JP2729520B2 - Elastic patch - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a patch used as a cataplasm, a plaster and the like.

2. Description of the Related Art Conventionally, cataplasms and plasters have been widely used as patches applied to the skin. Particularly, cataplasms have been studied in recent years, and hydrogel gels having high adhesive strength have been developed, and it is no longer necessary to fix them to the skin with an adhesive tape or the like (JP-A-59-110617 and JP-A-59-13718). .

However, lint cloths and non-woven fabrics used as a support in conventional cataplasms have little elasticity by themselves, so they cannot follow the movement of the human skin when applied, and peel off from the skin. It was easy to get lost.
In order to solve this problem, cataplasms using stretchable nonwoven fabric or stretchable knitted fabric have been developed (JP-A-63-122621, JP-A-1-121214,
Nos. 1-197434 and 1-228911.

However, these stretchable supports cannot be said to have sufficient stretchability, and in particular, are poor in return after stretching, and thus cannot always sufficiently follow large skin movements such as bending and stretching of joints. Therefore, after bending and stretching the joints and the like, it rises from the skin, and the adhesion to the skin deteriorates.
It causes peeling and has a problem in effectiveness.

Problems to be Solved by the Invention The present invention provides a patch with excellent followability, which follows a stretch of the skin and stretches with a small force, and also returns when the skin returns after stretching. To provide.

In the present invention, the above-mentioned problem has been solved by using a support having excellent elasticity.

That is, the patch of the present invention has a heat-shrinkable fiber exhibiting a three-dimensional clamp by heat treatment of 70% by weight or more in a patch having a support portion and a plaster portion, and has a melting point higher than that of the heat-shrinkable fiber. After being entangled and integrated with the low-melting fiber having a low melting point, the heat-shrinkable fiber is heated at a temperature equal to or lower than the melting point of the heat-shrinkable fiber and equal to or higher than the melting point of the low-melting fiber to form a three-dimensional crimp. A stretchable nonwoven fabric bonded with low-melting fibers is used for the support.

 Hereinafter, the present invention will be described in more detail.

The nonwoven fabric used as a support in the present invention has at least two fiber components, when viewed as its constituent fibers, namely,
A heat-shrinkable fiber expressing a three-dimensional crimp by heating,
And a low-melting fiber having a lower melting point than the heat-shrinkable fiber.

Examples of the heat-shrinkable fiber that develops a three-dimensional crimp by heating include a fiber having a bimetal structure as a composite in which two types of fibers having different heat-shrinkage rates are bonded together. The shrinkage of the heat-shrinkable fiber affects the stretchability of the obtained nonwoven fabric, and the shrinkage is preferably 10% or more, more preferably 25% or more. If the shrinkage is too small, a satisfactory stretchable nonwoven fabric cannot be obtained. Further, a simple heat-shrinkable fiber that does not exhibit three-dimensional crimps cannot provide sufficient elasticity.

As the two kinds of fibers constituting the heat-shrinkable fiber, polyester fiber, polyethylene fiber, polypropylene fiber,
Thermoplastic synthetic fibers such as polyamide fibers, polyvinyl chloride fibers, and polyvinyl alcohol fibers are used, and two of them having different heat shrinkage rates are combined. If the heat shrinkage ratios are different, the same type of fibers may be bonded or different types of fibers may be bonded.

Heat-shrinkable fibers that exhibit three-dimensional crimp
More than 70% (mixing ratio 70%), preferably%
Used above. If the mixing ratio is less than 70%, sufficient stretching performance cannot be obtained.

The low-melting fiber is a fiber that is melted by a heat treatment to bond fibers that have developed a three-dimensional crimp, and needs to have a lower melting point (softening point) than the above-described heat-shrinkable fiber. It is desirable that the value is large. As the low melting point fiber, the above-mentioned thermoplastic synthetic fiber or the like is used on condition that the melting point is low. The amount of the low-melting-point fiber in the nonwoven fabric is suitably 0.5 to 3.0% by weight, more preferably 1 to 10% by weight.

In the nonwoven fabric of the present invention, other fiber components may be blended in addition to the above fibers. Specific examples thereof include rayon, cupola, hemp, silk and the like in addition to the above-mentioned thermoplastic synthetic fibers. Non-thermoplastic fibers.

In the present invention, after the above-described fibers are entangled and integrated by needling or the like, the melting point of the heat-shrinkable fibers is equal to or lower than, and
Heat treatment at a temperature equal to or higher than the melting point of the low-melting fiber, to develop a three-dimensional crimp, and to melt the low-melting fiber,
The fibers forming the three-dimensional crimp are connected in a mesh form to form a non-woven fabric having high elasticity. This heating may be performed by a single-stage heat treatment in which the formation of the three-dimensional crimp and the melting of the low-melting fiber are performed at the same time.First, the three-dimensional crimp is generated by heating, and then further heated to reduce the low-melting fiber. Multi-stage heat treatment such as fusion bonding may be used.

The nonwoven fabric used as a support in the present invention aims at expanding and contracting in the same manner as human skin.

Even in the human body, the skin of the elbow, knee, neck and the like has particularly high elasticity, and the elasticity of these parts reaches a maximum of 1.4 to 1.5 times.
Therefore, the support of the adhesive patch to be applied to these sites is required to have an elongation rate of up to 1.5 times the original length.
In addition, the value of the load (50% modulus) for stretching to 1.5 times (50% elongation), which is the maximum elongation, depends on the adhesive strength of the plaster itself, but does not impair the strength of the support. It is desirable to be as small as possible within the range.
According to our studies, the 50% modulus is 0.1-2.0.
kg / 5 cm is suitable, and more preferably 0.1 to 0.8 kg / 5 cm.

In addition, even if the support elongates following the bending of the joint or the like, if the return of the elongation of the support (50% elongation recovery rate at elongation) is poor when this bending is restored, the It raises the body, reduces the effect of absorbing the active ingredient, and causes peeling of the patch. Thus, the support preferably has a higher elongation recovery rate during elongation. According to the study of the present inventors, in addition to the above-mentioned modulus value, the support of the elastic patch has an elongation recovery rate at 50% elongation of preferably 40% or more, more preferably 55% or more. is there.

As the plaster of the patch of the present invention, a plaster conventionally used, for example, a pharmacologically active ingredient, a water-soluble polymer, a mineral powder, a curing agent and water sufficiently kneaded can be used.

Although the medicinal ingredient is not particularly limited, for example, methyl salicylate, glycol salicylate, indomethacin, ketoprofen, flurbiprofen, ibuprofen, diclofenac sodium, mefenamic acid and its derivatives, flufenamic acid and its derivatives, bufexamac, ibfenac, alfa Herbal medicines such as Clofenac, Prednisolone, Hydrocortisone Acetate, Decitamezone, 1-Menthol, dl-Camphor, Crotamiton, Diphenhydranamine Hydrochloride, Chlorpheniramine Maleate, Tocopherol Acetate, Vanillylamide Nonylate, Naproxen, Piroxicam, Capsaicin, and Oakaku Powder, herbal extract such as capsicum extract, herbal dry extract such as oak dried extract, herbal extract such as assembly extract, alni Herbal tinctures, such as tincture, peppermint oil, and essential oils such as cinnamon oil.

Examples of the water-soluble polymer include gelatin, pectin, polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylpyrrolidone / vinyl acetate copolymer, polyethylene oxide, sodium carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, and sodium alginate. , Xanthan gum, arbia gum, tragacanth gum, karaya gum, methyl vinyl ether, maleic anhydride copolymer and the like.

Examples of the mineral powder include kaolin, bentonite, montmorillonite, zinc oxide, titanium oxide, and silicic anhydride.

Examples of the curing agent include potassium aluminum sulfate, magnesium aluminate silicate, aluminum hydroxide, magnesium aluminate hydroxide, magnesium aluminate metasilicate, synthetic hydrotalcite, dihydroxyaluminum aminoacetate, and the like.

In addition, humectants such as glycerin, sorbitol, and propylene glycol, and surfactants such as polysorbate 80, polyoxyethylene hydrogenated castor oil, and glycerin fatty acid ester can be blended.

Further, the patch of the present invention, in order to make full use of the advantage that the support is elastic, it is desirable that the adhesive strength of the plaster is sufficiently strong, the ball tack adhesive strength is No. 4 or more, preferably
It is desirable to be No. 10 or more.

The patch of the present invention can be produced by applying a plaster on the above-mentioned support by a known method.

Effect of the Invention According to the patch of the present invention, a heat-shrinkable fiber that exhibits three-dimensional crimp by heat treatment, and a stretchable nonwoven fabric that uses a low-melting-point fiber that fuses and bonds these by heat treatment are used. Thereby, excellent elasticity and high followability to skin can be obtained. As a result, the following operation and effect can be obtained.

As stretchability and followability are large and excellent in adhesion,
It is possible to prevent the effectiveness of the active ingredient from being deteriorated due to, for example, a decrease in the transfer of the active ingredient to the skin due to the lifting of the plaster.

Since the elasticity and followability are large, peeling of the patch from the skin is prevented.

EXAMPLES Example 1 A blended web composed of 98% of polyester fibers exhibiting three-dimensional crimp by heat treatment and 2% of low-melting polyester fibers having a melting point of about 150 ° C. is subjected to needle punching at a needle density of 50 p / cm ^2. After that, heat treatment was performed at 180 ° C. for 3 minutes to obtain a biaxially stretchable nonwoven fabric support for adhesive patches (product 1 of the present invention) having a basis weight of 100 g / m ² .

Example 2 80% polyester fiber expressing three-dimensional crimp by heat treatment, 12% normal polyester fiber, melting point about 15%
5% low-melting polyester fiber at 0 ° C, 3% rayon fiber
The blended web is needle-punched at a needle density of 50 p / cm ² and then heat-treated at 180 ° C. for 3 minutes to obtain a basis weight of 105%.
Thus, a nonwoven fabric support for a patch (inventive product 2) having a biaxial stretchability of g / m ² was obtained.

Comparative Example 1 A web made of 100% polyester fiber that expresses a three-dimensional crimp by heat treatment was subjected to needle punching at a needle density of 50 p / cm ² , and then heat-treated at 180 ° C. for 3 minutes to obtain a basis weight of 100 g / m ² . A biaxially stretchable nonwoven fabric support for patches was obtained.

Comparative Example 2 A blended web composed of 80% of polyester fiber expressing a three-dimensional crimp by heat treatment, 17% of ordinary polyester fiber, and 3% of rayon fiber was subjected to needle punching at a needle density of 50 p / cm ² . As a heat treatment at 180 ° C. for 3 minutes, a biaxially stretchable nonwoven fabric support having a basis weight of 105 g / m ² was obtained.

For each nonwoven fabric support obtained as above, 50%
Modulus and elongation recovery at 50% elongation were measured as follows.

For Examples 1 and 2 and Comparative Examples 1 and 2, the nonwoven fabric support was 50 mm ×
Take three 300mm specimens in the longitudinal direction (,,) and use a tensile strength tester to test them with a test length of 200mm and a pulling speed of 200mm.
It was stretched to 100 mm at a rate of mm / min, and the strength (kg) was measured to obtain a 50% modulus. Then return to the original position at the same speed and stretch again at the same speed. Initial length A at this time
(100 mm) and the residual elongation B (mm) were read from chart paper, and the elongation recovery rate at 50% elongation was calculated from the following equation.

The results of this invention shown in Table 1 for the product of the present invention were both elongation (50% modulus) and return after elongation (elongation recovery rate during elongation).
It turns out that it is excellent compared with the comparative example.

Example 3 Glue composition w / w% glycol salicylate 1.5 l-menthol 1.0 sodium polyacrylate (Aronbis SS) 1.0 20% aqueous solution of polyacrylic acid (julymer AC-10H) 20.0 ^{* 1} sodium carboxymethylcellulose (Daicel CMC-2100) 3.8 Glycerin 20.0 Propylene glycol 10.0 Kaolin 6.0 Polysorbate 80 1.0 Dihydroxyaluminum aminoacetate 0.06 Water Remaining 100.0 * 1) 4.0% as solid content Example 1 (Product 1 of the present invention), Example 2 (Product 2 of the present invention)
The bases of Comparative Example 1 and Comparative Example 2 were coated with the plaster of the above composition at a rate of 16 g per sheet (140 × 100 mm) and cut.

This sample was adhered to the left elbow of 10 healthy boys, and after doing push-ups 20 times, they were allowed to live normally and peeled off after 3 hours, and the content of glycol salicylate remaining in the plaster was measured, and the amount of absorption was measured. Calculated.

 The results are shown in Table-2.

As is clear from Table-2, the products 1 and 2 of the present invention are comparative examples 1 and 2.
As compared with the case of Comparative Example 1, it was excellent in elongation and return after elongation, so that it had excellent adhesion to the skin and good absorption of glycol salicylate as a medicinal ingredient.

Claims (1)

(57) [Claims] 1. A patch having a support portion and a plaster portion, wherein a heat-shrinkable fiber exhibiting a three-dimensional crimp by heat treatment is 70% by weight or more, and has a low melting point lower than the heat-shrinkable fiber. After being entangled and integrated with the fiber, the heat-shrinkable fiber that has been subjected to heat treatment at a temperature equal to or lower than the melting point of the heat-shrinkable fiber and equal to or higher than the melting point of the low-melting fiber is formed into a three-dimensional crimp with the low-melting fiber. An elastic patch, wherein the bonded elastic nonwoven fabric is used for a support.