JP2520437B2 - Cleaning agent for soft contact lenses and cleaning method - Google Patents

Description

TECHNICAL FIELD The present invention relates to a cleaning agent for soft contact lenses and a cleaning method. More specifically, the present invention relates to a cleaning agent and a cleaning method that are effective for removing stains such as proteins attached to water-containing soft contact lenses.

[Prior Art] As a cleaning method using particles as an abrasive material for a cleaning agent for contact lenses, inorganic substances such as silica and alumina (see JP-A-56-6512) and cellulose (JP-A-60).
No. 159721), polyethylene and polysiloxane (see JP-A-57-195922), water-insoluble particles are suspended in an aqueous solvent to form a contact lens cleaning agent. ing. However, in this method, water-insoluble particles remain on the surface of the contact lens unless the contact lens after washing is sufficiently rinsed, so care must be taken in rinsing after washing.

In particular, in the case of soft contact lenses, they tend to remain on the surface, which is problematic in terms of eye safety.

JP-A-57-195922 describes that the detergent can also be used for soft contact lenses, but its cleaning effect is slightly superior to that of conventional liquid detergents, and is still insufficient. There is also a problem with sex.

In addition, water-soluble substances such as sodium chloride and sodium hydrogencarbonate are crushed to 50-200 mesh (mesh, the numerical value is the same as the JIS standard sieve screen number, the same applies below) and suspended in an aqueous solvent at the time of use. A method of using a cleaning agent for contact lenses (see US Pat. No. 4,588,444) is known. In this method, since the water-soluble particles are used by suspending them in an aqueous catalyst, the particles are gradually dissolved in the solvent even if the preparation time is short, so that the particles are suspended in the solvent immediately before use. There is a need. Even if the particles are suspended in a solvent immediately before use, in this method, the cleaning effect is not constant because the particles start to dissolve immediately after preparation and the polishing effect is reduced. Further, since the mixing of the water-soluble particles and the aqueous solvent must be performed immediately before use, each user must mix the water-soluble particles and the aqueous solvent, and the mixing ratio is There are drawbacks, such as large differences in cleaning effect among individuals, since they vary from individual to individual.

Further, JP-A-62-242916 describes a detergent for contact lenses in which a water-soluble fine particle compound of 750 to 1 μm is mixed with a non-aqueous water-miscible organic solvent.
When this cleaning agent is applied to a water-containing soft contact lens, it has a defect that the lens is dehydrated and cured by an organic solvent, and it cannot be worn on the eye unless the lens is immersed in physiological saline or the like for a long time after cleaning. Therefore, it is difficult to put it into practical use as a cleaning agent for water-containing soft contact lenses. In addition, the diameter of the water-soluble fine particles used is approximately 149 μm.
If it is larger, there is a problem that the soft contact lens will be scratched when it is washed.

[Problems to be Solved by the Invention] In view of such circumstances, an object of the present invention is to provide a cleaning agent and a cleaning agent for soft contact lenses, which are easy to clean and rinse, do not scratch soft contact lenses, and do not cure the lenses. Is to provide a method.

[Means for Solving Problems] In order to achieve the above-mentioned object, it is particularly important to prevent hardening of the water-containing soft contact lens during cleaning. As a result of various investigations, the present inventors have found that there are two causes for lens hardening during cleaning. That is, during washing, the fine particles of the water-soluble compound increase in osmotic pressure due to dissolution in water. It is an action. For, it can be solved by using a compound having a salt value of 0.65 or less, but it can not be completely solved as long as a water-miscible non-aqueous solvent is used, but as a result of further studies by the present inventors, Prepare a paste-like detergent with the minimum amount of water-miscible pasting agent necessary to keep the detergent in paste form and keep the water-soluble compound particles in paste form, and then add a puff consisting of a porous sponge sheet. Water, place the cleaning agent paste on the water-containing puff, and spread it evenly to dilute the non-water pasting agent with the water content of the water-containing puff, and thus scrub the water-containing soft contact lens on the puff. Even if we found that problems such as lens hardening did not occur,
The present invention has been completed.

That is, the present invention, a water-miscible non-aqueous pasting agent of 50 to 20 wt% with respect to the total amount of the detergent, 50 to 80 wt% with respect to the total amount of the detergent, the salt value is 0.65 or less, The particle size is such that the particles are sieve number 100 (sieve nominal size 149 μm)
Cleaning agent for soft contact lenses containing 100% of JIS standard mesh sieve and 50% by weight or more of water-soluble compound fine particles of JIS standard mesh sieve of sieve number 635 (sieve nominal size 20 μm) And 50 to 20% by weight of the total amount of the detergent, a water-miscible non-aqueous pasting agent, and 50 to 80% by weight of the total amount of the detergent, and a salt value of 0.65.
The particle size is 100% of the JIS standard mesh sieve of sieve number 100 (sieve nominal size 149 μm) and 50% by weight or more of JIS standard mesh sieve of sieve number 635 (sieve nominal size 20 μm). A soft contact lens cleaning agent containing fine particles of a water-soluble compound in a range that does not pass is placed on a water-containing puff, and evenly spread, and then the soft contact lens is brought into contact with the surface of the puff to be washed by rubbing. The present invention relates to a method for cleaning a soft contact lens, which is characterized in that

[Operations and Examples] The particle size of the fine particles of the water-soluble compound used in the present invention is the JIS of the particles having a sieve number of 100 (sieve nominal size 149 μm).
Standard mesh sieve (hereinafter "sieve number XXX" is referred to as "XX mesh", "sieve nominal dimension XXμm" is simply referred to as "XXμm", and "JIS standard mesh sieve" is simply referred to as It should be in a range that does not pass through 635 mesh (more than 50% by weight of a 20 μm sieve) through 100% of the sieve.) If the particles do not pass through the 100 mesh sieve, the lens will be scratched. Easier to stick to, on the contrary 63
If there are too many small particles that retain less than 50% on a 5-mesh sieve, the cleaning effect will be poor because the small particles will quickly dissolve in water. The susceptibility to scratches varies depending on the type of lens and the cleaning method, and some differences are observed depending on the compound, but in any case, it is not preferable that the range is out of the above range. Particularly preferred fine particles of water-soluble compound are 1 through 200 mesh (74 μm) sieve.
It has a particle diameter in the range of not passing 50% by weight or more and 50% by weight of a 635 mesh (20 μm) sieve, and most preferably 100% of a 250 mesh (63 μm) sieve and 635 mesh. 50 (20 μm) sieve
It has a particle diameter within a range in which it does not pass by weight or more.

The water-soluble compound needs to have a salt value of 0.65 or less. Note that the salt value is a fixed amount (1
The amount of sodium chloride showing the same osmotic pressure as g) is expressed in grams.

When washing water-containing soft contact lenses, some of the fine particles of the water-soluble compound dissolve in water during washing.At this time, if the salt value is greater than 0.65, the osmotic pressure of the liquid increases and There is a problem in that the lens is dehydrated and the lens is hardened and the lens size is changed. Particularly, the salt value is preferably 0.4 or less. This dehydration phenomenon is particularly remarkable in soft contact lenses having a water content of 45% or less. When the dehydration phenomenon appears, it is difficult to wear the soft contact lens immediately after cleaning, and it becomes less practical as a daily cleaning agent.

Further, the water-soluble compound used in the cleaning agent of the present invention must be highly eye-safe when dissolved.

Examples of water-soluble compounds having the above properties include:
Ascorbic acid, sodium ascorbate, fructose, sodium citrate, calcium gluconate, glutamic acid, sucrose, glucose, lactose, sodium thiosulfate, calcium lactate, urea, boric acid, borax, magnesium sulfate, sodium chloride, sorbitol, inositol Organic or inorganic low molecular weight water-soluble compounds such as; methylcellulose, carboxymethylcellulose, alginic acid,
Polymeric water-soluble compounds such as hydroxypropylmethylcellulose, polyvinyl alcohol, and chitosan; water-soluble enzymes such as protease, cellulase, amylase, lipase, etc., and one or more selected from these To use. Among the above water-soluble compounds, low-molecular water-soluble compounds and water-soluble enzymes have a high cleaning effect and are preferably used. In particular, an organic low molecular weight compound is preferable because it has a low salt value, and has an appropriate level of easiness during washing and is excellent in detergency. Further, the water-soluble compound is preferably a mixture of an organic low molecular weight compound and an inorganic low molecular weight compound in order to enhance the cleaning effect.

Among the above water-soluble enzymes, protease is preferable. Examples of proteases include, for example, Bacillus subtilis, Bacillus licheniformis, Bacillus pumillis, Aspergillus
Orize (Aspergillus orysae), Streptomyces
Enzymes derived from microorganisms such as Glyceus (Streptomyces griseus), papain, bromelain and the like. Although it is possible to use only a water-soluble enzyme as the water-soluble compound, a part of the fine particles of the water-soluble compound may be fine particles of the enzyme, and the fine particles of the enzyme are 70% by weight of the whole fine particles of the water-soluble compound. % Or less is preferable. If it exceeds 70% by weight, the lens is too slippery due to the nature of the enzyme, so it is easy to clean. Also, when cleaning with a puff, it is desirable that the lens does not slip easily, so 40% by weight
It is preferable to set the following.

The fine particles of the water-soluble compound used in the detergent of the present invention are mixed with a water-miscible non-aqueous pasting agent to be used as a paste-like preparation, but the water-miscible non-aqueous compound is used to enhance the lipid removal effect. Part or all of the pasting agent may be a liquid surfactant, and the cleaning agent may contain a water-miscible non-aqueous paste agent and a miscible surfactant.

As the water-miscible non-aqueous pasting agent, it is preferable to use a water-soluble organic solvent which is highly safe to the eyes and has little influence on the material of the contact lens. Examples of the water-soluble organic solvent include, for example, polyethylene glycol, glycerin, ethylene glycol, propylene glycol, water-soluble silicone and the like, and one or more of these are selected and used. When cleaning a lens using a methacrylate-based polymer, glycerin, polyethylene glycol, water-soluble silicone and the like are preferable, and glycerin is most preferable, because they have less interaction with the lens.

A liquid or a surfactant that is miscible with the non-aqueous pasting agent may be added to the detergent of the present invention, but in some cases, the non-aqueous pasting agent may be substituted with a non-aqueous liquid surfactant. May be. As the surfactant, any one can be used as long as it is highly safe to the eyes, effective for removing lipid stains and the like, and can be mixed with the liquid or the above non-aqueous pasting agent. Examples thereof include polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monostearate, polyethylene and polypropylene block copolymer (Pronone 208 (Nippon Yushi Co., Ltd.),
Pronon 408 (Nippon Yushi Co., Ltd.), Tetronic T
R701 (manufactured by Asahi Denka Kogyo Co., Ltd.), Tetronic TR709 (manufactured by Asahi Denka Kogyo Co., Ltd.), polyoxyethylene secondary alkyl ether, etc., as well as anionic surfactants, amphoteric surfactants, etc. Can be used.

In addition to the above components, a water-soluble sequestering agent may be added to the detergent of the present invention in order to prevent an inorganic substance from sticking to the lens. Examples of the sequestering agent include EDTA, sodium salt of EDTA, potassium salt of EDTA, gluconic acid, citric acid, sodium salt of citric acid, and the like, and the sequestering agent is used as a part or all of the water-soluble compound. May be. The sequestering agent which does not meet the conditions of the water-soluble compound is used in an amount of 2% by weight or less based on the total amount of the detergent.

Further, since the formulation of the detergent of the present invention contains no or only a small amount of water, there is almost no growth of microorganisms during storage, but when washing with a puff, growth of microorganisms in the puff after use is prevented. To suppress it, a preservative such as sorbic acid, sorbate, sodium benzoate, or paraoxybenzoate may be added to the detergent. This preservative can also be added as a part of the fine particles of the water-soluble compound which is the main ingredient for washing, but it is usually contained in the fine particles of the water-soluble compound in an amount of 10% by weight or less.

When cleaning a water-containing soft contact lens, if the water-miscible non-water pasting agent is present in a large amount in the cleaning agent, the lens is dehydrated and hardened. It is necessary to minimize the amount.
That is, the minimum necessary pasting agent is used to keep the fine particles of the water-soluble compound in a paste form. For this reason,
The fine particles of the water-soluble compound are 50 to 80% by weight based on the total amount of the cleaning agent of the present invention, and the water-miscible non-water pasting agent is 50 to 20% by weight based on the total amount of the cleaning agent of the present invention. Must be Preferably, the fine particles of the water-soluble compound are 60-
75% by weight, 25-40% by weight of water-miscible non-water pasting agent
More preferably, the fine particles of the water-soluble compound are 65 to
72% by weight, 28-35% by weight of water-miscible non-water pasting agent
Is. When the fine particles of the water-soluble compound are more than 80% by weight, or when the water-miscible non-aqueous pasting agent is less than 20% by weight, it is difficult to form a good paste, When the amount of fine particles is less than 50% by weight or the amount of water-miscible non-water pasting agent is more than 50% by weight, the water-containing soft contact lens hardens during cleaning, and at the same time, soft contact such as lens size and base curve. Lens specifications change.

When water is added to the non-aqueous pasting agent, in order to maintain the particle shape of the fine particles of the water-soluble compound used,
The amount of water added varies depending on the type of pasting agent, but is usually 50% by weight or less, preferably 30% by weight or less, particularly preferably 20% by weight or less, based on the pasting agent.

In order to wash soft contact lenses with the detergent of the present invention, it is usually preferable to use a puff. That is, when the cleaning agent of the present invention contains a surfactant,
A sufficient amount of the detergent of the present invention for cleaning is placed on the puffed water, and then the detergent paste is evenly spread on the puff with a fingertip or the like to mix with the water contained in the puff. By this operation, the cleaning agent is automatically mixed with water suitable for cleaning immediately before use, and the non-water pasting agent, which has an adverse effect on the lens, has a small content in the cleaning agent and is diluted with water. Therefore, the influence on the lens is small, and the cleaning property is extremely good. Then, a soft contact lens is brought into contact with the surface of the puff to rub and wash the front and back of the soft contact lens. On the other hand, when the detergent of the present invention does not contain a surfactant, a water-containing puff is squeezed tightly, and a liquid detergent for soft contact lenses containing a commercially available surfactant is added to the detergent (for example, manufactured by Menicon Co., Ltd.). ,Product name:
It is preferable to pour Meniclean or Seed Co., Ltd., trade name: Sofpearl, etc., foam with a fingertip, and then wash with the detergent of the present invention as in the case where the detergent contains a surfactant. .

The puff cleaning method is not limited to the method with your fingertips,
A soft contact lens can be sandwiched between two water-containing puffs, and can be cleaned using various cleaning devices in which both surfaces of the lens are in contact with the cleaning agent of the present invention. Of course, the cleaning method using the cleaning agent of the present invention is not limited to the method of using a puff, and, for example, the cleaning agent of the present invention is placed on the palm of a hand on which water has been sufficiently placed, and the lens is spread evenly and well. A method of scrubbing is also possible.

In the present invention, the puff is used for cleaning soft contact lenses and includes silicone, polyurethane,
It is a porous sheet composed of a sponge of polyvinyl alcohol and other polymers. This has high water retention.

Next, Table 1 shows examples of water-soluble compounds used in the present invention and their salt values.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the examples.

Example 1 Japanese Pharmacopoeia lactose (salt value 0.2 or less) was passed through a 250-mesh sieve, and the portions that passed through the sieve were collected. This was further passed through a 635 mesh sieve, and the remaining portion on the sieve was collected. Next, 10 g of these particles were taken, and glycerin 3.5
g and 1 g of polyoxyethylene (20) sorbitan monolaurate were mixed and thoroughly kneaded to obtain a hard paste-like detergent.

The cleaning effect of the obtained cleaning agent was tested and evaluated by the method shown below.

A water-containing soft contact lens (manufactured by Menicon Co., Ltd., trade name: Menicon Soft M) is boiled for 30 minutes in 5 ml of artificial tear fluid per lens, and then a cleaning solution (manufactured by Menicon Co., Ltd., trade name: Meniclean) Was rubbed on a puff (manufactured by Menicon Co., Ltd., trade name: Menicon Puff) (hereinafter referred to as puff washing). After repeating this cycle 3 times, add 30 ml of artificial tears to each lens.
It was boiled for a minute, then rinsed with physiological saline, excess protein adhering to it was removed with a fingertip, and this was dried to give an artificial cloudy lens. The composition of the artificial tears used contained 1 ml of sodium chloride 9.00 mg lysozyme 1.20 mg albumin 3.88 mg γ-globulin 1.61 mg sodium dihydrogen phosphate (dihydrate) 1.04 mg calcium chloride (dihydrate) 0.15 mg The pH was adjusted to 7.0 with sodium hydroxide.

The dried artificial cloudy lens was immersed in a physiological saline solution for 1 hour or more to prepare a test lens.

About 0.7 g of the cleaning agent of the present invention was placed on the water-containing puff used in the puff cleaning, and it was evenly spread with a finger and bubbled. Then, the test lens was placed on the puff and rubbed on the front and back 5 times each with one finger. The washed lens was rinsed thoroughly with purified water, the attached water was removed using a non-woven fabric (trade name: Kimwipe, manufactured by Jujo Kimberley Co., Ltd.), and the lens was air-dried for 10 minutes. The lens was observed under a 16 × stereoscopic microscope to examine how far it fell. Also,
Immediately after rinsing, the lens was examined for the presence or absence of curing by a sensory test. Table 2 shows the results.

Next, instead of rubbing the test lens 5 times on the front and back, 120 times on the front and back, the same operation as above was repeated 5 times, and then scratched using a 16x stereoscopic microscope. The condition was observed. Table 2 shows the results.

(Evaluation of test results) Deterioration of dirt ◎: Almost no dirt remained ○: Some dirt remained Δ: Significant dirt remained ×: Almost no dirt removed Scratch condition ◎: Scratch Not observed ◯: Slightly scratched Δ: Slightly scratched ×: Marked scratches are hardened ◎: Not hardened ×: Hardened × ×: Markedly hardened Example 2 Lactose microparticles used in Example 1 (salt value 0.2 or less) 9.5 g
A paste-like cleaning agent was obtained in the same manner as in Example 1 except that 0.5 g of sodium benzoate that had been ground in a mortar and passed through a 250-mesh sieve was added.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Example 3 Glucose (special grade reagent, salt value 0.18) was ground in a mortar, and then the portions that passed through a 400-mesh screen were collected. When this was passed through a 635-mesh sieve, it hardly passed. Next, 10 g of the fine particles that did not pass through this 635-mesh sieve were taken, 3 g of polyethylene glycol 400 and 1 g of polyoxyethylene (20) sorbitan monooleate were mixed, and thoroughly kneaded to obtain a paste-like cleaning agent.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Example 4 Sucrose (special grade reagent, salt value 0.08) was ground in a mortar, and then the portions that passed through a 400-mesh sieve were collected. When this was passed through a 635-mesh sieve, it hardly passed. On the other hand, a mixture containing 10 parts of boric acid and 1 part of borax was ground in a mortar, and the parts that passed through a 400-mesh sieve were collected. When this was passed through a 635-mesh sieve, it hardly passed. Take 8 g of sucrose particles that did not pass through a 635 mesh sieve and 2 g of boric acid / borax mixture particles, add 4.5 g of glycerin in which 0.5 g of pronone 208 was dissolved, and knead well to form a paste-like detergent I got it.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Example 5 Biopulase XP which passed through a 120-mesh screen and did not pass through a 635-mesh screen was added to 8 g of fine particles of lactose (salt value of 0.2 or less) which passed through a 250-mesh screen and remained on the 635-mesh screen. 401 (Bacillus subtilis manufactured by Nagase Seikagaku Corporation)
s) -derived protease) 2 g, and mixed with polyethylene glycol 400 3.5 g and polyoxyethylene (20)
0.5 g of sorbitan monooleate was added and thoroughly kneaded to obtain a paste-like detergent.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Example 6 10 g of the lactose microparticles (salt value of 0.2 or less) used in Example 1 and 5 g of glycerin were mixed and kneaded well to form a paste to obtain a detergent. Separately, a commercially available puff (manufactured by Menicon Co., Ltd., trade name: Menicon Puff) was immersed in tap water and squeezed tightly. About 0.8 ml of a commercially available cleaning solution for soft contact lenses (manufactured by Menicon Co., Ltd., trade name: Meniclean) containing a surfactant as a main component was dropped on the puff and whipped with a finger.
Next, about 0.7 g of the above-mentioned cleaning agent was applied on the puff and evenly spread with a finger. The test lens prepared in the same manner as in Example 1 was rubbed on the puff and tested in the same manner as in Example 1, and the results are shown in Table 2.

Example 7 To 10 g of the lactose fine particles (salt value of 0.2 or less) used in Example 1, 3 g of polyethylene glycol, 1 g of water and polyoxyethylene secondary alkyl ether (MYN-76 manufactured by Matsumoto Yushi-Seiyaku Co., Ltd., 7 mol of polyoxyethylene, 0.2 g of alkyl carbon number 12-14) was added and shaken well to obtain a paste-like cleaning agent.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Example 8 To 10 g of the lactose fine particles (salt value of 0.2 or less) used in Example 1, 7 g of glycerin, 1 g of water and 0.3 g of the same liquid surfactant as in Example 7 were added, and the mixture was thoroughly kneaded to obtain a paste-like detergent. .

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Comparative Example 1 Sucrose (special grade reagent, salt value 0.08) was ground in a mortar, and the portions that passed through a 50-mesh sieve were collected. This part passed only about 50% through a 100 mesh screen. Glycerin (3.5 g) and polyoxyethylene (20) sorbitan monooleate (1 g) were well mixed with 10 g of the fine particles, and the mixture was thoroughly kneaded to obtain a paste-like detergent.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Comparative Example 2 10 g of fine particles of lactose (salt value of 0.2 or less) used in Example 1
Was uniformly mixed and suspended in a mixed solution of 60 g of glycerin and 1 g of polyoxyethylene (20) sorbitan monolaurate to obtain a liquid detergent.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Comparative Example 3 In Example 1, instead of using 0.7 g of the cleaning agent obtained in Example 1, a commercially available cleaning solution for soft contact lenses (manufactured by Menicon Co., Ltd., trade name: Meniclean (interface containing thickener) The same test as in Example 1 was conducted using 0.8 ml of the activator aqueous solution)). Table 2 shows the results.

Comparative Example 4 Sodium chloride (special grade reagent, salt value 1.0) was ground in a mortar and then sifted through a 350-mesh screen, and the passed portions were collected. When this was passed through a 635 mesh sieve, it hardly passed. Next, instead of using 10 g of lactose in Example 1, a paste-like cleaning agent was prepared in the same manner as in Example 1 except that 10 g of fine particles that did not pass through this 635 mesh sieve were used.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Comparative Example 5 Japanese Pharmacopoeia lactose used in Example 1 (salt value 0.2 or less)
Was further crushed in a mortar, and the portions that passed through a 635 mesh sieve were collected. 2 g of the fine particles were mixed with 1 g of glycerin to obtain a paste-like cleaning agent.

The cleaning agent thus obtained was tested in the same manner as in Example 6, and the results are shown in Table 2.

Comparative Example 6 Sucrose (special grade reagent, salt value 0.08) was crushed in a mortar and 100% passed through a 100-mesh sieve, and parts not passing through a 635-mesh sieve were collected. Polyoxyethylene sorbitan monolaurate was added to 50 ml of warmed polyethylene glycol having an average molecular weight of 2000 (JP-A-62-2429).
Tween 20 equivalent product described in No. 16 publication) 50 ml,
20 g of the above sucrose was added to and mixed with this to obtain a detergent.

The cleaning agent thus obtained was tested in the same manner as in Example 1, and the results are shown in Table 2.

Comparative Example 7 The same test as in Example 1 was carried out except that a few drops of the cleaning agent of Comparative Example 6 were dropped onto the same lens as in Comparative Example 6 and the surface of the lens was rubbed and washed using a palm. The results are shown in Table 2.

Comparative Example 8 Instead of sucrose, the lactose used in Example 1 (salt value of 0.
2 or less) was used and a detergent was prepared in the same manner as in Comparative Example 6, and the same test as in Example 1 was performed. The results are shown in Table 2.

[Effects of the Invention] The cleaning agent for soft contact lenses of the present invention exhibits a very good cleaning effect, and it is also good in removing stains caused by proteins, which was difficult with conventional liquid cleaning agents. Therefore, the proteolytic enzyme, which has been necessary in the past, becomes unnecessary.
Furthermore, no lens hardening or scratches are observed on the lens after washing.

Further, the cleaning agent for soft contact lenses of the present invention,
Since a water-soluble compound and a small amount of a water-miscible non-water pasting agent are used, the cleaning agent component does not remain on the soft contact lens by simply rinsing with water after cleaning, and soft contact after cleaning Rinse the lens easily,
In addition, even if the rinse is left, it is safe for the eyes.

Claims (11)

(57) [Claims] 1. Particles having a water-miscible non-water pasting agent of 50 to 20% by weight with respect to the total amount of the cleaning agent and 50 to 80% by weight of the total amount of the cleaning agent and having a salt value of 0.65 or less. 100% of the particles pass through JIS standard mesh sieve with sieve number 100 (sieve nominal size 149 μm) and sieve number 635 (sieve nominal size
A cleaning agent for soft contact lenses, containing fine particles of a water-soluble compound in a range that does not pass 50% by weight or more of JIS standard mesh sieve (20 μm). 2. The detergent for soft contact lenses according to claim 1, wherein a part or all of the water-miscible non-water pasting agent is a liquid surfactant. 3. The cleaning agent for soft contact lenses according to claim 1, which contains a water-miscible non-water pasting agent and a miscible surfactant. 4. The cleaning agent for soft contact lenses according to claim 1, 2, or 3, wherein the water-soluble compound is a compound having a salt value of 0.4 or less. 5. The cleaning agent for soft contact lenses according to claim 1, wherein the water-soluble compound is an organic low molecular weight compound. 6. The cleaning agent for soft contact lenses according to claim 1, wherein the water-soluble compound is a mixture of an organic low molecular weight compound and an inorganic low molecular weight compound. 7. The method according to claim 1, wherein the fine particles of the water-soluble compound are contained in an amount of 60 to 75% by weight based on the total amount of the detergent.
The cleaning agent for soft contact lenses according to item 3 or 4. 8. A water-soluble compound having a fine particle number of 200
Claims 1, 2 and 3 which pass 100% of JIS standard mesh sieve (nominal sieve size 74 μm).
The cleaning agent for soft contact lenses according to item 4 or 4. 9. The detergent for soft contact lenses according to claim 1 or 2, wherein a part or all of the fine particles of the water-soluble compound are fine particles of an enzyme. 10. A water-miscible non-water pasting agent of 50 to 20% by weight with respect to the total amount of the cleaning agent, and 50 to 80 with respect to the total amount of the cleaning agent.
100% by weight of the salt value is 0.65 or less, and the particle size passes 100% of the JIS standard mesh sieve of sieve number 100 (sieve nominal size 149 μm), and sieve number 635 (sieve nominal size 20 μm) JIS A soft contact lens cleaning agent containing fine particles of a water-soluble compound in a range that does not pass 50% by weight or more through a standard mesh sieve is placed on a water-filled puff and uniformly spread, and then soft contact is made on the puff surface. A method for cleaning a soft contact lens, which comprises contacting and rubbing the lens. 11. The soft contact according to claim 10, wherein the puff containing water is squeezed hard before the cleaning agent for a soft contact lens is placed, and a liquid cleaning agent containing a surfactant is previously poured on the puff. How to clean the lens.