JP3135940B2 - Hair growth inhibitor - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth inhibitor, and more particularly to a hair growth inhibitor containing a specific crude drug extract, having no irritation or damage to the skin and having an excellent hair regeneration inhibitory effect. Related to inhibitors.

[0002]

2. Description of the Related Art Conventionally, various attempts have been made to remove waste hair on the skin such as the face and limbs. For example, shaving with a shaver, removing hair using a mousse or tape, or removing hair using a high-frequency device are performed.

[0003]

However, of the conventional methods, shaving with a shaver has the problems that the skin is damaged during shaving and that the hair is regenerated quickly. In addition, since hair removal by mousse causes irritation to the skin, it has been desired to reduce the irritation while maintaining the hair growth inhibitory effect. In addition, hair removal using a tape is troublesome and often involves pain, so that there is a problem that sufficient removal cannot be performed. In addition, hair removal using a high-frequency device has a problem in that the device to be used is expensive and a skilled technique is required.

[0004] Therefore, there has been a demand for a hair growth inhibitor which is simple and does not damage the skin, and which has an excellent hair regeneration inhibitory effect.

[0005]

Means for Solving the Problems In view of such circumstances, the present inventors have conducted intensive studies on the hair growth inhibitory effects of various substances, and as a result, it has been found that a specific herbal extract can provide excellent hair regeneration without damaging the skin. The present inventors have found that the present invention exhibits a suppressing effect and completed the present invention.

[0006] That is, the present invention relates to a method for converting iku-li-jin and / or caronine into water, ethyl alcohol, glycerin, 1,3-
It is intended to provide a hair growth inhibitor characterized by containing an extract obtained by extraction with one or more solvents of butylene glycol.

[0007] Examples of the Iku-li-jin used in the present invention include dried seeds of small-li-jin (Niwame) or large-li-jin (Natura), a rose plant. Examples of the caronine include cucurbits, which are obtained by drying the seeds of Chinese cinchona cucurbit or Japanese cinnamon cucumber.

[0008] The method of preparing the extract of Iku-li-jin or caronine used in the hair growth inhibitor of the present invention is not particularly limited. For example, the extract is extracted from room temperature to under heating using various suitable solvents.
As the extraction solvent, water, ethyl alcohol, glycerin, a mixed solvent of one or two or more of 1,3-butylene glycol, and the extraction conditions are 1 to 1000 times the volume ratio of the crude drug, especially 5 to 100 times the crude drug. Using twice the amount of solvent,
It is preferable to carry out at a temperature of 4 ° C. or more, particularly 15 to 30 ° C. for 1 hour or more, especially 1 to 3 days.

The extract obtained under the above-mentioned conditions may be used as it is as an extracted solution. However, if necessary, those which have been subjected to treatments such as concentration and filtration may be appropriately used.

In the hair growth inhibitor of the present invention, the extract of Iku-li-jin and kaolin can be used either alone or in a mixture of both, and the content thereof is based on the dry solid content in the total amount of the hair growth inhibitor. Converted to 0.0001 to 10.
It is preferably 0% by weight, and particularly preferably in the range of 0.01 to 5.0% by weight. When the content is less than 0.0001% by weight, the effect is not sufficiently exhibited, and when the content exceeds 10.0% by weight, the effect is almost constant.

[0011] The hair growth inhibitor of the present invention includes, in addition to the above essential components, aqueous components, powders, surfactants, oils, humectants, alcohols, pH adjusters which are usually used in cosmetics, quasi-drugs, and pharmaceuticals. , A preservative, an antioxidant, a thickener, a coloring matter, a fragrance, and the like, if necessary.

The dosage form of the hair growth inhibitor of the present invention is not particularly limited, and various dosage forms such as a lotion, an emulsion, a cream, a pack, and an ointment can be used.

[0013]

EXAMPLES The present invention will be further described with reference to Test Examples and Examples, which should not be construed as limiting the present invention.

Test Example 75 parts by weight of a 70% v / v aqueous solution of ethyl alcohol were added to 25 parts by weight of fine powder of dried Iku-li-jin or caronine, each crude drug, and extracted at room temperature for 3 days with occasional stirring. A crude drug extract was obtained. Using each of these crude drug extracts and a 70 v / v% aqueous solution of ethyl alcohol as a control, the hair regeneration inhibiting effect was evaluated according to the following test method.

Test method for hair regeneration inhibitory effect: male C3H / He
NCCrj mice (8 weeks old) were grouped into 10 mice and the method of Ogawa et al. (Nisshin Gakkai: 96 (3), 195-197, 19)
86), the following test was conducted. That is, about 2 x 4 cm of the back of the mouse was shaved, and the crude drug extract or the control solution was applied once a day for each group once a day on the following day, and the skin color began to change from pink to gray. Table 1 below shows the area of (the part where hair regeneration started) and the state of its change.
Was visually evaluated according to the criteria described above. The evaluation result is the total score of the scores according to each standard as the hair regeneration score at that time,
An 11-level evaluation of 0 to 10 was made. Table 2 shows the results of calculating the average value of the hair regeneration score in each group on the ninth day, the twelfth day, the fifteenth day, the nineteenth day, and the twenty-second day after the sample application was started.

[0016]

[Table 1]

[0017]

[Table 2]

As is clear from the results in Table 2, the group to which the extract of Iku-li-jin or caronine, which is the active ingredient of the hair growth inhibitor of the present invention, was applied was slower in hair regeneration than the control group, and the hair regeneration was clearly inhibited. It was found to have an effect.

Example 1 Hair Growth Inhibitor (Hair Cream Type) (Component) (% by Weight) (1) Beeswax 1.0 (2) Liquid Paraffin 50.0 (3) Stearic Acid 3.0 (4) Sesquiolein Sorbitan acid 2.2 (5) Polyoxyethylene sorbitan monolaurate (20E.O.) 1.8 (6) Ikuryin extract ^{* 1} 1.0 (7) Fragrance 0.2 (8) Methyl paraoxybenzoate 0. 1 (9) Residual purified water * 1: About 3% dry solids. 50 v / v% 1,3-butylene glycol aqueous solution 90 in 10 parts by weight
A part by weight is added, extracted overnight, and filtered. (Production method) A. After mixing the components (1) to (5), they are heated and dissolved at 70 ° C. B. Components (8) and (9) are mixed and heated at 70 ° C. C. A was added to B and emulsified, and after cooling, components (6) and (7) were added at 30 ° C. and mixed and stirred to obtain a hair cream type hair growth inhibitor.

Example 2 Hair growth inhibitor (hair lotion type) (Component) (% by weight) (1) Salicylic acid 0.1 (2) Lactic acid 0.01 (3) Sodium lactate 0.05 (4) Ethyl alcohol 10 2.0 (5) Iku-li-jin extract ^{* 2} 2.0 (6) Fragrance 0.1 (7) Methyl parahydroxybenzoate 0.1 (8) Remaining purified water * 2: Contains about 30% dry solids . 90 parts by weight of purified water is added to 10 parts by weight of Iku Lee, extracted at 40 ° C. overnight, and filtered. (Preparation method) The components (1) to (8) were mixed and stirred to obtain a hair lotion type hair growth inhibitor.

Example 3 Hair Growth Inhibitor (Hair Liquid Type) (Component) (% by weight) (1) Polyoxypropylene butyl ether phosphate (35 PO) 9.0 (2) Polyoxypropylene monobutyl ether (60 P) .O.) 10.0 (3) Triethanolamine 1.0 (4) Sodium hyaluronate 0.05 (5) Caronine extract ^{* 3} 0.5 (6) Ethyl alcohol 30.0 (7) Fragrance 2 (8) Methyl parahydroxybenzoate 0.1 (9) Residual purified water * 3: Contains about 26% dry solids. Caronine 20
80 parts by weight of a 70% v / v aqueous solution of ethyl alcohol was added to the parts by weight, extracted at 60 ° C. for 3 hours, and filtered. (Preparation method) After dissolving the component (4) in the component (9), a mixture prepared by mixing and dissolving the components (1) to (3) and the components (5) to (8) is added thereto, followed by stirring and hair liquid type hair growth. An inhibitor was obtained.

[0022]

EFFECT OF THE INVENTION The hair growth inhibitor of the present invention has an excellent hair regeneration inhibitory effect and does not damage the skin, and has high safety.
Extremely useful.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-3-188013 (JP, A) Hiroshi Mitsuhashi eds., “Primary Color Makino Kazoku Herbal Encyclopedia”, Hokuryukan Co., Ltd., October 1988, p. 521 (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 A61K 35/78

Claims (1)

(57) [Claims] 1. Hair growth comprising an extract obtained by extracting Iku-jin and / or caronine with one or more solvents of water, ethyl alcohol, glycerin and 1,3-butylene glycol. Inhibitors.