JP3074869B2 - Chromatographic data processor - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a data processing device for a chromatograph, and more particularly to a data processing device for performing an automatic analysis according to a description of a sample table.

[0002]

2. Description of the Related Art A conventional chromatographic data processor generally performs an automatic analysis as follows.
That is, analysis conditions and apparatus parameters are determined for each sample, and a plurality of these are prepared as analysis condition files. Describe which analysis condition file to use for analysis.

Then, based on the description of the sample table, the analysis condition file is appropriately changed for each sample, and the data is automatically analyzed.

[0004]

However, the above-mentioned analysis condition file does not describe an apparatus environment enabling the analysis. Therefore, if the specified contents of the analysis condition file do not match the operation environment of the actually operating device, the analysis operation is performed on the non-existent device or the random analysis is performed. There is a problem.

The present invention has been made in view of this problem, and has as its object to provide a chromatographic data processing apparatus for performing automatic data analysis appropriate for an actual apparatus operating environment. .

[0006]

In order to achieve the above object, a chromatographic data processing apparatus according to the present invention comprises a series of automatic analysis procedures such as a vial number, a sample name, a sample amount, and an analysis condition file name. Having a sample table described for each sample, a chromatographic data processing device that performs automatic analysis according to the description of the sample table, device environment input means for receiving the actual device operating environment of the chromatograph, Analysis condition input means for reading the description contents of an analysis condition file describing analysis conditions, an apparatus environment enabling the analysis, and initial setting conditions for operating each apparatus; and The apparatus environment read by the analysis condition input means is compared with the actual apparatus operating environment received by the apparatus environment input means to determine the condition. Has characteristically an analysis selection means for automatic analysis only match items.

[0007]

The data processing apparatus for a chromatograph according to the present invention is an apparatus for appropriately performing automatic analysis of data in accordance with a description of a sample table created by a user. When the user instructs the start of the automatic analysis after creating the sample table, first, the apparatus environment input means receives the actual apparatus operating environment. Here, the device operating environment refers to, for example, data indicating a device name of a currently connected LC (liquid chromatographic device), a setting state of a pump, an autosampler, a degasser, and the like.

Next, the analysis condition input means reads the contents of the analysis condition file. The analysis selecting means determines whether or not the device environment described in the analysis condition file matches the currently configured device operating environment. Interrupt. On the other hand, if the currently constructed device operating environment is not complete but can be analyzed, automatic analysis is performed only for the range possible in the current device operating environment.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in more detail with reference to embodiments. FIG. 1 is a schematic block diagram of a chromatographic data processing apparatus according to an embodiment of the present invention. The apparatus includes an apparatus main body 2 that receives an apparatus operating environment from the analyzer 1 and performs appropriate automatic analysis, an external storage apparatus 3 that stores analysis files and the like,
It comprises a keyboard 4 used for creating a sample table and the like, and a CRT 5 for displaying analysis results and the like.

As the analyzer 1, for example, a solvent 6;
Pump 7, autosampler 8, LC9, detector 1
0, the waste liquid processing unit 11, and the communication device 12 that transmits the detection data of the detector 10 to the data processing device main body 2. As described above, this chromatographic data processing device is a device that performs automatic analysis in accordance with the description of the “sample table” created by the user, and stores the contents of the “analysis condition file” stored in the external storage device 3. It is a data processing device that reads every sample and performs appropriate automatic analysis.

[0011] Each row of the "sample table" contains, in addition to the vial number (the number of the bottle containing the sample), the name of the sample, the amount of the sample, etc., various conditions for the analysis. The file name of "File" is described. In the “analysis condition file”, analysis conditions, device environment, and device parameters are defined. In the analysis condition column, for example, (i) a method of quantification, (ii) a method of preparing a calibration curve, and (iii) data File name, (iv) raw chromatographic file name, (v) report output method, etc. are set. Note that (ii) how to create a calibration curve refers to instructions such as how many points to create data, how to find an average value, and whether the calibration curve is a graph based on the least squares method or a line graph.

In the column of the apparatus environment, the environment of the apparatus which enables the above-mentioned analysis is set, and what kinds of apparatuses are combined, for example, an autosampler, a pump, a liquid chromatograph (LC), and detection. It specifies what to use as a container. In the device parameter column, initial setting conditions for operating the device are described. For example, in order to normally operate the autosampler specified in the device environment column, the autosampler control device is controlled. Data (moved xcm in X direction,
Data that the needle moves to the position of the sample bin when it is moved by ycm in the Y direction and then lowered by zmm).

The operation of the chromatographic data processing apparatus 2 shown in FIG. 1 will be described based on the above points. FIG. 2 is a flowchart for explaining the operation of the data processing device 2, and FIG. 3 is a diagram schematically showing the contents of the memory of the data processing device 2. In FIG.
An apparatus operating environment from the analyzer 1 is stored in the apparatus state storage unit 20, and the contents of the analysis condition files are expanded by the number of analysis samples in the analysis condition storage unit 21. Is expanded with the data of the “upper / lower limit value file”. A sample table 23 is created using the keyboard 4 and the like, and the simulation routine 24 performs the following processing shown in FIG.
2 and 3).

After the user creates the sample table,
When the start of the automatic analysis process is instructed, the operation of the data processing device 2 is started (step ST (hereinafter abbreviated as ST)).
1) The data processing device 2 acquires data indicating the actual device operating environment from the analyzer 1 and stores it in the device status storage unit 20 (ST2). Specifically, for example,
Data indicating the type of the currently connected autosampler, pump, LC, detector, and the like, the power ON / OFF state, and the size of the autosampler's syringe, rack, and the like are acquired.

Next, based on the description in the sample table 23, the data processing device 2 reads the analysis conditions for one sample from the corresponding analysis condition file into the analysis condition storage unit 21 (ST3). Here, as a specific example, the autosampler is A, in the column of the apparatus environment in the analysis condition file.
B for pump, C for liquid chromatograph, U for detector
It is described that a V detector and an RF detector are used.

Subsequently, the data processing device 2 determines the device operating environment stored in the device status storage unit 20 in the process of ST2,
The consistency of the analysis conditions stored in the analysis condition storage unit 21 in the process of T3 is checked (ST4). Specifically, the apparatus environment column in the analysis condition storage unit 21 is compared with the actual apparatus operating environment. If the apparatus environment does not match at all and cannot be analyzed, the processing is interrupted. On the other hand, if the apparatus environment is ready, the process proceeds to the next ST5.

In ST5, the "upper / lower limit value file" that matches the device environment read in the process of ST3 is read from the external storage device 3 and stored in the upper / lower limit value check data section 22 (ST5). In other words, the upper and lower limits of operation of each device corresponding to the above device environment (A for the autosampler, B for the pump, C for the liquid chromatogram device, and the VV detector and the RF detector for the detector) are described. The read upper / lower limit value file is read (ST5).

Then, the value described in the sample table is
It is determined whether or not the value falls within the range of the upper and lower limits (ST6). More specifically, for example, the sample injection amount of the autosampler A is set to 0 ml to 20
If it is 00 ml, it is determined whether or not the amount of the sample described in the sample table is within the range of the upper and lower limits.
If there are too many samples described in the sample table, the fact is displayed on the CRT 5 and the mode returns to the sample table creation mode (ST6).

By the way, in the processing of ST4, the apparatus environment is compared. However, even when the apparatus environments do not completely match, the processing of ST7 may be performed through the processing of ST4 to ST5. However, in that case, analysis is performed only for the part where the environment matches (ST7). For example, when the UV detector and RF detector are used in the column of the device environment in the analysis file, it is described that the UV detector is turned off as the actual device environment. Then, only the data of the RF detector is analyzed thereafter. Therefore, an analysis operation is not performed on a device that does not exist.

Then, the processing of ST3 to ST7 is repeated according to the sample table until all the automatic analysis is completed (ST8).

[0021]

As described above, in the chromatographic data processing apparatus according to the present invention, since the apparatus environment is described in the analysis condition file, it is determined whether or not it matches the actual apparatus operating environment. It is possible to take necessary measures according to the determination result. That is, the analyzer does not malfunction, and the analysis need not be interrupted unnecessarily.

Further, even when the device environment described in the analysis condition file does not completely match the actual device environment, only the matching part can be analyzed. No need to rewrite.

[Brief description of the drawings]

FIG. 1 is a schematic block diagram of a chromatographic data processing apparatus according to an embodiment of the present invention.

FIG. 2 is a flowchart for explaining the operation of the apparatus of FIG. 1;

FIG. 3 illustrates the memory contents when the device of FIG. 1 operates.

[Explanation of symbols]

 ST2 Device environment input means ST3 Analysis condition input means ST4 to ST7 Analysis selection means

Claims (1)

(57) [Claims] 1. A sample table in which a series of automatic analysis procedures such as a vial number, a sample name, a sample amount, and an analysis condition file name are described for each sample, and an automatic analysis process is performed according to the description of the sample table. A data processing device for a chromatograph, a device environment input means for receiving an actual device operating environment of the chromatograph, an analysis condition, a device environment enabling the analysis, and an initial setting for operating each device. Analysis condition input means for reading the contents of the file from the analysis condition file describing the conditions; the device environment read by the analysis condition input means; and the actual device operating environment received by the device environment input means Analysis selection means for performing automatic analysis only for items that meet the conditions by comparing Off for data processing equipment.