JP2932400B2 - Livestock urolithiasis preventive and remedy - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a preventive and therapeutic agent for veterinary urolithiasis.

(Conventional technology) The occurrence of urolithiasis in fattening cattle has been seen sporadically since 1954, and has become frequent since the 1970s.

The possible causes are labor saving in breeding management and intensive feeding of concentrated feed. In general, it occurs frequently in winter when roughage is insufficient and water consumption is reduced. Urolithiasis was usually reported to occur frequently at the end of fattening in steers of 18-30 months of age in bulls.
The incidence of 6-month-old young cows is high, and the age difference in urolithiasis has disappeared.

As the treatment method, alone or vitamin A and ammonium chloride, a method of administering the admixture of vitamin D ₃ has been put into practical use, there is a variation in the effect by nature and composition of stones.

In addition, removal of a calculus by a surgical operation leads to a decrease in productivity and a high possibility of recurrence, which is not a suitable treatment method. There is an urgent need for fattening farmers to establish a treatment and prevention method for urolithiasis in order to cultivate international competitiveness, improve productivity and meat quality, and run a stable business.

Further, similar problems occur in dairy cows, pigs, dogs, cats, etc. in addition to fattening cows.

(Problems to be solved by the invention) An object of the present invention is to provide an ammonium chloride agent, vitamin A,
The problems solved regarding admixtures or surgery and vitamin D _3, to provide a more effective veterinary urolithiasis preventing or treating agent.

(Means for Solving the Problems) The present invention is a preventive and therapeutic agent for veterinary urolithiasis, which comprises ammonium chloride and urajirogashi extract as main components.

Urolithiasis in fattening cattle is difficult to urinate because calculi are formed in the kidneys and bladder due to high feeding of concentrated feed and a decrease in the calcium-to-phosphorus ratio in the feed, and they remain in the urethra as they flow out. Symptoms such as loss of appetite and loss of energy, and death or disuse due to uremia. The discovery is based on the adhesion of calculus to the pubic hair, the presence of dryness or inflammation, and the like.

In the present invention, the mixture of ammonium chloride and Virginia oak extract may further include salt, vitamin A, vitamin
It can contain D ₃ , calcium and various diuretics. The mixture in the present invention may be in the form of powders, powders, granules, tablets or the like in various dosage forms depending on the use, and these may be administered directly or mixed with drinking water or feed.

When used as a therapeutic agent, the mixture is administered for 1 to 10 days as 1 to 100 g of ammonium chloride per day and 1 to 100 g of urajirogashi extract per head by the first or middle stage showing the above-mentioned symptoms. Administer. Further, it is preferable to administer the mixture so that the dosage is 10 to 50 g as ammonium chloride and 2 to 30 g as urajirogashi extract per animal per day. In addition, when used as a prophylactic agent, even if one animal is diagnosed with urolithiasis or presents its symptoms, there is a possibility of multiple occurrence in the group, so 0.5 to 20 g of ammonium chloride per animal per day, Continuously administer 0.1 to 10 g of the mixture as Vladivostalis extract. Furthermore, it is 4 ~
It is preferable to administer the mixture so as to give a dose of 10 g, 0.2 to 5 g as a vulgaris extract.

REFERENCE EXAMPLE Preparation of Vulgaris extract Extract of dried twigs of Vulvulcus is roughly cut off, leached by adding water, the leachate is filtered, and the filtrate is concentrated under reduced pressure and dried by spraying to obtain a powder extract.

Formulation example Ammonium chloride 40 g Virgin oak extract 20 g Starch 40 g are mixed to make 100 g of powder.

Example 30 cattle diagnosed with urolithiasis were tested in a farmer who constantly raised 500 fattening cattle.

The rats were divided into three groups so that there was no difference between the groups according to body weight and symptoms.
), 50% Vuliragashi extract (this administration group is hereinafter referred to as U category) or the ammonium chloride: Viragiga extract mixture prepared in the above formulation example (this administration group is hereafter AU category). The specified amount was dissolved in water and gavaged for 5 days. Observation of calculus adhesion, inflammation and urinating behavior of the pubic hair, etc., judgment of the effect, healing of those who became completely normal, those of some improvement were regarded as effective, and the results are shown in Table 1. .

Three days after administration, 1 animal in Category A, 4 animals in Category U, and 8 animals in Category AU were cured, and 2, 1, and 2 animals were effective in each category. At the end of the administration (day 5 of administration), 2, 5, and 9 animals were cured in each category, and one animal each was effective. One week after the end of the administration, 3, 6, and 10 animals healed in each category.

 Table 2 shows the dose and the amount of the active ingredient.

(Effect of the Invention) The mixture of ammonium chloride and Virginia oak extract of the present invention showed a remarkable effect in the treatment of urolithiasis in cattle.

──────────────────────────────────────────────────続 き Continued on the front page (58) Fields surveyed (Int. Cl. ⁶ , DB name) A61K 35/78 A61K 33/02 CA (STN)

Claims (1)

(57) [Claims] 1. A preventive and therapeutic agent for urolithiasis for veterinary animals, comprising ammonium chloride and Virginia vulgaris extract as main components.