JP3758646B2 - Method for producing O / W type skin cream - Google Patents

Description

[0001]
[Industrial application fields]
The present invention relates to a method for producing an O / W type skin cream. The present invention avoids the oxidation / decomposition that occurs in the high-temperature dissolution treatment process of the oil phase component, especially when the O / W type skin cream is produced from the oil phase component and the water phase component, and also provides heat such as vitamins. Manufacturing to provide excellent quality O / W type skin cream that is contained in the product without the deterioration of the unstable ingredients, and the raw material components are not oxidized, decomposed or altered. Regarding the method.
[0002]
[Prior art and problems to be solved by the invention]
Skin cream is a particularly common dosage form for basic cosmetics and the like, and has been widely used for a long time. These creams are a kind of emulsion in which one of two liquids such as water and oil that do not dissolve each other is dispersed in the other dispersion medium in a stable state. Therefore, it is possible to take a wide range of stability, so that there is an advantage that various components can be blended. In addition, since it can be blended in a wide ratio of oil, moisturizer, and moisture, it is mainly suitable as a cosmetic suitable for being able to replenish moisture, moisturizer, and oil in order to maintain the moisture balance of the skin. Various types of cosmetics are manufactured as cosmetics suitable for imparting a function of softening. The cream is easy to use and easy to apply evenly, and as described above, it can be used in a wide range of formulas. For example, the cream is refreshing, oily or moist. It has various properties such as hard form, soft form, well-stretched, quickly adaptable to the skin, easy to wipe off by hand, difficult to remove once made up, washable with water, etc. Easy to use according to the purpose of use according to the season, the age of the user, the skin quality and condition that varies depending on the living environment, the difference in makeup habits and the preference. Is a highly useful dosage form that can be produced. Thus, the skin cream which can respond to various uses becomes important in fulfilling the role of enhancing the natural beauty, which is the original purpose of cosmetics, and further prolonging the beauty.
[0003]
At present, understanding of the living body is advanced and the importance of the physiological function is recognized for understanding the role of the skin and the like. The skin functions to protect the human body from chemical stimuli and actions as well as to buffer the mechanical action from the outside world so that it does not reach the inside of the body. In addition to such protective effects, the skin is also responsible for temperature regulation and other various effects. And it has been found that beautiful skin has the balance of functions and actions as described above, has a just-balanced state of moisture and oil, has freshness, and is glossy. In this way, as a property that should be possessed by a cream that is one of the cosmetics to keep the skin more beautiful, it is outside the stratum corneum of this skin, and it is a very thin film, but the moisture of this stratum corneum is controlled from the outside Recognizing that it is important to follow the function of the sebum membrane, which plays a variety of roles, such as stimulating the skin or defending the attack, wrapping dirt, and helping that function Has come to be made. By the way, it is known that sebum in this sebum film contains squalene, cholesterol ester, cholesterol, wax, triglyceride, diglyceride, monoglyceride, fatty acid, etc. It has been found that there are lipoproteins, polypeptides, lipopolysaccharides, sphingolipids, glycerides, phospholipids, and the like.
[0004]
Further, as a property of the cream, it is required to prevent the skin from being keratinized and to assist the function of the sebum film covering the stratum corneum in order to keep the skin fresh. As a cream with such a function, it is recommended to replenish a substance similar to the natural moisturizing factor (NMF = natural moisture factor) in the skin or prevent the NMF from flowing out and disappearing. It is also required to replenish various substances or to provide substances that help their work. By the way, glycolipids, phospholipids, amino acids and the like have been known so far as NMF. Among these, particularly important components are amino acids, pyrrolidone carboxylic acid (PCA), lactate, urea, glucosamine, creatine, and citric acid. It is said that organic acids, peptides, sodium, potassium, calcium, magnesium, etc., and keratin in the stratum corneum of skin are said to contribute to water retention. The skin cream that is required to have such a function and action is such that sebum components such as squalene, cholesterol ester, cholesterol, wax, triglyceride, diglyceride, monoglyceride and fatty acid are added as its use components, Or the thing of the property very similar to it is used, and in the case of the manufacture, the water phase component and the oil phase component are emulsified and manufactured. For example, a typical cream manufacturing process is as shown in FIG.
[0005]
By the way, since each water phase component and oil phase component must be uniformly dissolved in this emulsification treatment, both the water phase component and the oil phase component are both components prior to the emulsification treatment. Each must be heat-dissolved so as to mix or dissolve uniformly. And as mentioned above, in order to give the required function and action, certain components of both the aqueous phase and the oil phase must be blended at the minimum, while such components are emulsified with each other unless heat-treated. It cannot be uniformly dissolved and mixed so that it can be used for processing. In particular, components used as oil phase components are components that are solid at room temperature, and in order to uniformly mix or dissolve them, they must be heated to a high temperature or heated for a long time. In this way, the heat-dissolving treatment process cannot be omitted, but some of the components are oxidized or decomposed when heated to a high temperature or heated for a long time, and changed to their original properties. There is a problem in that the desired function is lost or even a harmful substance is changed. As described above, many components having desirable properties as components of skin creams, particularly those used as oil phase components, are sensitive to heat, and therefore, heating causes irritants and is not suitable for heating. On the other hand, there is a problem that an unstable component cannot be blended, or an antioxidant or the like must be added to prevent deterioration of the material although it is unstable after heat treatment.
[0006]
There are restrictions on the ingredients that should be added for the purpose of the creams used to keep the skin and skin beautiful as described above, or it is necessary to add undesirable ingredients such as antioxidants, or the heat treatment For this reason, it must be avoided that some ingredients are altered to cause problems such as allergies. Conventionally, heating to 70 ° C. or higher, particularly generally heating to 80 ° C. or higher, and emulsification processing while maintaining the temperature at 70 ° C. or higher, causing irritants to occur during the processing, or In order to suppress the generation of the irritant as much as possible, an antioxidant and the like had to be added. Further, additives such as antioxidants added in this way may cause further irritants during the heat treatment at 70 ° C. or higher, or may cause problems to the product once obtained. By the way, it is generally known that the boiling point of a liquid can be easily lowered by reducing the environment surrounding the liquid under reduced pressure, but in a solid, semi-solid, solid mixture, etc. It has been theoretically pointed out that even if the pressure is reduced, a decrease in the melting temperature cannot be expected. Since the raw material oil used as a component of the skin cream is solid, it is theoretically impossible to lower its melting temperature.
[0007]
[Means for Solving the Problems]
The present inventors have solved the above-mentioned problems by a simple method, avoiding the use of components with less restrictions on the components used and unfavorable to the skin. As a result of earnest research and development to develop products that can be used with peace of mind even for users who are hypersensitive and use normal cream to cause skin irritation and itching and redness. That led to
That is, in the present invention, in producing an O / W type skin cream from an oil phase component and an aqueous phase component, an oil phase component containing a solid oil or a semi-solid oil in an atmosphere excluding an inert atmosphere, Within the range of 40-65 ° C, and Normal O / W type skin cream production 0 to 200 mmHg which can be lower than the melting temperature of the solid oil or semi-solid oil dissolution stage Mix and dissolve under reduced pressure, then mix the oil phase component and aqueous phase component obtained in this way At a temperature of 40 to 65 ° C. and 0 to 200 mmHg. Emulsification process 1 or more selected from the group consisting of fragrances, preservatives, colorants, moisturizing agents, and chemicals that are components unstable to heat at 35 to 58 ° C. Add mixing process O / W type skin cream manufacturing method characterized by In law is there.
[0008]
In the present invention, the oil phase component mixing and dissolving treatment step is performed at about 40 ° C. to about 65 ° C., preferably about 45 ° C. to about 60 ° C., more preferably about 50 ° C. to about 59 ° C. Done. Of course, in the case of using a raw material in which the process of mixing and dissolving the oil phase component in normal O / W type skin cream production must be performed at a temperature of about 80 ° C. or higher, mixing of the oil phase component The dissolution treatment step may be performed at a temperature substantially lower than that, and does not necessarily have to be about 65 ° C. or lower. The process of mixing and dissolving the oil phase component in the present invention is performed, for example, at about 50 ° C. to about 64 ° C. under reduced pressure, preferably about 50 ° C. to about 60 ° C., more preferably about 50 ° C. to about 59 Can be performed at about 58 ° C. or less. In addition, in the case of using a raw material in which the process of mixing and dissolving the oil phase component in normal O / W type skin cream production must be performed at a temperature of about 70 ° C. or higher, mixing the oil phase component The dissolution treatment step is performed at about 40 ° C. to about 60 ° C. under reduced pressure, preferably about 45 ° C. to about 59 ° C., more preferably about 50 ° C. to about 58 ° C. The term “under reduced pressure” refers to a pressure lower than a normal pressure in a broad sense, but may be, for example, a pressure of about 0 to about 300 mmHg, and a narrow range is a pressure of about 0 to about 200 mmHg. Preferably, it may be under a pressure of about 0 to about 100 mmHg, more preferably under a pressure of about 0 to about 50 mmHg, even more preferably under a pressure of about 0 to about 10 mmHg. it can. In the present invention, the process of mixing and dissolving the oil phase components can be performed at a pressure of about 0 to about 200 mmHg at about 50 ° C. to about 60 ° C.
[0009]
In the present invention, the emulsification treatment step is performed at a low temperature. In this case, the emulsification treatment step at a low temperature may mean that the emulsification treatment step is performed at a temperature substantially lower than that in normal O / W type skin cream production. In the present invention, the emulsification treatment step may be performed under low temperature and reduced pressure. Further, in this case, the emulsification treatment step under low temperature and reduced pressure is performed under a temperature that is substantially lower and substantially lower than that in normal O / W type skin cream production. It may mean that. This treatment step can be performed in an inert atmosphere, for example, in a nitrogen stream. This emulsification treatment step can be carried out under a nitrogen atmosphere under a substantially reduced pressure, and is preferably carried out at a substantially lower temperature. In the emulsification treatment step, the oil phase component can be added to the water phase component being gradually stirred, and the oil phase component can be stirred and the water phase component can be gradually added thereto. . This treatment step can be performed in an inert atmosphere, for example, in a nitrogen stream. Under the low temperature and reduced pressure, the reduced pressure in the emulsification treatment step refers to a pressure lower than the normal pressure in a broad sense. For example, the pressure may be from about 0 to about 300 mmHg, and the narrow range is about 0. From about 0 to about 200 mmHg, preferably from about 0 to about 100 mmHg, more preferably from about 0 to about 50 mmHg, and even more preferably from about 0 to about 200 mmHg. It can be under a pressure of 10 mmHg. In the present invention, the emulsification treatment step may be performed at about 50 ° C. to about 60 ° C. under a pressure of about 0 to about 200 mmHg. In the present invention, the low temperature and low temperature of the emulsification treatment step may be about 40 ° C. to about 65 ° C., preferably about 45 ° C. to about 60 ° C., more preferably about 50 ° C. It may be about 59 ° C. Of course, when a raw material is used such that the emulsification treatment step in ordinary O / W type skin cream production must be performed at a temperature of about 80 ° C. or higher, the temperature is substantially lower than that. It is not necessarily required to be about 65 ° C. or lower as long as it is made. For example, it can be performed at about 50 ° C. to about 69 ° C. under reduced pressure, but it is preferably performed at a lower temperature. In addition, the emulsification treatment step can be performed at a temperature of about 50 ° C. to about 59 ° C. at a low temperature, but is preferably performed at a lower temperature. Preferably, it is performed at about 50 ° C. to about 58 ° C., more preferably about 57 ° C. or less. In addition, when a raw material is used in which the emulsification treatment step in normal O / W type skin cream production has to be performed at a temperature of about 70 ° C. or higher, the emulsification treatment step at a low temperature is about 40 From about 45 ° C. to about 59 ° C., more preferably from about 50 ° C. to about 58 ° C. Furthermore, in this invention, it is preferable that it is what is performed consistently under low temperature from the mixing dissolution process process of an oil phase component to the end of an emulsification process process. In this case, the low-temperature treatment step can mean that the treatment is performed at a temperature substantially lower than that in normal O / W type skin cream production. In the present invention, these treatment steps may be performed under a low temperature under reduced pressure, and preferably under a low temperature under reduced pressure. In this case, the low-temperature reduced-pressure treatment step means that the treatment is performed at a temperature substantially lower than that in normal O / W type skin cream production and a pressure sufficient to achieve a substantially lower temperature. May be. In the present invention, these treatment steps can be performed from about 50 ° C. to about 60 ° C. consistently under a pressure of about 0 to about 200 mmHg.
[0010]
In the present invention, the emulsification treatment step is performed under reduced pressure at about 40 ° C. to about 65 ° C., preferably about 0 to about 300 mmHg, about 50 ° C. to about 60 ° C., more preferably about 0 to about It can be carried out at a pressure of about 200 mmHg at about 50 ° C. to about 60 ° C., more preferably at a pressure of about 0 to about 100 mmHg at a lower temperature. In particular, the pressure is about 0 to about 10 mmHg. In the present invention, the emulsification treatment step is performed by, for example, a homomixer. In the present invention, a pre-emulsification treatment step may be provided before the emulsification step, and the pre-emulsification treatment step can be performed in the same manner as in the production of a normal O / W type skin cream, but at a low temperature. It can also be done. In this case, the pre-emulsification treatment step under a low temperature means that it is performed at a temperature substantially lower than that in the production of a normal O / W type skin cream, It may mean what is performed under reduced pressure. In the pre-emulsification processing step, the oil phase component can be added to the gradually stirred water phase component, and conversely, the water phase component can be added to the gradually stirred oil phase component. Can do. This treatment step can be performed in an inert atmosphere, for example, in a nitrogen stream. This pre-emulsification treatment step is performed under a pressure of about 0 to about 500 mmHg, preferably under a pressure of about 0 to about 200 mmHg, more preferably under a pressure of about 0 to about 100 mmHg, and more Preferably, it can be performed under a pressure of about 0 to about 10 mmHg.
[0011]
In the present invention, the preliminary emulsification treatment step is performed at about 40 ° C to about 65 ° C, preferably about 45 ° C to about 60 ° C, more preferably about 50 ° C to about 59 ° C. it can. Of course, in the case of using a raw material in which the pre-emulsification processing step in the production of a normal O / W type skin cream must be performed at a temperature of about 80 ° C. or higher, the temperature is substantially lower than that. It does not necessarily have to be about 65 ° C. or lower. For example, it can be performed at about 50 ° C. to about 69 ° C. under reduced pressure, but it is preferably performed at a lower temperature. The pre-emulsification treatment step at a low temperature is performed at about 50 ° C. to about 64 ° C., preferably about 50 ° C. to about 60 ° C., more preferably about 59 ° C. or less. In addition, when a raw material is used in which a pre-emulsification treatment step in normal O / W type skin cream production must be performed at a temperature of about 70 ° C. or higher, the pre-emulsification treatment step at low temperature is about It is carried out at 40 ° C. to about 59 ° C., preferably about 45 ° C. to about 58 ° C., more preferably about 50 ° C. to about 57 ° C. In the present invention, the preliminary emulsification treatment step is performed under reduced pressure at about 40 ° C. to about 65 ° C., preferably about 0 to about 500 mmHg, about 50 ° C. to about 60 ° C., more preferably about 0 From about 50 to about 59 ° C. under a pressure of about 200 mmHg, and even more preferably at a lower temperature under a pressure of about 0 to about 10 mmHg. In the present invention, heat-unstable components can be added and mixed following the emulsification treatment step, and this is preferably performed at a low temperature. In this case, the additive mixing treatment may be performed at a temperature substantially lower than that in the production of a normal O / W type skin cream, and this substantially lower temperature is performed, for example, under reduced pressure. It may mean that the treatment is performed at a temperature that does not adversely affect the heat-unstable compounding components such as the following drugs and moisturizing factors. This treatment step can be performed in an inert atmosphere, for example, in a nitrogen stream.
[0012]
In the present invention, the blending step is performed at about 10 ° C. to 60 ° C., preferably about 20 ° C. to 55 ° C., more preferably about 30 ° C. to about 50 ° C., more preferably It is carried out at about 35 ° C to about 45 ° C. In the present invention, this blending step can be performed under normal pressure, but in some cases, it can be performed under reduced pressure. The compounding process may be performed under a pressure of about 0 to about 760 mmHg, may be performed under a pressure of about 0 to about 500 mmHg, and may further be performed under a pressure of about 0 to about 300 mmHg, Can be performed under a pressure of about 0 to about 200 mm Hg. In the present invention, the blending step is performed at about 10 to 60 ° C. under normal pressure, preferably about 20 to 55 ° C. under normal pressure, more preferably about 30 to about 50 ° C. under normal pressure. More preferably from about 35 ° C. to about 45 ° C. under normal pressure. This blending process can be carried out at about 20 ° C. to 60 ° C. under reduced pressure, especially when dealing with thermally unstable materials, and is further carried out at about 20 ° C. to 60 ° C. under about 0 to about 500 mmHg, preferably Is carried out at about 0 to about 300 mm Hg at about 20 ° C. to 55 ° C., more preferably at a pressure of about 0 to about 200 mm Hg at about 20 ° C. to about 50 ° C., more preferably about 0 to about 100 mm Hg. At about 20 ° C. to about 45 ° C.
[0013]
In the present invention, the fragrance and other components can be added and mixed as necessary following the mixing and dissolution treatment of the oil phase component, and the group consisting of a surfactant, a fragrance, a preservative, a colorant, a moisturizing agent, and a drug. Those selected from the above can be added to and mixed with the oil phase component according to the purpose. In the present invention, a fragrance and other components can be added and mixed as necessary during or after the emulsification treatment, and the surfactant, fragrance, preservative, colorant, moisturizing agent, and chemical agent can be added. Those selected from the group consisting of can be added and mixed appropriately according to the purpose. Thus, in the present invention, vitamins or physiologically active substances can be added and blended in or after the emulsification treatment. These vitamins or physiologically active substances include those that can be added to the following, those that are relatively unstable or very unstable to heat, and one of the natural moisturizing factors or a function similar to that. And the like. For example, substances that help the stratum corneum to keep moisture as humectants such as glycerol, sorbitol, lactate, pyrrolidone carboxylate, lactic acid bacteria fermentation product, bifidobacteria fermentation product, sophorolipid, mitochondrial component, Inhibition of tyrosinase derived from chitin, chitosan, mushrooms derived from crustaceans such as cassamine, crab, shrimp, etc., hyaluronic acid obtained from yeast culture products, sophorolipid modified derivatives, streptococcus zooevidics, shikonin obtained from cell culture And bio-γ-linolenic acid, soluble collagen hydrolyzate, β-cyclodextrin and the like produced using an agent, filamentous fungus Mortierella isaverina and the like.
[0014]
These vitamins or physiologically active substances as described above can be mixed before being added in the emulsification treatment step. This mixing treatment can be performed in the same manner as in ordinary O / W type skin cream production, but can also be performed at a low temperature. In this case, the mixing treatment step at a low temperature means that the process is performed at a temperature substantially lower than that in normal O / W type skin cream production. It may mean what is performed under reduced pressure. This treatment step can be performed in an inert atmosphere, for example, in a nitrogen stream. In the present invention, the mixing step is performed at about 10 ° C. to 65 ° C., preferably about 20 ° C. to 60 ° C., more preferably about 30 ° C. to about 50 ° C., and more preferably It may be performed at about 35 ° C to about 45 ° C. In the present invention, this mixing treatment step is preferably performed under normal pressure, but in some cases, it is performed under reduced pressure. In the case of this reduced pressure, the mixing step is performed under about 0 to about 500 mmHg, or under about 0 to about 300 mmHg, even under about 0 to about 200 mmHg, and in particular from about 0. Performed at about 100 mmHg. This mixing process is performed at a pressure of about 10 ° C. to 60 ° C. under reduced pressure, particularly when dealing with thermally unstable materials, preferably about 10 to about 55 ° C. under about 0 to about 500 mmHg, and more It can also be carried out at a pressure of about 0 to about 300 mmHg, preferably about 10 ° C. to about 54 ° C. More preferably, it can be carried out at a pressure of about 0 to about 100 mmHg at about 10 ° C. to about 53 ° C.
[0015]
In the present invention, the mixing treatment step of the oil phase component, the fragrance, and other components can be performed in the same manner as in ordinary O / W type skin cream production, but can also be performed at a low temperature. In this case, the mixing treatment step of the low temperature oil phase component and the fragrance and other components means that it is performed at a temperature substantially lower than that in the ordinary O / W type skin cream production, The substantially low temperature may mean, for example, what is performed under reduced pressure. This treatment step can be performed in an inert atmosphere, for example, in a nitrogen stream. In the present invention, the mixing step of the oil phase component, the fragrance, and other components can be performed at about 40 ° C. to about 65 ° C., preferably about 45 ° C. to about 60 ° C., more preferably. It can be performed at about 50 ° C. to about 58 ° C. Of course, in the case of using a raw material in which the process of mixing the oil phase component with the fragrance and other components in normal O / W type skin cream production must be performed at a temperature of about 80 ° C. or higher. The mixing process step of the oil phase component under low temperature and the fragrance and other components may be performed at a temperature substantially lower than that, and does not necessarily have to be about 65 ° C. or less. For example, it can be performed at about 50 ° C. to about 69 ° C. under reduced pressure, but it is preferably performed at a lower temperature. For example, it can be performed at about 50 ° C to about 64 ° C, but can be performed at about 50 ° C to about 60 ° C, preferably at about 50 ° C to about 59 ° C, and even more preferably It is performed at about 58 ° C. or lower. In the case of using a raw material such that the process of mixing an oil phase component, a fragrance, and other components in normal O / W type skin cream production must be performed at a temperature of about 70 ° C. or higher. The low temperature oil phase component and the fragrance are mixed at about 40 ° C. to about 60 ° C., preferably about 45 ° C. to about 59 ° C., more preferably about 50 ° C. to about 58 ° C. To do.
[0016]
In the present invention, the reduced pressure in the mixing step of the oil phase component and the fragrance may be any temperature that can achieve a substantially lower temperature, for example, about 0 to about 500 mmHg, or about 0 to about 300 mmHg, preferably about 0 to about 200 mmHg, more preferably about 0 to about 100 mmHg, even more preferably about 0 to about 50 mmHg. It may be. In the preliminary emulsification treatment, pre-emulsification can generally be performed with a paddle type stirrer, but in this preliminary emulsification treatment, a better result is obtained by using a high-speed homomixer. In this emulsification treatment, better results can be obtained by using a high-speed homomixer. As an emulsifying device, there is an open type, but a sealed type is preferably used in order to make a product in a mixed state of air or aseptic conditions. Examples of the open type emulsifier include those having a paddle type stirrer and those having a propeller type stirrer. As the closed type emulsifying apparatus, one equipped with a homomixer (high speed stirrer) can be mentioned. As an emulsifier, there is a type in which a paddle type stirrer and a homomixer (high speed stirrer) are combined. The emulsification treatment can be performed by using these emulsifiers by mixer treatment, colloid mill treatment, homogenizer treatment, and ultrasonic treatment. In a homomixer or the like, rotation is performed at 1000 to 20000 rpm, preferably 2000 to 4000 rpm, and more preferably 2500 to 3500 rpm. For example, the preliminary emulsification treatment is performed by using a homomixer and applying rotation of 1000 to 20000 rpm, preferably 2000 to 4000 rpm, and more preferably 2500 to 3500 rpm. For example, the emulsification treatment is performed using a homomixer while applying rotation of 1000 to 20000 rpm, preferably 2000 to 4000 rpm, and more preferably 2500 to 3500 rpm.
[0017]
The cream obtained as described above is processed as usual to obtain a product. For example, the product obtained by the emulsification treatment is subjected to deaeration treatment, filtration treatment, cooling treatment, and the like, stored, and further filled into a container. Examples of the oil phase component used in the present invention include solid oil, semi-solid oil, fluid oil, and surfactant. Moreover, as an oil phase component of this invention, you may further contain what was chosen from the group which consists of surfactant, a fragrance | flavor, an antiseptic | preservative, a coloring agent, a moisturizer, and a chemical | medical agent. Representative oil phase components of the present invention include, for example, fatty acids, higher alcohols, fatty acid esters, fats and oils, waxes, and surfactants.
[0018]
Specific oil components of the oil phase component include hydrocarbons such as squalane, liquid paraffin, paraffin, petrolatum, solid paraffin, microcrystalline wax, ceresin, olive oil, camellia oil, almond oil, cacao butter, jojoba oil, Macadamia nut oil, avocado oil, hydrogenated palm oil, coconut oil, castor oil, sesame oil, sunflower oil, peanut oil, evening primrose oil, synthetic triglyceride and other oils, beeswax, lanolin, hydrogenated lanolin, carnauba wax, candelilla wax Fatty acids such as stearic acid, oleic acid, linoleic acid, isostearic acid, myristic acid, palmitic acid, palmitoleic acid, ricinoleic acid, lauric acid, behenic acid, cetanol, isocetyl alcohol, stearyl alcohol, isostearyl alcohol Cole, behenyl alcohol, hexadecyl alcohol, octyldodecyl alcohol, oleyl alcohol, higher alcohols such as cholesterol, cetyl isooctanoate, butyl stearate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, 2-octyldodecyl myristate, palmitate Isobutyl acid, hexadecyl adipate, cetyl 2-ethylhexanoate, diisostearyl malate, ceryl 16-hydroxypalmitate, ceryl palmitate, myristyl palmitate, cetyl palmitate, isopropyl laurate, hexyl laurate, mono Glyceryl ricinoleate, decyl oleate, di-n-butyl sebacate, glycerol tri-2-ethylhexanoate, Serine triester, pentaerythritol tetraester, synthetic esters such as cholesteryl esters, silicone oils such as methyl polysiloxane, dimethyl polysiloxane, methylphenyl polysiloxane, cyclomethicone, polyoxypropylene adducts, and the like. These can be used without any limitation as long as the purpose and intention of the present invention are followed. In particular, when silicone oils such as methylpolysiloxane are blended, it is difficult to carry out the dissolution treatment at a lower temperature under slightly reduced pressure conditions. It is preferable to mix and dissolve.
[0019]
Specific surfactants include glycerol monooleate, glycerol monostearate, diglycerol esters such as diglycerol dioleate, triglyceryl esters such as glyceryl trioctanoate, and trimethylol. Loppan ester, pentaerythritol ester, sorbitol ester, sucrose ester such as sucrose fatty acid ester, polyoxyethylene (POE) (20) sorbitan monolaurate, POE (20) sorbitan monostearate, POE ( 20) POE sorbitan fatty acid ester such as sorbitan monooleate, sorbitan ester such as sorbitan fatty acid ester, POE (20) cetyl alcohol ether, PO Nonionic substances such as POE glycerol fatty acid esters such as glycerol triisostearate, POE alkyl ethers such as POE (25) cetyl alcohol ether, propylene glycol monostearate, POE / POP block polymer, POE hydrogenated castor oil ester , Fatty acid soaps, anionic substances such as sodium alkyl sulfate, sodium alginate, starch derivatives, tragacanth gum, lecithin, phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and the like. These can be used without any limitation as long as the purpose and intention of the present invention are followed.
[0020]
Specific examples of typical combinations of oil phase components used in the present invention include those containing stearic acid, stearyl alcohol, and butyl stearate, stearic acid, stearyl alcohol, hydrogenated lanolin, squalane, and octyldodecyl alcohol. Including cetanol, stearic acid, petrolatum, squalane, and glycerol tri-2-ethylhexanoate, including solid paraffin, beeswax, petrolatum, and liquid paraffin, stearic acid, cetanol, petrolatum, liquid paraffin, and Contains isopropyl myristate, microcrystalline wax, solid paraffin, beeswax, petrolatum, hydrogenated lanolin, squalane, and hexadecyl adipate ester, squalane, steer Phosphoric acid, behenyl alcohol, octyldodecyl alcohol, glyceryl trioctanoate, POE (20) sorbitan monostearate, sorbitan monostearate, lipophilic glyceryl monostearate, avocado oil, methylpolysiloxane, concentrated glycerin, and 1, Examples include those containing 3-butylene glycol, squalane, behenyl alcohol, self-emulsifying glyceryl monostearate, octyldodecyl alcohol, lecithin, avocado oil, sesame oil, olive oil, and concentrated glycerin. It is also recognized that blends lacking methylpolysiloxane are preferred because they can be processed at lower temperatures. Furthermore, oil-soluble fragrances, humectants, oil-soluble mucous substances, oil-soluble colorants, oil-soluble drugs, and the like may be added to the oil phase component as appropriate. In particular, the humectant can be preferably blended in the oil phase component. These can be used without any limitation as long as the purpose and intention of the present invention are followed.
[0021]
As fragrances, natural fragrances such as plant fragrances obtained from plants, animal fragrances obtained from animal gland sac, etc., synthesized from natural fragrances or synthesized chemically based on them Examples include fragrances, blended fragrances obtained by blending various natural fragrances and synthetic fragrances. Specific examples of natural flavors include animal flavors such as musk, civet, castrium and ambergris, rose oil, jasmine oil, neroli oil, lavender oil, ylang ylang oil, tuberose oil, clarisage oil, clove oil, peppermint Plant flavors such as oil, geranium oil, patchouli oil, sandalwood oil, cinnamon oil, coriander oil, nutmeg oil, pepper oil, lemon oil, orange oil, bergamot oil, opoponax oil, vetiver oil, oris oil and oak moss oil can give. Specific examples of synthetic fragrances include hydrocarbons such as monoterpenes and sesquiterpenes, alcohols such as aliphatic alcohols, monoterpene alcohols, sesquiterpene alcohols, and aromatic alcohols, aliphatic aldehydes, terpene aldehydes, and aromatics. Aldehydes such as aldehydes, ketones such as alicyclic ketones, terpene ketones and macrocyclic ketones, esters such as terpene esters and aromatic esters, lactones such as undecalactone, and Schiff bases such as auranthiols Such as things,
[0022]
For example, l-citronellol, geraniol, l-linalool, d-linalool, linalyl acetate, limonene, damascon, damacenone, β-phenylethyl alcohol, farnesol, nonyl aldehyde, rose oxide, benzyl alcohol, benzyl acetate, benzylbenzoate, jasmon, cis Jasmon, jasmine lactone, indole, phytol, d-nerolidol, terpineol, pinene, nerol, camphene, cineol, geraniol ester, d-borneol, lavandulol, linalool ester, sesquiterpenes, methylbenzoate, methyl salicylate, methylanthrath Nilate, Nerolidol, Sclareol, Eugenol, Acetyl Eugenol, β-Caryophyllene, Methy Ru-n-amyl ketone, methyl heptyl ketone, l-menthol, menthone, isomenthone, 1,8-cineole, menthyl acetate, mentholfuran, geranyl formate, geranyl tiglate, citronellyl formate, patch jelly alcohol, patch urion, Patchurenone, α-Guyenene, β-Prunescene, α- or β-Santalol, Santen, Santenon, Santenol, Teresantalol, Santalon, α- or β-Santalene, Cynamic aldehyde, l-Ferrandolene, Pinene, α, β-pinene,
[0023]
n-decylaldehyde, sabinene, β-vinene, elemol, methylheptenone, α-bergamoten, β-bisabolen, n-nonyl alcohol, nootkatone, p-cymene, decanal, α, δ-casinene, ximol, beticerineol, α, β- Vetivone, vetiverol, vetiven, α, β, γ-iron, evernic acid, α, β-thuyon, atranoline, chloroatranoline, camphor, naphthalene, 3-methylcyclopentadecanone, mucopyridine, civeton, skatole, castrin , Castramine, isocastramine, bacdanol, bramanol, umbrain, terpineol, lyral, lyial, methylionone, iso-Esuper, acetyl cedrene, methyl dihydrojasmonate, methyl jasmonate, Black penta decanoate lid, ethylene brush rate, galactokinase solid and ambroxan the like. Examples of these fragrances include those produced by biotechnology such as ethylene brushate, 3-methylcyclopentadecanone, cyclopentadecanone, cyclopentadecanolide, and civeton. These can be used without any limitation as long as the purpose and intention of the present invention are followed. As a fragrance | flavor, the above can be used independently, or those arbitrary things can also be selected and used in combination. The perfume can be used in an amount sufficient to make the cream of the present invention acceptable to the user or to improve its comfort. Usually from about 0.0001 to about 10% by weight of the composition can be added.
[0024]
Examples of the aqueous phase component used in the present invention include purified water such as distilled water or ion-exchanged water, or purified water containing a humectant or an alkali. Among the aqueous phase components, those selected from the group consisting of surfactants, fragrances, preservatives, colorants, humectants, and drugs can also be contained. Further, among the water phase components, in particular, a mucous substance, a water-miscible organic solvent, a water-soluble component such as a water-soluble fragrance, a water-soluble colorant, a buffering agent, and a drug can be blended. These can be used without any limitation as long as the purpose and intention of the present invention are followed.
[0025]
Examples of the moisturizing agent include hydrophilic moisture-absorbing substances known as natural moisturizing factors (NMF = natural moisture factor) or derivatives thereof. For example, glycolipids, phospholipids, amino acids and the like are known. Among these, amino acids, pyrrolidone carboxylic acid (PCA), lactate, urea, ammonia, glucosamine, creatine, citrate, organic acid, peptide, sodium, potassium, calcium, magnesium, etc. It is done. Examples of the humectant include glycerin, propylene glycol, sorbit, polyethylene glycol (PEG) 200, PEG 600, PEG 1000, PEG 1500 and other polyethylene glycols, dipropylene glycol, 1,3-butylene glycol, diglycerin, mannitol, maltitol, POE. Hyaluronic acids such as methyl glycoside, hyaluronic acid, sodium hyaluronate, chondroitin sulfate, collagen, elastin, sodium pyrrolidonecarboxylate, amino acids, sugars, placenta extract, aloe extract, carrot extract, seaweed extract, milk extract, pearl solubilized product And so on.
[0026]
As the humectant, those described above can be used alone, or any one of them can be selected and used in combination. The moisturizing agent can be blended in an amount sufficient to give the cream of the present invention the function of moisturizing and softening the skin, and can be used in an amount that gives the user a superior feeling of use. . Usually from about 0.0001 to about 30% by weight of the composition can be added. Examples of mucus substances include polysaccharides obtained from plants or microorganisms, proteins obtained from animals, semisynthetic cellulose polymers, semisynthetic starch polymers, semisynthetic alginic acid polymers, polyvinyl polymers, alkylene oxide polymers. Etc.
[0027]
Typical examples of mucus substances include guar gum, locust bin gum, carrageenan, galactan, gum arabic, tragacanth gum, pectin, mannan, starch, methylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, ethylcellulose, hydroxypropylcellulose, etc. Cellulose derivatives, starch derivatives such as carboxymethyl starch and methyl starch, alginic acid derivatives such as propylene glycol alginate, xanthan gum, dextran, succinoglucan, curdlan, gelatin, quince seed, sodium alginate, soagina, casein, albumin, collagen, Carboxyvinyl polymer, sodium polyacrylate, polyvinyl Alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, polyethylene oxide. Examples of the water-miscible organic solvent include ethanol, isopropyl alcohol, ethylene glycol, tetrahydrofuran, ethylene glycol monoethyl ether and the like.
[0028]
Examples of the colorant include organic synthetic dyes, natural dyes, and inorganic pigments. Organic synthetic pigments include azo dyes such as Yellow No. 5 (Sunset Yellow FCF) and Red No. 505, Red No. 230 (Eosin YS), Red No. 104 (Phloxine B), Red No. 218 (Tetrachlorotetrabromofur) Olessein), xanthene dyes such as red 223, orange 201, red 213 (rhodamine B), quinoline dyes such as yellow 204 (Kirin Yellow SS), yellow 203 (Kirin Yellow WS), blue 1 and the like Triphenylmethane dyes, green 201 (alizanin cyanine green), green 202 (quinizarin green SS), purple 201 and other anthraquinone dyes, blue 2 and other indigo dyes, yellow 403 Nitro dyes such as green, pyrene dyes such as green 204, and nitroso dyes such as green 401 It is.
[0029]
Natural pigments such as carrot, orange, paprika, tomato, safflower, gardenia, perilla, turnip, grape, safflower, buckwheat, black oak skin, cacao bean, western red, purple root, beet, etc. , Mushrooms, yeasts, rackworms, cactus larvae, oak tree worms, Kermes larvae, pigments obtained from sea urchins, β-carotene, β-apo-8-carotenal, capsanthin, lilopine, bixin , Carotenoid pigments such as crocin, canthaxanthin, flavonoid pigments such as cysonin, raphanin, ninocyanin, calsamine, safrole yellow, rutin, quercetin, flavin pigments such as lipoflavin, lacaic acid, carminic acid, kermesic acid, alizarin, shikonin , Alkanine, nikinochrome Examples thereof include quinone dyes, porphyrin dyes such as chlorophyll, diketone dyes such as curcumin, and betacyanidine dyes such as betanin.
[0030]
Examples of inorganic pigments and other functional pigments include mica, talc, kaolin, calcium carbonate, magnesium carbonate, silicic acid anhydride, aluminum oxide, barium sulfate and other extender pigments, bengara, chromium oxide, yellow iron oxide, ultramarine, bitumen, Color pigments such as carbon black, white pigments such as ultrafine titanium dioxide and zinc oxide, pearlescent pigments such as titanium dioxide-coated mica, fish scale foil, bismuth oxychloride, boron nitride, polymer resin fine particles, synthetic mica, photochromic pigments Etc. Alkalis include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkali metal carbonates such as sodium carbonate and potassium carbonate, and alkaline earth metal hydroxides such as magnesium hydroxide and calcium hydroxide. , Alkaline earth metal carbonates such as magnesium carbonate and calcium carbonate, aliphatic amines such as triethanolamine, basic amino acids such as L-arginine, and borax. These can be used without any limitation as long as the purpose and intention of the present invention are followed. Drugs include vasodilators, antihistamines, anti-inflammatory agents, vitamins, nutrients, hormones, antiperspirants, anti-inflammatory agents, sebum suppressants, sebum secretion promoters, metabolism improvers, hair root function activators, peroxidation Examples thereof include lipid inhibitors, cell activators, bactericides, and the like. These can be used without any limitation as long as the purpose and intention of the present invention are followed.
[0031]
For example, representative drugs include melanin production inhibitors such as arbutin and kojic acid, γ-oryzanol, bio γ-linolenic acid oil, guaiazulene, β-carotene and other provitamin A, vitamin A acetate, vitamin A palmitate, etc. Vitamin A, vitamin C, vitamin C-2-phosphate, monostearyl ascorbate, vitamin C-2 such as vitamin C-2,6-dipalmitate, vitamin B1 such as thiamine nitrate, vitamin B2 such as riboflavin, vitamin B6, fatty acid ester of vitamin B6, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl ester, vitamin B6 such as pyridoxine, pyridoxal, pyridoxamine, vitamin B12 such as cyanocobalamin, tocopherol acetate, tocopherol Vitamin E such as calcium succinate and derivatives thereof, vitamin D such as cholecalciferol and ergocalciferol, pantothenic acids such as pantothenic acid and pantothenic acid ethyl ether, pantothenyl alcohol, biotin, assembly extract, cephalanthin, capsicum tincture , Ginger tincture, cantalis tincture, aloe extract, chamomile extract,
[0032]
Chlorella extract, Barley young leaf extract, Ginkgo biloba extract, Apricot extract, Ibukitorano, Ukogi extract, Jaundice, Huangren, Licorice extract, Camphor, Ginseng, Shikonin, Sembli extract, Mulberry bark, Japanese cabbage extract, Toki, Tomato Oil, traumatic acid, garlic extract, peppermint oil, hinokitiol, spotted extract, mugwort extract, garlic extract, quince mucilage, safflower, bitumen, rosemarinic acid extract, mini swordfish extract, yellow snake extract, cantalis tincture, protease Enzymes such as lysozyme, lipase, muramidase, tissue respiration promoting factor, female hormones such as acetylcholine, glutathione, estradiol, ethinylesladiol, male hormone, pituitary hormone, prostaglandin, diethylstil Follicular hormones such as strol, glycyrrhizic acid derivatives such as β-glycyrrhetinic acid, dipotassium glycyrrhizinate, allantoins such as allantoin, adrenocortical hormones such as azulene, ε-aminocaproic acid, hydrocortisone, prednisone, prednisolone, chlorpheniramine maleate, Urocanic acids such as diphenhydramine hydrochloride, acetylsalicylic acid, ibuprofen, oxyphenbutazone, flufenamic acid, indomethacin, sulindac, naproxen, ketoprofen, pranoprofen, piroxicam, ε-aminocaproic acid, sulfur, urocanic acid, 3- (3,4 -Dihydroxyphenyl) -L-alanine, succinic acid, diisopropylaminodichloroacetate,
[0033]
Examples include thioxolone, urea, potassium bromate, minoxidil, zinc pyrithione, picton olamine, chlorhexidines, and halocarban. In addition, L-cystine, L-cysteine, or derivatives thereof, superoxide dismutase (SOD), tannin, enju, rutin, pralmine, platonin, capsaicins, yellow gon extract, etc., known as lipid peroxide inhibitors Known as an activator, epicholestanol or its phosphate ester, EGF, ribonucleic acid, deoxyribonucleic acid, bovine placenta-derived skin fibroblast activator-containing liquid, calf serum extract, bovine spleen extract, L-arginine, Royal jelly etc. are mentioned. In addition, those mentioned as moisturizers, those mentioned as vitamins or physiologically active substances, and other additives are also considered as drugs when utilizing their specific activity, for example, biological activity.
[0034]
Representative specific examples of the aqueous phase component used in the present invention include purified water alone or purified water, 1,3-butylene glycol, and PEG 1500, purified water, glycerin, triethanolamine, and dipropylene. Examples include those containing glycol, purified water, and those containing propylene glycol. The ratio of the oil phase component used in the present invention is selected in a wide range depending on the purpose and the properties of the final product to be obtained. For example, it is 10 to 90% by weight, and more preferably 10 to 10% by weight for a vanishing cream or the like. It can be 30% by weight, 30% to 50% by weight for neutral creams, and 50% to 85% by weight for cold creams. More preferably, the ratio of the oil phase component used in the present invention is, for example, squalane, stearic acid, behenyl alcohol, octyldodecyl alcohol, glyceryl trioctanoate, POE (20) sorbitan monostearate, sorbitan as the oil phase component. Monostearic acid ester, lipophilic glyceryl monostearate, avocado oil, methylpolysiloxane,
[0035]
In the case of using concentrated glycerin and 1,3-butylene glycol, 25 to 45% by weight, more preferably 30 to 40% by weight, more preferably 33 to 36% by weight For example, when an oil phase component containing squalane, behenyl alcohol, self-emulsifying glyceryl monostearate, octyldodecyl alcohol, lecithin, avocado oil, sesame oil, olive oil, and concentrated glycerin is used in an amount of 25% to 50% by weight. More preferably 30% to 45% by weight, and even more preferably 34% to 38% by weight, including, for example, stearic acid, stearyl alcohol, hydrogenated lanolin, squalane, and octyldodecyl alcohol as oil phase components. Or cetanol, stearic acid, petrolatum, squalane, 20 to 45% by weight, more preferably 25 to 40% by weight, and more preferably 28 to 33.3% by weight when using glycerol tri-2-ethylhexanoate. It may be. In the present invention, the O / W emulsion is selected so that it can be stabilized, and depending on the components used, for example, fatty acids, higher alcohols, fatty acid esters, fats and oils, waxes, and surfactants, it is necessary. The HLB value is given. In the present invention, the use ratio of the oil phase component and the water phase component can be arbitrarily selected within a range that can stabilize the O / W emulsion, and the ratio is determined by the use components such as fatty acids, higher alcohols, fatty acids. Depending on the ester, oils and fats, waxes, surfactants, etc., the oil phase component is generally in the range of about 30-40% by weight and the water phase component is in the range of about 60-70% by weight. preferable.
[0036]
The mixing ratio of typical drugs used in the present invention is selected in a wide range according to the purpose and the properties of the final product to be obtained. For example, in the case of natural vitamin E, 0.001% to 1.00% by weight, It is preferably 0.010 wt% to 0.50 wt%, more preferably 0.15 wt% to 0.30 wt%, but more can be added. In the case of bio γ-linolenic acid oil or the like, 0.05 wt% to 3.00 wt%, preferably 0.10 wt% to 1.50 wt%, more preferably 0.50 wt% to 1. Although it is 00 weight%, it can also add more. Furthermore, in the case of guaiazulene or β-carotene, etc., 0.00001% to 1.00% by weight, preferably 0.0001% to 0.2% by weight, more preferably 0.0004% to 0.001%. Although it is 05 weight%, more than this can also be added. In the present invention, the product cream may further contain an ultraviolet control agent, an ultraviolet absorber, etc., for example, cinnamic acid ultraviolet absorber, benzoic acid ultraviolet absorber, dibenzoylmethane An ultraviolet absorber is mentioned. In the present invention, a chelating agent such as EDTA and a buffering agent such as sodium citrate, lactic acid and sodium lactate may be further added to the product cream. Moreover, although antiseptic | preservatives, such as a paraben, can also be added, the addition can be omitted when refrigerated or frozen storage of the product cream. The cream product of the present invention that has been refrigerated or frozen may exhibit an excellent feeling of use.
[0037]
【Example】
EXAMPLES Next, the present invention will be specifically described by way of examples. However, this is merely for better understanding of the present invention and is not intended to limit the present invention. Various aspects can be easily derived by those skilled in the art.
Example 1: Component Blending amount (a) Oil phase component (wt / wt)
(1) Behenyl alcohol 2.00 (2) Lipophilic glyceryl monostearate 2.00 (3) Stearic acid 2.00 (4) Squalane 6.00 (5) Glyceryl trioctanoate 8.00 (6) Adsorbed purified lanolin 2.00 (7) Shea butter 1.00 (8) Avocado oil 2.00 (9) Methylpolysiloxane 0.40 (10) 1,3-butylene glycol 4.00 (11) Concentrated glycerin 8.00 (b ) Water phase component (12) Purified water 61.39 (13) Potassium hydroxide 0.20 (c) Other components (14) Natural vitamin E 0.20 (15) Bio γ-linolenic acid oil 0.80 (16 ) Β-Carotene 0.01 Total 100.00
[0038]
The oil phase components (1) to (11) are combined, using a “Mizuho vacuum emulsifier PVQ-5”, a battle mixer at about 50 rpm, and a homomixer at about 1000 rpm with stirring at a pressure of about 20-30 mmHg. The mixture was gradually warmed and the solubility of the mixture was observed. The temperature increased from about 30 ° C. to about 50 ° C. over about 30 minutes, then increased to about 52 ° C. in about 3 minutes, and then increased to about 54 ° C. in about 3 minutes. At about 50 ° C., an insoluble material was observed in a part of the mixture, only a small amount of insoluble material was observed at about 52 ° C., and at about 54 ° C., an almost transparent solution was observed. Under the pressure of about 20 to 30 mmHg while gradually adding the water phase components (12) and (13) that have been dissolved and preliminarily set to about 54 ° C. to the oil phase component melt obtained at about 54 ° C. The battle mixer was stirred at about 30 rpm, and the homomixer was about 2500 rpm at about 54 ° C. with emulsification and mixing. Phase inversion occurred at about 60% of the aqueous phase.
[0039]
The mixture was then stirred under this reduced pressure to about 30 ° C. and cooled. To the emulsion thus obtained, a liquid obtained by adding and mixing component (14) natural vitamin E, (15) bio γ-linolenic acid oil and (16) β-carotene in advance at room temperature was brought to about 40 ° C. The mixture was mixed at 40 ° C., cooled with gentle stirring, and cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained. The sensory test by five panelists was performed on the cream thus obtained. The cream was applied to the skin of five women aged 20-30 years twice a day in the morning and evening for a week. As a result, the feeling of use was all good, and in any of the panelists, the cream was not irritated, and further, the skin did not become red or itchy at all.
[0040]
Example 2: The first oil phase components (1) to (11) of Example 1 were subjected to a dissolution treatment and an emulsification treatment with the addition of an aqueous phase component under a pressure of about 100 mmHg. Except for mixing at about 55 ° C., the same components as in Example 1 were used and treated in the same manner. In the mixture of the oil phase components (1) to (11), an insoluble matter was observed in a part of the mixture at about 50 ° C, a slight insoluble matter was observed at about 52 ° C, and a slight amount of insoluble matter was observed at about 53 ° C. A dissolved substance was observed, and at about 55 ° C., it was observed that the substance was dissolved almost transparently. Phase inversion occurred at about 60% of the aqueous phase. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained.
[0041]
Example 3: The mixture of the first oil phase components (1) to (11) and the emulsification treatment with the addition of the aqueous phase component are performed under a pressure of about 200 mmHg, and the aqueous phase component is about 56 ° C. Except for mixing, the same components as in Example 1 were used and treated in the same manner. In the mixture of the oil phase components (1) to (11), an insoluble matter was observed in a part of the mixture at about 50 ° C, a slight insoluble matter was observed at about 52 ° C, and a slight amount of insoluble matter was observed at about 54 ° C. A dissolved substance was observed, and at about 56 ° C., it was observed that the substance was dissolved almost transparently. Phase inversion occurred at about 60% of the aqueous phase. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained.
[0042]
Comparative Example 1: The first oil phase component (1) to (11) mixture of Example 1 was dissolved under normal pressure, and the aqueous phase component was added and emulsified under a pressure of about 460 mmHg. The same components were used as in Example 1 except that the aqueous phase components were mixed at about 57 ° C. and treated in the same manner. In the mixture of oil phase components (1) to (11), a part of the mixture is insoluble at about 50 ° C., a part of the insoluble matter is observed at about 52 ° C., and a slight amount of insoluble matter is observed at about 55 ° C. At about 57 ° C., it was finally observed that it was dissolved almost transparently. Phase inversion occurred at about 60% of the aqueous phase.
[0043]
Example 4: Component Blending amount (a) Oil phase component (wt / wt)
(1) Behenyl alcohol 4.00 (2) Stearic acid 2.00 (3) Octyldodecyl alcohol 2.00 (4) Glyceryl trioctanoate 4.00 (5) POE (20) Sorbitan mono 1.00 Stearic acid ester (6) ) Sorbitan monostearate 1.00 (7) Lipophilic glyceryl monostearate 2.00 (8) Squalane 8.00 (9) Avocado oil 2.00 (10) Methylpolysiloxane 0.40 (11) Concentrate Glycerol 4.00 (12) 1,3-butylene glycol 4.00 (b) Aqueous phase component (13) Purified water 64.59 (c) Other components (14) Natural vitamin E 0.20 (15) Bio γ -Linolenic acid oil 0.80 (16) Guaiazulene 0.01 Total 100.00
[0044]
The oil phase components (1) to (12) are combined, using a “Mizuho vacuum emulsifier PVQ-5”, a battle mixer at about 50 rpm, and a homomixer at about 1000 rpm with stirring at a pressure of about 20-30 mmHg. The mixture was gradually warmed and the solubility of the mixture was observed. At about 51 ° C., an insoluble material was observed in a part of the mixture, only a small amount of insoluble material was observed at about 55 ° C., and at about 56 ° C., an almost transparent solution was observed. To the lysate obtained at about 56 ° C., the water phase component (13), which has been dissolved and previously brought to about 56 ° C., is gradually added, under a pressure of about 20-30 mmHg, the battle mixer is about 30 rpm, and The homomixer was emulsified and mixed with stirring at about 2500 rpm at about 56 ° C. Phase inversion occurred at about 35% of the aqueous phase.
[0045]
The mixture was then stirred under this reduced pressure to about 30 ° C. and cooled. The liquid in which component (14) natural vitamin E, (15) bio γ-linolenic acid oil and (16) guaiazulene were previously mixed at room temperature was brought to about 40 ° C., and the resulting emulsion was about 40 The mixture was mixed at 0 ° C., cooled with gentle stirring, and cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained. The sensory test by five panelists was performed on the cream thus obtained. The cream was applied to the skin of five women aged 20-30 years twice a day in the morning and evening for a week. As a result, the feeling of use was all good, and in any of the panelists, the cream was not irritated, and further, the skin did not become red or itchy at all.
[0046]
Example 5: The first oil phase components (1) to (12) of Example 4 were subjected to a dissolution treatment and an emulsification treatment with the addition of an aqueous phase component under a pressure of about 100 mmHg. The same ingredients as in Example 4 were used and treated in the same manner except mixing at about 58 ° C. In the mixture of the oil phase components (1) to (12), insoluble matters are observed in a part of the mixture at about 54 ° C., only slight insoluble matters are observed at about 57 ° C., and almost transparent at about 58 ° C. It was observed that it dissolved. Phase inversion occurred at about 35% of the aqueous phase. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained.
[0047]
Comparative Example 2: The first oil phase component (1) to (12) mixture was dissolved under normal pressure, and the aqueous phase component was added and emulsified under a pressure of about 460 mmHg. Was processed at the same components as in Example 4 except that was mixed at about 59 ° C. The mixture of the oil phase components (1) to (12) was partially insoluble at about 55 ° C, partially insoluble at about 58 ° C, and finally dissolved almost transparently at about 59 ° C. It was observed. Phase inversion occurred at about 35% of the aqueous phase.
[0048]
Example 6: Component Blending amount (a) Oil phase component (wt / wt)
(1) Behenyl alcohol 2.0000 (2) Lipophilic glyceryl monostearate 2.0000 (3) Stearic acid 2.0000 (4) Squalane 6.0000 (5) Glyceryl tri-2-ethylhexanoate 8.0000 (6 ) Adsorption refined lanolin 2.000 (7) Olive oil 2.0000 (8) Shea butter 1.0000 (9) γ-linolenic acid oil (bio) 0.8000 (10) Natural vitamin E 0.2000 (11) Concentrated glycerin 8.00 (12) 1,3-butylene glycol 4.00 (b) Aqueous phase component (13) Potassium hydroxide 0.2000 (14) Purified water 60.2996 (c) Other components (15) β-carotene (30%) 0.0004 (16) Hinokitiol 0.0250 (17) Brucine modified 95 degree ethyl Alcohol 1.4750 a total of 100.0000
[0049]
The oil phase components (1) to (12) were combined, using a “Mizuho vacuum emulsifier PVQ-5” (capacity 5 liters), a battle mixer at about 50 rpm, and a homomixer at about 1000 rpm with stirring. The solution was gradually heated under a pressure of 0 to 10 mmHg, and the solubility of the mixture was observed. The temperature was raised from about 50 ° C. to about 55 ° C. over about 10 minutes and then held at about 55 ° C. for about 15 minutes. At about 50 ° C., an insoluble substance was observed in a part of the mixture, but at about 55 ° C., it was observed that it was dissolved transparently. While gradually adding the water-phase components (13) and (14), which had been dissolved and previously brought to about 55 ° C., to the lysate obtained at about 55 ° C. under reduced pressure, the battle mixer was about 30 rpm, and The mixer was emulsified and mixed by stirring at about 2500 rpm at about 55 ° C. The mixture was then stirred under this reduced pressure to about 30 ° C. and cooled. Component (15) β-carotene (30%), (16) hinokitiol, and (17) brucine-modified 95 ° ethyl alcohol mixed beforehand at room temperature was brought to about 40 ° C., and the emulsion thus obtained The mixture was mixed at about 40 ° C., cooled with gentle stirring, and cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained.
[0050]
Example 7: The first oil phase components (1) to (12) of Example 6 were subjected to a dissolution treatment and an emulsification treatment with the addition of an aqueous phase component under a pressure of about 50 mmHg. The same components were used as in Example 6 except that the mixture was mixed at about 57 ° C. and treated in the same manner. In the mixture of the oil phase components (1) to (12), an insoluble matter was observed in a part of the mixture at about 50 ° C., a slight insoluble matter was observed at about 55 ° C., and almost transparent at about 57 ° C. It was observed that it dissolved. Phase inversion occurred at about 40% of the aqueous phase. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained. When the viscosity was measured, it was 18500 cps (Tokyo Keiki B-type viscometer: 30 ° C., 12 rpm. 2 min. Rotor No. 4), pH (20 ° C.) was 7.73, and POV peracid value was 0.37. .
[0051]
Example 8: Dissolution treatment of the mixture of the first oil phase components (1) to (12) and emulsification treatment with addition of the aqueous phase component are performed under a pressure of about 100 mmHg, and the aqueous phase component is about 59 ° C. Except for mixing, the same components as in Example 6 were used and treated in the same manner. In the mixture of the oil phase components (1) to (12), an insoluble substance was observed in a part of the mixture at about 50 ° C., a slight insoluble substance was observed at about 55 ° C., and a slight insoluble substance was observed at about 57 ° C. A dissolved substance was observed, and at about 59 ° C., it was observed that the substance was dissolved almost transparently. Phase inversion occurred at about 40% of the aqueous phase. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained. When the viscosity was measured, it was 17,200 cps (Tokyo Keiki B-type viscometer: 30 ° C., 12 rpm. 2 min. Rotor No. 4), and the pH (20 ° C.) was 7.82.
[0052]
Example 9: Dissolution treatment of the first mixture of oil phase components (1) to (12) and emulsification treatment by adding the aqueous phase component are performed under a pressure of about 200 mmHg, and the aqueous phase component is about 65 ° C. Except for mixing, the same components as in Example 6 were used and treated in the same manner. In the mixture of oil phase components (1) to (12), an insoluble substance was observed in a part of the mixture at about 50 ° C., and it was observed that the mixture was almost transparent at about 65 ° C. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained.
[0053]
Example 10: Dissolution treatment of the first mixture of oil phase components (1) to (12) and emulsification treatment by adding an aqueous phase component are performed under a pressure of about 300 mmHg, and the aqueous phase component is about 66 ° C. Except for mixing, the same components as in Example 6 were used and treated in the same manner. In the mixture of the oil phase components (1) to (12), an insoluble matter was observed in a part of the mixture at about 50 ° C, a slight insoluble matter was observed at about 55 ° C, and a slight amount of insoluble matter was observed at about 62 ° C. A dissolved substance was observed, and at about 66 ° C., it was observed that the substance was dissolved almost transparently. Phase inversion occurred at about 40% of the aqueous phase. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. A fine and uniform cream was obtained. When the viscosity was measured, it was 15,050 cps (Tokyo Keiki B-type viscometer: 30 ° C., 12 rpm. 2 min. Rotor No. 4), and the pH (20 ° C.) was 7.84.
[0054]
Comparative Example 3: The first oil phase component (1) to (12) mixture was dissolved under normal pressure. Stirring was performed at about 400 rpm. The mixture of the oil phase components (1) to (12) was observed to be insoluble in a part of the mixture at about 55 ° C., and was a viscous liquid, and dissolved somewhat transparent at about 65 ° C. It was observed that the liquid became transparent. The emulsification treatment with the addition of the aqueous phase component was carried out under a pressure of about 460 mmHg, and the same treatment as in Example 1 was performed except that the aqueous phase component was mixed at about 59 ° C. The mixture of the oil phase components (1) to (12) was partially insoluble at about 55 ° C, partially insoluble at about 58 ° C, and finally dissolved almost transparently at about 59 ° C. It was observed. Phase inversion occurred at about 35% of the aqueous phase.
[0055]
As is apparent from the above Examples and Comparative Examples, it was unexpectedly revealed that the dissolution treatment can be performed at a lower temperature by dissolving the oil phase component under reduced pressure. In general, the oil phase component has different melting temperatures depending on where it is obtained, whether it is natural or synthetic, and also depending on the composition of the mixed components. It has been found that it can be dissolved by being heated up to the above, but can be dissolved for use in the production of a cosmetic cream at a substantially lower temperature by heating under reduced pressure. This is completely unexpected from the physicochemical theoretical prediction that, unlike the boiling point, except for special ones that sublimate, a decrease in melting point cannot be expected even under reduced pressure. The melting point of the mixture shows the behavior of melting at a lower temperature and in a wider range than the pure product, and then completely melting. However, from the relationship between the melting point and the pressure, even if the pressure is reduced to 0 mmHg, it is higher than 1 ° C. The melting point should not drop. It is not known that the oil phase component mixture that is the raw material of the cosmetic cream can be dissolved at such a lower temperature by applying a reduced pressure. This is not based on theoretical or detailed phenomenon observations, but the oil phase ingredient mixture, which is the raw material for cosmetic creams, contains a large amount of air, etc. It appears that the melt could not be achieved unless the temperature was raised to a high temperature by a normal melting treatment as a result of acting as a heat insulating layer on the surface of the solid and inhibiting heat transfer. However, it is considered that in a reduced pressure state, air that forms a heat insulating layer can be efficiently removed from the surface of the solid and the like, and heat conductivity is not hindered. Therefore, the present invention includes an embodiment that includes a method for achieving the dissolution treatment of the oil phase component mixture that is a raw material of the cosmetic cream that is substantially milder by any method based on such a concept. Some cosmetic oil phase component mixtures may be oxidized or decomposed when heated for a long time or at a high temperature, but some components having a complex composition may be oxidized or decomposed according to the method of the present invention. Can be effectively prevented.
[0056]
Example 11: Component Blending amount (a) Oil phase component (wt / wt)
(1) Behenyl alcohol 4.00 (2) Self-emulsifying glyceryl monostearate 4.00 (3) Octyldodecyl alcohol 2.00 (4) Squalane 4.00 (5) Lecithin 2.00 (6) Avocado oil 00 (7) Sesame oil 0.80 (8) Olive oil 2.00 (9) Concentrated glycerin 16.00 (b) Aqueous phase component (10) Purified water 62.19 (c) Other components (11) Natural vitamin E 0 20 (12) Bio γ-linolenic acid oil 0.80 (13) β-carotene 0.01 Total 100.00
[0057]
The oil phase components (1) to (9) are combined, mixed and dissolved with stirring using a homomixer under the same conditions as in Example 1 and Examples 6 to 10, and the resulting dissolved product is heated in advance. (10) Emulsified and mixed while gradually adding purified water, which is a water phase component. Component (11) natural vitamin E, (12) bio γ-linolenic acid oil and (13) β-carotene previously mixed at room temperature to about 40 ° C. and mixed with the emulsion thus obtained The mixture was then cooled with gentle stirring, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. The sensory test by five panelists was performed on the cream thus obtained. The cream is applied to the skin of five women aged 20 to 30 twice a day in the morning and evening for a week. As a result, the feeling of use was all good, and the cream was not irritated in any of the panelists. Further, when the skin became red, it did not cause itching.
[0058]
Example 12: Component Blending amount (a) Oil phase component (wt / wt)
(1) Stearyl alcohol 4.00 (2) Stearic acid 2.00 (3) Hydrogenated lanolin 4.00 (4) Squalane 9.00 (5) Octyldodecyl alcohol 10.00 (6) POE (20) Cetyl alcohol Ether 3.00 (7) Glycerol monostearate 2.00 (b) Aqueous phase component (9) Purified water 56.00 (10) 1,3-butylene glycol 4.00 (11) PEG 1500 4.00 (12 ) Natural moisturizer 0.99 (c) Other ingredients (13) Natural vitamin E 0.20 (14) Bio γ-linolenic acid oil 0.80 (15) β-carotene 0.01 Total 100.00
[0059]
The oil phase components (1) to (7) are combined, mixed and dissolved under stirring under the same conditions as in Examples 1 and 6 to 10, and added in advance to the resulting melt. The mixture of (9) to (12), which was a warm aqueous phase component, was stirred and emulsified and mixed while gradually adding. Component (13) natural vitamin E, (14) bio γ-linolenic acid oil and (15) β-carotene were mixed in advance at room temperature to a temperature of about 40 ° C., and the emulsion thus obtained was The mixture was mixed at about 40 ° C., cooled with gentle stirring, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration. The sensory test by five panelists is performed on the cream thus obtained. The cream is applied to the skin of five women aged 20 to 30 twice a day in the morning and evening for a week. As a result, the feeling of use is all good, and the cream is not irritated by any panelists. Further, when the skin becomes red, it does not itch. In addition to the above-described composition components, the product added with a preservative and a fragrance also had an excellent emulsified state.
[0060]
Example 13: Component Blending amount (a) Oil phase component (wt / wt)
(1) Stearyl alcohol 4.00 (2) Stearic acid 8.00 (3) Butyl stearate 6.00 (4) Glycerol monostearate 2.00 (b) Water phase component (5) Purified water 72.09 ( 6) Propylene glycol 5.00 (7) Potassium hydroxide 0.40 (8) Natural moisturizer 1.00 (c) Fragrance 0.50 (d) Other ingredients (9) Natural vitamin E 0.20 (10) Bio γ-Linolenic acid oil 0.80 (11) β-Carotene 0.01 Total 100.00
[0061]
The oil phase components (1) to (4) are combined, mixed and dissolved under stirring under the same conditions as in Examples 1 and 6 to 10, and a fragrance is added to the obtained dissolved product under the same conditions. The mixture thus obtained is emulsified and mixed by stirring while gradually adding an aqueous phase mixture prepared by heating. Component (9) natural vitamin E, (10) bio γ-linolenic acid oil and (11) β-carotene mixed in advance at room temperature are brought to about 40 ° C., and the resulting emulsion is obtained. , Mixed at about 40 ° C., cooled, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent. The stability was also good after storage for 1 week under refrigeration.
[0062]
Example 14: Component Blending amount (a) Oil phase component (wt / wt)
(1) Cetyl alcohol 5.00 (2) Stearic acid 3.00 (3) Petrolatum 5.00 (4) Squalane 10.00 (5) Glycerol tri-2-ethylhexanoate 7.00 (6) Propylene glycol mono Stearic acid ester 3.00 (7) POE (20) Cetyl alcohol ether 3.00 (b) Aqueous phase component (8) Purified water 49.49 (9) Dipropylene glycol 5.00 (10) Triethanolamine 00 (11) Glycerin 2.00 (12) Bifidobacteria milk fermented product 5.00 (c) Fragrance 0.50 (d) Other ingredients (13) Natural vitamin E 0.20 (14) Bio γ-linolenic acid oil 0.80 (15) β-carotene 0.01 Total 100.00
[0063]
The oil phase components (1) to (7) are combined, mixed and dissolved under stirring under the same conditions as in Examples 1 and 6 to 10, and a fragrance is added to the obtained dissolved product under the same conditions. The mixture thus obtained was emulsified and mixed by stirring while gradually adding a preliminarily heated aqueous phase mixture. Component (13) natural vitamin E, (14) bio γ-linolenic acid oil and (15) β-carotene mixed beforehand at room temperature are brought to about 40 ° C., and the resulting emulsion is obtained. , Mixed at about 40 ° C., cooled, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent and it was a cream with a refreshing feel. The stability was also good after storage for 1 week under refrigeration.
[0064]
Example 15: Component Blending amount (a) Oil phase component (wt / wt)
(1) Solid paraffin 5.00 (2) Beeswax 10.00 (3) Petrolatum 15.00 (4) Liquid paraffin 31.00 (5) Glycerol monostearate 2.00 (6) POE (20) Sorbitan monolauric acid Ester 2.00 (b) Aqueous phase component (7) Purified water 28.29 (8) 1,3-butylene glycol 2.00 (9) Borax 0.20 (10) Bifidobacteria milk fermented product 3.00 ( c) Fragrance 0.50 (d) Other ingredients (11) Natural vitamin E 0.20 (12) Bio γ-linolenic acid oil 0.80 (13) β-carotene 0.01 Total 100.00
[0065]
The oil phase components (1) to (6) are combined and mixed and dissolved under stirring under the same conditions as in Examples 1 and 6 to 10, and a fragrance is added to the resulting dissolved product under the same conditions, thus The obtained mixture was stirred and emulsified and mixed while gradually adding an aqueous phase mixture prepared in advance. Component (11) natural vitamin E, (12) bio γ-linolenic acid oil and (13) β-carotene previously mixed at room temperature are brought to about 40 ° C., and the resulting emulsion is obtained. , Mixed at about 40 ° C., cooled, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent and it was a cream with a refreshing feel. The stability was also good after storage for 1 week under refrigeration.
[0066]
Example 16: Component Blending amount (a) Oil phase component (wt / wt)
(1) Microcrystalline wax 9.00 (2) Solid paraffin 2.00 (3) Beeswax 3.00 (4) Petrolatum 5.00 (5) Reduced lanolin 5.00 (6) Squalane 29.00 (7) Hexa Decyl adipate 10.00 (8) Glycerol monooleate 3.50 (9) POE (20) Sorbitan monooleate 1.00 (b) Water phase component (10) Purified water 25.99 (12) Propylene Glycol 3.00 (13) Bifidobacteria milk fermented product 2.00 (c) Fragrance 0.50 (d) Other ingredients (14) Natural vitamin E 0.20 (15) Bio γ-linolenic acid oil 0.80 ( 16) β-Carotene 0.01 Total 100.00
[0067]
Oil phase components (1) to (9) are combined, mixed and dissolved under stirring under the same conditions as in Example 1 and Examples 6 to 10, and a fragrance is added to the resulting melt under the same conditions. The mixture thus obtained was emulsified and mixed by stirring while gradually adding a preliminarily heated aqueous phase mixture. Component (14) natural vitamin E, (15) bio γ-linolenic acid oil and (16) β-carotene previously mixed at room temperature is brought to about 40 ° C., and the resulting emulsion is obtained. , Mixed at about 40 ° C., cooled, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent and it was a cream with a refreshing feel. The stability was also good after storage for 1 week under refrigeration.
[0068]
Example 17: Component Compounding amount (a) Oil phase component (wt / wt)
(1) Stearic acid 2.00 (2) Cetyl alcohol 3.00 (3) Petrolatum 10.00 (4) Liquid paraffin 33.00 (5) Isopropyl myristate 10.00 (6) Glycerol monostearate 2.50 (7) POE (20) sorbitan monostearate 2.50 (b) aqueous phase component (8) purified water 30.89 (9) potassium hydroxide 0.10 (10) propylene glycol 3.00 (11) bifidos Fermented milk product 2.00 (c) Fragrance 0.50 (d) Other ingredients (12) Natural vitamin E 0.20 (13) Bio γ-linolenic acid oil 0.80 (14) β-Carotene 0.01 Total 100.00
[0069]
The oil phase components (1) to (7) are combined, mixed and dissolved under stirring under the same conditions as in Examples 1 and 6 to 10, and a fragrance is added to the obtained dissolved product under the same conditions. The mixture thus obtained was emulsified and mixed with stirring while gradually adding an aqueous phase mixture prepared by heating at about 60 ° C. in advance. Ingredient (12) natural vitamin E, (13) bio γ-linolenic acid oil and (14) β-carotene mixed in advance at room temperature are brought to about 40 ° C., and the resulting emulsion is obtained. , Mixed at about 40 ° C., cooled, and further cooled to about 30 ° C. to obtain the desired cream. The emulsified state of the product was excellent and it was a cream with a refreshing feel. The stability was also good after storage for 1 week under refrigeration.
[0070]
【The invention's effect】
In the present invention, the prior art High in At temperature Oil phase ingredients It is heated and dissolved, followed by emulsification Process To avoid Contains solid or semi-solid oil Oil phase ingredients In an atmosphere excluding an inert atmosphere, it can be dissolved at a temperature of 40 ° C. to 65 ° C., which is a lower temperature than in ordinary O / W skin cream production Therefore, useful components that are unstable to heat can be arbitrarily blended, and decomposition thereof can be prevented.
As a result, useful ingredients that are unstable to heat can be added arbitrarily, and the decomposition thereof can be prevented, the generation of irritants can be suppressed, and the use of the cream for a long time causes allergies. The problem of redness or itchy skin does not occur. And in the method of this invention, although it manufactures under low temperature, the quality of a product is also favorable and the usability | use_condition can be satisfied. In the present invention, since all production can be performed at a low temperature, it is possible to omit the addition of an antioxidant and the like, and it is possible to prevent problems associated with decomposition of components. The product produced by the method of the present invention can omit the addition of an antioxidant and the like, and the quality is good even if it is stored at a low temperature. In some cases, the cream can be stored frozen and has no problem in use or quality, and is excellent in use. In addition, since an alkali is used for the emulsification process in the vanishing cream, the emulsification process must be performed at a high temperature of 75 ° C. to 85 ° C., and a component unstable to heat could not be used. However, in the present invention, a product that can be processed at a lower temperature and has no problem in use feeling can be obtained.
[Brief description of the drawings]
FIG. 1 is a production process diagram of an O / W type cream according to a conventional method.

Claims (5)

In producing an O / W type skin cream from an oil phase component and an aqueous phase component, an oil phase component containing a solid oil or a semi-solid oil is heated at a temperature of 40 to 65 ° C. in an atmosphere excluding an inert atmosphere . Within the range and mixed and dissolved under a reduced pressure of 0 to 200 mmHg, which can be lower than the melting temperature of the solid oil or semi-solid oil dissolution stage at the time of production of the O / W type skin cream, The oil phase component and aqueous phase component thus obtained are mixed and emulsified at a temperature of 40 to 65 ° C. and 0 to 200 mmHg, and the product thus obtained is heated to 35 to 58 ° C. A method for producing an O / W type skin cream characterized by adding and mixing one or more selected from the group consisting of a fragrance, an antiseptic, a colorant, a moisturizing agent, and a drug that are unstable ingredients . The oil phase component comprises behenyl alcohol, lipophilic glyceryl monostearate, stearic acid, squalane, glyceryl trioctanoate, adsorbed purified lanolin, shea butter, avocado oil, 1,3-butylene glycol and concentrated glycerin, Or behenyl alcohol, stearic acid, octyldodecyl alcohol, glyceryl trioctanoate, POE (20) sorbitan monostearate, sorbitan monostearate, lipophilic glyceryl monostearate, squalane, avocado oil, methylpolysiloxane, concentrated glycerin, And the method for producing an O / W type skin cream according to claim 1, which is selected from the group consisting of 1,3-butylene glycol . The O / W type according to any one of claims 1 and 2, wherein the thermally unstable component is selected from the group consisting of natural vitamin E, bio γ-linolenic acid oil, β-carotene, and guaiazulene. A method for producing a skin cream. The oil phase component containing solid oil or semi-solid oil was mixed and dissolved at 50 to 60 ° C. under 0 to 200 mmHg, and the oil phase component and the aqueous phase component obtained by subsequent dissolution treatment were mixed at 0 to 200 mmHg. mixed emulsified under 50-60 ° C., subsequently in the course of cooling thus obtained emulsified product to any one of claims 1 to 3 is intended to incorporate labile components into heat 35 to 58 ° C. The manufacturing method of the cream for O / W type | mold skin of description. The method for producing an O / W type skin cream according to any one of claims 1 to 4, wherein the oil phase component is 30 to 40% by weight and the water phase component is 60 to 70% by weight .

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