JP3352802B2 - Agent for contact lenses - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a contact lens agent. More specifically, the present invention relates to a contact lens agent that can be suitably used, for example, as a contact lens cleaning agent, a contact lens preservative, and the like.

[0002]

2. Description of the Related Art Conventionally, agents for contact lenses include polyvinyl alcohol and hydroxyethyl cellulose as components for imparting a builder effect for improving the cleaning efficiency of the contact lens and a cushioning effect for preventing the contact lens from being damaged. Surfactants are used as a thickener such as methylcellulose, sodium alginate, sodium carboxymethylcellulose, and a component for removing lipids and proteins attached to contact lenses.

[0003] However, if the contact lens is washed or stored using a contact lens cleaning and preserving solution to which a surfactant has been added, and if the surfactant is not completely removed, the conjunctiva during wearing of the contact lens may be lost. In some cases, disorders such as hyperemia, corneal opacity, and corneal epidermal detachment may occur. In particular, when the contact lens cleaning and preserving solution is used for a contact lens mainly containing hydroxyethyl methacrylate, which has a water absorbing property, the contact lens is impregnated with the cleaning and preserving solution, which may cause various obstacles. There is.

In order to solve such a danger, Japanese Patent Laid-Open No.
JP-A-2-70812 proposes a contact lens agent containing an isobutylene-maleic anhydride copolymer. When such a contact lens agent is used, the contact lens can be completely washed in a short period of time and has a suitable viscosity, so that it is useful as a thickener.

However, since the isobutylene-maleic anhydride copolymer is not usually dissolved in water having a pH lower than neutrality and a small pH, it is dissolved at about 90 ° C. using an aqueous solution of sodium hydroxide or ammonia water. Had to be heated. Some isobutylene-maleic anhydride copolymers have been given water solubility by preliminarily subjecting them to alkali treatment, but when such compounds are used, the pH after dissolution in water gradually increases. , And the pH stability was not sufficient.

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned prior art, and has an appropriate viscosity for completely and completely cleaning a contact lens in a short time, and has a high pH stability. An object of the present invention is to provide an excellent agent for contact lenses.

[0007]

DISCLOSURE OF THE INVENTION The present invention relates to a methyl vinyl ether-maleic anhydride copolymer, a ring-opening product of a methyl vinyl ether-maleic anhydride copolymer, and a ring-opening of a methyl vinyl ether-maleic anhydride copolymer. The present invention relates to a contact lens agent comprising at least one methyl vinyl ether-maleic anhydride copolymer of a salt of a product and a surfactant .

[0008]

As described above, the agent for contact lenses of the present invention comprises a methyl vinyl ether-maleic anhydride copolymer, a ring-opened product of a methyl vinyl ether-maleic anhydride copolymer and a methyl vinyl ether-
It contains at least one methylvinyl ether-maleic anhydride copolymer of a salt of a ring-opening product of a maleic anhydride copolymer, and has a suitable viscosity for cleaning contact lenses, that is, a viscosity of 1 to 3. 50,000 cP (2
5 ° C.), easily dissolves in water in a wide range of pH, and has excellent long-term pH stability. In the present invention, the viscosity of the contact lens agent is 1 to 1000 cP, preferably 1 to 1000 cP.
It is preferably 100 cP (25 ° C.).

The methyl vinyl ether-maleic anhydride copolymer has the formula:

[0010]

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And a repeating unit represented by the formula:

[0012]

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A copolymer having a repeating unit represented by the following formula:

The ratio (methyl vinyl ether / maleic anhydride: molar ratio) of methyl vinyl ether and maleic anhydride constituting the above-mentioned methyl vinyl ether-maleic anhydride copolymer may be too large if the ratio of methyl vinyl ether is too large. Since a contact lens agent having a desired detergency tends to be difficult to obtain, and maleic anhydride does not polymerize alone and the ratio of methyl vinyl ether is 50 mol% or more, it is 5/5 to 9 / 1,
Preferably, it is 5/5 to 7/3.

The ring-opened product of the methyl vinyl ether-maleic anhydride copolymer is obtained by ring-opening the acid anhydride group of the methyl vinyl ether-maleic anhydride copolymer, and has the formula:

[0016]

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And a repeating unit represented by the formula:

[0018]

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(Wherein R ¹ and R ² each independently represent a hydroxyl group, an amino group or an alkoxyl group). The alkoxyl group for R ¹ and R ² preferably has 1 to 4 carbon atoms.

The salt of the ring-opened product of the methyl vinyl ether-maleic anhydride copolymer is a salt obtained by ring-opening the acid anhydride group of the methyl vinyl ether-maleic anhydride copolymer, formula:

[0021]

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And a repeating unit represented by the formula:

[0023]

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(Wherein X ¹ and X ² independently represent an alkali metal atom, an ammonium group or a quaternary ammonium group). Representative examples of the alkali metal atom include a sodium atom and a potassium atom. Representative examples of the quaternary ammonium group include a dimethyldiphenylammonium group, a tetramethylammonium group, and a triethylphenylammonium group.

The ring-opened product of the above-mentioned methyl vinyl ether-maleic anhydride copolymer can be usually obtained by dissolving a methyl vinyl ether-maleic anhydride copolymer in, for example, water or alcohol. The salt of the ring-opened product can be obtained, for example, by neutralizing the ring-opened product with an alkali or the like. Therefore, methyl vinyl ether-
The maleic anhydride-based copolymer can exist in various states in the formulation using the contact lens agent.

If the weight-average molecular weight of the methyl vinyl ether-maleic anhydride copolymer is too low, the viscosity tends to be low and the slip property tends not to be sufficiently exhibited. 10
If it is too high, the solubility in water is reduced, and it tends to become cloudy without completely dissolving. Therefore, it should be 500,000 or less, especially 100,000 or less. Is preferred.

The content of the methyl vinyl ether-maleic anhydride copolymer in the contact lens agent depends on the type and molecular weight of the methyl vinyl ether-maleic anhydride copolymer to be used. In some cases, the viscosity is not sufficiently imparted, and the slipperiness and detergency tend not to be sufficiently exhibited.
It is desirable that the amount is 005% by weight or more, preferably 0.01% by weight or more. If the amount is too large, the resulting contact lens agent gels, the fluidity decreases, and the detergency decreases. Therefore, it is desirable that the content be 35% by weight or less, preferably 10% by weight or less, more preferably 5% by weight or less.

The contact lens agent of the present invention
, A surfactant is further added as an essential component.

The surfactant has a property of enhancing the cleaning effect of the contact lens agent.

[0030] The surfactant, such as those composed of an anionic surfactant, a nonionic surfactant, an anionic surfactant and nonionic surfactant there
In the present invention, any surfactant may be used.

Representative examples of anionic surfactants include:
For example, sodium alkyl sulfate, sodium alkylbenzenesulfonate, sodium alkylloylmethyltaurine, sodium alkylloylsarcosine, sodium α-olefin sulfonate, sodium polyoxyethylene alkyl ether phosphate, sodium polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl Examples thereof include sodium phenyl ether sulfate and sodium di (polyoxyethylene alkyl ether) phosphate. Among these, sodium alkyl sulfate, sodium alkylbenzene sulfonate, sodium α-olefin sulfonate, sodium polyoxyethylene alkyl ether sulfate, Sodium polyoxyethylene alkyl phenyl ether sulfate has an excellent cleaning effect, When a surfactant is used in combination, an effective washing effect can be exhibited by immersion storage for a short time.

The content of the anionic surfactant in the contact lens agent is preferably 0.01% by weight or more, especially 0.0%, in order to impart a sufficient cleaning effect.
It is preferably at least 2% by weight. If the content of the anionic surfactant is too large, the cleaning effect is not so high, which may result in rough hands. Therefore, the content is 10% by weight or less, especially 5% by weight or less. Is preferred.

Representative examples of the nonionic surfactant include, for example, polyethylene glycol adducts of higher alkylamines, polyethylene glycol adducts of higher fatty acid amides, polyglycerol esters of higher fatty acids, polyethylene glycol esters of higher fatty acids, and higher fatty acids. Polyalkylene glycols, polyethylene glycol copolymer esters, polyhydric alcohol esters to which polyethylene glycol of higher fatty acids are added, polyethylene glycol ethers of higher alcohols, polyglycerin ethers of higher alcohols, polyethylene glycol ethers of alkyl phenols, polyethylene glycol ethers of alkylene phenols Formaldehyde condensate, polypropylene glycol-polyethylene glycol copolymer, Esters, castor oil, hydrogenated castor oil, polyethylene glycol sorbitan alkyl esters, polyethylene glycol adducts of sterols and the like. Among these, polyethylene glycol ethers of higher alcohols, polyethylene glycol esters of higher fatty acids, polyglycerin esters of higher fatty acids, polyethylene glycol ethers of alkyl phenols, and polyethylene glycol sorbitan alkyl esters are preferred because they exhibit excellent cleaning effects.

The content of the nonionic surfactant in the contact lens agent is preferably 0.01% by weight or more, especially 0.0%, in order to impart a sufficient cleaning effect.
It is preferably at least 2% by weight. If the content of the nonionic surfactant is too large, the cleaning effect is not so high, which may result in rough hands. Therefore, the content is preferably 10% by weight or less, especially 5% by weight or less. Is preferred.

When an anionic surfactant and a nonionic surfactant are used in combination, the contents of the anionic surfactant and the nonionic surfactant are within the above-mentioned ranges, respectively, and the total amount is 0%. .02 to 20% by weight,
In particular, it is preferably 0.05 to 10% by weight.

Further, the contact lens agent of the present invention
If necessary, buffer, tonicity agent, thickener, chelate
Contains at least one selected from a preservative and a preservative
You may squeeze. The buffering agent keeps the pH of the obtained contact lens agent constant in the range of 5.0 to 9.0, which is close to that of tears, suppresses a change in pH due to external factors, and provides a contact lens for washing or storing. Has the property of protecting the shape and optical properties of the

Representative examples of the buffer include boric acid and its sodium salt, phosphoric acid and its sodium salt,
Ophthalmic physiologically acceptable buffers such as citric acid and its sodium salt, lactic acid and its sodium salt, amino acids such as glycine and glutamic acid and its sodium salt, and malic acid and its sodium salt.

The content of the buffer in the contact lens agent is 0.01 mol / l or more, preferably 0.05 mol / l, in order to impart a sufficient buffer effect.
It is preferably at least 1. If the content of the buffer is too large, the buffer effect is not so high, and the shape of the contact lens is affected by increasing the osmotic pressure.
1 or less, preferably 0.15 mol / l or less.

The isotonicity agent is used to reduce the osmotic pressure of the obtained contact lens agent to the osmotic pressure of tears (280 to 300 mOs).
/ Kg) and maintain the shape of the contact lens when washed and stored.

Representative examples of the tonicity agent include ophthalmologically acceptable inorganic salts such as sodium chloride, potassium chloride and calcium chloride, and the above-mentioned buffers.

The content of the tonicity agent in the contact lens agent is preferably 0.01 mol / l or more, more preferably 0.05 mol / l, in order to impart a sufficient osmotic pressure.
It is preferably at least 1. If the content of the tonicity agent is too large, the osmotic pressure increases and the shape of the contact lens is affected, so that the content is 0.5 mol / l or less, especially 0.15 mol / l. Mol /
It is preferably set to 1 or less.

The above-mentioned thickener has a property of improving the feel during washing and protecting the contact lens from external physical force during washing or storage.

Representative examples of the thickener include polyvinyl alcohol, poly-N-vinylpyrrolidone, polyacrylamide and its hydrolysates, polyacrylic acid, xanthan gum, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxyethyl cellulose, methyl hydroxyethyl cellulose. Propylcellulose, methylcellulose, sodium alginate, polyethylene glycol, gelatin, chondroitin sodium sulfate,
Ophthalmic physiologically acceptable viscous bases such as gum arabic and guar gum.

The content of the thickening agent in the contact lens agent is preferably 0.01% by weight or more in order to sufficiently protect the contact lens from external stress when the contact lens is washed or stored. 0.
It is preferably at least 02% by weight. If the content of such a thickener is too large, the resulting contact lens agent tends to gel and the washing property and the storage stability tend to decrease. Therefore, the content is 10% by weight or less, especially 5% by weight. It is preferable to set the following.

The chelating agent has a property of preventing calcium and the like contained in the contact lens agent and the attached tear fluid from being deposited on the contact lens.

Representative examples of the chelating agent include, for example, ethylenediaminetetraacetic acid and its sodium salt,
Phytic acid, citric acid and the like.

The content of the chelating agent in the contact lens agent is preferably at least 0.001 mol / l, more preferably at least 0.0015 mol / l in order to sufficiently prevent calcium and the like from depositing on the contact lens. It is preferred that Incidentally, if the content of such a chelating agent is too large, the improvement of the effect by containing more is small, rather uneconomical,
It is preferably at most 0.1 mol / l, particularly preferably at most 0.05 mol / l.

The preservative has the property of preventing the contact lens agent from being contaminated with bacteria and preventing the contact lens from being contaminated with bacteria during washing or storage.

Representative examples of the above preservatives include phenylmercury preservatives such as phenylmercuric nitrate and phenylmercuric acetate; benzalkonium chloride, pyridinium bromide;
Surfactant preservatives such as chlorohexidine and polyhexamethylene biguanide; alcohol preservatives such as chlorobutanol; thimerosal; methylparaben, propylparaben, bronopol, dimethyloldimethylhydantoin, imidazolium urea and the like.

The content of the preservative in the agent for contact lenses is preferably 0.00001% by weight or more, more preferably 0.00001% by weight, in order to sufficiently prevent the contact lenses from being contaminated by bacteria during washing or storage. 000
It is preferably at least 03% by weight. If the content of such a preservative is too large, there is a risk that the preservative may damage the eyes if it enters the eyes directly, or depending on the type of preservative. Since there is a tendency that a bad influence may be exerted on the specifications and properties of the contact lens, the content is preferably 0.5% by weight or less, particularly preferably 0.3% by weight or less.

The buffers, isotonic agents, thickeners, chelating agents and preservatives may each be used alone.
A mixture of two or more species may be used.

The contact lens agent of the present invention can be prepared, for example, in the form of an aqueous solution or granules.

For example, in the case of an aqueous solution, a methyl vinyl ether-maleic anhydride copolymer and a surfactant are added to a predetermined amount of purified water, and a buffer, if necessary,
It is obtained by adding at least one compounding agent selected from a tonicity agent, a thickener, a chelating agent and a preservative, thoroughly mixing and stirring to dissolve, and filtering.

In the case of granulation, the above components are finely powdered, mixed and stirred in purified water, and then kneaded with an excipient, if necessary. Next, after passing through a mesh, it is obtained by heating and drying. In use, the granules are dissolved in a predetermined amount of purified water at the time of use and used as an aqueous solution.

The contact lens agent of the present invention includes
In addition to the above, aqueous bond breaking agents such as guanidine and urea,
Salts exhibiting a salt dissolving effect such as sodium thiocyanate may be added.

Next, the contact lens agent of the present invention will be described in more detail with reference to Examples, but the present invention is not limited to only these Examples.

Example 1 0.5 g of a methyl vinyl ether-maleic anhydride copolymer (weight average molecular weight: about 40,000) was added to about 50 m of purified water.
and left at room temperature for about 2 hours to obtain a homogeneous solution. The pH of the resulting solution was adjusted to about 7 by adding a 0.1N aqueous sodium hydroxide solution, and 0.5 mL of sodium alkylbenzene sulfonate was added as an anionic surfactant.
g was added to bring the total volume to 100 ml.

The viscosity (25 ° C.) of the prepared solution was measured with a B-type viscometer, and the solution was left at 40 ° C. for one month.
The pH before and after that is measured using a glass electrode type pH meter (HORI
BApH METER F-13, manufactured by Horiba, Ltd.), and the change was examined. Table 1 shows the results.

The above solution was used to randomly select 1
Zero men and women were washed for 30 seconds with contact lenses (trade name: Menicon EX, manufactured by Menicon Co., Ltd.), and the cleaning properties were evaluated. As a result, all ten persons evaluated that the cleanability was good.

Further, using the above solution, the detergency of the contact lens to which the artificial eye oil was adhered was examined as follows.

6% by weight of sorbitan monooleate, 16% by weight of castor oil, 35% by weight of lanolin, 5% by weight of oleic acid, 4% by weight of sorbitan trioleate, 2% by weight of cetyl alcohol, 2% by weight of cholesterol and 30% by weight of cholesterol acetate % Of artificial eye oil was dissolved in a mixed solvent of ethanol and hexane (weight ratio 1: 1) to prepare a 2.5% artificial eye oil solution. 3 μl of this 2.5% artificial eye oil solution was adhered to the surface of a contact lens (trade name: Menicon EX, manufactured by Menicon Co., Ltd.) and then dried to prepare a soiled contact lens.

[0062] Ten such soiled contact lenses were washed with the above solution for 30 seconds, and the detergency was evaluated. As a result, the stain was completely removed from all the ten soiled contact lenses, and the detergency of the solution against eye oil was large.

As described above, it was found that the solution can completely and completely clean the contact lens in a short time.

Example 2 5.0 g of a methyl vinyl ether-maleic anhydride copolymer (weight average molecular weight: about 20,000) was dispersed in about 60 ml of a 0.5N aqueous sodium hydroxide solution, and heated until dissolved in a 90 ° C. water bath. As a result, it dissolved in about 15 minutes, and a homogeneous solution was obtained. 0.5 g of sodium α-olefin sulfonate as an anionic surfactant was added to the obtained solution, about 30 ml of purified water was added, and the pH was adjusted to about 7 with a 0.5N aqueous sodium hydroxide solution. Purified water was added to bring the total volume to 100 ml.

Next, the viscosity (25 ° C.) of the obtained solution and the change in pH of the solution were examined in the same manner as in Example 1.
Table 1 shows the results.

Further, using the above solution, the detergency and the detergency for eye oil of 10 men and women were examined in the same manner as in Example 1. As a result, all ten persons evaluated that the detergency was good, and the dirt was completely removed from all ten dirt contact lenses, and the detergency of the solution against eye oil was large. . As described above, it was found that the solution can completely and completely clean the contact lens in a short time.

Example 3 0.5 g of a methyl vinyl ether-maleic anhydride copolymer (weight average molecular weight: about 20,000) was dispersed in about 60 ml of a 0.05 N aqueous sodium hydroxide solution, and heated until dissolved in a water bath at 90 ° C. Then, it was dissolved in about 10 minutes. The resulting solution was added with 0.5% of polyoxyethylene alkylphenyl ether sulfate as an anionic surfactant.
g, 0.5 g of polyoxyethylene (20) sorbitan monooleate as a nonionic surfactant and about 30 ml of purified water were added and dissolved, and the pH was adjusted to about 7 using a 0.05N aqueous sodium hydroxide solution. Then, purified water was added to make the total volume 100 ml, and a homogeneous washing solution was obtained.

Next, the viscosity of the obtained solution (25 ° C.) and the change in the pH of the solution were examined in the same manner as in Example 1.
Table 1 shows the results.

Further, using the above solution, the detergency and the detergency for eye oil of 10 men and women were examined in the same manner as in Example 1. As a result, all ten persons evaluated that the detergency was good, and the dirt was completely removed from all ten dirt contact lenses, and the detergency of the solution against eye oil was large. . As described above, it was found that the solution can completely and completely clean the contact lens in a short time.

Example 4 0.5 g of a methyl vinyl ether-maleic anhydride copolymer (weight average molecular weight: about 20,000) was added to about 50 m of purified water.
and left at room temperature for about 3 hours to obtain a homogeneous solution. The pH of the resulting solution was adjusted to about 7 by adding a 0.1N aqueous sodium hydroxide solution, and 0.5 mL of sodium alkylbenzene sulfonate was added as an anionic surfactant.
g, ethylenediaminetetraacetic acid 0.1 as a chelating agent
g and 0.01 g of methylparaben as a preservative were added and dissolved to make a total volume of 100 ml.

Next, the viscosity of the obtained solution (25 ° C.) and the change in the pH of the solution were examined in the same manner as in Example 1.
Table 1 shows the results.

Further, using the above solution, the detergency and the detergency of eye oil by 10 men and women were examined in the same manner as in Example 1. As a result, all ten persons evaluated that the detergency was good, and the dirt was completely removed from all ten dirt contact lenses, and the detergency of the solution against eye oil was large. . As described above, it was found that the solution can completely and completely clean the contact lens in a short time.

Example 5 5.0 g of a methyl vinyl ether-maleic anhydride copolymer (weight average molecular weight: about 20,000) and 2.0 g of polyvinyl alcohol as a thickener were dispersed in about 60 ml of a 0.5N aqueous sodium hydroxide solution. When the mixture was heated in a water bath at 90 ° C. until dissolved, the mixture was dissolved in about 15 minutes, and a homogeneous solution was obtained. 0.5 g of sodium α-olefin sulfonate as an anionic surfactant and 0.5 g of boric acid as a buffer were added to the obtained solution,
About 30 ml of purified water was added, and the pH was adjusted to about 7 with a 0.5N aqueous solution of sodium hydroxide, and then purified water was added to make a total volume of 100 ml.

Next, the viscosity (25 ° C.) of the obtained solution and the change in pH of the solution were examined in the same manner as in Example 1.
Table 1 shows the results.

Further, using the above solution, the detergency and the detergency for eye oil of 10 men and women were examined in the same manner as in Example 1. As a result, all ten persons evaluated that the detergency was good, and the dirt was completely removed from all ten dirt contact lenses, and the detergency of the solution against eye oil was large. . As described above, it was found that the solution can completely and completely clean the contact lens in a short time.

Comparative Example 1 0.5 g of an isobutylene-maleic anhydride copolymer (weight average molecular weight: about 180,000) was dispersed in 100 ml of purified water, and heated until dissolved in a water bath at 90 ° C.
Did not dissolve.

COMPARATIVE EXAMPLE 2 0.5 g of an isobutylene-maleic anhydride copolymer (weight average molecular weight: about 180,000) was dispersed in about 60 ml of a 0.05 N aqueous sodium hydroxide solution, and left standing at room temperature for about 3 hours. Did not.

Comparative Example 3 0.5 g of a water-soluble isobutylene-maleic anhydride copolymer (weight average molecular weight: about 200,000) was dispersed in about 60 ml of purified water, and heated in a water bath at 90 ° C. until dissolved. However, it was homogeneously dissolved in about 20 minutes. After dissolution, 0.5 g of polyoxyethylene alkylphenyl ether sulfate as an anionic surfactant, 0.5 g of polyoxyethylene (20) sorbitan monooleate as a nonionic surfactant and about 30 ml of purified water are added and dissolved. The pH was adjusted to about 7 using a 0.05N aqueous sodium hydroxide solution, and purified water was added to adjust the total amount to 1.
00 ml.

Next, the viscosity (at 25 ° C.) of the obtained solution and the change in the pH of the solution were examined in the same manner as in Example 1.
Table 1 shows the results.

Table 1 also shows the time required for dissolution as solubility, and the difference between the pH immediately after preparation of the solution and the pH after standing at 40 ° C. for one month.

[0081]

[Table 1]

From the results shown in Table 1, in Examples 1 to 5, the contact lens agent could be adjusted quickly, and the obtained contact lens agent had a viscosity of about 4 to 30 cP. It can be seen that the change in pH is extremely small even when it is maintained for a long period (one month).

[0083]

The contact lens agent of the present invention has an appropriate viscosity for completely and completely washing the contact lens in a short time, and is excellent in pH stability.

The contact lens agent of the present invention comprises
Since it has appropriate viscosity and slipperiness, the contact lens can be easily and completely cleaned in a short time.

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int.Cl. ⁷ , DB name) G02C 13/00

Claims (4)

(57) [Claims] At least one of a methyl vinyl ether-maleic anhydride copolymer, a ring-opening product of a methyl vinyl ether-maleic anhydride copolymer and a salt of a ring-opening product of a methyl vinyl ether-maleic anhydride copolymer methyl vinyl ether - maleic anhydride copolymer and
Agent for contact lenses, characterized in that contains a surfactant. Wherein said methyl vinyl ether - content of maleic anhydride copolymer is 0.005 to 35 wt% der
Wherein the surfactant is an anionic surfactant, a nonionic surfactant
The agent for a contact lens according to claim 1, which is at least one kind of a surfactant. 3. The surfactant according to claim 1, wherein the surfactant is an anionic surfactant.
Wherein sodium alkylsulfate, alkylbenzene
Sodium sulfonate, alkyloylmethyltaurina
Thorium, sodium alkyloyl sarcosine, α-o
Sodium refin sulfonate, polyoxyethylene
Sodium alkyl ether phosphate, polyoxyethylene
Sodium alkyl ether sulfate, polyoxyethylene
Sodium alkyl phenyl ether sulfate,
Xylene ethylene ether) from sodium phosphate
3. The component according to claim 1, which is at least one selected from the group consisting of:
Agent for tact lens. 4. The above-mentioned methyl vinyl ether-anhydrous maleic
The weight average molecular weight of the acid-based copolymer is 5,000 or more, 50
4. The agent for contact lenses according to claim 1 , wherein the amount is not more than 10,000 .