JP7625845B2 - Oral Composition - Google Patents

Description

The present invention relates to an oral composition containing dextranase that provides a high feeling of effectiveness in the oral cavity and is effective in preventing or inhibiting dental caries.

Dextranase has the effect of chemically removing plaque by breaking down the water-insoluble glucan that forms plaque, and also has the effect of inhibiting plaque formation, so it has been incorporated into oral compositions as an ingredient for preventing or inhibiting dental caries (Patent Documents 1 to 4; JP 2011-132139 A, JP 2002-187829 A, JP 2001-163747 A, JP 2015-20970 A).

However, the above-mentioned effects of dextranase are difficult to recognize visually, and it is difficult to feel the effectiveness of use, which can lead to failure to maintain users' motivation to use the product. In order to maximize the effects of dextranase, it is important to maintain users' motivation to use the product and encourage continued use. To achieve this, it is believed to be effective to increase motivation by making users feel that the product is working in the oral cavity with each use, for example by giving them a refreshing feeling of plaque removal.

JP 2011-132139 A JP 2002-187829 A JP 2001-163747 A JP 2015-20970 A

The present invention has been made in consideration of the above circumstances, and aims to provide an oral composition containing dextranase that provides a high feeling of effectiveness in the oral cavity and is effective in preventing or inhibiting dental caries.

The present inventors conducted extensive research to achieve the above object, and discovered that when a water-soluble tin salt and a cationic cellulose and/or an α-olefin sulfonate are combined in an oral composition containing dextranase, a unique and long-lasting, remarkable refreshing feeling is imparted to the oral cavity, and thus each time the composition is used in the oral cavity, not only is the composition effective in removing plaque and inhibiting plaque formation, but the user is also able to feel a high level of effectiveness due to the refreshing feeling, and the composition also has a good taste. That is, the present invention has been made based on the discovery that an oral composition containing (A) dextranase, (B) a water-soluble tin salt, and (C) one or more selected from cationic cellulose (C1) and α-olefin sulfonate (C2) imparts a high level of effectiveness in the oral cavity even with a single use, has a good taste when used, and is effective for preventing or inhibiting dental caries.

More specifically, in the present invention, by using the component (A) in combination with the component (B) in the oral cavity composition, a unique, long-lasting, and remarkable fresh feeling in the oral cavity (a unique sensation that the oral cavity is cleaned and continues to remain even after time has passed since use, which is sometimes abbreviated as "fresh feeling in the oral cavity") can be given, and a high sense of effectiveness can be imparted. The fresh feeling in the oral cavity is a unique sensation that is specifically obtained by using the component (A) in combination with the component (B), and is different from the refreshing feeling obtained by, for example, general oral fragrances such as menthol or ethanol. Furthermore, when the component (A) is used in combination with the component (B), the bad aftertaste derived from the component (B) stands out as an unpleasant taste, and a problem occurs in that the aftertaste becomes bad even when a general oral fragrance is added. However, by further adding the component (C), it is possible to suppress the unpleasant taste without causing an unpleasant aftertaste as described above, ensure good taste, and impart a high sense of effectiveness through the fresh feeling in the oral cavity.
As shown in the comparative examples described later, when the oral composition contained the component (A) but did not contain the components (B) and (C), the perceived effect (refreshing feeling in the oral cavity, and the refreshing feeling in the oral cavity immediately after use and 10 minutes after use) was low (Comparative Example 1), and when the oral composition contained the components (A) and (B) but did not contain the component (C), the lack of unpleasant taste after use was poor (Comparative Example 2). In contrast, the oral composition of the present invention containing the components (A), (B), and (C) shown in the examples provided a high perceived effect (refreshing feeling in the oral cavity) and a good lack of unpleasant taste after use.
Patent Documents 1 and 2 describe the improvement of the retention of dextranase in the oral cavity by a cationic polymer, Patent Document 3 describes the improvement of the effect of dextranase in inhibiting plaque reattachment by a cationic polymer, and Patent Document 4 describes the removal of oral biofilms by a combination of α-olefin sulfonic acid, dextranase, and sugar alcohol. In contrast, the present invention combines components (A), (B), and (C) to impart a unique, long-lasting, and remarkable feeling of freshness in the oral cavity, improving the perceived effect derived from component (A) and also improving the unpleasant taste.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) dextranase,
An oral composition comprising (B) a water-soluble tin salt and (C) one or more members selected from the group consisting of cationized cellulose (C1) and α-olefin sulfonate (C2).
[2]
The oral composition according to claim 1, wherein the water-soluble tin salt (B) is one or more selected from tin chloride and tin fluoride.
[3]
The oral composition according to [1] or [2], wherein the cationic cellulose (C1) is one or more selected from the group consisting of hydroxyethyl cellulose dimethyl diallyl ammonium chloride and O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride.
[4]
The oral composition according to any one of [1] to [3], wherein the α-olefin sulfonate (C2) is sodium α-olefin sulfonate having 14 to 16 carbon atoms.
[5]
The oral composition according to any one of [1] to [4], wherein when the component (C) contains cationic cellulose (C1), the mass ratio of (B) (the amount of tin ions in component (B))/(C1) is 0.3 to 30, and when the component (C2) contains α-olefin sulfonate (C2), the mass ratio of (B) (the amount of tin ions in component (B))/(C2) is 0.02 to 5.
[6]
The oral composition according to any one of [1] to [5], wherein, when the oral composition contains a cationic cellulose (C1) as the component (C), the content of the cationic cellulose (C1) is 0.02 to 0.2 mass%, and when the oral composition contains an α-olefin sulfonate (C2), the content of the cationic cellulose (C1) is 0.1 to 3 mass%.
[7]
The oral composition according to any one of [1] to [6], wherein the content of the (A) component is 0.0077 to 1.54 mass%, and the content of the (B) component is 0.02 to 1 mass% as tin ions.
[8]
The oral composition according to any one of [1] to [7], further comprising (D) one or more selected from N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate.
[9]
The oral composition according to claim 8, wherein the content of component (D) is 0.00001 to 0.1 mass%.
[10]
The oral composition according to any one of [1] to [9], which is a dentifrice, a mouthwash, or a mouth spray.

According to the present invention, it is possible to provide an oral composition that not only provides the actual effect of removing plaque and inhibiting plaque formation by component (A), but also gives a high feeling of effectiveness that makes the user feel that component (A) is working, and also has a good taste. The oral composition of the present invention effectively exhibits the functional effects of removing plaque and inhibiting plaque formation by component (A), and is effective for preventing or inhibiting dental caries.

The present invention will now be described in further detail.
The oral composition of the present invention contains (A) dextranase, (B) a water-soluble tin salt, and (C) one or more members selected from the group consisting of cationized cellulose (C1) and α-olefin sulfonate (C2).

(A) Dextranase has the effect of chemically removing plaque by breaking down the water-insoluble glucan that forms plaque, and has the effect of removing plaque and inhibiting plaque formation.
As dextranase, a product having a dextranase concentration of 10,000 to 14,000 units/g is usually used, and when a product having a dextranase concentration of 13,000 units/g is used, the amount of dextranase to be blended is preferably 0.0077 to 1.54% (mass%, the same applies below) of the entire composition, and more preferably 0.015 to 0.38%. The greater the amount of dextranase blended, the greater the effect of removing plaque and the effect of inhibiting plaque formation, but if the amount is too high, this may affect palatability, and a blending amount of 1.54% or less can sufficiently ensure good taste.
Furthermore, the content of the dextranase bulk substance in the composition is preferably 1 to 200 units/g, more preferably 2 to 20 units/g.
Here, one unit of dextranase is the amount of dextranase that produces free reducing sugars equivalent to 1 μmol of glucose per minute when dextran is used as a substrate for the reaction.

The water-soluble tin salt (B), when used in combination with component (A), provides a unique, long-lasting and remarkable feeling of freshness in the oral cavity, and this freshness has the effect of imparting a sense of efficacy.
(B) Examples of water-soluble tin salts include tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, tin phosphate, tin pyrophosphate, and tin metaphosphate. Of these, tin chloride and tin fluoride are preferred.
As the tin chloride, tin(II) chloride (stannous chloride) can be used, and it may be a hydrate such as tin(II) chloride dihydrate. As the tin fluoride, tin(II) fluoride (stannous fluoride) or tin(IV) fluoride (stannic fluoride) can be used. In particular, tin(II) fluoride (stannous fluoride) is preferred because it can also impart a caries prevention effect. These may be used alone or in combination of two or more.

The amount of water-soluble tin salt (B) is preferably 0.02-1% of the total composition in terms of tin ions, and more preferably 0.1-0.65%. If the tin ion content is 0.02% or more, a sufficiently refreshing feeling in the oral cavity is obtained, and if it is 1% or less, the unpleasant taste improving effect of component (C) is fully exerted and the stability of the appearance is ensured.

The component (C) is at least one selected from the group consisting of cationic cellulose (C1) and α-olefin sulfonate (C2), and it is also possible to use cationic cellulose (C1) and α-olefin sulfonate (C2). The component (C) has the effect of improving the unpleasant taste caused by the combined use of the components (A) and (B).

Cationized cellulose (C1) includes cellulose derivatives to which dimethyldiallylammonium, 2-hydroxy-3(trimethylammonio)propyl, etc., as cationic groups have been added. For example, hydroxyethylcellulose dimethyldiallylammonium chloride, O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride, etc. are included, and hydroxyethylcellulose dimethyldiallylammonium chloride is particularly preferred from the viewpoint of improving unpleasant taste. The nitrogen content is preferably 0.1 to 3%, more preferably 0.5 to 2.5%. These may be used alone or in combination of two or more.

Specifically, hydroxyethyl cellulose dimethyl diallyl ammonium chloride is obtained by graft polymerization of dimethyl diallyl ammonium salt to hydroxyethyl cellulose, and a 2% aqueous solution having a viscosity of 10 to 3,000 mPa·s (BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 21°C) can be used. For example, Celcoat L-200 (2% aqueous solution viscosity: 35 to 350 mPa·s, BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 21°C, measurement time 1 minute) manufactured by AkzoNobel Co., Ltd., Celcoat H-100 (2% aqueous solution viscosity: 500 to 2,750 mPa·s, BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 21°C, measurement time 1 minute) and the like can be mentioned. In addition, CELQUAT L-200 manufactured by Nouryon Japan Co., Ltd. can also be used.
In addition, the viscosity of O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride can be measured in a 1% or 2% aqueous solution, and one having a viscosity of 500 to 2,600 mPa·s in a 1% aqueous solution (BH Brookfield viscometer, rotor No. 2, 20 rpm, 25° C.) or one having a viscosity of 5 to 800 mPa·s in a 2% aqueous solution (BL viscometer, rotor No. 2, 30 rpm, 25° C.) can be used. Examples of such a surfactant include Leoguard KGP (viscosity of 2% aqueous solution: 5 to 50 mPa·s), Leoguard G (viscosity of 2% aqueous solution: 100 to 600 mPa·s), Leoguard GP (viscosity of 2% aqueous solution: 100 to 600 mPa·s), Leoguard LP (viscosity of 2% aqueous solution: 300 to 800 mPa·s), and Leoguard MGP (viscosity of 1% aqueous solution: 500 to 1,200 mPa·s), and Leoguard MLP (viscosity of 1% aqueous solution: 1,000 to 2,600 mPa·s), all of which are manufactured by Lion Corporation.

When cationic cellulose (C1) is used as component (C), its amount is preferably 0.02 to 0.2% of the total composition, and more preferably 0.05 to 0.1%. When the amount is 0.02% or more, the unpleasant taste improvement effect is sufficiently obtained and the unpleasant taste is suppressed. When the amount is 0.2% or less, a refreshing feeling in the mouth is sufficiently maintained, and the unpleasant taste (bitterness) of the cellulose itself is prevented from appearing, and the unpleasant taste improvement effect is sufficiently maintained.

As the α-olefin sulfonate (C2), an alkali metal salt such as a sodium salt or potassium salt of an α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and preferably an α-olefin sulfonate having 14 carbon atoms, particularly a sodium salt (generic name: sodium tetradecene sulfonate). These are commercially available products that can be used in oral preparations, and for example, the product name "K Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
When α-olefin sulfonate (C2) is blended as component (C), the blending amount is preferably 0.1 to 3% of the total composition, more preferably 0.4 to 2.5%, and even more preferably 0.4 to 2%. When the blending amount is 0.1% or more, the unpleasant taste improving effect is sufficiently obtained and the unpleasant taste is suppressed. When the blending amount is 3% or less, the refreshing feeling in the oral cavity is sufficiently maintained, and the unpleasant taste (bitterness) of the composition itself is prevented from appearing, and the unpleasant taste improving effect is sufficiently maintained.

In the present invention, the ratio of the blending amount of component (B) (blended amount as tin ions) to the blending amount of component (C) (component (C1) and/or (C2)) is preferably in the following range.
When cationic cellulose (C1) is blended as component (C), the mass ratio of (B)/(C1) is preferably 0.3 to 30, more preferably 1.5 to 10. When the mass ratio of (B)/(C1) is within the above range, the oral cavity is more refreshing and the unpleasant taste improving effect is also more excellent. When the mass ratio of (B)/(C1) is less than 0.3, the stickiness of component (C1) may adversely affect the oral cavity's refreshing feeling, resulting in a decrease in the oral cavity's refreshing feeling, whereas when it exceeds 30, the unpleasant taste improving effect may not be sufficiently obtained.
Furthermore, when α-olefin sulfonate (C2) is blended as component (C), the mass ratio of (B)/(C2) is preferably 0.02 to 5, more preferably 0.05 to 1.5. When the mass ratio of (B)/(C2) is within the above range, the fresh feeling in the oral cavity is more excellent, and the effect of improving unpleasant taste is also more excellent. When the mass ratio of (B)/(C2) is less than 0.02, the degreasing feeling of component (C2) may adversely affect the fresh feeling in the oral cavity, resulting in a decrease in the fresh feeling in the oral cavity.

The oral cavity composition of the present invention may further contain a cooling agent (D). By adding the component (D), the refreshing feeling in the oral cavity is further enhanced, and the effect is further improved.
Examples of component (D) include N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate. Of these, N-(4-cyanomethylphenyl)-p-menthanecarboxamide and N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide) are preferred. These may be used alone or in combination of two or more.

Specifically, the following commercially available products can be used.
N-Ethyl-p-menthane-3-carboxamide; Symrise, WS-3
Ethyl 3-(p-menthane-carboxamide) acetate; Toyotama Fragrance Co., Ltd., WS-5
N-(4-cyanomethylphenyl)-p-menthanecarboxamide: EVERCOOL 180, manufactured by Givaudan Japan Ltd.
N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide); EVERCOOL 190, manufactured by Givaudan Japan Ltd.
2-Isopropyl-N,2,3-trimethylbutyramide; WS-23, manufactured by Givaudan Japan Ltd.
Menthone glycerol acetal; MGA, manufactured by Symrise
Menthoxypropane-1,2-diol; manufactured by Takasago International Corporation, CA10
Menthyl lactate: manufactured by Symrise Menthyl succinate (monomenthyl succinate): manufactured by Vimanfis

When component (D) is included, the amount is preferably 0.00001 to 0.1% of the total composition, more preferably 0.00003 to 0.07%, and particularly preferably 0.00005 to 0.05%.

The oral cavity composition of the present invention can be prepared in the form of a paste, gel, liquid, etc., and used as a dentifrice such as toothpaste, gel dentifrice, liquid dentifrice, lubricant dentifrice, etc., a mouthwash, a spray, etc., for use. Among them, it is suitable as a dentifrice, a mouthwash, or a spray, particularly as a dentifrice. The preparation method can be a conventional method according to the form and dosage form.
In this case, other optional components may be added as necessary in addition to the above-mentioned components depending on the purpose, dosage form, etc. of the oral composition. Examples of optional components include surfactants, abrasives, thickeners, humectants, solvents, sweeteners, flavorings, preservatives, colorants, active ingredients, etc.
Specific examples of optional components are shown below. These optional components may be blended alone or in combination of two or more, and the blend amount of each optional component may be a normal amount within a range that does not impair the effects of the present invention.

Optional Surfactants:
The surfactant may be an anionic surfactant other than the α-olefin sulfonate (C2), a nonionic surfactant, or an amphoteric surfactant. Specific examples of the surfactant include those listed in (i) to (iii) below.
(i) Anionic Surfactants Examples of anionic surfactants include alkyl sulfates such as lauryl sulfate, acyl sarcosine salts, acyl methyl taurine salts, and acyl glutamate salts. As the above salts, alkali metal salts such as sodium salts and potassium salts are preferred.
(ii) Nonionic Surfactants Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, and fatty acid monoglyceride.
(iii) Amphoteric Surfactants Examples of amphoteric surfactants include fatty acid amidopropyl betaines such as coconut oil fatty acid amidopropyl betaine, and N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts.
The amount of any surfactant added is preferably 0.001 to 10%, and more preferably 0.1 to 5%, of the total composition.

Abrasives:
Examples of the abrasive include silica-based abrasives such as silicic anhydride, zeolite, calcium carbonate, aluminum hydroxide, and aluminum oxide.
The amount of the abrasive blended is usually from 2 to 50%, particularly from 10 to 40%, of the entire composition.

Optional thickeners:
The thickener may be an organic thickener other than the cationic cellulose (C1) or an inorganic thickener. Specific examples of the thickener include organic thickeners such as xanthan gum, sodium alginate, hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate, and carboxyvinyl polymer, and inorganic thickeners such as thickening silica.
The amount of any thickener blended is preferably 0.1 to 10%, particularly preferably 0.1 to 8%, of the total composition.

Wetting Agent:
Examples of the alcohol include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol (PEG).
The amount of the wetting agent is usually 2 to 50% of the total composition.

solvent:
Examples of the alcohol include purified water and lower alcohols having 1 to 3 carbon atoms, such as ethanol. When ethanol is added, it may be 25% or less of the total composition, or it may not be added at all.
Sweeteners:
Examples include saccharin, sodium saccharin, and sucralose.

Fragrance:
Examples of such oils include menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil. These oils may be used alone or in combination of two or more.
The amount of the fragrance blended is usually 0.01 to 2% of the total composition.

Preservatives:
Examples include paraoxybenzoic acid esters and sodium benzoate.
Colorants:
Examples include Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium oxide, and titanium mica.

Optional Active Ingredients:
Examples of suitable antibacterial agents include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, sodium pyrrolidone carboxylate, tranexamic acid, epsilon-aminocaproic acid, allantoin, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, isopropylmethylphenol, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, pyrophosphate, polyphosphate, metaphosphate, zeolite, aluminum lactate, potassium nitrate, calcium glycerophosphate, and Phellodendron Bark extract.

The present invention will be specifically explained below with examples, comparative examples, and formulation examples, but the present invention is not limited to the following examples. In the following examples, % indicates mass % unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 4 were prepared by conventional methods and evaluated by the following methods. The results are also shown in the tables.
In addition, all of the dentifrice compositions of the examples containing (A) dextranase had the plaque removing effect and plaque formation inhibiting effect derived from the component (A).

(1) Evaluation method for effect (refreshing feeling in the oral cavity) A sensory evaluation was carried out using 10 expert panelists as subjects. The dentifrice composition filled in a laminated tube was pressed out 1 cm onto a toothbrush, and the subject brushed their teeth for 3 minutes in the usual way, rinsed their oral cavity with water, and evaluated the refreshing feeling in the oral cavity immediately after use and 10 minutes after use according to the following evaluation criteria.
Here, the fresh feeling in the oral cavity refers to a distinctive sensation in which the feeling that the oral cavity has been cleaned is sustained even after the passage of time from immediately after use, and is felt prominently.
Evaluation criteria: 5 points: Very strong refreshing sensation immediately after use and after 10 minutes 4 points: Strong refreshing sensation immediately after use and after 10 minutes 3 points: Refreshing sensation immediately after use and after 10 minutes 2 points: Slight refreshing sensation immediately after use and after 10 minutes 1 point: No refreshing sensation immediately after use and after 10 minutes The average of the evaluation results of 10 people was calculated and evaluated according to the following evaluation criteria. Dentifrice compositions that secured the evaluations of ◯, ◎, and ☆ were judged to have an excellent refreshing sensation in the oral cavity and a high realization of the effect of inhibiting plaque formation by dextranase (A).
Evaluation criteria: ☆: Average score of 4.5 points or more ◎: Average score of 4.0 points or more and less than 4.5 points ○: Average score of 3.0 points or more and less than 4.0 points △: Average score of 2.0 points or more and less than 3.0 points ×: Average score of 1.0 points or more and less than 2.0 points

(2) Evaluation method for non-offensive taste after use A sensory evaluation was carried out using 10 expert panelists as subjects. The toothpaste composition filled in a laminated tube was pressed out 1 cm onto a toothbrush, and the subjects brushed their teeth for 3 minutes in the same way as usual. The non-offensive taste (non-offensive taste) remaining in the mouth 10 minutes after use was evaluated according to the following criteria.
Evaluation criteria: 4 points: no unpleasant taste at all 3 points: slight unpleasant taste 2 points: unpleasant taste 1 point: very strong unpleasant taste The average of the evaluation results of the 10 people was calculated and evaluated according to the following evaluation criteria. Those that secured the evaluations of ◎ and ○ were judged to be dentifrice compositions that left no unpleasant taste after use and had a good taste.
Evaluation criteria: ◎: average score of 4 points or more ○: average score of 3.0 points or more and less than 4 points △: average score of 2.0 points or more and less than 3.0 points ×: average score of 1.0 points or more and less than 2.0 points

Details of the raw materials used are shown below.
(A) Dextranase (13,000 units/g); manufactured by Daiichi Sankyo Propharma Co., Ltd. (B) Tin chloride; manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., tin(II) chloride dihydrate (B) Tin fluoride; manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., tin(II) fluoride
(C) Cationic cellulose; CELQUAT L-200, manufactured by Nouryon Japan Co., Ltd.
(C) Sodium tetradecene sulfonate; K-Liporan PJ-400CJ, manufactured by Lion Specialty Chemicals Co., Ltd.
(D) N-(4-cyanomethylphenyl)-p-menthanecarboxamide;
Givaudan Japan Co., Ltd., Evercool 180
(D) N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide);
Givaudan Japan Co., Ltd., Evercool 190
The composition of fragrance A will be described in detail below.

注；（Ｂ）／（Ｃ１）は、（（Ｂ）成分のスズイオンとしての配合量）／（（Ｃ１）成分の配合量）の質量比であり、（Ｂ）／（Ｃ２）は、（（Ｂ）成分のスズイオンとしての配合量）／（（Ｃ２）成分の配合量）の質量比である（以下同様）。

Note: (B)/(C1) is the mass ratio of (the amount of component (B) blended as tin ions)/(the amount of component (C1) blended), and (B)/(C2) is the mass ratio of (the amount of component (B) blended as tin ions)/(the amount of component (C2) blended) (the same applies below).

Composition of fragrance A:
Peppermint oil 50
Peppermint refined oil (20% pre-distillate cut) 5
Peppermint refined oil (15% front and rear part cut) 5
Spearmint oil 1
Spearmint refined oil (20% pre-distillate cut) 1
Japanese peppermint oil 1
Japanese peppermint refined oil (30% of the front part cut) 1
Menthol 10
Carbone 1
1,8-cineole 1
Anethole 5
Cinnamic aldehyde 1
Eugenol 1
Methyl Salicylate 1
Flavor 1 (Table 5) 1
Flavor 2 (Table 6) 1
Flavor 3 (Table 7) 1
Flavor 4 (Table 8) 1
Flavor 5 (Table 9) 1
Flavor 6 (Table 10) 1
Flavor 7 (Table 11) 1
Solvent (Table 12) Remainder
Total 100%

An example prescription is shown below.

[Formulation Example 1] Dentifrice (A) Dextranase (13,000 units/g) 0.15
(B) Tin fluoride (stannous fluoride) 0.4
(C) Sodium tetradecene sulfonate 1
(C) Cationic cellulose 0.05
Sodium monofluorophosphate 0.38
Tranexamic acid 0.05
Tocopherol acetate 0.1
Isopropyl methylphenol 0.05
Aluminum lactate 2
Potassium nitrate 5
Sodium citrate 0.5
Sodium hexametaphosphate 1
Abrasive Silica 18
Sodium methyl lauroyl taurate 0.6
Polyoxyethylene (20) hydrogenated castor oil 1
Sodium lauroyl glutamate 0.1
70% sorbitol solution 30
Propylene glycol 3
Xanthan gum 0.3
Sodium carboxymethylcellulose 1.0
Polyethylene glycol 4000 0.5
Copper gluconate 0.1
Viscosifying Silica 1
Titanium oxide 0.4
Sodium saccharin 0.08
Sodium hydroxide (adjust pH to 5.7)
Fragrance A 1.3
Purified water Balance
Total 100%

[Formulation Example 2] Dentifrice (A) Dextranase (13,000 units/g) 0.15
(B) Tin fluoride (stannous fluoride) 0.4
(C) Sodium tetradecene sulfonate 1
(C) Cationic cellulose 0.05
Sodium fluoride 0.11
Epsilon Aminocaproic Acid 0.05
Tocopherol acetate 0.1
Isopropyl methylphenol 0.05
Aluminum lactate 2
Potassium nitrate 5
Sodium citrate 0.5
Sodium hexametaphosphate 1
Abrasive Silica 15
Sodium lauryl sulfate 0.6
Sodium lauroyl sarcosine 0.2
Coconut oil fatty acid amidopropyl betaine solution (30%) 0.9
85% glycerin solution 28
Propylene glycol 3
Carrageenan 0.3
Xanthan gum 0.3
Sodium carboxymethylcellulose 0.7
Sodium pyrrolidone carboxylate 3.0
Viscosifying Silica 2
Titanium oxide 0.3
Sodium saccharin 0.1
Sodium hydroxide (adjust pH to 6.1)
Fragrance A 1.3
Purified water Balance
Total 100%

[Formulation Example 3] Mouthwash (A) Dextranase (13,000 units/g) 0.15
(B) Tin fluoride (stannous fluoride) 0.1
(C) Sodium tetradecene sulfonate 0.4
(C) Cationic cellulose 0.05
Tranexamic acid 0.05
Tocopherol acetate 0.1
Isopropyl methylphenol 0.05
70% sorbitol solution 5
85% glycerin solution 1
Xylitol 1
Sodium lauroyl sarcosine 0.1
Propylene glycol alginate 0.1
Polyoxyethylene (60) hydrogenated castor oil 0.3
Polyoxyethylene (15) cetyl ether 0.1
Propylene glycol 3
Ethanol 10
Citric acid 0.05
Sodium citrate 0.3
Sodium hydroxide (adjust pH to 6.0)
Fragrance A 0.1
Purified water Balance
Total 100%

Formulation Example 4: Mouth spray (A) Dextranase (13,000 units/g) 0.15
(B) Tin fluoride (stannous fluoride) 0.1
(C) Sodium tetradecene sulfonate 0.4
(C) Cationic cellulose 0.05
Tranexamic acid 0.05
Tocopherol acetate 0.1
Isopropyl methylphenol 0.05
Sodium hexametaphosphate 0.01
85% glycerin solution 30
70% sorbitol solution 4
Polyethylene glycol 400 2
Xylitol 1
Cetylpyridinium chloride 0.05
Ethanol 25
Polyoxyethylene (60) hydrogenated castor oil 2
Copper gluconate 0.01
Citric acid 0.05
Sodium citrate 0.3
Sodium hydroxide (adjust pH to 6.0)
Fragrance A 0.5
Purified water Balance
Total 100%

Claims (10)

(A) dextranase,
An oral composition comprising (B) a water-soluble tin salt and (C) one or more members selected from the group consisting of cationized cellulose (C1) and α-olefin sulfonate (C2). The oral composition according to claim 1, wherein (B) the water-soluble tin salt is at least one selected from tin chloride and tin fluoride. The oral composition according to claim 1 or 2, wherein the cationic cellulose (C1) is one or more selected from hydroxyethyl cellulose dimethyl diallyl ammonium chloride and O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride. The oral composition according to any one of claims 1 to 3, wherein the α-olefin sulfonate (C2) is sodium α-olefin sulfonate having 14 to 16 carbon atoms. The oral composition according to any one of claims 1 to 4, in which when the component (C) contains cationized cellulose (C1), the mass ratio of (B) (the amount of tin ions in the component (B))/(C1) is 0.3 to 30, and when the component (C2) contains α-olefin sulfonate (C2), the mass ratio of (B) (the amount of tin ions in the component (B))/(C2) is 0.02 to 5. The oral composition according to any one of claims 1 to 5, in which, when the component (C) contains cationized cellulose (C1), its content is 0.02 to 0.2 mass%, and when the component (C) contains α-olefin sulfonate (C2), its content is 0.1 to 3 mass%. The oral composition according to any one of claims 1 to 6, wherein the content of component (A) is 0.0077 to 1.54 mass%, and the content of component (B) is 0.02 to 1 mass% as tin ions. The oral composition according to any one of claims 1 to 7 further contains (D) one or more selected from N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate. The oral composition according to claim 8, wherein the content of component (D) is 0.00001 to 0.1% by mass. The oral composition according to any one of claims 1 to 9, which is a dentifrice, a mouthwash or a mouth spray.