JP3538465B2 - Infusion bag - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to compartmental sealing of a bag-like container formed of a tubular thermoplastic synthetic resin film, and forming a strong seal portion and a weak seal portion on the obtained compartment seal portion. It relates to an infusion bag. More specifically, it is divided into a plurality of upper and lower chambers, and there is no risk of leakage and mixing of the two liquids until the medicinal liquids contained in the respective chambers are mixed and used for infusion. In this case, only the weak seal portion of the partition seal portion is peeled off, and the mixing of the two chemicals can be easily, completely and aseptically performed. And a method for manufacturing the same.

[0002]

2. Description of the Related Art In one field in which a medical infusion bag is used, a plurality of chemicals may be mixed and infused immediately before infusion. There has been a demand for an infusion bag having a sanitary epidemiological function capable of preventing contamination, invasion of various bacteria, and the like, but as a countermeasure, weakly seal the inner wall surface of the bag-shaped container formed of a cylindrical synthetic resin film. By dividing into a plurality of chambers, each chamber is pre-filled with a drug solution for mixing, and when an infusion is required, the seal portion of the compartment is peeled or broken, and the infusion bag is made into one chamber, so that a plurality of types of drug solutions are provided There is known an infusion bag which can be mixed in a sterile environment.

[0003] In such an infusion bag, the weakly sealed portion must be placed in the infusion bag until the mixed chemicals are separated and mixed until the infusion is performed. The necessary normal handling steps, such as washing, dispensing, sterilization, etc., should not be easy to peel off, but when mixing chemicals and using them for the original purpose of infusion It is required that the weak seal portion can be peeled or broken only by a suitable means such as pressurization of the bag by hand without peeling of the strong seal portion of the infusion bag main body.

Various types of infusion bags have been proposed to satisfy such requirements (for example, JP-A-63-19149, JP-A-1-240469, and JP-A-2-4671). JP-A-6-39018
However, the conventional one uses a bag-like container formed by mixing two types of synthetic resins having high compatibility with each other as a means for forming the weak seal portion, and the inner surface of the container is subjected to normal heat bonding. Typical examples include an easy-peel type in which a high adhesive strength cannot be obtained by doing so, and a type in which another film is laminated on the inner surface of the infusion bag as a layer having a function of fusing and peeling.

Conventionally, for infusion bags, synthetic resins having relatively low rigidity, such as polyethylene and ethylene vinyl acetate polymer, have been mainly used due to demands for high productivity and the like in addition to easy flattening characteristics during infusion of a chemical solution. These synthetic resins are formed into a tubular film by inflation molding or by folding and heat-bonding a flat band-like film, and cut into a desired length. At least one of the upper and lower cut openings is made of synthetic resin pharmaceutical. High air-tightness, liquid-tightness, and non-peelable thermal bonding are required together with the liquid filling or taking out port member. Usually, under a condition of high temperature and high pressure, a wide strong sealing heat bonding zone is formed. In this thermal bonding, even when the synthetic resin having relatively low rigidity is used, the folded portions at both ends along the length direction of the tubular film have an elastic recovery force peculiar to the synthetic resin. In consideration of the melting point of the synthetic resin used, liquid leakage will occur unless heat fusion is performed at a considerably high temperature, high pressure, and a long pressurizing time.

The infusion bag according to the present invention has at least one partition seal in the middle between the upper and lower ends, and both end portions of the partition seal have elastic recovery characteristics of the folded portion of the film. In order to achieve a complete seal, extremely severe conditions are required, and as a result, a strong sealing state similar to the strong seal at the upper and lower ends of the bag-shaped container must be obtained. Therefore, it is difficult to obtain a weak seal state that can be peeled off during the infusion operation, similar to the weak seal portion at the central portion of the partition seal portion. Conventionally, both ends of the partition seal are non-peelable strong seals even when the chemical is mixed before the infusion work, and only the central portion sandwiched between the strong seals on both side ends is a peelable weak seal. The form has been adopted.

However, the shape of the conventional strong seal portion is as follows.
A narrow, band-shaped weak seal portion at the center portion is continuously widened toward the folds on both side edges, and specifically, for example, as disclosed in Japanese Patent Application Laid-Open No. 6-39018, a linear shape. The weak seal portion was vertically symmetrical, and was continuously widened by drawing a concave curve inside the infusion bag, and the widened shape portion was a partition seal portion corresponding to the strong seal portion. . Naturally, in the case of the strong seal portion of this shape, since it also includes the fold portions at both end portions, it is considered that considerably stricter sealing conditions are adopted than the weak seal portion at the center portion, For example, conditions such as high-temperature pressurization, multiple pressurization, and long-time pressurization can be considered.

Since the strong seal portion seen in the above conventional example is on a continuous extension line of the weak seal portion, the boundary with the weak seal portion has a sharp projection shape. If you accidentally drop the bag after peeling or breaking,
There is a drawback that instantaneous tensile elongation stress tends to concentrate on the boundary of the projection shape, and breakage or pinholes are easily generated in the portion. Also, during the infusion, the drug solution easily accumulates in the concave curved portion of the strong seal portion, which hinders the infusion and has been regarded as a problem.

[0009]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to solve the above-mentioned problems of the conventional infusion bag partitioned near the center, and more specifically, a partition seal portion. peeling the weak seal part of, before after chemical mixing infusion, small quantity or takes Kano pressure, or inadvertently be rapidly applied internal pressure and落袋, the strong seal part of the location that was connected with weak seal There is no danger that stress concentration like breakage will occur in the bag, therefore, breakage of the bag in this part, generation of pinholes can be prevented as much as possible, and furthermore, the partition seal shape of a shape that can easily drop the chemical solution without stagnation during infusion work, In particular, it is an object of the present invention to find a preferable shape of a strong seal portion constituting the same, and to provide a method of manufacturing an infusion bag capable of efficiently forming such a preferable partition seal portion.

[0010]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have made intensive studies, and as a result, the strong seal portion of the conventional partition seal portion is formed by forming a specific circular shape. And completed the present invention. That is, the gist of the present invention is as follows. (1) It is formed of a flat cylindrical synthetic resin film having a desired length and has folds on both side ends, and at least one end in the length direction is used for filling or taking out a synthetic resin pharmaceutical liquid. A bag-like container in which a mouth member is sandwiched and a strong seal portion attached in a liquid-tight manner is formed, and an intermediate portion between both ends is formed with a liquid-tight partition seal portion in the width direction of the bag-like container. The partition seal portion is composed of a strong seal portion at both end portions of the bag-shaped container and a band-like weak seal portion at the center portion sandwiched between the strong seal portions, and the strong seal portion is symmetrical in the vertical direction of the weak seal portion. The formed circular shape having the side ends as chords, 10 mm <radius of curvature R <35 mm, 3 mm <height S <10 mm.
An infusion bag that is partially circular without the center . (Second) The strong seal portion of the partition seal portion has a flat or twill-like concave groove formed on one surface and a twill-like convex ridge formed on the other surface. 2. The infusion bag according to the first aspect, wherein the infusion bag is formed back to back with a parallel convex portion on the other surface. (3) The infusion bag according to the above (2), wherein the depth of the concave groove and the height of the ridge of the strong seal portion of the partition seal portion are sequentially increased toward both side ends of the bag-shaped container. (Fourth) A flat tubular synthetic resin film having folds at both ends is cut to a desired length, and at least one of the obtained upper and lower ends is provided with a mouth member for filling or taking out the synthetic resin pharmaceutical liquid. A method for manufacturing an infusion bag, wherein a bag-like container is formed by sandwiching and forming a strong liquid-tight seal portion, and then forming a partitioned seal portion extending in the width direction of the bag-like container at an intermediate portion between the both ends. Wherein the section seal portion is
It is obtained by forming each strong seal portion at both end portions in the width direction of the bag-like container and the weak seal portion at the central portion sandwiched between them in this order or in reverse order, and the weak seal portion is formed of two strips. It is formed by pressure contact with a seal bar, and the strong seal portion straddles the folds at both ends of the bag-shaped container, and is pressed by two circular or partial circular seal disks each having 10 mm <curvature radius R <35 mm. Is a string, and 3 mm <height S <
A method for manufacturing an infusion bag having a partial circular shape not including a center of a circular shape and having a length of 10 mm and extending symmetrically above and below the weak seal portion. (Fifth) One inner surface of the two opposing seal disks is formed into a flat or ridge-shaped ridge, and the other inner surface is formed into a ridge-shaped groove. 5. The method of manufacturing an infusion bag according to the above item 4, wherein the strong seal portion of the partition seal portion is formed by adjusting the positions of the seal portions to be opposed to each other. (Sixth) A seal disk in which the height of a flat or ridge-shaped ridge on one inner surface of the seal disk and the depth of the ridge-shaped concave groove on the other inner surface are sequentially increased toward both side ends. The method for producing an infusion bag according to the fifth aspect, which is used.

Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 is a plan view of an example of a polyethylene infusion bag according to the first invention. This polyethylene infusion bag is not limited to a single polyethylene film, but may be a laminated film of two or more types of polyethylene films or polyethylene and another. It may be composed of a laminated film of various types of synthetic resin films.

Folds are formed at both ends 2 and 2 along the length direction AA of the cylindrical film (not shown) of the infusion bag 1 before molding, and the upper and lower ends in the AA direction have respective cut openings. The liquid-filling port member 7 and the take-out port member 8 are sandwiched between them, and a bag-like container in which the strong sealing portions 5 and 6 adhered in a liquid-tight manner together with the cylindrical film is obtained. A partition seal 9 is formed in the middle of the bag-shaped container AA along the width direction BB, and the partition seal is a weak seal 1.
0 and a strong seal portion 11. By the formation of the partition seal portion 9, the bag-like container becomes an infusion bag divided into the first chemical solution chamber 3 and the second chemical solution chamber 4, and the chemical solutions filled in both chambers are not mixed until the infusion operation. Put in isolation.

The weak seal referred to in the present invention does not easily peel off during various handlings of the infusion bag until the infusion operation is performed, and the mixing chemical solution sealed in each partitioned chamber can be preserved as it is. If the internal pressure of the compartment is intentionally increased to a predetermined value or more by hand pressure or the like at the time of mixing the chemical solution immediately before entering the infusion work, a uniform and stable peeling over the weak seal portion on the inner wall surface of the infusion bag. It is necessary to form the infusion bag itself as the strong seal portions 5 and 6 on the outer periphery of the infusion bag,
Moreover, it means a seal having only a very low fusion strength compared to the peel strength of the seal portion that is not allowed to be peeled, and the specific seal strength or its range is the shape, size, It is appropriately set according to the amount of the chemical solution for mixing.

The infusion bag 1 is manufactured by flatly folding a cylindrical film, and the both sides 2 and 2 have a fold of the cylindrical film. The fold has an elastic recovery characteristic of a synthetic resin. However, even if heat sealing is performed under the same conditions as those of the portion other than the fold portion, it is difficult to obtain the same sealed state. That is,
If the fold is not sealed under a condition of high temperature, high pressure and long time, a liquid-tight seal cannot be obtained. On the contrary,
The portions other than the folds can be sealed liquid-tight even under weaker conditions. In addition, the partition seal portion needs to have a portion having a weak seal property that can be peeled or broken during the infusion operation. In the present invention, the partition seal portion 9 is formed with a specific strong seal portion 11 which does not cause peeling or the like at the time of mixing the chemical solution at the fold portions on both side ends, and a portion sandwiched between the strong seal portions at both ends is formed as a weak seal portion 10. In addition, when the weak seal portion is peeled or broken and opened, it is intended to satisfy the requirement that the strong seal portion 11 in contact with the weak seal portion 10 does not cause breakage or pinholes. It is.

It is already known that the partition seal portion is composed of a strong seal portion and a weak seal portion. FIG. 7 is a partially cutaway enlarged view of the periphery of the partition seal portion 9 in a conventionally known infusion bag. As shown in the figure, the partition seal portion 9 forming the drug solution chambers 3 and 4 includes a weak seal portion 10 and a strong seal portion 16, and the strong seal portion 16 has a concave curve toward the inside of the infusion bag, that is, toward the drug solution chamber. In addition, the weak seal portion side forms a sharp projection 17 . The conventional infusion bag is liable to break or pinhole at the tip of the strong seal portion when it is accidentally dropped after the chemical solution mixing operation. It is thought that it is easy to concentrate suddenly. In addition, since the curve is concave inward of the bag as described above, there is a problem that the drug solution is likely to stay during infusion, and complete infusion of all drug solutions cannot be expected.

In the present invention, as can be seen from FIGS. 3, 4, 5 and 6 showing a partially cut-out state around the partition seal portion 9, the strong seal portion 11 is located at both ends of the weak seal portion in a vertically symmetric manner. It has a partially circular shape. In other words, the first characteristic is that it is a partial circular shape having a curve that is convex toward the inside of the infusion bag (on the side of the drug solution chambers 3 and 4). The circular shape is a perfect circle, an ellipse, an ellipse, or the like. The partial circular shape means that the crease 2 is a chord of the circular shape, and does not include the center of the circular shape.
It means a low partial circular shape. 1 and 3 to 5 are examples of partial circles, and FIG. 6 is an example of partial ellipses having a chord parallel to the major axis.

A second feature of the present invention is that the curvature radius R of the partially circular portion of the strong seal portion 11 is 10 mm <R <35 mm.
A range of values is required. If R is 10mm or less, or for curved portions component is short, when dropped accidentally infusion bag, tends to concentrate stress breakage or pinholes generate in the weak seal portion of the strong seal part is broken It is not preferable because it raises a bag. On the other hand, when the length is 35 mm or more, wrinkles are generated near both side edges of the bag when the bag is suspended in performing the infusion, and the discharge state of the infusion solution is deteriorated, which is problematic.

A third feature of the present invention is that the height S of the circular portion of the strong seal portion 11, that is, the side end 2 and the tangent line X- of the circular portion parallel to the side end 2 as shown in FIGS. X-ray and Y
The distances S ₁ and S _{2 from} −Y must be in the range of 3 mm <S ₁ <10 mm and 3 mm <S ₂ <10 mm. If S ₁ and S ₂ are 3 mm or less, it becomes difficult to form the strong seal portions 11 on both sides at the time of manufacturing an infusion bag evenly. It is considered that this is because the sealing area becomes too small and stable sealing work becomes difficult. On the other hand, if it is 10 mm or more, there is a disadvantage that the bag is easily broken when the bag is accidentally dropped. It is considered that this is because the strong seal portion having high rigidity is widely formed in the central portion of the infusion bag.

The strong seal portion must have a large difference in seal strength from the weak seal portion. For this reason, the strong seal portion employs a sealing method in which twill-shaped or flat-shaped unevenness is formed on the front and back sides of each other. Is preferred. Specifically, as shown in FIG. 4, a twill (or plain) pattern is formed on the surface of the strong seal portion 11 by the concave grooves 13, and as shown in FIG. 14 and stronger by forming a parallel set of concave grooves or flat patterns of the twill pattern on the front surface and a concave groove of the parallel pattern of the twill pattern on the back surface. High sealing strength. The structure pattern of this sealing surface is such that a parallel set of the former twill pattern is provided by providing a twill or flat pattern with a convex streak on one inner surface of the heat bonding board and providing a twill pattern with a concave groove on the other inner surface. It can be easily formed by adjusting the convex ridges or the flat ridges and the parallel set of concave ridges of the latter twill pattern so as to fit each other.

Next, a method of forming the partition seal portion in the infusion bag according to the present invention will be described. FIG. 2 shows a state in which a weak seal portion 10 is provided at the center of the infusion bag in the AA direction, leaving the vicinity of both sides 2 and 2. This seal portion is applied by a band-shaped seal plate from the front and back of the infusion bag. It can be easily formed by pressing. The peel strength of the weak seal portion must be controlled in a desired range so that a plurality of types of chemicals stored in the infusion bag according to the present invention can be properly mixed. In order to maintain the infusion bag pressure, the infusion bag internal pressure is 0.02 to 0.15 kgf / cm, although it is a range of values determined by the length, width, and amount of the drug solution, and cannot be expressed as a specific value.
^A pressure-resistant strength at which peeling starts when the pressure is increased to ² is preferable.

After the weak seal portion 10 is formed, partially circular strong seal portions 11 and 11 are formed on both sides of the weak seal portion 10 and have the folded end portions 2 and 2 as chords. If a seal disk of the same size and shape is used to form this partially circular strong seal portion, it is difficult to completely seal the fold portion at both end portions, so it is necessary to straddle the fold portion. It is preferred to use a sealing disc. Weak seal part 10
The strong seal portion 11 and the strong seal portion 11 need to be formed to sufficiently overlap each other as shown in FIGS. 3 to 6. As a result, when only a part of the width of the weak seal portion 10 overlaps the strong seal portion, The width of the weak seal portion becomes small, and the expected function of the partition seal portion cannot be fulfilled. In the above description, the method of forming the weak seal portion first and then forming the strong seal portion has been described. However, in order to form the partition seal portion having the function according to the present invention, the order is reversed. Of course, it may be.

The structure of the front and back surfaces of the strong seal portion in the above description may be flat. However, in order to further increase the peel strength as compared with the weak seal portion, a structure in which the inner surfaces of the opposing heat seal boards are engaged with each other, Preferably, a heat seal device is used in which one of the inner surfaces is formed in a twill pattern or a flat pattern, and the other inner surface is in a twill pattern formed by a concave groove into which the ridge is fitted. In addition, as a structure of the heat sealing board, it is conceivable that the one inner surface has a flat pattern and the other inner surface has a similar flat pattern, but the engagement between the straight lines is difficult to achieve a complete liquid-tight seal. Not preferred.

It should be noted that the weak seal portion can also have a twill pattern or a plain pattern on one side and a twill pattern on the other side, and can be used for internal pressure management as described above. However, if the weak seal part is too deeply meshed with the irregularities, it will be difficult to peel off when mixing the chemical solution, so by cutting off the tip of one of the ridges of the heat seal bar, the cross section is made to be a trapezoidal ridge. Thus, the degree of engagement between the two boards is weakened, and the peel strength can be adjusted to be lower than that of the strong seal portion.

Next, the present invention will be described with reference to Examples and Comparative Examples. (Examples 1 to 8 and Comparative Examples 1 to 9) In the present example, specific numerical values are applied to the drawings described in the description using the drawings. The infusion bag was cut into a linear low-density polyethylene tubular film having a film thickness of 250 μm and a folding diameter (width of a flatly folded infusion bag) of 190 mm to a length of 900 mm, and the upper and lower openings were cut as shown in FIG. A bag-like container was prepared by heat-sealing the container together with the mouth members 7 and 8 in a liquid-tight manner. Various heat seal bars are used at the center of the bag-like container in the longitudinal direction to form a partition seal, at a temperature of 123 ° C., a pressing force of 4 kg, and a pressing time of 4 sec.
To form a rectangular weak seal portion 10 having a width of 10 mm and a length of 180 mm. Further, heat sealing disks of various circular shapes were applied to both sides thereof and sufficiently overlapped with the weak seal portion to form a strong seal portion. The heat sealing conditions in this case were as follows: the temperature of the heat sealing board was 145 ° C., the pressing force was 4 kg, and the pressing time was 1.5 sec. Next, a total of 90
Fill with 0 ml of water and seal each mouth member to 115
° C x 30 min. After the retort treatment, the weak seal was peeled off, the water temperature in the bag was set to 5 ° C, the bag was dropped from a height of 1.5 m, and the bag breaking condition at the boundary between the weak seal and the strong seal was visually observed. The evaluation results were expressed by ○ (breakage, no liquid leakage) and × (breakage, liquid leakage) and evaluated. In addition, the infusion bag is hung according to the actual situation, and wrinkles on the surface (which affects the flow of the liquid during infusion, and also affects the liquid level position observation and the ease of management) are visually observed. It was expressed and evaluated as good (no wrinkles) and bad (wrinkles). The results are summarized in Table 1.

[0025]

[Table 1]

[0026]

The infusion bag is divided into a plurality of chambers by a partition seal having a weak seal in the center, each chamber is filled with a chemical, and the weak seal is peeled off to mix the respective chemicals. If the strong seal part following both sides of the part is formed into a partial circular shape having a specific radius of curvature and height with chords at both ends of the bag, the strong seal in the compartment seal part even if the bag is accidentally dropped It was found to be very effective in preventing the occurrence of bag breakage or pinholes at the boundary between the seal portion and the weak seal portion. When a twill or a flat pattern and a twill pattern were formed on the front and back surfaces of the strong seal portion, the peel strength of the strong seal portion was further increased, but the bag break at the boundary between the strong seal portion and the weak seal portion, etc. The situation was not affected.

[Brief description of the drawings]

FIG. 1 shows a plan view of one embodiment of an infusion bag of the present invention.

FIG. 2 shows a state in which a weak seal portion of the partition seal portion is formed.

FIG. 3 Overlaps both ends of the weak seal portion, and on both sides of the infusion bag,
This shows a state in which a strong seal portion composed of a partial circle having a smooth surface is formed.

FIG. 4 shows a state in which a twill pattern is formed by a concave groove on one surface of the strong seal portion of FIG. 3;

FIG. 5 shows a state in which a twill pattern is formed by ridges on the other surface of the strong seal portion of FIG. 4;

FIG. 6 shows a state in which a strong seal portion is formed as a partial ellipse instead of the partial circle in FIG. 3;

FIG. 7 shows a conventional sealing section sealing section including a strong sealing section and a weak sealing section.

[Explanation of symbols]

1: Infusion bag 2: Side end 3: First chemical chamber 4: Second chemical chamber 5: Strong seal at upper end of infusion bag 6: Strong seal at lower end of infusion bag 7: Chemical liquid filling or taking-out member 8: Chemical liquid filling Or take-out opening member 9: partition seal part 10: weak seal part 11: strong seal part 13 of partition seal part: concave groove 14 of twill pattern: ridge 16 of twill pattern: conventional strong seal part 17: conventional strong seal portion of the tip portion S _1: strength height of the portion circle of the seal portion S _2: height of the portion ellipse strong seal portion

──────────────────────────────────────────────────続 き Continuation of front page (72) Inventor Nobuyuki Tanaka 3-2 Chidori-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa Prefecture Showa Denko KK Kawasaki Resin Laboratory (56) References JP-A-6-39018 (JP, A) JP-A-57-170264 (JP, A) JP-A-6-7411 (JP, A) JP-A-3-64732 (JP, U) WO 94/025252 (WO, A1) (58) Int.Cl. ⁷ , DB name) A61J 1/05

Claims (6)

(57) [Claims] 1. A flat cylindrical synthetic resin film having a fold at both ends and having a desired length, and at least one end in the length direction is used for filling or taking out a synthetic resin pharmaceutical liquid. Is a bag-shaped container in which a mouth member is sandwiched and a strong seal portion attached in a liquid-tight manner is formed, and a partition seal portion is formed in a liquid-tight manner in the width direction of the bag-shaped container at an intermediate portion between both ends. The partition seal portion is composed of a strong seal portion at both end portions of the bag-like container and a band-like weak seal portion at the center portion sandwiched between the seal portions, and the strong seal portion is vertically symmetrical with the weak seal portion. formed, and the chord of the end, 10 mm <radius of curvature R <35 mm, 3 mm <a height of S <10 mm, circular
An infusion bag having a partial circular shape that does not include the center of the shape . 2. The strong seal portion of the partition seal portion has a flat or twill-like concave groove formed on one surface and a twill-like convex groove formed on the other surface. 2. The infusion bag according to claim 1, wherein the bag is formed back-to-back with the parallel projection on the other surface. 3. The infusion bag according to claim 2, wherein the depth of the concave groove and the height of the ridge of the strong seal portion of the partition seal portion are sequentially increased toward both side ends of the bag-like container. 4. A flat cylindrical synthetic resin film having folds at both ends is cut to a desired length, and at least one of the obtained upper and lower ends is filled with or taken out of a synthetic resin pharmaceutical liquid. Production of an infusion bag in which a liquid-tight strong seal portion is formed to form a bag-shaped container, and then a partition seal portion is formed at an intermediate portion between the both end portions over the entire length of the bag-shaped container in the width direction. In the method, the compartment seal portion is obtained by forming each strong seal portion at both end portions in the width direction of the bag-like container and a weak seal portion at the central portion sandwiched therebetween in this order or in the reverse order. The weak seal portion is formed by pressure contact with two band-shaped seal bars, and the strong seal portion straddles the folds at both ends of the bag-shaped container, and is formed of two circular shapes each having 10 mm <curvature radius R <35 mm. Press in with a partial circular seal board and fold the strings And, 3mm in a bag-like container inwardly <height S
A method for manufacturing an infusion bag, wherein the infusion bag has a shape of <10 mm and extends symmetrically vertically above and below the weakly sealed portion and does not include a circular center . 5. An inner surface of one of the two opposing seal disks is formed as a flat or ridge-shaped convex ridge, and the other inner surface is formed as a traverse-shaped concave groove. 5. The method for manufacturing an infusion bag according to claim 4, wherein the ridges are adjusted to positions opposed to each other to form a strong seal portion of the partition seal portion. 6. A seal disk in which the height of a flat or ridge-shaped ridge on one inner surface of the seal disk and the depth of a ridge-shaped concave groove on the other inner surface are sequentially increased toward both side ends. The method for producing an infusion bag according to claim 5, wherein