JP3151638B2 - Stabilized water-suspended pesticide composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pesticide oil suspension, which is obtained by emulsifying and dispersing a pesticide oil base, particularly an organophosphorus pesticide oil base, in water by utilizing the surface-active action of phospholipids. is there.

[0002]

2. Description of the Related Art At present, most pesticidal oily drug substances are formulated and marketed as powders, wettable powders and emulsions. Among them, the emulsion is obtained by adding an emulsifier to an agricultural chemical component and dissolving it in a solvent such as xylol, and is generally used by emulsifying and dispersing in water. Emulsions are relatively easy to formulate and can be stored for long periods of time.
When diluted with water at the time of use, there is an advantage that the powder is not bothered by dust unlike a wettable powder and the insecticidal effect is excellent. On the other hand, in recent years, while securing the safety of pesticides and pesticide formulations for the environment and humans has been taken up as an important issue, the effect of organic solvents contained in emulsions on humans and plants has become a problem. Also, the dangers during transportation and storage have been raised. Prior art in which a phospholipid according to the present invention described below is applied to an agricultural chemical formulation is disclosed in JP-B-51-18501 and JP-B-53-1858.
No. 1 and Japanese Patent Publication No. 56-8804 are known. However, these are all used as active ingredients in which phospholipids have bactericidal properties, and do not utilize the surface activity of phospholipids. The same applies to JP-A-51-104033. Next, JP-A-56-140910
No. 2-19309 is a miticide containing a phospholipid as an active ingredient, and JP-A-2-19309 is intended to reduce the phytotoxicity by adding a phospholipid to a machine oil for a machine oil emulsion. It does not use the surface activity of phospholipids in the formulation.

[0003]

DISCLOSURE OF THE INVENTION The present inventors have studied to improve such a problem. When changing the dosage form of an emulsion containing oily pesticide ingredients to a wettable powder or a powder, it is difficult to formulate an emulsion containing a high concentration of the active ingredient, such as an emulsion. It was thought that the problem of pesticide exposure could occur. Therefore, the present inventors do not use an organic solvent, and are safe for humans and animals without concern about environmental pollution because they are pure natural products, and are widely used in food, cosmetics, petroleum products and other fields. Using the surfactant activity of phospholipids as an indispensable condition, we conducted intensive studies on formulations in which oily pesticide active ingredients were emulsified and dispersed in water. The present inventors have found a formulation of a storable water-suspended pesticide formulation and completed the present invention. As apparent from the above description, an object of the present invention is a pesticide suspension in water based on a bulk of an organophosphorus pesticide which is an oily liquid at room temperature, and uses an organic solvent. An object of the present invention is to provide a product which has good stability of an active ingredient and can be stored for a long period of time by incorporating a phospholipid, and a method for producing the same.

[0004]

The present invention has the following constitutions (1) and (2). (1) Active substance 4 of organophosphorus pesticide which is oily liquid at normal temperature
0 to 50 parts by weight phospholipid 4 to 12 parts by weight and water 30 to
A stabilized pesticide suspension in water, which is obtained by mixing 50 parts by weight. (2) O, O-dimethyl-O- (3-methyl-4-nitrophenyl) thiophosphate, (2-isopropyl-4-methylpyrimidyl-6), which is an organophosphorus pesticide which is an oily liquid at room temperature 2. The pesticide formulation in suspension in water according to claim 1, which is one or more active substances selected from diethylthiophosphate, dimethyldicarbethoxyethyldithiophosphate and ethyl dimethyldithiophosphorylphenylacetate.

The configuration and effect of the present invention will be described in detail below. The composition of the present invention comprises an organophosphorus pesticide oil bulk 40.
30-50 parts by weight of water, phospholipid 4
By adding up to 12 parts by weight and, if necessary, adding an antifreezing agent, a dispersing agent or the like, an aqueous pesticide formulation having no unevenness in color tone, having a uniform concentration and no separation can be obtained. Further, in the case of a preparation obtained by emulsifying and dispersing an organophosphorus pesticide oil base in water, there is concern about hydrolysis of the pesticide component, but the preparation of the present invention is less affected by hydrolysis and can be stored for a long period of time. It also has advantages. For example, when O, O-dimethyl-O- (3-methyl-4-nitrophenyl) thiophosphate (generic name: MEP) is used as the drug substance, 40 to 50 parts by weight of the drug substance and phospholipid (trade name) : 4-9 parts by weight of Basis LG-10E, LG-40S manufactured by Nisshin Oil Co., Ltd.), the remaining amount of tap water was added, and glass beads (φ1 mm) were added in the same amount as the preparation amount, and a paint shaker was added. Vigorous mixing for 15 minutes to obtain a milky-white MEP-in-water suspension pesticide formulation.

The organophosphorus pesticide other than MEP which can be formulated as the water-suspended pesticide preparation of the present invention includes (2)
-Isopropyl-4-methylpyrimidyl-6) -diethylthiophosphate; common name diazinon, dimethyldicarbethoxyethyldithiophosphate; common name marathon, dimethyldithiophosphorylphenylacetate ethyl; common name paption, (RS)-[O-1 ( 4-chlorophenyl) pyrazol-4-yl] = O-ethyl = S-propyl = phosphorothioate; a common name is pyraclofos, and if it is an organophosphorus pesticide which is oily at room temperature,
It can be used as the pesticidal suspension in water of the present invention.

[0007] The phospholipid used in the water-suspended pesticide formulation of the present invention is a general term for lipids containing phosphorus and nitrogen, and is not particularly limited. Specific examples thereof include soybean phospholipids such as lecithin DX, basis LP-20 and basis LG-4.
0S, Basis LG-10E (all trade names of Nisshin Oil Co., Ltd.), TD-974 (trade name of Nippon Emulsifier Co., Ltd.)
Besides, rapeseed phospholipid, safflower phospholipid, cottonseed phospholipid, egg yolk lecithin and the like can be used.

[0008]

EXAMPLES Hereinafter, the present invention will be described with reference to Examples and Test Examples, but these do not limit the present invention. Example 1 40 parts by weight of MEP bulk (hereinafter, parts by weight are simply expressed as parts) and phospholipid (trade name: LG-40S manufactured by Nisshin Oil Co., Ltd.) 4
Part, phospholipid (trade name: TD-974 Nippon Emulsifier Co., Ltd.)
10 parts), distilled water was added, and the same amount of glass beads (φ1 mm) as the preparation was added. The mixture was mixed for 15 minutes with a paint shaker to prepare a pesticide suspension in water (Sample A).
Was manufactured.

Example 2 50 parts by weight of the MEP drug substance and a phospholipid (trade name: LG-10)
9 parts of E. Nisshin Oil Co., Ltd.), add distilled water, and add the same amount of glass beads (φ1 mm) as the preparation amount, mix with a paint shaker for 15 minutes, and suspend in water. A formulation (Sample B) was produced.

Example 3 40 parts by weight of a diazinon drug substance and a phospholipid (trade name: LG)
9 parts of -10E Nisshin Oil Co., Ltd.) and 10 parts of TD-974 (manufactured by Nippon Emulsifier Co., Ltd.) are mixed, distilled water is added to the remaining amount, and glass beads (φ1 mm) are equal to the preparation amount. In addition, the mixture was mixed with a paint shaker for 15 minutes to produce a pesticide formulation suspended in water (sample C).

Example 4 40 parts by weight of a marathon drug substance and a phospholipid (trade name: LG-1)
9E Nisshin Oil Co., Ltd.), add distilled water, and add glass beads (φ1 mm) in the same amount as the preparation charge, mix with a paint shaker for 15 minutes, and mix in suspension in water. (Sample D) was produced.

Example 5 40 parts by weight of a papthione drug substance and a phospholipid (trade name: LG-
9E (manufactured by Nisshin Oil Co., Ltd.), distilled water was added, and the same amount of glass beads (φ1 mm) as the preparation was added. The mixture was mixed for 15 minutes with a paint shaker to prepare a suspension of the pesticide in water. (Sample E) was produced.

Test Example 1 Samples A to E were stored in a thermostat at 50 ° C., and after 15 days, 30
The formulation stability after day was confirmed. As a control, each drug substance 40
And 20 parts of a general emulsifier, and the same test was conducted using 40 parts of distilled water. Table 1 shows the results.

[0014]

[Table 1]

Test Example 2 Samples A to E were stored in a thermostat at 50 ° C., and after 15 days, 30
The active ingredient after day was analyzed to confirm the stability of the active ingredient. As a control, the same test was carried out using a mixture of 40 parts of each drug substance, 20 parts of a trade name of Solpol 3005X and 20 parts of Solpol 2960KX, trade name of Toho Chemical Industry Co., Ltd., and 40 parts of distilled water. Table 2 shows the results.

[0016]

[Table 2]

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Claims (2)

(57) [Claims] 1. A stabilized suspension in water obtained by mixing 40 to 50 parts by weight of an organophosphorus pesticide, which is an oily liquid at room temperature, 4 to 12 parts by weight of a phospholipid and 30 to 50 parts by weight of water. Pesticide composition. 2. An organophosphorus pesticide which is an oily liquid at room temperature is composed of O, O-dimethyl-O- (3-methyl-4-nitrophenyl) thiophosphate and (2-isopropyl-4-methylpyrimidyl-). 6) The pesticidal composition in suspension in water according to claim 1, which is one or more active substances selected from -diethylthiophosphate, dimethyldicarbethoxyethyldithiophosphate and ethyl dimethyldithiophosphorylphenylacetate.