JP3283600B2 - Resistant housefly control composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition for controlling resistant house flies.

[0002]

2. Description of the Related Art With respect to the insecticidal effect of housefly, for example, on the effect of mixing malathion with a synergist and the effect of mixing sumithion with other insecticides, insecticide science vol.38-III, 158-164, which is a well-known publication. The effect of tocthione on house flies is also described in insect repellent science, Vol. 40-IV, pp. 121-123, and a number of studies have been conducted on the insecticide resistance of house flies on Tokyo Yumenoshima. ing. (Sanitary animals 1966, vol. 17, No. 1, pages 71 to 73; 1973, vol. 23, No. 3, 255-2.
56 pages, 1975, vol. 26, no. 4,2
57-258, 1978, vol. 29, N
o. 2,205-208 pages, 1988, vo
l. 39, no. (See pages 1, 43-47)
JP-A-55-129209 and JP-A-59-129210
The article describes the insecticidal effect of a mixed composition of two organophosphorus insecticides on Lepidoptera.

[0003]

The control of house flies has been started with organochlorine pesticides in the past, and as a result of using many organophosphorus pesticides for many years,
The emergence of house flies that have developed resistance has become a widespread social problem, not to mention environmentally. In particular,
The house fly on Yumenoshima, a landfill located in Tokyo Bay, has recently developed a high degree of resistance, and there has been a problem that conventional drugs do not exhibit satisfactory effects.

[0004]

Means for Solving the Problems As a means for solving the above problems, the present inventors have now found that the following compositions exhibit extremely remarkable and satisfactory effects. As active ingredients, O-2,4-dichlorophenyl O-ethyl S-propyl phosphorodithioate and O, O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate or O, O-diethyl O- 3,5
6. A resistant housefly control composition comprising 6-trichloro-2-pyridyl phosphorothioate.

[0005] Surprisingly, the composition of the present invention is obtained by mixing the two active ingredients, so that the additive effect of each of the two active ingredients substantially exceeds the so-called additive effect. By exhibiting a synergistic synergistic effect, it exerts a very pronounced and precise insecticidal effect on resistant house flies. In the composition of the present invention, O-2,4-dichlorophenyl O-ethyl S- used as an active ingredient
Propyl phosphorodithioate (generic name prothiophos) is a known compound already described in JP-B-49-24656, and likewise O, O-dimethyl-3,5,6-trichloro-2-pyridyl Phosphorothioate (common name chlorpyrifosmethyl) and O, O-
Diethyl-3,5,6-trichloro-2-pyridyl phosphorothioate (common name chloropyrifos) is a known compound already described in U.S. Pat. No. 3,244,586.

[0006] In a composition of the present invention, a preferred combination thereof is a composition comprising prothiophos and chlorpyrifosmethyl as active ingredients.
The mixing weight ratio of the active ingredients in the composition of the present invention can be changed in a relatively wide range, but generally,
Chlorpyrifos methyl or chlorpyrifos is about 0.25 to 4 parts by weight, preferably about 0.5 to 1 part by weight, based on 1 part by weight of prothiophos.

[0007] The compositions of the present invention exhibit an extremely potent insecticidal effect on resistant house flies. Therefore, the composition of the present invention can be used as a resistant housefly control composition. The resistant housefly to be controlled by the composition of the present invention is a housefly belonging to the order Diptera (Musca domestic).
stica), including those that have acquired resistance and those that have developed resistance to high strength. The composition of the present invention can be made into a usual formulation. In particular, such forms include, for example, liquids (eg, emulsions) and wettable powders.

[0008] These preparations can be manufactured by a known method. Such methods include, for example, using an active compound with a developing agent, ie, a liquid diluent; a solid diluent or carrier, optionally with a surfactant, ie, an emulsifier and / or dispersant and / or foam former. , By mixing. If water is used as the developing agent, for example, organic solvents can also be used as auxiliary solvents. Liquid diluents or carriers generally include aromatic hydrocarbons (eg, xylene, toluene, alkylnaphthalene, etc.), chlorinated aromatic or chlorinated aliphatic hydrocarbons (eg, chlorobenzenes, ethylene chlorides, chlorides). Methylene, etc.), aliphatic hydrocarbons [eg, cyclohexane, etc., paraffins (eg, mineral oil fractions, etc.)], alcohols (eg, butanol, glycol and their ethers, esters, etc.), ketones (eg, acetone,
Mention may also be made of methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strong polar solvents (eg dimethylformamide, dimethyl sulfoxide, etc.) and water.

Examples of the solid diluent include soil natural minerals (eg, kaolin, clay, talc, chalk, quartz, attapull guide, montmorillonite or diatomaceous earth), and soil synthetic minerals (eg, highly dispersed silicic acid, alumina, silicate, etc.). ). Examples of the emulsifier and / or foaming agent include nonionic and anionic emulsifiers [for example, polyoxyethylene fatty acid ester, polyoxyethylene fatty acid alcohol ether (for example, alkylaryl polyglycol ether, alkyl sulfonate, alkyl sulfate, aryl sulfone). Acid salt)] and albumin hydrolysis products.

When the composition of the present invention is used, it can be used in the form of, for example, an emulsion or a wettable powder as described above, or can be used in the form of a preparation prepared by further diluting it. It can also be used in a preparation solution. The composition may be sprayed with watering, spraying.
g, atomizing). The present invention
Furthermore, the present invention provides a method for controlling resistant house flies, which comprises using a mixed composition containing prothiophos and chlorpyrifos-methyl or chlorpyrifos as active ingredients.

In carrying out the control method,
By applying the detailed composition in the desired formulation to the resistant house fly directly or to its habitat, the control of the resistant house fly can be achieved and at the same time its occurrence can be reduced. Can be prevented. When using the composition of the present invention and carrying out the control method, it is also possible to mix each of the active ingredients in the composition in the form of a tank before use and practice, and then use the mixture in a tank. It is. Next, the present invention will be specifically illustrated by the following examples, but the present invention should not be limited to these.

[0012]

【Example】

Test example. Test for strong drug resistance Yumenoshima housefly Test insect Takatsuki housefly: Transferred from the National Institute of Health and Sanitation in 1969 and subsequently reared in our laboratory. Yumenoshima '91: National Institute of Health and Sanitation, January 1991
What was collected on the third dream island in January, January 1992
It has been transferred from Tsuki Dojo and has been bred successively in our laboratory. Female adults 3 days after emergence were used for the microdropping method, and second-instar larvae were used for the medium mixing method. Reagents Microdropping method: Prothiophos drug substance (93.7%) Chlorpyrifos methyl 25% emulsion Media mixing method: Prothiophos 20% emulsion Chlorpyrifos methyl 25% Emulsion Chlorpyrifos 25% wettable powder

Test method: Microdrop method Acetone solution diluted to each concentration was dropped at 1 μl per animal by a microsyringe onto the dorsum of the test insects anesthetized with ether using a microsyringe, and the mortality was determined after 24 hours and 48 hours. . Medium Mixing Method A mixture of powdered feed (Nihon Clare CA-1) and bran at a ratio of 1: 1 is weighed into a 22 g polycup. 1 ml of the drug diluent is placed in 27 ml of water, and this solution is all placed in the previously weighed feed and mixed well. Release 50 housefly larvae into this and cover with tissue paper. After 7 days, the pupae are removed from the cup, the number is determined, and the pupa is transferred to another cup. After 7 days, the emergence ratio was determined. The test was performed in a two-part system. (Substantially in accordance with the Guidelines for Examination of Sanitary Animals / Supervised by the Ministry of Health and Welfare.) The obtained mortality and emergence rates were Abbott-corrected, and LD (C) 50 and LD (C) were obtained by the Probit method.
95 was sought. The synergy coefficient is Sun & Johnson
(1960. J. Econ. Ent., Vol. 53,
pp887-892). The results are shown in Tables 1 to 3.
It was shown to.

[0014]

[Table 1] Table 1 (Microdrop method) 夢 Yumenoshima '91有 Active ingredient μg / ♀ Housefly 24 hours μg / ♀ Housefly 48 hours ───────── ── ─────────── LD 50 LD 95 LD 50 LD 95 ───────────────────────────── ─────── Prothiophos + 4.55 7.19 4.46 7.32 Chlorpyrifos methyl (4: 1) (258) ^* (346) ^* (245) ^* (296) ^* Prothiophos + 3.93 7.78 4.01 8.04 Chlorpyrifos methyl (2: 1) ( 335) ^* (370) ^* (302) ^* (311) ^* Prothiophos + 4.70 6.89 4.63 6.76 Chlorpyrifos methyl (1: 1) (330) ^* (521) ^* (302) ^* (459) ^* Prothiophos + 7.78 11.50 8.04 13.65 Chlorpyrifos methyl (1: 2) (243) ^* (413) ^* (206) ^* (299) ^* Prothiophos + 9.41 14.24 9.4 5 13.26 Chlorpyrifos methyl (1: 4) (243) ^* (451) ^* (206) ^* (412) ^* Prothiophos 10.09 20.66 9.54 18.06 Chlorpyrifos methyl 33.42 135.8 26.25 110.6 (Death rate in control plot: 0%-24 hours 0 % -48 hours)

[0015]

[Table note]

1. () ^* : ^Indicates synergy coefficient. 2. Female adults 3 days after the onset were subjected to the test.

[0016]

[Table 2] Table 2 (Media mixing method) ──────────────────────────────────── Yumenoshima '91 ──────────── Effective component LC 50 LC 50 (ppm) ─────────────────────────── ───────── Prothiophos 50% Chlorpyrifos methyl 50% 30.14 85.34 (1: 1) (443) ^* (593) ^* Prothiophos 67% Chlorpyrifos methyl 33% 34.76 127.44 (2: 1) (359) ^* ( 343) ^* Prothiophos 110.6 343.5 Chlorpyrifosmethyl 168.2 961.8 (Death rate of control: 9%) ───────────────────────────── ───────

[0017]

[Table note]

() ^* : ^Indicates synergy coefficient.

[0018]

[Table 3] Table 3 (Medium mixing method) ──────────────────────────────────── Yumenoshima '91有 Effective component LC 50 LC 95 (ppm) ─────────────────────────── ───────── Prothiophos 50% Chlorpyrifos 50% 50.96 85.26 (1: 1) (243) ^* (258) ^* Prothiophos 67% Chlorpyrifos 33% 35.01 65.06 (2: 1) (303) ^* (277) ^* Prothiophos 82.59 113.0 Chlorpyrifos 245.4 628.6 (Death rate of control: 29%) ： ────

[0019]

[Table note]

() ^* : ^Indicates synergy coefficient.

[0020]

The composition of the present invention exerts a very remarkable control effect on resistant house flies by synergistic synergism.

Continuation of front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A01N 57/14 A01N 57/16

Claims (4)

(57) [Claims] An active ingredient comprising O-2,4-dichlorophenyl O-ethyl S-propyl phosphorodithioate and O, O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate or O, A resistant housefly control composition comprising O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate. 2. The active ingredient is O-2,4-dichlorophenyl O-ethyl S-propyl phosphorodithioate and O, O-dimethyl O-3,5,6-trichloro-2.
A pyridyl phosphorothioate comprising at least one of the following:
Composition. 3. As an active ingredient, O, O-dimethyl O-3,5 is added to 1 part by weight of O-2,4-dichlorophenyl O-ethyl S-propyl phosphorodithioate.
6-trichloro-2-pyridyl phosphorothioate or O, O-diethyl O-3,5,6-trichloro-2-
The composition of claim 1, comprising about 0.25 to 4 parts by weight of pyridyl phosphorothioate. 4. O-2,4-dichlorophenyl O-ethyl S-propyl phosphorodithioate and O, O-
Dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate or O, O-diethyl O-3,
A method for controlling resistant house flies, comprising using a mixed composition containing 5,6-trichloro-2-pyridyl phosphorothioate as an active ingredient.