JP2807331B2 - Denture fixing adhesive - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial application field) The present invention provides, for example, an adhesive for fixing a denture, which has an effect of improving the adhesive fit between a denture and gums and stabilizing the fixation of a denture. It is about.

(Prior Art) A denture fixing adhesive using natural polymer powder such as karaya rubber, natural polymer derivative powder such as carboxymethyl cellulose, or synthetic polymer powder such as polyethylene oxide or polyacrylate has been devised.

(Problems to be Solved by the Invention) However, in the case of powders such as natural polymers such as karaya gum, natural polymer derivatives such as carboxymethylcellulose, and synthetic polymers such as polyethylene oxide and polyacrylate, tackiness and durability are poor. Insufficient. For example, in a denture fixation adhesive containing only polyacrylate powder, the polyacrylate has high water-swelling property, and the formed water-absorbing gel also shows rubber elasticity with a soft eye, so that the adhesion persistence is sufficient. It is hard to say. Also, the polyacrylate is dissolved
Because the pH is alkaline, low-molecular-weight organic or inorganic acids have been added to adjust the pH. However, salty taste, stickiness in the oral cavity, reduced stickiness, etc. It is still insufficient, and further improvement is desired.

(Means for Solving the Problems) The present inventors have conducted various studies and found that the hardness and strength of the water-absorbing gel were increased, the solubility in water was controlled, the cushioning property at the time of wearing was moderate, and the oral cavity was further improved. It has been found that the formulation of a non-spinning polymer that is food-grade or pharmaceutically acceptable is effective for alleviating the stickiness in the inside and prolonging the sticking time. The polyacrylate aqueous solution is usually 9 to 10
The pH value is shown.At this time, the pH can be lowered by blending a low molecular acid.However, only the acid is dissolved first in the oral cavity and partially neutralized. Inconveniences such as feeling and a feeling of neutralization were found. Thus, as a result of various studies, the present inventors have found that since the dissolution rate of the high-molecular organic acid is lower than that of the low-molecular compound, these disadvantages can be avoided and the pH can be adjusted appropriately. It is also important to note that the high molecular weight organic acid exerts its own tackiness without reducing the tackiness of the polyacrylate and has the effect of significantly increasing the tackiness between the denture and the gum. Was done.

The present invention has been completed on the basis of the above findings, and relates to a denture fixing adhesive having excellent tackiness and durability, an appropriate pH at the time of dissolution, and a good feeling in use. That is, the present invention relates to a powdery bed comprising three types of powders of spinnable polymer polyacrylate powder, high molecular weight organic acid powder and non-spinning polymer for food use or pharmaceutically acceptable. The present invention relates to a denture fixing adhesive.

As the polyacrylate used in the present invention, sodium salts of polyacrylic acid, alkali metal salts such as potassium salts, ammonium salts, calcium salts, aluminum salts,
Salts such as iron salts and the like having spinnability (having a thread-drawing property when prepared as a 0.5% aqueous solution) are exemplified, and sodium salts are preferred. In the case of salts with polyvalent metals such as calcium salts, alkynium salts and iron salts, the degree of substitution is 100
% Salt undesirably loses spinnability.
Those having a degree of substitution of about 50% or less are preferred. The polyacrylate powder has an ultimate particle size value of preferably 0.30 or more.
The particle size should be 50 g / or more, and the particle size should be 100 mesh (Tyler) or less, more preferably 200 mesh or less.

As the high molecular weight organic acid, those having an aqueous solution whose pH is lower than pH 4.5 are preferably food-grade or pharmaceutically acceptable, for example, carboxyvinyl polymer, acrylic acid polymer such as polyacrylic acid, chondroitin sulfate, hyaluronic acid. Examples thereof include acidic mucopolysaccharides such as acids, alginic acid and the like, and carboxyvinyl polymers such as carbopol are preferred. Further, the molecular weight is preferably about 10,000 or more in average molecular weight, and the particle size of the powder is 100 mesh (Tyler) or less, preferably 200 mesh or less.

Further, as the non-spinning water-soluble polymer for food or pharmaceutically acceptable, for example, carboxymethylcellulose sodium, methylcellulose, cellulose ether derivatives such as hydroxypropylmethylcellulose, casein,
Examples include water-soluble plant gums such as sodium deoxyliponucleic acid, soluble starch, gum arabic, gum tragacanth, guar gum, and xanthan gum, and polyethylene oxide. Cellulose ether derivatives such as sodium carboxymethylcellulose are preferred. Further, the molecular weight is preferably about 10,000 or more in average molecular weight.
A mesh of 0 mesh (Tyler) or less, more preferably 200 mesh or less is good. A single or two or more of these are selected and used in combination with a polyacrylate powder.

The proportion of each component in the denture fixing adhesive of the present invention is preferably about 20 to 95 W / W%, more preferably about 60 to 80 W / W%, for the powder of the polyacrylate, and about 60 to 80 W / W% for the powder of the high molecular organic acid. 2-40W / W%,
More preferably, about 4 to 20 W / W%, and the powder of the non-spinnable polymer for food or pharmaceutically acceptable is about 4 to 60 W / W%, more preferably about 10 to 25 W / W%. . In addition, the denture fixing adhesive of the present invention may optionally contain a fragrance or other additives as long as the adhesiveness is not impaired.

(Effects of the Invention) Adhesive strength, sticking persistence, and feeling of use were observed for the denture fixing adhesive according to the present invention described in the examples and the comparative examples (PANA alone and commercial products).

1. Experimental method i. Measurement of adhesive strength Place 0.3 g of the denture fixing adhesive on the lower movable methacrylic plate of a rheometer (manufactured by Fujitsu Industries Co., Ltd.)
Add 1.0 ml with a microsyringe and mix thoroughly to absorb water. After standing for 10 minutes, this is strongly pressed by hand against a denture resin plate-adhering support disk (1.5 cm in diameter) on the end of a stainless steel spindle fixed to the machine for 15 seconds, and allowed to stand for 2 minutes. Next, the lower movable methacrylic plate is 2cm /
It moves downward at a speed of one minute, and at this time, the value of the resistance effect (g: that is, adhesive force) displayed on the meter is read.

ii. Observation of stickiness persistence Five people wearing complete dentures alternately use powdered denture fixation adhesives of the present invention and commercial products to maintain stickiness, that is, persistence of denture stabilization Were compared. The evaluation was made when the product of the present invention was found to be very good compared to the commercial product.
There were five levels: 2, good +1, equivalent 0, bad -1, and very bad -2.

iii. Observation of feeling of use Five people wearing complete dentures alternately use the powdered denture fixing adhesive of the present invention and a commercially available product, and have a feeling of use, ie, stickiness, saltiness, and roughness in the oral cavity. The feeling of discomfort such as cushioning and the feeling of use during meals were compared. The evaluation was +2 when the product of the present invention was found to be very good compared to the commercial product,
Good +1, equivalent 0, bad -1, very bad-
There were five stages of 2.

2. Experimental results The results are shown in Table 1. In addition, each component in the table was described by the following abbreviations.

PANA: sodium polyacrylate, R: malic acid, CP: carbopol 940, CMC: sodium carboxymethylcellulose, SS: soluble starch, PEO: polyethylene oxide, KG: karaya gum.

As is clear from this table, the powder denture fixing adhesive of the present invention is a powder denture fixing adhesive containing only polyacrylic acid powder or a high molecular weight organic acid as a tackifier, or a commercially available product. It was confirmed that the denture could be stably fixed locally because the adhesive force was stronger and the effect lasted. In addition, it was confirmed that there was no discomfort at the time of use and that the use feeling during meals was good.

Example 1. Using a mixer, the limiting viscosity value was 0.89 g / (2N-NaO
H), 75 parts of powder of sodium polyacrylate having a particle size of 200 mesh, 18 parts of sodium carboxymethylcellulose (Selogen HP-3HS) and 7 parts of carboxyvinyl polymer (Carbopol 940) are added, and mixed sufficiently uniformly.
Products.

Example 2. Using a mixer, the limiting viscosity value was 0.89 g / (2N-NaO
H), 60 parts of sodium polyacrylate powder having a particle size of 200 mesh throughout are added with 33 parts of sodium carboxymethylcellulose (Selogen HP-3HS) and 7 parts of carboxyvinyl polymer (Carbopol 940), and mixed sufficiently uniformly.
Products.

Example 3. Using a mixer, the limiting viscosity value was 0.89 g / (2N-NaO
H), Add 64 parts of sodium polyacrylate powder having a particle size of 200 mesh, 18 parts of sodium carboxymethylcellulose (Selogen HP-3HS) and 18 parts of carboxyvinyl polymer (Carbopol 940), and mix thoroughly.
Products.

Example 4. Using a mixer, the limiting viscosity value was 0.89 g / (2N-NaO
H) Add 49 parts of sodium polyacrylate powder having a particle size of 200 mesh, 17 parts of sodium carboxymethylcellulose (Selogen HP-3HS), 17 parts of soluble starch, and 17 parts of carboxyvinyl polymer (Carbopol 940). Mix evenly to form a product.

Example 5. Using a mixer, the limiting viscosity value was 0.89 g / (2N-NaO
H), add 78 parts of powder of sodium polyacrylate having a particle size of 200 mesh, 18 parts of sodium carboxymethylcellulose (Selogen HP-3HS) and 4 parts of carboxyvinyl polymer (Carbopol 940), and mix thoroughly.
Products.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-4-95006 (JP, A) JP-A-2-196705 (JP, A) JP-A-2-200624 (JP, A) JP-A-63-1988 77806 (JP, A) JP-A-61-87608 (JP, A) JP-A-55-38143 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 6/00

Claims (1)

(57) [Claims] 1. A powdery denture fixing adhesive comprising a spinnable polymer polyacrylate powder, a high molecular weight organic acid powder and a non-spinnable polymer powder for food use or pharmaceutically acceptable.