JP2512459B2 - Hair growth and hair growth promotion charges - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel hair growth / hair growth promoter, which is safe without skin irritation.

Conventionally, an aloe extract has been applied as a hair growth and hair growth promoter, but it has not shown a remarkable effect because it is mixed in a crude extract simply extracted from aloe. As a result of various experimental studies, the inventor of the present invention obtained aloenin from aloe as a compound having such a hair growth and hair growth promoting action, and arrived at the present invention.

The present invention relates to a hair-growth / hair-growth-promoting agent containing 0.5 to 10% by weight of aloenin.

Here, the amount of aloenin contained as an active ingredient of the hair growth and hair growth-promoting agent according to the present invention is 0.5 to 10.0% by weight, preferably 0.5 to 2.0% by weight. That is, if the amount is less than 0.5% by weight, the effect of promoting hair growth and hair growth cannot be sufficiently exhibited. On the other hand, if the amount exceeds 10% by weight, not only the effect is not enhanced, but also irritation becomes strong and there is a safety problem. Cause

The hair-growing / hair-growth promoting agent containing aloenine applied to the present invention is conventionally applied as a hair-growing / hair-growth promoting agent in the method for measuring the density of hair growth of mice shown in Table 1 below, that is, Test Method I. Compared with the existing aloe extract, a remarkable effect is shown. This is aloenin,
As a result of stimulating the hair matrix of the hair root part and stimulating the growth of the hair matrix, the hair regeneration was promoted.

Brief Description of Test Method I Using 9-week-old C3H mice, one group has 10 mice,
7 groups were prepared, and 0.02 g of the specimens were applied to the area where the hair was removed to a width of 2.0 cm × 2.0 cm on the back, and 0.02 g of each sample was applied on the next day. Then, on the 9th, 11th, and 14th days, The density of hair growth is captured as a degree of increase in blackness using a color difference meter, and is compared with an aloe extract that has been applied to conventional hair growth and hair growth promoters and a 99.5% ethanol solution as a control.

The aloe extract used as a comparative substance in Table 1 was obtained by digesting 100 g of aloe with 1 liter of methanol three times each for 2 hours, and combining these extracts (total 3
(L) After suction filtration, it was concentrated to dryness under reduced pressure to prepare.

In each sample applied in Table-1, A is 99.5% containing 2% by weight of the aloe extract prepared by the above method.
An ethanol solution, B is a 99.5% ethanol solution containing 10% by weight of the aloe extract prepared by the above method, C is a 99.5% ethanol solution containing 0.1% by weight of aloenin, and D is 0.5% by weight of aloenin. 99.5% ethanol solution, E is 99.5% containing 2% by weight of aloenin.
% Ethanol solution, F is a 99.5% ethanol solution containing 5% by weight of aloenine, and G is 9 as a control.
It is 9.5% ethanol.

As shown in the results of Table 1, Samples D, E, and F containing 0.5% by weight or more of aloenin were Samples A and B containing the extract of Aloe, and Sample C and 0.1% by weight of aloenin. It was demonstrated that the L value was extremely small compared to a certain G, and that it had a significant effect on promoting hair growth and hair growth.

 Next, examples of clinical trials will be shown.

A 99.5% ethanol solution containing 2% by weight of aloenin was used as a sample.

Example 1 A woman with an alopecia of 3 cm in diameter on the back of her head (age 44
Alopecia areata patients aged once a day (3-5 times a time)
g) When applied, short vellus hair was produced at the hair loss site after about 3 months, and after 6 months, hair became bristles and the hair loss site disappeared.

Example 2: A male (aged 36 years old) alopecia areata patient with a 2.5 cm hair loss site on each of the crown and temporal region was applied with the sample once a day (3 to 5 g each time), and the result was 3 months. Downy hairs were produced at the hair loss site of the occipital parietal region and the temporal region, and the hair loss site disappeared.

In both Examples 1 and 2, no skin damage due to continuous application for 6 months was observed.

 Next, prescription examples are shown. The mixing ratio is parts by weight.

Example 1 Hair Tonic Aloenin 2.0 Menthol 0.2 99.5% Ethanol 60.0 Purified water 37.8 Method Aloenin and menthol were dissolved in 99.5% ethanol and then purified water was added.

Example 2 Hair cream Aloenin 1.0 Vaseline 7.0 Beeswax 8.0 Cristol 37.0 Emulsifier 5.5 Purified water 41.5 Method Aloenin, Vaseline, Beeswax, Cristol and emulsifier are mixed and dissolved at 80 ° C., then purified water at 80 ° C. Is gradually added to the oil phase to form a cream.

Example 3 Ointment Aloenin 1.5 Isopropyl myristate 10.0 Cetanol 2.0 Paraffin wax 6.0 Microcristanlin wax 10.0 Emulsifier 11.0 Purified water 59.5 Manufacturing method Aloenin, isopropylmyristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier are heated and melted, Separately, add purified water heated to 70 ° C or higher and stir, and cool to 40 ° C with stirring.

Claims (1)

(57) [Claims] 1. An aloenin represented by the following structural formula (1):
Hair growth and hair growth promoting agent, characterized by being mixed in an amount of 0.5 to 10% by weight.