JP2926352B2 - How to treat cows with no or no estrus - Google Patents
How to treat cows with no or no estrusInfo
- Publication number
- JP2926352B2 JP2926352B2 JP2123166A JP12316690A JP2926352B2 JP 2926352 B2 JP2926352 B2 JP 2926352B2 JP 2123166 A JP2123166 A JP 2123166A JP 12316690 A JP12316690 A JP 12316690A JP 2926352 B2 JP2926352 B2 JP 2926352B2
- Authority
- JP
- Japan
- Prior art keywords
- estrus
- methionine
- days
- rumen
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000012173 estrus Effects 0.000 title claims description 20
- 241000283690 Bos taurus Species 0.000 title description 20
- 229930182817 methionine Natural products 0.000 claims description 19
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 17
- 210000004767 rumen Anatomy 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 5
- 235000006109 methionine Nutrition 0.000 description 18
- 229960004452 methionine Drugs 0.000 description 17
- 230000009027 insemination Effects 0.000 description 11
- 238000001647 drug administration Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000001850 reproductive effect Effects 0.000 description 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000004470 DL Methionine Substances 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 241000282849 Ruminantia Species 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- CKEQIHCSVXGCGD-WCCKRBBISA-N (2s)-2-amino-4-methylsulfanylbutanoic acid;2-hydroxy-4-methylsulfanylbutanoic acid Chemical compound CSCC[C@H](N)C(O)=O.CSCCC(O)C(O)=O CKEQIHCSVXGCGD-WCCKRBBISA-N 0.000 description 1
- 208000010711 Cattle disease Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 210000003165 abomasum Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- -1 aroyl methionine Chemical compound 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000022676 rumination Effects 0.000 description 1
- 208000015212 rumination disease Diseases 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は無発情または鈍性発情牛の治療方法に係わ
り、さらに詳しくはルーメンバイパスするメチオニンを
給与することによる無発情または鈍性発情牛の治療方法
に関する。Description: FIELD OF THE INVENTION The present invention relates to a method of treating anestrous or dull estrus cattle, and more particularly, to the treatment of anestrous or dull estrus cattle by feeding methionine to bypass the rumen. Regarding treatment methods.
牛の疾病の一つに繁殖障害がある。症状としては主に
卵巣静止、卵巣に黄体や卵胞が触知できても発情の外部
徴候が認められないといった無発情または鈍性発情であ
り、分娩後50〜90日頃に多発し、これらの牛は多くの場
合分娩後100日以上すると自然に発情が回帰するが、回
帰しないものもある。この繁殖障害に対してはビタミン
剤、ホルモン剤による治療が行われているが必ずしも充
分な効果が得られるわけではなく、廃用にされることが
少なくない。One of the cattle diseases is reproductive disorders. Symptoms are mainly oestrus or dull estrus, with no external signs of estrus even though the ovary can be palpated with the corpus luteum or follicles.The symptoms occur frequently about 50 to 90 days after parturition. In many cases, estrus returns spontaneously after 100 days of delivery, but some do not. The reproductive disorders are treated with vitamins and hormonal agents, but they do not always provide sufficient effects and are often abolished.
今までに、メチオニンを用いた繁殖障害の治療試験の
報告例として、DL-メチオニン単独、又はＬ−リジンとD
L−メチオニンの1:2の混合物を繁殖障害の治療に試みた
例があるが（家畜診療、第206号、第27〜34頁（1980
年）及び同、第217号、第39〜41頁（1981年））、DL−
メチオニン単独使用については効果の記載はなく、Ｌ−
リジンとDL−メチオニンの1:2の混合物を使用した場合
でも必ずしも90％以上発情するわけではなく充分な効果
があったとは言えない。To date, reports on treatment tests for reproductive disorders using methionine include DL-methionine alone, L-lysine and D-lysine.
There has been an attempt to use a 1: 2 mixture of L-methionine to treat reproductive disorders (Livestock Medicine, No. 206, pp. 27-34 (1980).
No. 217, pp. 39-41 (1981)), DL-
No effect was described for methionine alone, and L-
Even when a 1: 2 mixture of lysine and DL-methionine is used, estrus does not necessarily reach 90% or more, and it cannot be said that a sufficient effect was obtained.
一方、アミノ酸、タンパク質等の生物学的活性物質を
反芻動物に経口投与した場合、反芻動物の第１胃の胃液
に存在する微生物により分解され、そのまま吸収される
ことはないので、これらの生物学的活性物質を効率よく
吸収させることを目的として、生物学的活性物質を油脂
等の第１胃胃液に対して安定な物質で被覆保護し、第４
胃以降の消化器官で生物学的活性物質を放出させる反芻
動物用飼料添加剤（以下ルーメンバイパス製剤と記す）
が種々提案されており（特開昭56−154956号公報、特開
昭61−151133号公報等参照）、本発明の出願人もメチオ
ニンを、硬化油等にその第４胃以降の消化器官における
崩壊性を付与する目的でキトサンを加えた保護物質で被
覆保護した製剤を提案し（特開昭58−175449号公報、特
開昭59−198946号公報参照）、ラクテット の名称で上
市している。しかし、このラクテット は健康な牛に給
与し産乳量の増加等の効果を狙ったものであり、ラクテ
ット で病気の牛を治療したという報告はない。 On the other hand, biologically active substances such as amino acids and proteins
When administered orally to ruminants, rumen gastric fluid from ruminants
Decomposed by microorganisms present in
So that these biologically active substances can be efficiently
For the purpose of absorption, the biologically active substance
Protecting the stomach with a stable substance against gastric juice
Rumination releasing biologically active substances in the digestive tract after the stomach
Animal feed additive (hereinafter referred to as rumen bypass preparation)
Have been proposed (JP-A-56-155496,
And the applicant of the present invention has
Nin is converted to hydrogenated oil, etc. in the digestive tract after the abomasum.
Protected with chitosan added to provide disintegration
We have proposed a protected formulation (JP-A-58-175449,
JP-A-59-198946), Lactet On the name of
Has a city. But this lactet Feeds a healthy cow
To increase milk production
To There are no reports of treating sick cows in the country.
本発明は、従来の技術の有する前記問題点を鑑みてな
されたものであり、安全、容易で効果的な、無発情また
は鈍性発情牛の治療方法を提供することを目的とする。The present invention has been made in view of the above-mentioned problems of the related art, and has as its object to provide a safe, easy, and effective method for treating anestrous or dull estrus cattle.
上記目的を達成するために本発明者等は鋭意研究した
結果、無発情または鈍性発情牛にルーメンバイパスする
メチオニンを給与すると効果的に治療されることを見出
し本発明を完成するに到った。In order to achieve the above object, the present inventors have conducted intensive studies, and as a result, they found that it was effective to supply methionine that bypasses the rumen to anestrous or dull estrus cattle, and completed the present invention. .
本発明は、ルーメンバイパスするメチオニンを給与す
ることを特徴とする無発情または鈍性発情牛の治療方法
である。The present invention relates to a method for treating anestrous or blunt estrus cattle, which comprises supplying methionine which bypasses the rumen.
本発明で用いられるルーメンバイパスするメチオニン
は、前記したルーメンバイパス製剤のうち、牛の第１胃
（ルーメン）の胃液から保護され、第４胃以降で消化吸
収されメチオニンとしての活性を示すようにしたルーメ
ンバイパス製剤である。例えば、メチオニン、Ｎ−ステ
アロイルメチオニンのようなメチオニン誘導体又はその
塩、２−ヒドロキシ−４−メチルメルカプト酪酸のよう
なメチオニン同族化合物又はその塩を油脂、脂肪酸又は
その塩等で保護した製剤であり、例えば前記ラクテット
（日本曹達株式会社製）が挙げられる。 Rumen bypass methionine used in the present invention
Is the rumen of cattle,
(Rumen) is protected from gastric juice,
Lume collected to show activity as methionine
It is a bypass preparation. For example, methionine, N-
Methionine derivatives such as aroyl methionine or the like
Salt, such as 2-hydroxy-4-methylmercaptobutyric acid
Methionine homologous compounds or salts thereof, fats and oils, fatty acids or
Preparations protected with salts and the like, for example, the lactet
(Manufactured by Nippon Soda Co., Ltd.).
このルーメンバイパスするメチオニンの牛への給与
は、分娩後50日以上経過しても無発情または微弱発情で
人工授精を行えない牛に１週間〜１箇月間好ましくは10
〜20日間給与するが、メチオニンは単なるアミノ酸であ
るのでそれ以上給与してもよい。The methionine that bypasses the rumen should be fed to cows that cannot undergo artificial insemination due to no or weak estrus even after 50 days or more, preferably 10 to 10 months.
It is given for 2020 days, but methionine is a mere amino acid and may be given more.
ルーメンバイパスするメチオニンの牛への給与は、通
常エサに添加して行い、その給与量は、メチオニンのル
ーメンをバイパスする程度、牛の状態等により異なる
が、通常１日にメチオニンの量として10〜50g給与す
る。The supply of methionine to the cows to bypass the rumen is usually performed by adding it to the food, and the amount of the supply varies depending on the degree of bypass of the methionine rumen and the condition of the cow. Pay 50g.
また本発明は栄養物を牛に給与するのであるから他の
薬剤とも安心して併用することができる。In addition, since the present invention supplies nutrients to cattle, it can be used safely with other drugs.
本発明を、実施例により更に詳細に説明する。ただ
し、本発明の範囲は、以下の実施例により何等の制限を
受けるものではない。The present invention will be described in more detail by way of examples. However, the scope of the present invention is not limited by the following examples.
北海道十勝支庁管内４町の農家で飼養され分娩後50日
以上経過しても無発情又は微弱白状で人工授精を行えな
いホルスタイン種乳牛で子宮などに感染症のない供試牛
をランダムに４群に分け、ルーメンバイパスするメチオ
ニンの製剤であるラクテット （日本曹達株式会社製、
製剤100g中にメチオニンを30g含有し、牛脂硬化油等で
メチオニンを保護している、以下RB−Metと記す）を１
日１頭あたり50g、100g、150g又は比較例として牛脂硬
化油100gを20日間飼料に混合、投与し、その後の人工授
精状況等を調査した。またRB−Metを１日１頭あたり100
gを10日間投与した場合の人工授精状況等の調査もし
た。供試牛は、分娩後170日を越えている牛及び卵巣の
う種と診断された牛を除いた104頭で、各群の頭数、分
娩から薬剤（又は牛脂硬化油）投与開始までの平均日
数、薬剤投与開始から人工授精までの平均日数及び薬剤
投与開始から受胎するまでの平均日数を第１表に示し
た。 50 days after delivery, bred by farmers in four towns in the Tokachi branch of Hokkaido
Even after the above, artificial insemination could not be performed with no estrus or faint whiteness
Test cow with no infectious diseases such as uterus
Is randomly divided into four groups, and the lumen bypass
Lactet, a formulation of Nin (Nippon Soda Co., Ltd.
Contains 30 g of methionine in 100 g of preparation,
Protecting methionine, hereinafter referred to as RB-Met)
50g, 100g, 150g per head per day or tallow as a comparative example
100 g of oil for oil mixing and administration for 20 days.
We investigated the situation. 100 RB-Met per day
Investigation into the status of artificial insemination when g was administered for 10 days
Was. The test cows are cattle and ovaries that have been
104 cows excluding cattle diagnosed as slaughter
Average day from delivery to the start of drug (or tallow hardened oil) administration
Number, average number of days from start of drug administration to artificial insemination and drug
Table 1 shows the average number of days from the start of administration to conception.
Was.
また、各群の薬剤投与開始後の日数と初回人工授精実
施率との関係を第１図に示した。FIG. 1 shows the relationship between the number of days after the start of drug administration and the rate of initial artificial insemination in each group.
第１表に示すように分娩から薬剤投与開始までの日数
は各群とも平均70〜80日と大きな差はないが、薬剤投与
開始から初回人工授精までの日数は実施例がいずれも比
較例より短く標準偏差も小さい傾向が認められ、薬剤投
与開始から受胎するまでの日数では実施例がいずれも比
較例より短い傾向が認められた。 As shown in Table 1, the number of days from delivery to the start of drug administration was not significantly different from the average of 70 to 80 days in each group, but the number of days from the start of drug administration to the first artificial insemination was greater in the Examples than in the Comparative Examples Shorter standard deviations tended to be shorter, and the number of days from the start of drug administration to conception was shorter in all Examples than in Comparative Examples.
また、第１図に示すように、RB−Metを150g×20日投
与した群では薬剤投与開始後20日及び30日の人工授精実
施率が77.7％及び94.4％であり、比較例のそれと比べて
有意に高かった（それぞれＰ＜0.05）。60日目には実施
例はいずれも94.4％〜100％の人工授精率となった。In addition, as shown in FIG. 1, in the group administered with 150 g of RB-Met for 20 days, the artificial insemination rates on the 20th and 30th days after the start of the drug administration were 77.7% and 94.4%, which were compared with those of the comparative example. Significantly higher (P <0.05 each). On the 60th day, all of the examples had artificial insemination rates of 94.4% to 100%.
無発情または鈍性発情牛に対して本発明を施したとこ
ろ、人工授精までの日数及び受胎までの日数が短くなる
傾向があり、薬剤投与開始後60日目には94.4％以上の牛
に人工授精が実施できたことは本発明が有効であったこ
とを示している。When the present invention was applied to non-estrus or dull estrus cattle, the number of days until artificial insemination and the number of days before conception tended to be shorter. The fact that insemination could be performed indicates that the present invention was effective.
本発明によれば、栄養素の一つであるメチオニンまた
はその同族体を含有する製剤を飼料に混合するだけで、
容易、安全でありながら効果的に無発情または鈍性発情
牛の発情を誘起、受胎させることができる。このことは
農家にとって有効な手段であり、本発明の畜産分野を始
めとする産業上の意義は極めて大きい。According to the present invention, a formulation containing one of the nutrients, methionine or a homolog thereof, is simply mixed into the feed,
It is easy, safe, and effective for inducing and conception of estrus in non-estrus or dull estrus cows. This is an effective means for the farmer, and the industrial significance of the present invention including the livestock field is extremely large.
第１図は実施例及び比較例の薬剤投与開始後の日数と初
回人工授精実施率との関係を示す折れ線グラフである。
ただし、図中の各折れ線と実施例、比較例の関係は次の
通りである。 FIG. 1 is a line graph showing the relationship between the number of days after the start of drug administration and the rate of initial artificial insemination in Examples and Comparative Examples.
However, the relationship between each polygonal line in the figure and the examples and comparative examples is as follows.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) A01K 31/195,67/02 A23K 1/16 ＣＡ（ＳＴＮ)──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. 6 , DB name) A01K 31 / 195,67 / 02 A23K 1/16 CA (STN)
Claims (1)
ることを特徴とする無発情または鈍性発情牛の治療方法1. A method for treating estrus or blunt estrus comprising feeding methionine to bypass the rumen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2123166A JP2926352B2 (en) | 1990-05-15 | 1990-05-15 | How to treat cows with no or no estrus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2123166A JP2926352B2 (en) | 1990-05-15 | 1990-05-15 | How to treat cows with no or no estrus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0421631A JPH0421631A (en) | 1992-01-24 |
| JP2926352B2 true JP2926352B2 (en) | 1999-07-28 |
Family
ID=14853821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2123166A Expired - Lifetime JP2926352B2 (en) | 1990-05-15 | 1990-05-15 | How to treat cows with no or no estrus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2926352B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006055470A1 (en) * | 2006-11-24 | 2008-05-29 | Evonik Degussa Gmbh | Ketomethionine ketals and their derivatives |
-
1990
- 1990-05-15 JP JP2123166A patent/JP2926352B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0421631A (en) | 1992-01-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60212964T2 (en) | COMPOSITIONS FOR THE TREATMENT OF ANIMAL DISEASES AND SYNDROMES WITH TRANSFER FACTOR | |
| MacAllister et al. | Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial | |
| JP2926352B2 (en) | How to treat cows with no or no estrus | |
| RU2694572C1 (en) | Method for increasing intensity of growth and preservation of newborn calves | |
| JP2001211781A (en) | Method for preventing reproductive disorders in cattle and feed composition used for the method | |
| DE3527356A1 (en) | METHOD FOR IMPROVING THE FERTILITY OF PETS | |
| RU2085074C1 (en) | Method for prophylaxis, normalization and therapy of metabolic disturbances and diseases of young cattle | |
| Abdelhakiem et al. | Milk-sucking in Cows and Buffaloes of Egyptian Western Area with Special Reference to the Outcome of Treatment | |
| Sutherland et al. | Effect of a buccal meloxicam formulation on the behavioural response to ring castration of calves | |
| US20240261320A1 (en) | Therapeutic method of using a veterinary supplement composition to prevent the onset of horse colic | |
| RU2404728C1 (en) | Method for increasing overall resistance of organism, prophylactics and treatment of respiratory, gastrointestinal and gynaecological diseases, prophylactics of embryonic mortality in animals and medicinal agent for its realisation | |
| JPH06319466A (en) | Method for inducing bovine estrus capable of performing artificial fertilization and raising conception rate and pharmaceutical preparation | |
| US20250262180A1 (en) | Fatty acid compositions | |
| Bailey | Bloat in cattle and sheep | |
| RU2026067C1 (en) | Method for treating cattle stock demodecosis | |
| Khalikov et al. | Effectiveness of Eleovit Preparation with Tissue Preparations in Calves | |
| Cooper et al. | Veterinary uses of prostaglandins | |
| RU2070389C1 (en) | Cow reproductive ability regulation method | |
| JP2932400B2 (en) | Livestock urolithiasis preventive and remedy | |
| Henry et al. | Surgical approach to the equine brachial plexus | |
| UA39443U (en) | Nanopreparation of broad therapeutic range for treating diseases of cattle and fowl | |
| SU1625490A1 (en) | Preparation for preventing hypotrophy of piglets | |
| Nay et al. | Swine First Aid, Basic Care, and Common Diseases in Show Hogs, Flip Booklet | |
| Stevenson | Recent Progress in Veterinary Medecine | |
| Seiden et al. | Livestock health encyclopedia |