acid; and calcium tocopherol succinate. Among them, tocopherol acetate and tocopherol nicotinate are preferred, and dl-α-tocopherol acetate and dl-α-tocopherol nicotinic acid are particularly preferred. These can be used alone or in combination of two or more.

They can use substances that meet the old cosmetic ingredient standards (cosmetic raw materials) or quasi-drug ingredient specifications 2006, and can use commercially available products manufactured by DSM Corporation, Eisai Food & Chemical Co., Ltd., BASF Japan Co., Ltd., etc.

The amount of component (B) is preferably 0.01% to 0.5% of the total composition, more preferably 0.02% to 0.3%, and even more preferably 0.03% to 0.2%. When the amount is 0.01% or more, a preventive or inhibitory effect on periodontal disease can be obtained, and the frictional feel of component (A) can be sufficiently suppressed. An amount of 0.5% or less is suitable for ensuring sufficient appearance stability and imparting a refreshing feel.

In this invention, the ratio of (A) to (B), representing the molar ratio of component (A) to component (B), is preferably 0.1 to 200 by mass, more preferably 0.6 to 40, even more preferably 1.5 to 20, and particularly preferably 5.0 to 10. Within the above range, the appearance stability and refreshing feel are more excellent, and the friction sensation is further suppressed.

(C) Nonionic surfactants, as solubilizers, play a role in ensuring appearance stability.

Examples of nonionic surfactants include glycerol fatty acid esters, polyglycerol fatty acid esters, polyoxyethylene glycerol fatty acid esters, sucrose fatty acid esters, sugar alcohol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and other polyoxyethylene fatty acid esters, polyoxyethylene alkyl ethers, fatty acid diethanolamides, sorbitan fatty acid esters, polyoxyethylene higher alcohol ethers, and polyoxyethylene polyoxypropylene copolymers.

From the perspective of appearance stability and refreshing feel, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, and polyoxyethylene polyoxypropylene copolymers are preferred, more preferably polyoxyethylene fatty acid esters and polyoxyethylene alkyl ethers. Polyoxyethylene hydrogenated castor oil with an average addition molar number of ethylene oxide of 40 to 100, polyoxyethylene alkyl ether with an average addition molar number of ethylene oxide of 10 to 17, and polyoxyethylene alkyl ether with 14 to 18 carbon atoms of alkyl groups are particularly preferred.

These can be used individually or in combination of two or more. In addition, commercially available products can be used.

(C) The amount of the nonionic surfactant is preferably 0.1% to 2% of the total composition, more preferably 0.2% to 1.5%, and even more preferably 0.3% to 1.0%. When the amount is 0.1% or more, sufficient appearance stability can be obtained. When the amount is 2% or less, the appearance of its own bitterness and off-flavor can be sufficiently suppressed, and a refreshing feeling can be fully ensured.

Furthermore, the ratio of (A) to (C), representing the molar ratio of component (A) to component (C), is preferably 0.005 to 20 by mass, more preferably 0.1 to 5, even more preferably 0.2 to 4, and particularly preferably 0.6 to 2. Within the above range, the appearance stability and refreshing feel are superior, and the friction sensation is further suppressed.

It should be noted that, in this invention, it is even more preferred that the mass ratios of (A)/(B) and (A)/(C) are within the ranges described above.

In the liquid oral composition of the present invention, ordinary water (purified water) can be used as a solvent, and lower monohydric alcohols with 2 to 4 carbon atoms, such as ethanol, can also be used.

The water (purified water) content (moisture content) is preferably 65% to 98% of the total composition, more preferably 70% to 98%, and even more preferably 75% to 98%.

The aforementioned lower monohydric alcohols, particularly ethanol, may be absent, but if present, their content is preferably 0.1% to 20% of the total composition, more preferably 0.5% to 15%, further preferably 1% to 10%, and particularly preferably 1% to 5%. In this invention, even alcohol-free liquid oral compositions can impart a high-intensity refreshing sensation.

It should be noted that in non-alcoholic liquid oral compositions, trace amounts of ethanol from the raw materials are sometimes contained in the formulated flavorings. Therefore, taking this into account, it is possible to produce a composition that contains no ethanol except for the trace amounts of ethanol contained in the flavorings. In this case, the ethanol content in the composition is preferably less than 1%, more preferably less than 0.5%, further preferably less than 0.1%, particularly preferably less than 0.05%, and may also be 0% (lower limit).

In addition, the pH of the composition is not particularly limited as long as it is within the range that is safe in the oral cavity. It can be set to a pH (25°C) range of 4 to 9, particularly preferably 5 to 8, and even more preferably 5 to 7.

The liquid oral composition of the present invention can be prepared and used in dosage forms such as mouthwash, oral cooling agent, and concentrated mouthwash. In particular, the mouthwash, in addition to the above-mentioned components, can also contain appropriate known components corresponding to its dosage form as needed. For example, it can contain humectants, thickeners, surfactants, pH adjusters, preservatives, sweeteners, flavorings, active ingredients, colorants, etc. Furthermore, the liquid oral composition generally does not contain abrasives.

Wetting agent:

Examples include polyols such as glycerol, sorbitol, propylene glycol, ethylene glycol, and polyethylene glycol, as well as sugar alcohols such as xylitol, maltitol, and lactitol.

Thickener:

Examples include xanthan gum, carrageenan, carboxymethyl cellulose, hydroxyethyl cellulose, sodium alginate, and polyvinyl alcohol.

Any surfactant:

Surfactants other than component (C) include, for example, alkyl sulfate salts such as sodium lauryl sulfate, acyl taurate such as sodium lauroyl methyl taurate, anionic surfactants such as sodium dodecylbenzene sulfonate, sodium α-sulfofatty acid alkyl ester, and alkyl phosphate salts; acetate-betaine type amphoteric surfactants such as alkyl dimethyl aminoacetic acid betaine and fatty acid amamidopropyl dimethyl aminoacetic acid betaine; and imidazoline type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salt.

The amount of these arbitrary surfactants can be 0% to 10%, preferably 0.001% to 5%.

pH adjuster:

Examples include phosphoric acid, phthalic acid, acetic acid, fumaric acid, carbonic acid, their potassium, sodium, and ammonium salts, as well as ribonucleic acid and its salts.

preservative:

Sodium benzoate, methylparaben, ethylparaben, propylparaben, butylparaben, and other paraben esters, benzoic acid or its salts such as sodium benzoate, alkyl diaminoethyl glycine hydrochloride, and potassium sorbate.

Sweeteners:

Sodium saccharin, stevia, sucralose, reduced paraffinose, erythritol, etc.

spices:

Peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracress oil, and other natural essential oils; menthol, carvone, 1,8-cineole, anethole, cinnamaldehyde, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol, and other fragrance components found in the aforementioned natural essential oils. Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anisyl acetate, ethyl methyl phenyl glycidyl ester, benzaldehyde, vanillin, ethyl vanillin, furanone, maltol, ethyl maltol, γ/δ-decanoic acid lactone, γ/δ-undecanoic acid lactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate, or blended flavorings such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat grape, wine, cherry, pumpkin, coffee, brandy, and yogurt, made from a combination of several flavoring ingredients or natural essential oils.

Any active ingredient:

Substances other than components (A) and (B), such as plant extracts like thyme, scutellaria, clove, and witch hazel; fluorinated compounds like sodium fluoride, sodium monofluorophosphate, and tin fluoride; bactericides like isopropyl methylphenol, triclosan, sodium lauroyl sarcosinate, cetylpyridine chloride, benzyl chloride, and benzalkonium chloride; anti-inflammatory agents like tranexamic acid, ε-aminocaproic acid, β-glycyrrhetinic acid, and dipotassium glycyrrhetinate; and enzymes like dextranase, amylase, protease, mutanase, and lysozyme. Enzymes such as lytic enzymes and reductases, aluminum chlorohydroxyl-allantoin, allantoin, azulene, chlorinated lysozyme, ascorbic acid and other vitamin C or its derivatives, dihydrocholesterol, glycyrrhetinic acid, glycyrrhetinic acid, dehydrocholesterol, chlorophyll, sodium copper chlorophyll, copper gluconate, Calllopeptide, water-soluble inorganic phosphate compounds, polyethylene glycol, polyvinylpyrrolidone, dental calculus inhibitors, dental plaque inhibitors, potassium nitrate, aluminum lactate, polyoxyethylene lauryl ether.

Colorant:

Examples of highly safe, water-soluble pigments include Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105.

The liquid oral composition of the present invention can be filled into a general container. The container material can be PET (polyethylene terephthalate), glass, polypropylene, or polyethylene. From the perspective of inhibiting fragrance adsorption, PET and glass are preferred.

[Example]

The following examples, comparative examples, and formulation examples are provided to specifically illustrate the present invention, but the present invention is not limited to the following examples. It should be noted that, unless otherwise specified, % in the following examples refers to mass percentages.

[Example, Comparative Example]

Liquid oral compositions (mouthwashes) with the compositions shown in Tables 1 to 3 were prepared using conventional methods, and these compositions were used as samples and evaluated using the methods described below. The results are recorded in the tables.

The liquid oral composition of the embodiment has a pH (25°C) of 4 to 9, and also has the effects of preventing or inhibiting periodontal disease and preventing or inhibiting tartar deposition.

(1) Appearance stability after high temperature storage (no white turbidity or liquid separation after storage at 70℃ for 1 week)

The sample's liquid oral composition was filled into 50 mL vials and stored in a 70°C constant temperature bath (YAMATO Scientific Corporation, DVS402/602 type) for 1 week. The appearance stability (no turbidity, no liquid separation) was visually assessed according to the following evaluation criteria, evaluated on a four-level scale. ○ or above is considered合格 (qualified).

In addition, the liquid oral composition of the embodiments is clear immediately after preparation.

Evaluation Criteria

◎: No turbidity or liquid separation was observed.

○: A small amount of turbidity and/or liquid separation was observed, but it was at a level that was not problematic.

△: Slight turbidity and/or liquid separation were observed.

×: Significant turbidity and/or liquid separation were observed.

(2) The refreshing feeling after use

Five subjects held 10 mL of the sample (liquid oral composition) in their mouths and rinsed for 30 seconds. The feeling of freshness in the mouth after rinsing was evaluated on a four-level scale according to the following evaluation criteria.

Here, "freshness" refers to the refreshing feeling without any residual bitterness, odor, or greasiness on the tooth surface or in the mouth, and without any accompanying discomfort.

Evaluation Criteria

4 points: It feels quite refreshing.

3 points: Slightly refreshing.

2 points: Almost no refreshing feeling.

1 point: Not refreshing.

Calculate the average score from the 5 user reviews to determine the refreshing feeling after use. An average score of 3 or higher is preferred, 3.2 or higher is even better, 3.6 or higher is still preferred, and 4 points is the most desirable.

(3) No friction after use

Five subjects held 10 mL of the sample (liquid oral composition) in their mouths and rinsed for 30 seconds. The sensation of tooth surface friction after rinsing was evaluated on a four-level scale according to the following evaluation criteria.

Here, friction refers to the feeling of friction that occurs when teeth rub against each other, as the surface is not smooth.

Evaluation Criteria

4 points: No friction.

3 points: There is almost no friction.

2 points: There is a slight friction.

1 point: It has a lot of friction.

Calculate the average score of the 5 people's evaluation results to determine the friction feeling after use. The preferred average score is 3 points or above, the more preferred is 3.2 points or above, the further preferred is 3.6 points or above, and the most preferred is 4 points.

The details of the raw materials used are shown below.

(A) Sodium tripolyphosphate;

Sodium tripolyphosphate manufactured by Taihei Chemical Industry Co., Ltd.

(A) Sodium pyrophosphate;

Sodium pyrophosphate (anhydride), manufactured by Taihei Chemical Industry Co., Ltd.

(A) Sodium hexametaphosphate;

ICL Japan Co., Ltd., Sodium hexametaphosphate

(A) Hyperphosphoric acid;

Ultraporine manufactured by Taihei Chemical Industry Co., Ltd.

(B) Tocopherol acetate;

Manufactured by DSM Corporation, dl-α-tocopherol acetate

(B) Tocopheryl nicotinate;

Eisai Food & Chemical Co., Ltd., Niacin Tocopherol

(C) Polyoxyethylene hydrogenated castor oil 60;

Manufactured by Nikko Chemicals CO.,LTD., NIKKOL HCO-60

(C) Polyoxyethylene hydrogenated castor oil 100;

Manufactured by Nikko Chemicals CO.,LTD., NIKKOL HCO-100

(C) Polyoxyethylene hydrogenated castor oil 40;

Manufactured by Nikko Chemicals CO.,LTD., NIKKOL HCO-40

(C) Polyoxyethylene hexadecyl ether 15;

Manufactured by Nikko Chemicals CO.,LTD., NIKKOL BC-15

(C) Polyoxyethylene-polyoxypropylene copolymer (poloxamer407);

Manufactured by BASF Japan Co., Ltd., Kolliphor P 407

The composition of the spices used will be described later.

[Table 1]

[Table 2]

[Table 3]

The composition of the spices used is shown in Tables 4 to 12.

In addition, flavoring compositions B to P were used instead of flavoring composition A used in the above examples, and the same evaluation was performed. The evaluation results were all good.

[Table 4]

[Table 5]

Flavor 1 Quality Linalool 1 Menthofuran 1 Fennel Brain 1 Menthone 1 Menthyl acetate 1 total 5

[Table 6]

Flavor 2 Quality Orange oil 1 Orange refined oil (80% first fraction) 1 Lemon oil 1 Lemon refined oil (95% first fraction) 1 lime oil 1 grapefruit oil 1 Citrus oil 1 grapefruit oil 1 citral 1 decanal 1 total 10

[Table 7]

Flavor 3 Quality Fennel oil 1 Eucalyptus oil 1 Cinnamon oil 1 Clove oil 1 Thyme oil 1 Sage oil 1 Cardamom oil 1 Coriander oil 1 Rosemary oil 1 Laurel oil 1 Chamomile oil 1 Caraway oil 1 Basil oil 1 total 13

[Table 8]

[Table 9]

Flavor 5 Quality Menthyl lactate 1 3-L-Menthoxypropane-1,2-diol 1 Menthol glyceryl ether 1 Menthyl succinate 1 Isopyramine 1 N-substituted-p-menthane-formamide 1 Dried chamomile amide 1 Linalool Oxide 1 Vanillyl Butyl Ether 1 Capsicum extract 1 ginger extract 1 Pink pepper extract 1 Sichuan pepper extract 1 total 13

[Table 10]

Flavor 6 Quality maltol 1 Ethyl maltol 1 Vanillin 1 Ethyl vanillin 1 furanone 1 Ethylcyclopentenolone 1 3-Hydroxy-4,5-dimethylfuran-2-one 1 Methylcyclopentenolone 1 2-Methylbutyric acid 1 Acetic acid 1 propionic acid 1 total 11

[Table 11]

[Table 12]

solvent Quality ethanol 1 Propylene glycol 1 Glycerol fatty acid esters 1 Triacetylglycerol 1 total 4

The following is a formulation example. The raw materials used are the same as those described above, and the fragrance used is fragrance composition A.

The mouthwash in the formulation example has a pH (25°C) of 4–9 and also exhibits preventive or inhibitory effects against periodontal disease and tartar buildup. The evaluation was conducted in the same manner as in the examples, and the results were all satisfactory.

[Formulation Example 1] Mouthwash

The mass ratio of (A) to (B) is 1.4.

The mass ratio of (A) to (C) is 0.2.

[Formulation Example 2] Mouthwash

The mass ratio of (A) to (B) is: 6

The mass ratio of (A) to (C) is 0.6.

[Formulation Example 3] Mouthwash

The mass ratio of (A) to (B) is 5.

The mass ratio of (A) to (C) is 0.8.

[Formulation Example 4] Mouthwash

The mass ratio of (A) to (B) is 1.4.

The mass ratio of (A) to (C) is 0.2.

[Formulation Example 5] Mouthwash

The mass ratio of (A) to (B) is: 6

The mass ratio of (A) to (C) is 0.6.

[Formulation Example 6] Mouthwash

The mass ratio of (A) to (B) is 5.

The mass ratio of (A) to (C) is 0.8.

Claims (8)

1. A liquid oral composition, characterized in that it comprises: (A) Condensed phosphate or its salt. (B) Tocopherols, esters of tocopherols with organic acids, or their salts, and (C) Nonionic surfactants; The water content is 65% to 98% by mass. 2. The liquid oral composition according to claim 1, wherein (C) the nonionic surfactant is selected from one or more of polyoxyethylene fatty acid esters, polyoxyethylene alkyl ethers, and polyoxyethylene polyoxypropylene copolymers. 3. The liquid oral composition according to claim 1 or 2, wherein the liquid oral composition contains 0.01% to 2% by mass of component (A), 0.01% to 0.5% by mass of component (B), and 0.1% to 2% by mass of component (C). 4. The liquid oral composition according to any one of claims 1 to 3, wherein (A)/(B) is 0.1 to 200 by mass. 5. The liquid oral composition according to any one of claims 1 to 4, wherein (A)/(C) is 0.005 to 20 by mass. 6. The liquid oral composition according to any one of claims 1 to 5, wherein, further, the ethanol content is 0% to 20% by mass. 7. The liquid oral composition according to claim 6, wherein the ethanol content is 0% by mass to less than 1% by mass. 8. The liquid oral composition according to any one of claims 1 to 7, wherein the liquid oral composition is a mouthwash.