JP6478400B2 - Bag-shaped container, medical multi-chamber container, mold and method of forming curvilinear belt-like weak seal - Google Patents

Description

  The present invention relates to a bag-like container, a medical multi-chamber container, a mold and a method of forming a curvilinear belt-like weak seal.

In a multi-chamber bag-shaped container such as a multi-chamber container for medical use, powder and liquid, or a plurality of different types of liquids are respectively contained so that the powder and the liquid or plural types of liquids can be mixed at the time of use There is something that
For example, as a medical multi-chamber container for containing a drug for drip treatment in the medical field, different types of drugs are used for each of a plurality of drug chambers made of a flexible film and partitioned by a partition provided in the container. The one containing the As a combination of a plurality of drugs, there are, for example, amino acids and glucose infusion, antibiotics and their solutions, etc. which may cause deterioration over time if they are mixed and stored. Each drug chamber of the medical multi-chamber container is formed by sealing two flexible films along the outer peripheral shape of each drug chamber by welding or the like. The partition wall provided between the drug chambers adjacent to each other is a weakly sealed portion having a low seal strength as compared with the seal portion along the outer peripheral shape of each drug chamber. Thereby, in the part of a partition, two flexible films which form a medical multi-chamber container are sealed in the state which can be peeled off.

  When performing infusion treatment using a medical multi-chamber container, an internal pressure is applied to the drug by externally pressing one chamber containing the liquid drug before use. Then, in the weakly sealed portion, the two flexible films separate from each other to break the partition, and drug chambers adjacent to each other with the partition interposed communicate with each other. Thereby, a plurality of medicines contained in the respective medicine rooms are aseptically mixed in the medical multi-chamber container. The mixed drug is drained from the drain port of the container via the needle and tube of the infusion set and is administered to the patient.

  Thus, in the case of the drip treatment using the medical multiple-chamber container which mixes and uses a some chemical | medical agent, it does not destroy the partition of a medical multiple-chamber container, and it drips by mistake the medicine which has not been mixed It is pointed out that there is a risk of

Therefore, in order to prevent the medicine before mixing from being administered and to improve the safety in use, a medical double seal provided with a weak seal portion for inflow prevention that blocks communication between the medicine chamber and the discharge port. A chamber container is disclosed (see, for example, Patent Document 1).
Two weakly sealed parts are provided in the medical multi-chamber container described in Patent Document 1. The first weak seal portion is a partition that divides the first and second drug chambers, and the partition weak seal portion is provided in a linear band shape with a constant width so as to cross the container body. The second weak seal portion serves as a partition that prevents only the drug solution in the first medicine chamber from being mixed out from the discharge port, and the weak seal portion for inflow prevention surrounds the discharge port. It is provided in the shape of a band combining a straight line and a curve in width. The partitioning weak seal portion is opposed to the inflow blocking weak seal portion that inhibits communication between the discharge port provided on the first medicine chamber side and the first medicine chamber. When using this medical multi-chamber container, the second drug chamber in which the weak seal portion for inflow prevention does not exist is pressed from the outside to increase the fluid pressure in the second drug chamber. Then, the partition weak seal part peeled off, the first drug chamber and the second drug chamber communicated, and the drug in the second drug chamber in which the fluid pressure was increased was peeled off at the partition weak seal part It flows into the first medicine chamber through the part. As a result, the fluid pressure in the first medicine chamber also increases, and the fluid pressure acts on the inflow preventing weak seal part, and the inflow preventing weak seal part is peeled off. This makes it possible to infuse the drug which is a mixture of the two drugs from the discharge port.
As described above, the communication operation between the first drug chamber and the second drug chamber and the peeling operation of the inflow preventing weak seal portion can be performed by a single operation of pressing one drug chamber. .

By the way, if the multi-chamber container as described above is dropped by mistake, for example, at the time of transportation etc., the pressure of the drug stored in the first drug chamber or the second drug chamber increases due to the impact at the time of dropping. Peeling may occur at the weak sealing portion, and the first drug chamber may communicate with the second drug chamber.
Therefore, as described in Patent Document 2, the multi-chamber container is housed in the packing box in a state of being folded by the partitioning weak seal portion which is the first weak seal portion partitioning the plurality of chambers. Will be packed. By folding the multi-chamber container at the weak sealing portion for division, peeling at the weak sealing portion for division occurs due to the impact of falling of the packing box or the like, and the occurrence of unintended opening is prevented.

However, as in the configuration disclosed in Patent Document 2, in the method of folding the multi-chamber container, the weak seal portion for preventing inflow, which is the second weak seal portion partially in a curvilinear band shape, is protected. In the second medicine chamber, the pressure of the medicine in the second medicine chamber is increased, and the possibility of peeling occurring at the weak sealing portion for preventing inflow can not be excluded.
Then, in order to prevent unintended opening in the inflow preventing weak seal portion, Patent Document 3 discloses a configuration in which a protective member for protecting the inflow preventing weak seal portion is provided in the packing box.

Unexamined-Japanese-Patent No. 2006-43061 JP 2004-149124 A Utility Model Registration No. 3160045

However, in the configuration as disclosed in Patent Document 3, the use of the protective member results in an increase in the cost of the packaging material and also wastes.
Therefore, the present invention has been made in view of the above circumstances, and without using a protective member, an unintended peeling does not occur due to an impact such as falling, and a curvilinear belt-like weak seal can be easily opened when necessary. The present invention provides a bag-like container provided with the above, a medical multi-chamber container provided with a curvilinear strip-like weak sealing portion for inflow prevention, a mold and a method of forming a curvilinear strip-like weak seal portion.

  In order to solve the above problems, the bag-like container of the present invention is formed by sealing the peripheries of overlapping films, and a curvilinear belt-like weak seal is provided so as to partition the chamber containing the substance and the chamber. A linear seal portion extending along a direction in which the curved band-like weak seal portion is continuous is formed on at least one surface of the curved band-like weak seal portion.

  According to the present invention, when a pressure is applied to the bag-like container from the outside and the pressure of the articles contained in the chamber is increased, the pressure is a direction in which the curvilinear belt-like weak seal part is continuous with the curvilinear belt-like weak seal part. Act in a direction that crosses the The curvilinear belt-like weak seal portion is formed with a linear seal portion extending along the direction in which the curvilinear belt-like weak seal portion is continuous, so that concentration of acting pressure is prevented, and the curvilinear belt-like weak seal portion is careless It is possible to suppress peeling.

  In addition, it has a plurality of chambers, and a weak sealing portion for partitioning which divides the plurality of chambers in communication, and a port provided in one of the chambers, and the curvilinear belt-like weak sealing portion The inflow blocking weak seal portion is formed so as to protrude toward the weak sealing portion side for partitioning and surround the port, and temporarily block the flow of the substance contained in the chamber into the port. Good.

  According to the present invention, when a pressure is applied to the bag-like container from the outside and the pressure of the articles contained in the chamber is increased, the pressure is such that the weak seal part for inflow prevention is continuous to the weak seal part for inflow prevention. Act in a direction that intersects the The inflow prevention weak seal portion is formed with a linear seal portion extending along the direction in which the inflow prevention weak seal portion continues, so that the applied pressure is prevented from concentrating, and the inflow prevention weak seal portion Can be prevented from coming off carelessly.

  Further, the medical multi-chamber container of the present invention is formed by sealing the peripheries of the overlapping films, and a plurality of drug chambers, a partitioning weak seal portion partitioning the plurality of drug chambers in communication with each other, and A medical multiple chamber having a port for drug discharge provided in one of the drug chambers, and a curvilinear belt-like weak seal portion formed so as to protrude toward the weak seal portion for dividing and surround the port. In the container, the curvilinear belt-like weak seal portion is an inflow preventing weak seal portion for temporarily blocking the inflow of the medicine contained in the medicine chamber into the port, and A linear seal portion extending along a direction in which the inflow preventing weak seal portion is formed is formed on at least one surface.

  According to the present invention, when external pressure is applied to the medical multi-chamber container to increase the pressure of the medicine contained in the medicine chamber, the pressure is applied to the inflow preventing weak seal against the inflow preventing weak seal portion. It acts in a direction that crosses the direction in which the parts continue. On the other hand, since the inflow preventing weak seal portion is formed with a linear seal portion extending along the direction in which the inflow preventing weak seal portion continues, concentration of acting pressure is prevented, and the inflow preventing portion is prevented. It is possible to suppress inadvertent peeling of the for-use weak seal portion.

Further, on the other surface of the inflow preventing weak seal portion, a plurality of point-like seal portions spaced along a direction in which the inflow preventing weak seal portion is continuous face the linear seal portion. It may be formed in
In this manner, by providing a point-like seal part facing the linear seal part, unintended peeling does not occur due to impact such as falling, and there is little variation in peel strength that can be easily opened when necessary. And a weakly sealed portion having stable peel strength.

Further, the linear seal portion may be formed at least at a tip end portion of the weakly sealing portion for preventing inflow that protrudes toward the weak sealing portion for division.
The pressure of the medicine contained in the medicine chamber acts on the tip of the weak sealing portion for preventing inflow, which is concentrated toward the weak sealing portion for division. Therefore, by providing the linear seal portion at the front end portion, it is possible to effectively suppress inadvertent peeling of the inflow preventing weak seal portion.

The mold according to the present invention is a mold for forming the curvilinear belt-like weak seal portion as described above, and a ridge extending in a direction in which the curvilinear belt-like weak seal portion is formed is formed on the pressing surface. It is characterized by being done.
The method for forming a curvilinear belt-like weak seal portion according to the present invention is a method for forming the curvilinear belt-like weak seal portion as described above, and extends along a direction in which the curvilinear belt-like weak seal portion is continuous with a pressing surface. The mold on which the ridges are formed is heated and pressed against the surface of the film, and the ridges form the linear seal portion on the surface of the curvilinear belt-like weak seal portion.

  By pressing such a mold against the surface of the film while heating, a linear seal can be formed on the surface of the curvilinear belt-like weak seal by the ridges.

  ADVANTAGE OF THE INVENTION According to this invention, it can suppress that a curvilinear strip | belt-shaped weak seal part peels carelessly. As a result, even if the protective member is not used as in the prior art, unintended peeling of the curvilinear belt-like weak seal part does not occur by an impact such as falling, and the curvilinear belt-like weak seal part can be easily opened when necessary.

It is a top view which shows the structure of the medical multi-chamber container in one Embodiment of this invention. It is an enlarged plan view of a partial region of the weak seal portion for inflow prevention. FIG. 3 is a perspective sectional view taken along the line A-A of FIG. It is a perspective cross-sectional view which follows the BB line of FIG. It is sectional drawing which follows the CC line of FIG. It is a top view which shows the press surface of the metal mold | die for forming a groove | channel. It is sectional drawing in alignment with the DD line of FIG. It is a top view which shows the metal mold | die surface of the metal mold | die for forming a recessed part. It is a top view which shows the structure of the medical multiple-chamber container which concerns on other embodiment. It is a top view which shows the die surface of one die | dye used for the seal | sticker of a comparative example. It is a top view which shows the mold surface of the other metal mold | die used for the seal | sticker of a comparative example. It is a schematic diagram which shows the accommodation state of the medical multi-chamber container at the time of performing a drop test.

Next, an embodiment of the present invention will be described based on the drawings.
FIG. 1 is a plan view showing the configuration of a medical multi-chamber container in an embodiment of the present invention.
As shown in FIG. 1, the medical multiple-chamber container 1 which is a kind of bag-like container is a medicine chamber (corresponding to a "chamber" in the claims) provided in a plurality (two in the present embodiment) side by side. (12A, 12B) and the port 14 are provided.
Here, in the following description, in the medical multi-chamber container 1, the direction in which the two drug chambers 12A and 12B are arranged is the vertical direction Y, and the direction orthogonal to the vertical direction Y on the surface of the film 11 is the width direction X. .

  The medical multi-chamber container 1 is formed in a substantially rectangular shape in a plan view, and the two films 11 are superimposed on each other, and the peripheral seal portion 17, the concave seal portion 16, and the weak seal portion 13 for division; It is formed by sealing with the inflow preventing weak seal portion 15 which is a curvilinear belt-like weak seal portion.

  The drug chambers 12A and 12B are formed by dividing the space surrounded by the peripheral seal portion 17 sealed along the peripheries of the two films 11 into two in the vertical direction Y by the partition weak seal portion 13. ing.

  The peripheral seal portions 17 are formed on both ends in the width direction X of the medical multi-chamber container 1 and are formed on the side seals 17A and 17A extending in the vertical direction Y and on both ends in the vertical direction Y of the medical multi-chamber container 1 And an upper seal portion 17B and a lower seal portion 17C extending in the width direction X. The upper seal portion 17B and the lower seal portion 17C are each formed to have a wider seal width than the side seal portion 17A.

  At the middle part of the side seal parts 17A and 17A in the vertical direction Y, a concave seal part 16 which is recessed in a substantially U shape toward the central part in the width direction X, that is, the inward of the medical multi-chamber container 1 is provided. It is formed. In each concave seal portion 16, a tip end portion 16 a protruding toward the most central portion in the width direction X is formed to overlap an end portion in the width direction X of the weak sealing portion for division 13.

  In the concave seal portion 16, the depression height H representing the degree of depression toward the inside of the medical multi-chamber container 1 in the width direction X is a total 2H of the depression heights of the pair of concave seal portions 16 and 16 The total width W (length in the width direction X) of the multi-chamber container 1 is preferably 10 to 50%, and more preferably 15 to 45%. If the total 2H of the recess height is 10% or more, the unopened portion is unlikely to remain at the longitudinal end of the weak sealing portion 13 for division, and the unopened portion of the medical double-chamber container 1 is dropped It is less likely to cause a bag from near the end. In addition, if the total 2H of the recess height is 50% or less, the storage capacity of the contents of the medicine chamber 12 can be sufficiently maintained.

The concave seal portion 16 preferably has a radius of curvature of 15 mm to 30 mm at the tip end portion 16 a that protrudes inward in the width direction X. If this curvature radius is 15 mm or more, it will become difficult to produce a bag breakage, even if it falls. In addition, if the radius of curvature is 30 mm or less, the storage capacity of the contents of the medicine chamber 12 can be sufficiently maintained.
Moreover, although the concave seal parts 16 shown in FIG. 1 are made symmetrical in the width direction X in the present embodiment, the present invention is not limited to this and may be asymmetrical.

  In the upper seal portion 17B, portions (first unbonded portions 11a) in which the overlapping films 11, 11 are not bonded are formed on both left and right sides in the width direction X. Further, in the upper seal portion 17B, a suspension hole 18 is formed between the first unbonded portions 11a and 11a on the left and right sides in the width direction X and at the center in the width direction X. The hanging holes 18 are formed through the two films 11, 11. The suspension hole 18 is a hole used when the medical multi-chamber container 1 is suspended and used.

  In the lower sealing portion 17C, a portion (second non-adhered portion 11b) in which the overlapping films 11 are not adhered is formed on one side in the left-right direction of the width direction X. Further, on the other side in the left-right direction of the width direction X, a planned filling port portion to be used as a filling port for the drug chamber 12B protruding outward from the outer shape of the approximately rectangular medical multi-chamber container 1 is formed It is done. The planned filling port may be provided on any side of the rectangle, or a plurality may be provided. In addition, the filling port to 12 A of drug chambers is abbreviate | omitted in FIG.

  The port 14 is provided on the opposite side of the weak sealing portion 13 in the one drug chamber 12 (here, the drug chamber 12B). The port 14 is provided at the center of the lower seal portion 17C in the width direction X. The port 14 is sandwiched and fixed between the two films 11 in the lower seal portion 17C. The port 14 is a passage which is used for injection and discharge of medicine and allows access from the outside of the container to the inside of the container. The port 14 is provided such that the central axis of the passage formed by the port 14 coincides with the vertical direction when the medical multi-chamber container 1 is suspended by the suspension hole 18. The port 14 is an injection-molded product of a thermoplastic resin, and the opening is sealed by an elastic body such as rubber (not shown) which can be pierced in order to enable insertion of a needle. The port 14 may be replaced by a tube.

The partitioning weak seal portion 13 is formed in a linear band shape along the width direction X so as to connect the tip portions 16a, 16a of the pair of left and right concave seal portions 16, 16. The partitioning weak seal portion 13 is provided at a position facing the inflow preventing weak seal portion 15 provided in the medicine chamber 12B. Although the width dimension D1 of the weak sealing portion 13 for division is not particularly limited, it is determined to be, for example, about 5 mm to 20 mm.
It is also preferable that the partitioning weak seal portion 13 be long until it passes through the tip portions 16a, 16a of the pair of left and right concave seal portions 16, 16 and reaches the side seal portions 17A, 17A. The reason for this is that, in a weak sealing mold having a linear belt-like heating part for producing the division weak sealing part 13, the longitudinal direction central part of the linear belt-like heating part is stably maintained at a constant temperature. It is difficult to maintain a stable constant temperature under the influence of the outside because the end is the end of the mold compared to the case, but the variation in peel strength may increase with this, but the weak seal The divisional weak seal part 13 uses only the longitudinal direction central part stabilized at a constant temperature if the mold is reached or longer than reaching the side seal parts 17A, 17A of the divisional weak seal part 13 This makes it possible to manufacture As a result, it is possible to provide the section weak seal portion 13 which does not cause an unintended peeling due to an impact such as falling easily, and exhibits a strength that can be easily opened when necessary.

  The partitioning weak seal portion 13 is configured such that the two overlapping films 11, 11 are peelably sealed, and isolates the two medicine chambers 12A, 12B so as to allow communication. The partition weak seal portion 13 isolates the drug chambers 12A and 12B in a state before use, and blocks the communication between both. The division weak sealing portion 13 can be peeled off by pressing the drug chamber 12A or 12B adjacent to the outside from the outside during use to increase the internal pressure. The drug chambers 12A and 12B communicate with each other by the separation weak sealing portion 13 being separated.

  The weak seal portion 13 for section preferably has a T-shaped peel strength measured at a tensile speed of 300 mm / min according to JIS K 6854-3, as a width of 1 to 8 N / 10 mm, and further preferably 1.5 to 5 N / 10 mm. It is more preferable to set the width. The communication strength when the medicine chamber 12A or the medicine chamber 12B is pressed from the outside and the partitioning weak seal portion 13 is separated and communicated is preferably 200 N to 800 N, and more preferably 300 N to 700 N . By setting it as such a range, there is an advantage that the division weak seal portion 13 can be peeled off without requiring an excessive force at the time of use and without destroying the medical multi-chamber container 1.

Also, the peel strength of the weak sealing portion 13 for division may be constant in the width direction X of the medical multi-chamber container 1, but it is also preferable to change in the width direction X of the medical multi-chamber container 1 is there. For example, it is also preferable to increase the peel strength of the central portion 13a in the width direction X of the partitioning weak seal portion 13 and to lower the peel strength of the both end portions 13b and 13c in the width direction X than the central portion 13a. Specifically, it is preferable to set the peel strength of the both end portions 13b and 13c to 20 to 80% of the peel strength of the central portion 13a.
By doing this, it is possible to minimize or eliminate the remaining unpeeled portions of the both end portions 13b and 13c after the communication. If the non-peeling part remains, the end of the remaining weak sealing part for division 13 becomes a stress concentration part at the time of drop of the medical multi-chamber container 1, and the medical multi-chamber container 1 becomes easy to tear. If the peel strength of both end portions 13b and 13c in the width direction X is lowered in the weak sealing portion 13 for division, the unpeeled portion becomes difficult to remain, and even if it remains temporarily, the peel strength of the central portion 13a in the width direction X Of the weak sealing portion 13 having low peeling strength and capable of peeling, it becomes a weak sealing portion which is further easily peeled. As a result, it is possible to prevent, as much as possible, the stress concentration portion where the division weak seal portion 13 leads to a broken bag. This can prevent the medical multiple-chamber container 1 from being broken.

  In the weak sealing portion 13 for division, in order to increase the peeling strength of the central portion 13a in the width direction X and to decrease the peeling strength of both end portions 13b and 13c in the width direction X, heat at the time of manufacturing the weak sealing portion 13 for division The seal temperature is set so that the central portion 13a is high and the both end portions 13b and 13c are low, and the seal pressure of the central portion 13a is high due to the shape of the seal mold at the time of manufacturing the seal portion. There are a method of adjusting the pressure low, a method of increasing the amount of heat per unit time received by the central portion 13a by the seal pattern of the seal mold and reducing the amount of heat per unit time received by the both end portions 13b and 13c.

In addition, when the weak sealing portion 13 for sectioning is peeled by pressing the drug chamber 12A from the outside to raise the internal pressure of the drug chamber 12A, the weak sealing portion 15 for inflow prevention can be easily peeled continuously. In this case, it is preferable to set the peel strength of the central portion 13a of the weak sealing portion 13 for division lower than the peel strength of the both end portions 13b and 13c.
By doing this, when the central portion 13a of the weak sealing portion for section 13 peels off, the drug in the drug chamber 12A concentrates on the central portion 13a, and from one side in the vertical direction Y of the drug chamber 12B, the drug chamber It becomes easy to flow into the central part of width direction X of 12B. The pressure of the medicine that has flowed into the medicine chamber 12B acts on the weakly sealed portion 15 for inflow prevention located at the central portion in the width direction X on the other side in the vertical direction Y of the medicine chamber 12B, as described later Peeling of the weak seal portion for prevention 15 is facilitated.

  Thus, in the weak sealing portion 13 for division, in order to reduce the peeling strength of the central portion 13a in the width direction X and to increase the peeling strength of the both end portions 13b and 13c in the width direction X, the weak sealing portion 13 for division The heat seal temperature at the time of manufacture is set so that the central portion 13a is low and the both end portions 13b and 13c are high, and the seal pressure of the central portion 13a is low due to the shape of the seal mold at the time of manufacturing the seal portion. The method of adjusting the sealing pressure of 13c high, the method of reducing the amount of heat per unit time received by the central portion 13a by the seal pattern of the sealing die and increasing the amount of heat per unit time received by the both end portions 13b and 13c It can be mentioned.

The inflow preventing weak seal portion 15 is formed to surround the port 14 in the medicine chamber 12 B in which the port 14 is provided. The inflow preventing weak seal portion 15 prevents the unmixed drug from being administered to the patient by temporarily blocking the inflow of the drug into the port 14.
The inflow preventing weak seal portion 15 includes linear seal portions 15a and 15a and a curved seal portion (corresponding to a "tip portion" in the claims) 15b.

  The straight seal portions 15 a, 15 a are formed symmetrically with respect to the center in the width direction X. Each linear seal portion 15a is formed to extend obliquely and linearly in the lower seal portion 17C from a position away from the port 14 in the width direction X so as to gradually approach the center side in the width direction X upward. It is done.

  The curved seal portion 15b is continuously formed between the upper end portions of the linear seal portions 15a, 15a. The curved seal portion 15 b is formed to be convex upward. The radius of curvature of the curved seal portion 15b is preferably about 20 mm to 40 mm, and more preferably about 25 mm to 35 mm. When the radius of curvature of the curved seal portion 15 b decreases, the weak seal portion 15 for inflow prevention tends to peel off, and tends to easily peel off when the container is transferred. In the curved seal portion 15b, when the radius of curvature increases, the area surrounded by the inflow preventing weak seal portion 15 and the lower seal portion 17C becomes larger, and the amount of drug solution that can be filled in the medicine chamber 12B decreases.

  The shape of the inflow preventing weak seal portion 15 is not limited to the above-described shape, and can be an arbitrary curved shape such as a semicircular shape, a semi-elliptical shape, or a partial shape of a polygon. In the inflow preventing weak seal portion 15, the number of the convex portions toward the upper side may be one or more. In addition, as shown in FIG. 1, in the case where there is one curved seal portion 15b which is convex, the curved seal portion 15b is positioned at a position closest to the partitioning weak seal portion 13 in the inflow preventing weak seal portion 15. Let's do it. The curve seal portion 15b, which is a convex portion, is a portion where the weak sealing portion for section 13 peels off and the drug solution flowing from the drug chamber 12A into the drug chamber 12B first reaches to concentrate the stress. 15 is preferable in order to facilitate the start of peeling. Further, it is preferable that the shape of the inflow preventing weak seal portion 15 be symmetrical in shape with the axis in the longitudinal direction of the port as the target axis.

  Although the seal width dimensions of the linear seal portion 15a and the curved seal portion 15b constituting the band-like weak seal portion for inflow prevention 15 are not particularly limited, for example, it is preferable to be about 5 mm to 20 mm. Further, the straight seal portion 15a and the curved seal portion 15b all have the same fixed width, and for example, the portion near the lower seal portion 17C in the inflow preventing weak seal portion 15 is partially narrowed. For example, the portion that is more difficult to peel compared to the top may be made easier to peel.

FIG. 2 is an enlarged plan view of a partial region R of the inflow preventing weak seal part surrounded by a broken line in FIG. FIG. 2 shows the pattern of one outer surface shown by a solid line and the pattern of the other outer surface shown by a broken line. FIG. 3 is a perspective sectional view taken along the line AA of FIG. FIG. 4 is a perspective sectional view taken along the line B-B of FIG. FIG. 5 is a cross-sectional view taken along the line C-C of FIG.
As shown in FIG. 2 to FIG. 5, the inflow preventing weak seal portion 15 is continuous with the inflow preventing weak seal portion 15 on the outer surface 11 f of one of the two films 11 and 11. Along the direction, a plurality of grooves (corresponding to the “linear seal portion” in the claims) 21 are formed. The plurality of grooves 21 are formed at intervals in the width direction of the inflow preventing weak seal portion 15. Each groove 21 has a groove bottom 21a having a predetermined width. In addition, each groove 21 is formed so that the groove width dimension gradually decreases from the outer surface 11 f side of the film 11 toward the groove bottom 21 a.

  Further, as shown in FIG. 2, FIG. 3 and FIG. 5, the inflow preventing weak seal portion 15 has a plurality of concave portions (claims) on the outer surface 11g of the other film 11 of the two films 11 and 11. It corresponds to the "point-like seal portion" in the paragraph)) 22 is formed. These recessed portions 22 are provided in a plurality of rows at intervals in the width direction of the inflow preventing weak seal portion 15. In each row, a plurality of recessed portions 22 are provided at intervals along the direction in which the weak inflow preventing seal portions 15 continue. Further, the recesses 22 in each row are formed at positions facing the grooves 21. Each recess 22 has a recess bottom surface 22a having a predetermined width. Each recess 22 is formed such that the cross-sectional area of the recess along the plane parallel to the recess bottom 22a gradually decreases from the outer surface 11g side of the film 11 toward the recess bottom 22a. Further, in addition to the recess 22 in each row being formed at a position facing the groove 21, as is understood from FIGS. 2 and 3, the groove bottom 21a and the recess bottom 22a are also facing each other. Preferably, it is formed. The groove bottom 21a and the concave bottom 22a face each other, so that unintended peeling does not occur due to impact such as falling, and the inflow with stable peeling strength with little variation in peeling strength that can be easily opened when necessary. It becomes easy to set it as the weak seal part 15 for prevention.

FIG. 6 is a plan view showing a pressing surface of a mold for forming a groove. 7 is a cross-sectional view taken along the line D-D of FIG. FIG. 8 is a plan view showing a mold surface of a mold for forming a recess.
The inflow preventing weak seal portion 15 as described above arranges the mold 30A (see FIG. 6 and FIG. 7) on one side of the two films 11 stacked on each other, and the mold on the other side. 30B (see FIG. 8) is formed, and these molds 30A, 30B are formed by heating and pressing.

  As shown in FIGS. 6 and 7, in the mold 30A, ridges 31 which are continuous along the contour of the inflow preventing weak seal portion 15 to be formed are spaced apart in the width direction. Several are formed. Each protrusion 31 has a trapezoidal cross-sectional shape, and the groove 21 is formed by heating and pressing the pressing surface 30 f of the mold 30 A to the outer surface 11 f of the film 11. Here, the protrusion 31 is formed to have a width of, for example, 1 mm, the pressing surface 30 f which is the top surface of the protrusion 31 is formed to have a width of 0.4 mm, and the top surfaces of the protrusions 31 and 31 adjacent to each other. The distance between the end of the ridge and the end of the top surface adjacent to each other is set to, for example, 0.6 mm, and the bases of the ridges 31 are provided in close contact. In other words, in the mold surface of the mold 30A, a groove having a cross-sectional inverse triangle with a width of 0.6 mm continuous along the outline of the weak seal portion 15 for inflow prevention to be formed is the deepest part of the groove A plurality of members are formed in the width direction so as to have an interval of 1 mm.

As shown in FIG. 8, in the mold surface 30g of the mold 30B, a groove 32 having a cross-sectional reverse triangle continuous along the outline of the inflow preventing weak seal portion 15 (see FIG. 1) to be formed has a width A plurality is formed at intervals in the direction. Further, on the mold surface 30g, a plurality of grooves 33 having a cross-sectional inverse triangle extending in a direction intersecting with the grooves 32 are formed in parallel with one another. The grooves 32 and the grooves 33 form a plurality of substantially square pyramidal projections 34 spaced apart from one another.
Here, the grooves 32 are formed to have a width of, for example, 0.6 mm, and the distance between the deepest portions of the grooves 32, 32 adjacent to each other is set to, for example, 1 mm. The grooves 33 intersecting with the grooves 32 are formed to have a width of, for example, 0.6 mm, and the distance between the deepest portions of the grooves 32, 32 adjacent to each other is set to, for example, 1 mm. The top surface of each projection 34 is formed to have an outer dimension of, for example, about 0.4 mm square, and the portion forming the curved seal portion at the tip end is approximately square and forms a linear seal portion other than the tip end. The part is a parallelogram. In other words, in the mold 30B, a square frustum close to a square or a parallelogram having a bottom surface of about 1 mm on one side and a top surface of about 0.4 mm on one side is formed in close contact with the bottom surface.

  Here, in the mold for manufacturing the weak seal portion 15 for inflow prevention, the external shape of the protrusions 31 and the projections 34 located at the peripheral edge on the medicine chamber 12B side is parallel to the outline shape of the weak seal portion 15 for inflow prevention Although it is preferable to form it, it may be formed to be inclined within a range of, for example, about 10 ° from parallel.

  The inflow preventing weak seal portion 15 is sandwiched between the molds 30A and 30B as described above in a state in which the two films 11 and 11 are superimposed, and for example, the pressure is 0.05 to 120 ° C. It is preferable to form by heat-pressing by 2 MPa and time 0.5 to 10 sec. More specifically, when the films 11, 11 are polyethylene resin, for example, the heat sealing with the molds 30A, 30B is performed at 120 ° C. to 135 ° C. and a pressure of 0.1 to 1 MPa to weakly seal the inflow preventing weak seal portion 15. It is preferable to form.

  In addition, the peel strength at the time of peeling of the weak seal part 15 for inflow prevention by the liquid pressure of the medicine of medicine room 12B or the medicine which medicines of medicine room 12A and 12B mixed in use is JIS K6854-3. The T-peel strength measured at a tensile speed of 300 mm / min according to the above is preferably 4 to 20 N / 10 mm in width, and more preferably 7 to 12 N / 10 mm in width. Further, it is preferable that the peeling strength of the inflow preventing weak seal portion 15 be higher than the peel strength of the dividing weak seal portion 13. Further, the peel strength of the partitioning weak seal portion 13 and the inflow preventing weak seal portion 15 is set to be lower than the peel strength of the peripheral seal portion 17.

  In this way, when the drug chamber 12B provided with the port 14 is pressed from the outside, the partitioning weak seal portion 13 does not peel off after the inflow blocking weak seal portion 15, and the inflow blocking weak Only the seal portion 15 is peeled off, and unmixed drug does not flow out of the port 14. Thus, the inflow preventing weak seal portion 15 has a function of temporarily preventing the unmixed drug from flowing into the port 14. The communication strength when the medicine chamber 12B is pressed from the outside and the inflow preventing weak seal portion 15 is separated and communicated is 500N to 2000N, preferably, 600N to 1500N, the inflow preventing weak seal portion 15 can be easily opened.

  As described above, the inflow preventing weak seal portion 15 is formed by forming the linear groove 21 and the point concave portion 22 in the outer surfaces 11 f and 11 g of the films 11 and 11 by the ridges 31 and the protrusions 34. As compared with the case where the films 11 and 11 are sealed in a planar shape, the films 11 and 11 can be pressed with a higher pressure with a limited area and reliably sealed. Further, the mold 30A and the mold 30B are manufactured so that the top surface of the projection 31 and the top surface of the projection 34 can face each other, and the top surface and the projection of the projection 31 are manufactured using these molds 30A and 30B. It is preferable to seal the films 11 and 11 so that the top surface of 34 faces. As a result, unintended peeling does not occur due to impact such as falling, and when necessary, it is easy to form a weakly sealed inflow preventing weak seal portion 15 having stable peeling strength with little variation in peeling strength that can be easily opened. It becomes.

In the region where the linear grooves 21 and the point-like concave portions 22 are formed on the outer surfaces 11 f and 11 g of the films 11 and 11 by the ridges 31 and the projections 34 as described above, The entire area, that is, the entire area of the linear seal portion 15a and the curved seal portion 15b may be used, but not limited thereto. A linear groove 21 and a point-like concave portion 22 are formed at least at the top of the curved seal portion 15b which is convex toward the dividing weak seal portion 13 in the inflow preventing weak seal portion 15 to form the films 11, 11 May be sealed. Furthermore, the linear grooves 21 and the point-like concave portions 22 may be formed only on the side of the drug chamber 12B in the width direction of the curved seal portion 15b to seal the films 11, 11. More specifically, although depending on the filling amount of the drug solution, it may be formed and sealed to about 1/3 of the width of the curve seal portion 15b on the side of the drug chamber 12B in the width direction of the curve seal portion 15b.
That is, the linear seal portion 15a which is less likely to peel off due to impact than the curved seal portion 15b is not limited to the seal structure including the groove 21 and the recess 22. For example, another seal structure such as planar sealing may be used. Moreover, although the linear groove | channel 21 and the recessed part 22 are provided at equal intervals at intervals in the width direction of the curve seal part 15b, intervals other than equal intervals may be used. Further, the concave portions 22 are also provided at equal intervals in the direction in which the weak sealing portions 15 for inflow prevention continue, but may be intervals other than equal intervals.
Alternatively, the inflow preventing weak seal portion 15 may be formed by combining a mold 30A having the ridges 31 or a mold 30B having the projections 34 with a planar mold (not shown). Furthermore, the planar mold may have its surface covered, for example, with a glass fiber reinforced fluororesin film.

  In the space between the weak sealing portion for inflow prevention 15 and the port 14, a small amount such as 0.01 mL to 1 mL of physiological saline or distilled water is present so as to sterilize the space when the temperature is raised. Is preferred. In addition, a slit-like unsealed portion where only a sufficient amount of sterilizing fluid can flow from the drug chamber 12 to the weakly sealed portion 15 for inflow prevention is within a range that does not contradict the gist of the present invention and does not affect drop impact strength. You may provide.

The material of the film 11 and the port 14 constituting the medical multiple-chamber container 1 of the present embodiment is made of a thermoplastic resin.
The thermoplastic resin is not particularly limited as long as it is used in the medical field, and may be vinyl chloride, ethylene vinyl acetate copolymer, polyolefin, polyamide, polyester, polyether sulfone, cyclic polyolefin, cyclic polyolefin Copolymers, ethylene-based elastomers, styrenic elastomers, and mixtures of these resins may be mentioned.
In addition, these thermoplastic resins are partially crosslinked for the purpose of improving heat resistance, etc., or in order to positively block, it is possible to mix low melting point components such as ultra low density polyethylene, ethylene based elastomers and styrene based elastomers You may

  Among these thermoplastic resins, polyolefin is preferable because it is inexpensive and is excellent in transparency and flexibility. Examples of polyolefins include polyethylene resins such as high density polyethylene, low density polyethylene, linear low density polyethylene, olefin elastomers such as ethylene-butadiene random copolymer, polypropylene, and propylene comprising ethylene or α-olefin and propylene A random copolymer and a polypropylene block copolymer based resin containing an ethylene-propylene copolymer elastomer can be mentioned. Furthermore, among these polyolefin resins, polyethylene resins are preferable because they do not contain additives and are excellent in hygiene.

The film 11 constituting the medical multi-chamber container 1 may be a single layer film made of one type of film or a multilayer film in a form in which a plurality of types of films are laminated. In the case of a single layer film, linear low density polyethylene, an ethylene propylene random copolymer, an ethylene propylene block copolymer, a mixture of a polypropylene resin and a styrene elastomer, and the like because they are excellent in transparency and flexibility. Films are preferred.
Moreover, when the film 11 is a multilayer film, the film used for the above-mentioned single layer film is used for a multilayer film, and the multilayer film made into the main layer with the highest thickness ratio is preferable. Furthermore, this main layer is used on the inner layer side of the medical multi-chamber container 1, and a multilayer provided with an outer layer having a high heat resistance such as a high softening temperature and a melting point rather than an inner layer consisting of polyamide, polyester, polyether sulfone or the like. It may be a film. As a result, the film 11 can be heated and melted to shorten the time for manufacturing the medical multi-chamber container 1, which is preferable because the productivity becomes high. An inner layer of the film 11 and an outer layer thereof may be adhered with an adhesive. In addition, an inner layer surface layer of 10% or less of the total layer thickness of the film 11 is provided on the inner layer of the film 11 on the side to be a liquid contact surface in the drug chambers 12A and 12B in order to improve the properties of the inner layer surface. Is also preferred.
Furthermore, the film 11 may be provided with an outer layer having heat resistance, and the inner layer may be a multilayer film having the main layer, and the outer layer may be 10% or less and the inner layer 70% or more with respect to the total layer thickness of the film 11. preferable.

  These films 11 are manufactured by a manufacturing method such as T-die molding, water cooling or air-cooling inflation molding, laminate molding, multilayer coextrusion molding and the like. From the viewpoint of transparency and hygiene, a film 11 produced by water-cooled inflation molding is preferable. The thickness of the film 11 is about 5 to 1000 μm, preferably about 50 to 500 μm.

Here, the manufacturing method of the medical multiple-chamber container 1 mentioned above is demonstrated. The formation of the inflow preventing weak seal portion 15 is as described above. With respect to the other parts, the laminated film 11 is sealed in a desired shape to make the medical multi-chamber container 1. As a sealing method, a method using heat sealing or impulse sealing in which pressure is applied to the heating plate to press down the film 11 can be adopted. Further, a hot mold can be used to seal the port 14 and the film 11. When the volume of the medical multi-chamber container 1 is about 100 mL to 5 L, the seal width D2 of the concave seal part 16 and the side seal part 17A is in the range of 3 mm to 15 mm, preferably 4 mm to 10 mm. is there.
Moreover, as a combination of drugs, a combination of an amino acid infusion and a glucose infusion, an antibiotic and a solution thereof and the like can be mentioned.

  Next, the operation of the medical multi-chamber container 1 of the present embodiment configured as described above will be described based on the drawings.

In order to inject the medicine mixed from the port 14 using the medical multi-chamber container 1 of the present embodiment shown in FIG. 1 and administer it to the patient, first, the upper side not having the inflow preventing weak seal portion 15 The drug chamber 12A is pressed from the outside. Then, the internal pressure of the drug chamber 12A increases, and the section weak seal portion 13 peels off. As a result, the medicine flows from the separated weak sealing portion 13 into the lower drug chamber 12 B having the inflow preventing weak sealing portion 15. The inflow of the drug causes the drug in the drug chamber 12B to collide with the weak seal portion 15 for inflow prevention opposed to the weak seal portion 13 for partition, and the internal pressure of the drug chamber 12B also increases. Peel off. As a result, the drugs in the two drug chambers 12A and 12B are mixed, and the mixed drug can be instilled from the port 14. Therefore, the operation of causing the upper and lower drug chambers 12A and 12B to communicate with each other and the operation of peeling the inflow preventing weak seal portion 15 can be performed by a series of operations of pressing the drug chamber 12A from the outside.
At this time, since the inflow blocking weak seal portion 15 for temporarily blocking the drug inflow into the port 14 is provided, the drugs in the upper and lower drug chambers 12A and 12B partitioned by the partitioning weak seal portion 13 It is possible to prevent the drug from being administered before it is mixed.

When the drug chamber 12B is pressed from the outside, the partitioning weak seal portion 13 peels off earlier than the inflow preventing weak seal portion 15, and the drug in the drug chamber 12A and the drug in the drug chamber 12B mix. In this state, since the inflow preventing weak seal portion 15 is not peeled off, the drug does not flow out from the port 14. Therefore, when the chamber consisting of the drug chamber 12A and the drug chamber 12B from which the partitioning weak seal portion 13 is peeled is pressed from the outside, the inflow blocking weak seal portion 15 is peeled off, and the mixed chemical solution flows out from the port 14 It can be done.
As described above, even when any drug chamber of the drug chamber 12A or the drug chamber 12B is pressed, it is possible to prevent the unmixed drug from being administered.

  In addition, even when an unexpected pressing force is applied, such as at the time of transportation, the medicine before mixing is reliably prevented from being administered without peeling of the curvilinear band-like weak seal portion 15 for inflow prevention.

  According to the configuration as described above, it is formed so as to protrude toward the weak sealing portion 13 side so as to surround the port 14 and temporarily flow the medicine contained in the medicine chambers 12A and 12B into the port 14. A groove 21 extending along the direction in which the inflow preventing weak seal portion 15 continues is formed on the surface of the inflow preventing weak seal portion 15 to be blocked. According to such a configuration, for example, when a pressure is applied to the medical multi-chamber container 1 from the outside to increase the pressure of the medicine contained in the medicine chambers 12A and 12B, the pressure is reduced by the weak sealing portion 15 for inflow prevention. On the other hand, the inflow preventing weak seal portion 15 acts in a direction intersecting with the continuous direction. On the other hand, since the groove 21 extending in the direction in which the inflow preventing weak seal portion 15 continues is formed in the inflow preventing weak seal portion 15, concentration of the applied pressure can be prevented. .

  Further, the groove 21 is formed at least in the curved seal portion 15 b protruding toward the dividing weak seal portion 13 in the inflow preventing weak seal portion 15. The pressure of the medicine contained in the medicine chambers 12A and 12B particularly acts on the curved seal portion 15b protruding toward the dividing weak seal portion 13 in the inflow preventing weak seal portion 15. Therefore, by providing the groove 21 in the curved seal portion 15 b, it is possible to effectively suppress the inadvertent peeling of the inflow preventing weak seal portion 15.

  Further, on the other surface of the inflow preventing weak seal portion 15, a plurality of recessed portions 22 spaced along the direction in which the inflow preventing weak seal portion 15 continues are formed to face the groove 21. . Thereby, it can be more reliably suppressed that the inflow preventing weak seal portion 15 is peeled carelessly.

  In this manner, it is possible to prevent the inflow preventing weak seal portion 15 from being peeled off carelessly, and to improve the impact resistance of the inflow preventing weak seal portion 15 due to vibration during handling such as transportation or falling. . Therefore, even if the protective member is not used as in the prior art, unintentional peeling of the weak seal portion 15 for inflow prevention does not occur by an impact such as falling, and the weak seal portion 15 for inflow prevention is easily opened when necessary. Can.

  Further, by forming the groove 21 and the recess 22 so as to be opposed to each other, the peeling strength at the time when the sealing condition such as temperature changes is made as compared with the case where the groove 21 and the recess 22 are shifted. It is preferable because a weak change in the inflow preventing weak seal portion 15 can be obtained.

  As mentioned above, although embodiment of the medical multiple room container by this invention was described, this invention is not limited to said embodiment, It can change suitably in the range which does not deviate from the meaning.

  For example, in the embodiment described above, the groove 21 is formed as a linear seal portion in the inflow preventing weak seal portion 15, and the concave portion 22 is formed as a point seal portion. However, if the films 11, 11 forming the medical multi-chamber container 1 are hard materials, the inflow preventing weak seal portion 15 is sealed by heat welding, ultrasonic welding or the like by the molds 30A, 30B. The groove 21 and the recess 22 may not be formed.

  Moreover, in the above-mentioned embodiment, although it is set as the medical multiple-chamber container 1 which provided the upper and lower two drug chamber 12A, 12B, three or more drug chambers are divided and provided by the division weak seal part 13 It is also good.

FIG. 9 is a plan view showing the configuration of a medical multi-chamber container according to another embodiment.
Moreover, in the above-mentioned embodiment, although the medical multiple-chamber container was illustrated as an example of a bag-like container, it may be a medical container which has one medicine room, and it is bag-like which has a curvilinear belt-like weak seal part which can be peeled off. As long as it is a container, it can be used for other uses such as food, such as a combination of a seasoning liquid and a food, and industrial use, such as a two-liquid mixing adhesive, without being limited thereto. For example, as in the medical multi-chamber container 110A according to the other embodiment shown in FIG. 9, the curvilinear belt-like weak seal portion 115 divides the chamber 112 by the straight seal portions 115a and 115a and the curvilinear seal portion 115b. It may be provided.

  In addition, without departing from the spirit of the present invention, it is possible to replace components in the above-described embodiment with known components as appropriate.

  Next, an example for supporting the effect of the medical multiple-chamber container according to the above-described embodiment will be described below.

[Example]
The medical multi-chamber container shown in FIG. 1 was prepared as follows. The outer dimensions of the film are 40 cm × 30 cm.
(Manufacture of multilayer film)
Using the multilayer film of the following constitution prepared by the multilayer co-extrusion water cooling inflation method, it has the constitution of the container shown in FIG. 1 and measures the peel strength and communication strength of the inflow preventing weak seal part and packages the container Drop test was conducted to confirm the function of the container.

A film is a multilayer film which consists of the following resin which consists of outer layer / adhesion layer / inner layer / inner layer surface layer, and consists of thickness of each layer 15 micrometers / 20 micrometers / 200 micrometers / 15 micrometers. In the following description of the resin, the melt mass flow rate (hereinafter referred to as “MFR”) of the polyethylene resin is a value measured at a temperature of 190 ° C. and a load of 21.18 N in accordance with JIS K 7210. The MFR of the maleic anhydride graft modified polypropylene is a value measured in the same manner as in the case of the polyethylene resin except that the temperature is set to 230 ° C.
Outer layer: polyamide 11, Rilsan B BESV O A FDA, manufactured by Arkema Co., Ltd. Adhesive layer: maleic anhydride graft modified polypropylene, MFR 2.8 g / 10 min Inner layer: linear low density polyethylene, density 917 kg / m ³ , MFR 1.1 g / 10 minutes Inner layer surface layer: High density polyethylene, density 955 kg / m ³ , MFR 1.8 g / 10 min

(Manufacture of weak seal for inflow prevention)
The inflow preventing weak seal portion was heat sealed by sandwiching and heat-pressing the two films so as to surround the port on the medicine chamber side using the following two sets of molds. The seal width of the inflow preventing weak seal portion is constant 12 mm, the curvature radius of the curved seal portion is 28 mm, the height direction of the upper inflow preventing weak seal portion is 44 mm, and the width direction in the left and right is 95 mm.
Here, one of the two sets of molds has the configuration shown in FIG. 6 and FIG. 7, and the top face extending along the direction in which the weak seal portion for inflow prevention continues is a 0.4 mm wide protrusion The strips were provided so that the gap between adjacent top surfaces was 0.6 mm.
The other of the two sets of molds has the configuration shown in FIG. 8, and the top surface extending along the direction in which the weak inflow preventing seal portion continues is a top surface adjacent to a 0.4 mm wide ridge. In addition to providing the gap between the surfaces to be 0.6 mm, a ridge extending in the vertical direction has a width of 0.4 mm so that the gap between the adjacent top surfaces is 0.6 mm.

  Heat sealing is performed using these two sets of molds under the conditions of a mold temperature of 126 to 132 ° C, a pressure of 0.3 to 0.5 MPa, a pressure holding time of 2 to 8 seconds, and a cooling time of 4 to 12 seconds. A weakly sealed portion for preventing inflow is formed which has a peel strength of 7.5 N / 10 mm width (Example 1) and 10.5 N / 10 mm width (Example 2).

  A weak sealing portion for sectioning was provided at a position of 18 cm in the longitudinal direction from the side with the port, 1 cm wide and in a straight band shape across both sides. Heat sealing is performed under the conditions of film heating temperature: 123 to 129 ° C, pressure: 0.4 MPa, sealing time: 5 seconds, cooling time: 4 seconds, peel strength 3.0 N / 10 mm width (Example 1), 3.2 N / 10 mm width A weak sealing portion for partition serving as (Example 2) was formed.

(Exterior seal, port seal)
Heat-sealed rim of medical multi-chamber container under the condition of mold temperature 180 ° C, pressure 0.4 MPa and pressure holding time 4 seconds, cooling time 4 seconds Sealed. Also, the port was heat sealed with a port seal mold to produce a medical multi-chamber container.

  From the opening made by cutting two parts of the container, 1400 ml is filled in one medicine chamber from the opening, and 600 ml of purified water is filled in the other medicine chamber, and the opening is sealed by heat sealing under the same conditions as the outer shape seal. It destroyed. After heating with a shower-type high-pressure steam sterilizer at 106 ° C. for 25 minutes, it was cooled to obtain a medical multi-chamber container for evaluation.

[Comparative example]
FIG. 10 is a plan view showing the mold surface of one mold used for the seal of the comparative example, and FIG. 11 is a plan view showing the mold surface of the other mold used for the seal of the comparative example.
As a comparative example, the following two sets of molds different in the surface shape of the mold from those of Example 1 and Example 2 are used to seal the weak seal portion for section and the weak seal portion for inflow prevention, for medical use A multi-chambered container was formed.
Here, as shown in FIG. 10, a linear seal portion extending in the width direction of the container is formed on the surface of the container after sealing in the mold 130A of one set of two used in the comparative example. As described above, the grooves 131 having a straight cross-sectional inverted triangle with a width of 0.6 mm extending in the width direction are formed such that the deepest portions of the grooves are at equal intervals of 1 mm in the vertical direction.
Further, as shown in FIG. 11, in the other mold 130B of a pair, the groove 132 of a straight cross-sectional inverse triangle with a width of 0.6 mm extending in the width direction is equal to 1 mm of the deepest portion of the groove In addition to being formed to have a space, a groove 133 with a width of 0.6 mm extending in the vertical direction is provided so that the deepest part of the groove has a space of 1 mm in the width direction.

  Then, using these two sets of molds, as in the example, the mold temperature is 126 to 132 ° C., the pressure is 0.3 to 0.5 MPa, the pressure holding time is 2 to 8 seconds, and the cooling time is 4 to 12 seconds Heat sealing was performed under the following conditions to form an inflow preventing weakly sealed portion having a peel strength of 7.6 N / 10 mm width (comparative example 1) and 10.4 N / 10 mm width (comparative example 2).

  In addition, a weak sealing portion for sectioning was provided so as to be positioned in a straight band shape across the both sides from a position of 18 cm in the longitudinal direction from the side with the port and at a position of 18 cm. Heat sealing is performed under the conditions of film heating temperature: 123 to 129 ° C, pressure: 0.4 MPa, sealing time: 5 seconds, cooling time: 4 seconds, peel strength 3.0 N / 10 mm width (comparative example 1), 3.3 N / 10 mm width A weak sealing portion for division serving as (Comparative Example 2) was formed.

(Evaluation of the physical properties)
The peel strength of the weak seal portion for preventing inflow, the peel strength of the weak seal portion for division, the communication strength and the drop strength were evaluated and evaluated.

(Peeling strength of weak seal for inflow prevention)
In the inflow prevention weak seal part, a rectangular test piece of width 10 mm × length 70 mm is cut out from the container from the part on the extension line of the port so as to cross the inflow prevention weak seal part and a test piece for peel strength test I got The obtained test piece measured T-type peeling strength based on JISK6854-3 at 300 mm / min of tensile velocity.

(Peeling strength of weak seal for compartments)
A strip of 10 cm wide and 70 mm long in the direction of 90 degrees was cut out from the multi-chamber container for medical use, and the test piece for peel strength test was obtained. . The peel strength of the test piece of the weak seal for partition was measured in the same manner as the weak seal for inflow prevention.

(Communication strength)
The communication strength is heat sealed so that the weak sealing part for division does not communicate, and the port side drug chamber is pressed by 500 mm / min with a plate of 100 mm × 300 mm, and the weak seal for inflow prevention peels off and communicates The strength of the was measured.

(Fall strength)
FIG. 12 is a schematic view showing the accommodation state of the medical multi-chamber container when the drop test is performed.
The pharmaceutical multi-chamber container 1 having a size of 20 cm × 30 cm when folded in half at the division weak seal portion 13 was enclosed in an outer bag (not shown) consisting of a 40 cm × 30 cm four-sided seal bag.
Furthermore, as shown in FIG. 12, a 30 cm × 20 cm surface of the cardboard box is placed on a 30 cm × 30 cm × 20 cm cardboard box 100 by folding a thickness-folded outer package into a corrugated double-folded container 100. In parallel with the above, 5 bags were stacked and packed up and down.
The cardboard box was dropped twice from the height of 80 cm, in a direction in which five bags were stacked up and down, with the outer packaging medical multi-chamber container 1 being stacked up and down. Among the five bags of medical multi-chamber containers 1 with outer bags, one medical multi-chamber container 1 on the bottom side is also subjected to the largest force because the load of the other four medical multi-chamber containers 1 is also applied. The weakly sealed portion 15 for preventing inflow and the weakly sealed portion 13 for division are the containers most easily peeled off.
After the drop experiment, one medical double-chamber container 1 closest to the bottom was taken out, and the presence or absence of communication between the inflow preventing weak seal part 15 and the dividing weak seal part 13 was evaluated.
For the inflow preventing weak seal portion 15, the presence or absence of water in the region surrounded by the inflow preventing weak seal portion 15 and the lower side seal portion 17C is visually observed to confirm the presence of water x. The case where the presence of water could not be confirmed was evaluated as ○. About division weak seal part 13, the case where exfoliation was observed in part by visual observation was evaluated as x, and the case where exfoliation was not observed was evaluated as O.

The evaluation results are shown in Table 1.

  As shown in Table 1, in Example 1 and Example 2, although the communication strength at the weak sealing portion for division is slightly higher than Comparative Example 1 and Comparative Example 2, substantially equivalent openability is obtained. The On the other hand, in the drop strength, although peeling occurred in the weak seal portion for inflow prevention in Comparative Example 1 and Comparative Example 2, peeling in the weak seal portion for inflow prevention was not recognized in Example 1 and Example 2 The

1 Multi-chamber container for medical use (bag-like container)
11 film 11 f outer surface (surface)
11g Outer surface (surface)
12, 12A, 12B drug room (room)
112 chamber 13 section weak sealing part 14 port 15 inflow preventing weak sealing part (curved band weak seal part)
15b Curved seal (tip)
21 Groove (Linear seal part)
22 Concave part (Point shaped seal part)
30A mold 30B mold 30f pressing surface 31 protrusion

Claims (7)

Formed by sealing the edges of overlapping films,
A room containing the substance,
A curvilinear belt-like weak seal portion provided to partition the chamber;
Have
Wherein both surfaces of the curved strip weak seal portion, bag-like container, characterized in that said linear seal unit you continuous along the contour of the curved strip weak seal portion is formed. Have multiple rooms,
A weak sealing portion for partitioning which communicably partitions the plurality of chambers;
A port provided in one of the rooms;
Have
The curvilinear belt-like weak seal portion is formed so as to protrude toward the partition weak seal portion side to surround the port, and prevents inflow of the substance contained in the chamber into the port temporarily. It is a weak seal part, The bag-like container of Claim 1 characterized by the above-mentioned. Formed by sealing the edges of overlapping films,
With multiple drug rooms,
A weak sealing portion for partitioning which communicably partitions the plurality of drug chambers;
A port for drug discharge provided in one of the drug chambers;
A curvilinear belt-like weak seal portion formed so as to project toward the side of the divisional weak seal portion and surround the port;
A medical multi-chamber container having
The curvilinear belt-like weak seal portion is a weak seal portion for inflow blocking which temporarily blocks the inflow of the medicine contained in the medicine chamber into the port,
Wherein both surfaces of the inflow blocking weak seal portion, a multi-chamber medical container, characterized in that the linear sealing portion you continuously along the contour of the inflow blocking weak seal portion is formed. Formed by sealing the edges of overlapping films,
With multiple drug rooms,
A weak sealing portion for partitioning which communicably partitions the plurality of drug chambers;
A port for drug discharge provided in one of the drug chambers;
A curve formed so as to protrude toward the weak sealing portion side for partitioning and surround the port
Line-like weak seal part,
A medical multi-chamber container having
The curvilinear belt-like weak seal portion temporarily flows in the medicine into the port.
A weak seal for preventing inflow,
A linear seal that is continuous along the contour of the inflow preventing weak seal is formed on one surface of the inflow preventing weak seal.
A plurality of point-like seal parts spaced along the contour of the inflow prevention weak seal part are formed on the other surface of the inflow prevention weak seal part so as to face the linear seal part it said that you are physicians Ryoyo multi-chamber container.   The medical treatment device according to claim 3 or 4, wherein the linear seal portion is formed at least at a tip of the weak sealing portion for blocking the inflow, which protrudes toward the weak sealing portion for division. Room container. A mold for forming the curvilinear belt-like weak seal portion according to any one of claims 1 to 5,
A mold characterized in that a ridge extending along a direction in which the curved belt-like weak seal portion is continuous is formed on a pressing surface. A method of forming the curvilinear belt-like weak seal portion according to any one of claims 1 to 5, wherein
The mold is pressed against the surface of the film while heating a die having a ridge extending along the direction in which the curved belt-like weak seal portion continues on the pressing surface, and the curved ribbon-like weak seal part is produced by the ridge Forming the linear seal portion on the surface of the curved belt-like weak seal portion.

Images