JP2807320B2 - paste - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a paste which has, for example, an effect of making adhesion between dentures and gums good and stabilizing the mounting of a denture.

(Prior Art) Denture stabilizers using polyacrylate powder are already known (Japanese Patent Application Laid-Open No. 55-38143) (Problems to be Solved by the Invention) The denture stabilizer used has insufficient performance (ease of use) such as adhesiveness and spreadability, and polyacrylate has a high water-swelling property, and the formed water-absorbing gel flows out with a soft eye. It is difficult to say that its sticking durability is sufficient because it is easy and also shows rubber elasticity, and further improvement is desired.

(Means for Solving the Problems) Accordingly, the present inventors have conducted various studies and found that the hardness and strength of the water-absorbing gel of polyacrylate are increased, the diffusion solubility in water is controlled, and the cushioning property at the time of wearing is improved. It has been found that the formulation of a food-grade or pharmaceutically acceptable non-spinning water-soluble polymer is effective for the purpose of reducing the stickiness in the mouth and prolonging the sticking time in the mouth. Was. It was also found that the high molecular weight organic acid increased the affinity between the polyacrylate and the oil-based ointment base, and consequently had the effect of significantly increasing the adhesiveness of the paste.

The present invention has been completed based on the above findings. That is, the present invention comprises three kinds of powders each of a spinning polymer polyacrylate, a high molecular organic acid, a food-grade or pharmaceutically acceptable non-spinning water-soluble polymer, and an oily ointment base. Regarding paste.

As the polyacrylate used in the present invention, sodium salts of polyacrylic acid, alkali metal salts such as potassium salts, ammonium salts, calcium salts, aluminum salts,
Salts such as iron salts and the like having spinning properties (in the case of a 0.5% aqueous solution, having thread-drawing properties) can be mentioned, and sodium salts are preferred. In the case of salts with polyvalent metals such as calcium salts, aluminum salts and iron salts, the degree of substitution is 100
% Salt undesirably loses spinnability.
Those having a degree of substitution of about 50% or less are preferred. The polyacrylate powder has an intrinsic viscosity of 0.30 or more, more preferably 0.45 or more, and a particle size of 60 mesh (Tyler) or less.
More preferably, the size is 100 mesh or less.

As the high molecular weight organic acid, those having an aqueous solution whose pH is lower than pH 4.5 are preferably food-grade or pharmaceutically acceptable, for example, carboxyvinyl polymer, acrylic acid polymer such as polyacrylic acid, chondroitin sulfate, hyaluronic acid. Examples thereof include acidic mucopolysaccharides such as acids, alginic acid and the like, and carboxyvinyl polymers such as carbopol are preferred. The molecular weight is preferably about 10,000 or more in average molecular weight, and the particle size of the powder is 60 mesh (Tyler) or less, preferably 100 mesh or less. Also,
As a non-spinning water-soluble polymer for food use or pharmaceutically acceptable, a 0.5% aqueous solution having a pH of about 4.5 to 8.5 and showing no thread-drawing properties, such as sodium carboxymethylcellulose , Methylcellulose, cellulose ether derivatives such as hydroxypropylmethylcellulose, casein, sodium deoxyliponucleic acid, soluble starch, gum arabic, gum tragacanth, guar gum,
Examples thereof include water-soluble plant gums such as xanthan gum and polyethylene oxide, and cellulose ether derivatives such as sodium carboxymethylcellulose are preferred.
The molecular weight is preferably about 10,000 or more in average molecular weight.
The particle size of the powder is preferably 60 mesh (Tyler) or less, more preferably 100 mesh or less, and one or two or more of these are used together with the polyacrylate salt powder. As the base of the oily ointment, for example, vaseline, plastibase (manufactured by Plasutibase Squibb), liquid paraffin and the like are preferable, and a mixture of vegetable oil and beeswax is also used. If necessary, medicinal ingredients such as anti-inflammatory agents and antibiotics and various surfactants may be appropriately added.

The proportion of each component in the paste denture stabilizer of the present invention,
Polyacrylate powder is about 20-65 W / W%, more preferably about 30-55 W / W%, high molecular organic acid is about 1-25 W / W%, more preferably about 2-20 W / W%, About 2 to 40 W / W% of a non-spinning water-soluble polymer powder for food use or pharmaceutically acceptable,
More preferably, about 5 to 30 W / W%, and more preferably about 6
5 to 10 W / W%, more preferably about 60 to 20 W / W% is good.

(Effects of the Invention) Adhesive strength, wet adhesive strength, sticking persistence and spreadability of the paste-like denture stabilizer according to the present invention described in the Examples and Comparative Examples (combined products of PANA alone and commercial products) were observed.

1. Experimental method i. Measurement of adhesive strength A 0.5 ml paste-like denture stabilizer was placed on the lower movable methacrylic plate of a rheometer (manufactured by Fudosan Co., Ltd.), and the tip of a stainless steel spindle fixed to the machine Adhesive treatment of denture resin plate Supporting disk (1.5cm diameter) by hand
Press strongly for 2 seconds and let it stand for 2 minutes. Next, move the lower movable methacryl plate downward at a speed of 2 cm / min,
At this time, the value of the resistance (g: adhesive force) displayed on the meter is read.

ii. Measurement of wet adhesive strength 0.5 ml of paste denture stabilizer was placed on the lower movable methacrylic plate of a rheometer (manufactured by FUJI KOGYO CO., LTD.), and 1 ml of water was added with a microsyringe and mixed. Let water absorb. After leaving it for 5 minutes, it is measured according to the measurement of adhesive strength.

iii. Observation of adhesive persistence Three people wearing complete dentures alternately use the paste denture stabilizer of the present invention and a commercial product to determine the persistence of adhesiveness, that is, the persistence of denture stabilization. Compared. The evaluation was made when the product of the present invention was found to be very good compared to the commercial product.
There were five levels: 2, good +1, equivalent 0, bad -1, and very bad -2.

iv. Measurement of Spreadability 0.5 ml (1 cm ² × 0.5 cm) of paste denture stabilizer was set on the scale plate of a spread meter (manufactured by Rigosha Co., Ltd.), and a 263 g glass plate was gently placed on top of the spreader. Measure the diameter (cm).

2. Experimental results The results are shown in Table 1. In addition, each component in the table was described by the following abbreviations.

PANA: sodium polyacrylate, Al: alginic acid, CP:
Carbopol 940, CNC: sodium carboxymethylcellulose, SS: soluble starch, ZG: xanthan gum, GG: guar gum, HPM hydroxypropyl methylcellulose, PB:
Plastibase 50W, PA: liquid paraffin, As is clear from this table, the paste denture stabilizer of the present invention is a paste denture stabilizer (sample of No. 13 of JP-A-55-38143) containing only polyacrylate powder as a tackifier. It has been confirmed that the adhesive strength and the wet adhesive strength are both stronger than those of the product, and that the effect lasts, so that the denture can be stably fixed locally. Further, it is desirable that the paste is prepared so as to be easily extruded from the ointment tube, easily applied to the denture, and hardly protruded from between the denture and the installation site in the oral cavity.In this case, the spreadability value is 2.
It is almost satisfied in the range of 0 to 2.5. 2.1 of the product of the present invention
Comparative Example 1 was 1.6, compared with -2.3, indicating an unsatisfactory tendency. The product of the present invention was easy to wash off.

Example 1 Using a grinder, 45 parts of Plastibase 50W and 4 parts of carboxyvir polymer (Carbopol 940) are kneaded sufficiently and uniformly, and then 10 parts of sodium carboxymethylcellulose (Cellogen HP-3HS) is added and kneaded. Further, 41 parts of sodium polyacrylate powder having an intrinsic viscosity of 0.86 (2N-NaOH) and a particle size of 200 mesh is added and kneaded sufficiently uniformly, and then filled into a tube for ointment.

Example 2 Using a crusher, 40 parts of Plastibase 50W, 5 parts of liquid paraffin and a carboxyvir polymer (Carbopol 94)
0) 4 parts were uniformly kneaded, and then 20 parts of sodium carboxymethylcellulose (Selogen HP-3HS) was added and kneaded. The intrinsic viscosity was 0.86 (2N-NaOH) and the particle size was
200 mesh sodium polyacrylate powder 31
After adding the parts and kneading sufficiently uniformly, the mixture is filled into a tube for ointment.

Example 3 Using a screw kneader, 47 parts of Plastibase 50W and 4 parts of carboxyvir polymer (Carbopol 940) are kneaded sufficiently uniformly, and then kneaded by adding 19 parts of sodium carboxymethylcellulose (Cellogen HP-3HS). And
Further, 30 parts of sodium polyacrylate powder having an intrinsic viscosity value of 0.86 (2N-NaOH) and a particle size of 200 mesh is added and kneaded sufficiently uniformly, and then filled into a tube for ointment.

Example 4 Using a crusher, 45 parts of Plastibase 50W and 4 parts of carboxyvir polymer (Carbopol 940) are kneaded sufficiently uniformly, and then 1 part of sodium carboxymethylcellulose (Cellogen HP-3HS) is added and kneaded. In this case, 50 parts of sodium polyacrylate powder having an intrinsic viscosity value of 0.86 (2N-NaOH) and a particle size of 200 mesh are added and kneaded sufficiently uniformly, and then filled into a tube for ointment.

Example 5 A composition consisting of 45 parts of Plastibase 50W, 10 parts of alginic acid, and 45 parts of powder of sodium polyacrylate having an intrinsic viscosity of 0.86 (2N-NaOH) and a particle size of 200 mesh was treated in the same manner as in Example 1. Products.

Example 6 A composition comprising 45 parts of Plastibase 50W, 5 parts of alginic acid, 4 parts of intrinsic viscosity of 0.86 (2N-NaOH) and 4 parts of Carbopol 940) and 46 parts of powder of sodium polyacrylate having a particle size of 200 mesh throughout was carried out. The product is processed in the same manner as in Example 1.

Example 7 45 parts of Plastibase 50W, 10 parts of soluble starch, 4 parts of Carbopol 940, intrinsic viscosity value of 0.86 (2N-NaOH) and particle size of 2
A composition comprising 41 parts of sodium polyacrylate powder throughout the 00 mesh was treated in the same manner as in Example 1 to obtain a product.

Example 8 45 parts of Plastibase 50W, 10 parts of Zankan gum, 4 parts of Carbopol 940, powder of sodium polyacrylate 4 having an intrinsic viscosity of 0.86 (2N-NaOH) and a particle size of 200 mesh throughout
The composition consisting of 1 part is treated in the same manner as in Example 1 to obtain a product.

Example 9 45 parts of Plastibase 50W, 10 parts of hydroxypropylcellulose, 4 parts of Carbopol 940, intrinsic viscosity value of 0.86 (2
N-NaOH), a composition comprising 41 parts of sodium polyacrylate powder having a particle size of 200 mesh throughout was treated in the same manner as in Example 1 to obtain a product.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-2-196705 (JP, A) JP-A-2-200624 (JP, A) JP-A-63-77806 (JP, A) JP-A-55-1979 38143 (JP, A) JP-A-61-87608 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 6/00

Claims (1)

(57) [Claims] 1. A paste comprising a spinning polymer polyacrylate powder, a polymer organic acid powder, a non-spinning water-soluble polymer powder for food use or pharmaceutically acceptable, and an oily ointment base.