JP3991312B2 - Moisturizer and external preparation for skin - Google Patents

Description

【００４３】
表１から明らかなように、各実施例の試料は、比較例１の試料よりも保湿性に対して優れた効果を示した。また、これらの効果には有意な差があると認められた。
【００４４】
＜試験２＞
試験２は、試験１と同様の実施例１、２及び比較例１を試料として、肌荒れ防止・改善効果をクレーマーの検定法により判断した。
【００４５】
専門パネル１５名が、実施例と比較例１の２種類の化粧用ローションを盲試料として顔面に塗布し、１０日間連続使用の後、肌荒れ防止・改善効果が優れている方に２点、劣っている方に１点という評価を付した。各評価点の人数と、合計点を表２に示した。なお、実施例として異なるシラネアオイ抽出物を配合した２種類の化粧用ローションを用意したので、上記試験を２回行った。
【００４６】
【表２】

【００４７】
表２から明らかなように、各実施例の試料は、比較例１の試料よりも肌荒れ防止・改善に対して優れた効果を示した。また、これらの効果には有意な差があると認められた。
【００４８】
＜試験３＞
試験３は、上記した本発明に係る皮膚外用剤についての処方例のうち、処方例９、１０の化粧水をそれぞれ実施例３、４として、肌荒れ防止・改善効果をクレーマーの検定法により判断した。比較例２として、処方例９のシラネアオイ抽出物に代えて、５０重量％１，３−ブチレングリコールを配合したものを用意した。
【００４９】
試験方法及び評価方法は試験２と同様である。
【００５０】
【表３】

【００５１】
表３から明らかなように、各実施例の試料は、比較例２の試料よりも肌荒れ防止・改善に対して優れた効果を示した。また、これらの効果には有意な差があると認められた。
【００５２】
＜試験４＞
上記試験２及び試験３の試験後、引き続き同一パネルに実施例の試料を２０日間（合計３０日）連続で使用させた後、皮膚の異常の有無を確認したが、目視および自覚症状の両面で異常は見られなかった。
【００５３】
【発明の効果】
以上詳述したのように、本発明によれば、安全性が高く保湿効果に優れた保湿剤を提供することができるという効果を奏する。また、安全性が高く保湿効果、肌荒れ防止・改善効果に優れた皮膚外用剤を提供することができるという効果を奏する。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a skin moisturizer and a skin external preparation excellent in moisture retention and excellent in preventing and improving rough skin.
[0002]
[Prior art]
Various active ingredients are blended in the external preparation for skin. Moisturizing effect, skin roughening prevention / improvement effect is one of its medicinal effects, and as an active ingredient of skin external preparations such as cosmetics intended for these medicinal effects, amino acids, polysaccharides, lipids, plant extract etc. have been conventionally used It has been used for its ability to prevent skin inflammation and loss of water in the stratum corneum. Known plant extracts include aloe extract, apricot extract, kyoukatsu extract, kudzu extract, licorice extract, kohon extract, psycho extract, senkyu extract, touki extract, carrot extract, and yokuinin extract.
[0003]
[Problems to be solved by the invention]
However, any of the external preparations for skin containing the above active ingredients is not necessarily sufficient in its moisturizing effect and prevention / improvement effect on rough skin, and the development of more effective active ingredients has been expected. This invention is made | formed in view of the said situation, The subject is providing the skin external preparation excellent in the moisturizing agent excellent in moisture retention, and excellent in the rough skin prevention and improvement.
[0004]
[Means for Solving the Problems]
In order to solve the above-mentioned problems, the present inventors have conducted extensive research to obtain a component excellent in moisture retention and excellent in preventing and improving rough skin. As a result, the extraction of Shiraneae ( Glaucidium palmatum Sieb.et Zucc.) It was found that the product was excellent in moisture retention and excellent in preventing and improving rough skin, and the present invention was completed.
[0005]
That is, the present invention provides a moisturizer and a skin external preparation containing an extract of Shiraneae ( Glaucidium palmatum Sieb.et Zucc.).
[0006]
Shiraneae ( Glaucidium palmatum Sieb.et Zucc.) Is a plant belonging to the genus Shiraneae.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described in detail.
[0008]
The present invention relates to a moisturizer and an external preparation for skin containing an extract of Shiraneae ( Glaucidium palmatum Sieb.et Zucc.). The humectant can be used by blending with an external preparation for skin, a skin cleanser and the like.
[0009]
The extract of Shiraneae used in the present invention can be obtained by a conventional method. For example, it can be obtained by extracting the whole plant of Shiraneae or various parts (flowers, leaves, stems, etc.) raw or after drying and grinding with a solvent.
[0010]
The extraction solvent is not particularly limited, and water, alcohols (ethanol, methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octyl alcohol and other monovalent alcohols, glycerin, ethylene, etc. Glycols, ethylene glycol monomethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, polyhydric alcohols such as triethylene glycol, 1,3-butylene glycol and hexylene glycol or derivatives thereof, ketones (acetone, Methyl ethyl ketone, methyl isobutyl ketone, methyl-n-propyl ketone, etc.), esters (ethyl acetate, isopropyl acetate, etc.), ethers (ethyl ether) Isopropyl ether, n-butyl ether, etc.), polar solvents such as acetonitrile, liquid hydrocarbons such as n-pentane and n-hexane, non- (low) polar solvents such as supercritical fluids of carbon dioxide, or a combination of two or more Mixtures can be used in any combination.
[0011]
Among these solvents, water, alcohols (ethanol, methanol, isopropanol, isobutanol, n-hexanol, methyl amyl alcohol, 2-ethylbutanol, n-octyl alcohol and other monohydric alcohols, glycerin, ethylene glycol, ethylene Solvents are distilled off for extracts of glycol monomethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol and other polyhydric alcohols or derivatives thereof) You may use without.
[0012]
Moreover, the polar solvent which added inorganic salts, such as phosphate buffered saline, and the solvent which added surfactant can also be used.
[0013]
The extraction method is not particularly limited, a method of extraction by impregnation at room temperature or in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, a method of extraction using a supercritical extraction device, or There is a method of obtaining an extract by squeezing a Shiraneae. These methods are extracted alone or in combination of two or more. The ratio of the plant body and the solvent during the extraction is not particularly limited, but is preferably 0.1 to 1000 times by weight of the solvent with respect to the silane mushroom body 1, and more preferably 0.5 to 100 times by weight in terms of extraction operation and efficiency.
[0014]
Cilanae mushroom extract can be used as it is, but it can be used as a fraction by adding purification operations such as deodorization, decolorization, concentration, etc., as long as the effect is not lost. May be. These extracts, purified products, and fractions can be dried by removing the solvent from them, and can also be used in a form solubilized in a solvent such as alcohol, or in the form of an emulsion. it can.
[0015]
The amount of these extracts to be added to the external preparation for skin is preferably in the range of 0.00001 to 20% by weight, more preferably 0.0001 to 10% by weight, considering the effect, smell when added, and color tone. More preferably.
[0016]
The external preparation for skin of the present invention is generally used for external preparations for skin such as cosmetics, quasi-drugs, and pharmaceuticals, as long as the effects of the present invention are not impaired, if necessary, in addition to the above extract. Components such as aqueous components, oily components, powder components, humectants, thickeners, ultraviolet absorbers, preservatives, antioxidants, fragrances, colorants, various skin nutrients, and the like can be blended.
[0017]
In addition, hot water extraction of edetate disodium, edetate trisodium, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid and other metal sequestering agents, caffeine, tannin, licorice extract, grabrizine and karin fruit Products, various crude drugs, drugs such as tocopherol acetate, glycyrrhizic acid and its derivatives or their salts, vitamins (vitamin C, vitamin A, vitamin E, etc.), arbutin, kojic acid, sugars (glucose, fructose, trehalose, etc.) It can mix | blend suitably.
[0018]
The dosage form of the external preparation for skin of the present invention is arbitrary, for example, a solubilizing system such as skin lotion, an emulsifying system such as emulsion or cream, or an ointment, powder dispersion system, water-oil two-phase system, water-oil- Any dosage form such as a powder three-phase system or an aerosol filled with a propellant may be used.
[0019]
【Example】
In the following, the present invention will be described in more detail with reference to production examples of citrus mallow extract, formulation examples as skin external preparations, test examples, but the technical scope of the present invention is not limited thereby. Needless to say.
[0020]
<Production Example 1>
Only the whole plant and flower parts of Shiraneae were dried and pulverized, extracted for 5 hours under conditions of heating to 50 ° C. in 50% by weight ethanol aqueous solution, filtered, and the solvent of the filtrate was distilled off. Shiraneae extract (only for whole grass and flower part) was obtained.
[0021]
<Production Example 2>
The whole plant and flower part of Shiraneae were dried and pulverized, extracted for 5 hours under conditions of heating to 50 ° C. in n-hexane, filtered, and the solvent of the filtrate was distilled off. Extracts (for whole grass and flower parts only) were obtained.
[0022]
<Production Example 3>
The whole plant and flower part of Shiraneae were dried and ground, respectively, extracted in 50% by weight 1,3-butylene glycol at room temperature for 2 weeks and filtered, and the extract of Shiraneae (only plant and flower part only) Got about).
[0023]
<Production Example 4>
The whole plant and flower part of Shiraneae were extracted using a supercritical fluid of carbon dioxide at 40 ° C. and atmospheric pressure of 15 MPa each. The extract was collected to obtain a Shiraneae extract (whole plant and flower part only).
[0024]
Examples of prescriptions are shown below, but the prescriptions may be manufactured by conventional methods in the production of each product, and the Shiraneae extract in each formulation example is an extract of either the whole plant of Silaneae or only the flower part. In each formulation example, two types of external preparations using these different extracts were formulated. All compounding amounts are shown in wt%.
[0025]
<Formulation Example 1: Skin Lotion>
(1) Glycerol 10.0, (2) Sodium lactate 0.5, (3) Polyoxyethylene hydrogenated castor oil (60E.O.) 0.2, (4) Shiraneae extract (extract according to Production Example 1) 0.2, (5) Purification After mixing and homogenizing the components of the residue (production method) (1) to (4) to be water 100, (5) was added and stirred uniformly to obtain a skin lotion.
[0026]
<Formulation Example 2: Skin Lotion>
(1) Glycerol 10.0, (2) Sodium lactate 0.5, (3) Polyoxyethylene hydrogenated castor oil (60E.O.) 0.2, (4) Shiraneae extract (extract according to Production Example 3) 0.2, (5) Purification Residue (preparation method) with 100 water is applied according to Recipe Example 1.
[0027]
<Prescription Example 3: Skin Lotion>
(1) Ethanol 10.0, (2) 1% by weight hydroxyethyl cellulose aqueous solution 20.0, (3) Shiraneae extract (extract according to Production Example 4) 0.1, (4) Glycerol 7.0, (5) Sodium guaiazulene sulfonate 0.5, (6 ) After the remainder (production method) (1) to (6) to be purified water 100 was mixed, it was made uniform and a skin lotion was obtained.
[0028]
<Prescription Example 4: Essence>
(1) squalane 5.0, (2) white petrolatum 2.0, (3) beeswax 0.5, (4) sorbitan sesquiolate 0.8, (5) polyoxyethylene oleyl ether (20E.O.) 1.2, (6) propylene glycol 5.0, (7) Residue to be purified water 100, (8) 1 wt% carboxyvinyl polymer aqueous solution 20.0, (9) Shiraneae extract (extract according to Production Example 2) 0.5, (10) 10 wt% potassium hydroxide aqueous solution 1.0, (11) Ethanol 5.0, (12) Fragrance 0.2
(Production Method) The oil phase components (1) to (5) were mixed and heated to 75 ° C. to dissolve and homogenize. On the other hand, the aqueous phase components (6) to (8) are mixed and dissolved, heated to 75 ° C., the oil phase component is added and pre-emulsified, and the pH is adjusted by adding (10), and then the homomixer Emulsified. After cooling, (11), (9) and (12) were added and mixed at 40 ° C. to obtain a serum.
[0029]
<Formulation Example 5: Skin emulsion>
(1) Squalane 15.0, (2) Cetanol 1.2, (3) Petrolatum 3.0, (4) Polyoxyethylene sorbitan monostearate (20E.O.) 1.3, (5) Sorbitan monostearate 1.0, (6) Paraoxybenzoic acid Methyl acid 0.2, (7) 1,3-butylene glycol 10.0, (8) 1 wt% carboxyvinyl polymer aqueous solution 15.0, (9) Residual water 100, (10) 10 wt% L-arginine aqueous solution 2.0, ( 11) Shiraneae extract (extract according to Production Example 1) 2.0
(Production Method) The oil phase components (1) to (5) were mixed, heated to 75 ° C., and dissolved and homogenized. On the other hand, the water phase components (6) to (9) are mixed and heated to 75 ° C. to dissolve and homogenize, then the oil phase component is added and pre-emulsified, and (10) is added to adjust the pH. After adjustment, the mixture was emulsified with a homomixer. After cooling, (11) was added at 40 ° C. and mixed to obtain a skin emulsion.
[0030]
<Formulation Example 6: Gel for skin>
(1) 1% by weight carboxyvinyl polymer aqueous solution 50.0, (2) polyoxyethylene hydrogenated castor oil (50E.O.) 0.5, (3) Shiraneae extract (extract according to Production Example 1) 0.5, (4) dipropylene Glycol 8.0, (5) 10% by weight potassium hydroxide aqueous solution 1.0, (6) Purified water 100 (Residue) (Production method) (1) with (2) to (4) uniformly dissolved was added and stirred uniformly. . An aqueous solution in which (5) was dissolved in (6) was added thereto to increase the viscosity to obtain a gel for skin.
[0031]
<Prescription Example 7: Cream for skin>
(1) Beeswax 6.0, (2) Cetanol 1.5, (3) Reduced lanolin 8.0, (4) Squalane 29.5, (5) Lipophilic monostearate glyceride 4.0, (6) Polyoxyethylene sorbitan monolaurate (20E.O .) 5.0, (7) Propylene glycol 5.0, (8) Shiraneae extract (extract according to Production Example 1) 0.5, (9) Residue (production method) (1) to (6) oil phase components as purified water 100 Were mixed, dissolved and heated to 75 ° C. On the other hand, the aqueous phase components (7) and (9) were mixed, dissolved, and heated to 75 ° C. Next, the oil phase component was added to the water phase component and pre-emulsified, and then uniformly emulsified with a homomixer. After cooling, (8) was added at 45 ° C. to obtain a skin cream.
[0032]
<Prescription Example 8: Oil-in-water emulsion ointment>
(1) White petrolatum 25.0, (2) Stearyl alcohol 25.0, (3) Glycerol 10.0, (4) Sodium lauryl sulfate 1.0, (5) Shiraneae extract (extract according to Production Example 1) 0.5, (6) Purified water 100 The oil phase components (1) to (4) are mixed, dissolved, and made uniform, and heated to 75 ° C. The oil phase component was added to (6) heated to 75 ° C. to emulsify, and after cooling, (5) was added at 45 ° C. to obtain an oil-in-water emulsion ointment.
[0033]
<Formulation example 9: lotion>
(1) Ethanol 10.0, (2) 1,3-butylene glycol 5.0, (3) Shiraneae extract (extract according to Production Example 1) 10.0, (4) Dipotassium glycyrrhizinate, (5) Fragrance 0.1, (6) Polyoxyethylene hydrogenated castor oil (60E.O.) 0.2, (7) Purified water 100 (residue) (1), (2), (5), (6) are uniformly dissolved, Dissolved (7) was added, and (3) was added to mix and dissolve uniformly to obtain a skin lotion.
[0034]
<Formulation example 10: lotion>
(1) Ethanol 10.0, (2) 1,3-butylene glycol 5.0, (3) Shiraneae extract (extract according to Production Example 4) 10.0, (4) Dipotassium glycyrrhizinate 0.5, (5) Fragrance 0.1, (6) Residue (preparation method) formulation example 9 with polyoxyethylene hydrogenated castor oil (60E.O.) 0.2, (7) purified water 100 is applied.
[0035]
<Prescription Example 11: Makeup Base Cream>
(1) stearic acid 1.2, (2) cetanol 2.0, (3) glyceryl tri-2-ethylhexanoate 2.5, (4) self-emulsifying glyceride monostearate 2.0, (5) propylene glycol 10.0, (6) 10 weight % Potassium hydroxide aqueous solution 1.5, (7) Shiraneae extract (extract according to Production Example 1) 0.3, (8) Residue to be purified water 100, (9) Titanium oxide 1.0, (10) Bengala 0.1, (11) Yellow Iron oxide 0.4, (12) Fragrance 0.1
(Production Method) The oil phase components (1) to (4) were mixed and heated to 75 ° C. to make it uniform. On the other hand, the components (5), (6) and (8) are mixed, heated and dissolved at 75 ° C. to make it uniform, and the pigments (9) to (11) are added to this and homogenized with a homomixer. To obtain an aqueous phase component. The oil phase component was added to the water phase component, emulsified with a homomixer, cooled, and the components (12) and (7) were added and mixed at 40 ° C. to obtain a makeup base cream.
[0036]
<Prescription Example 12: Milky Foundation>
(1) stearic acid 2.0, (2) squalane 5.0, (3) octyldodecyl myristate 5.0, (4) cetanol 1.0, (5) glyceride monostearate 1.0, (6) 1,3-butylene glycol 8.0, (7 ) 10 wt% potassium hydroxide aqueous solution 2.0, (8) Shiraneae extract (extract according to Production Example 1) 0.3, (9) Residue to be purified water 100, (10) Titanium oxide 9.0, (11) Talc 7.4, ( 12) Bengala 0.5, (13) Yellow iron oxide 1.1, (14) Black iron oxide 0.1, (15) Fragrance 0.1
(Production Method) The oil phase components (1) to (5) were mixed and heated to 75 ° C. to make it uniform. On the other hand, the aqueous phase components (6), (7), and (9) are mixed, heated and dissolved at 75 ° C. to make uniform, and the pigments (10) to (14) are added to this and added to the homomixer. Then, the mixture was cooled and then cooled, and (15) and (8) were added at 40 ° C. to obtain an emulsion foundation.
[0037]
<Prescription Example 13: Hand cream>
Cetanol 1.5, (2) Petrolatum 2.0, (3) Liquid paraffin 10.0, (4) Monostearate glyceride 1.5, (5) Polyoxyethylene glyceryl isostearate (60E.O.) 2.5, (6) Tocopherol acetate 0.5, ( 7) Glycerol 20.0, (8) Methyl paraoxybenzoate 0.1, (9) Shiraneaoi extract (extract according to Production Example 1) 0.5, (10) Residue (production method) (1) to (6) of purified water 100 The oil phase components were mixed, dissolved and heated to 75 ° C. On the other hand, the aqueous phase components (7), (8), and (10) were mixed, dissolved, and heated to 75 ° C. Subsequently, the oil phase component was added to the water phase component and pre-emulsified, and then uniformly emulsified with a homomixer, then cooled to 40 ° C., and (9) was added to obtain a hand cream.
[0038]
<Prescription Example 14: Hair Lotion>
(1) Polyoxyethylene hydrogenated castor oil (50E.O.) 0.2, (2) Shiraneae extract (extract according to Production Example 3) 5.0, (3) Fragrance 0.1, (4) Ethanol 50.0, (5) Panthenol 0.5, (6) 1,3-butylene glycol 5.0, (7) purified water
(2) and (3) are dissolved in the remainder (production method) (1) to be 100, and then (4) is added and dissolved uniformly. To this was added a homogenized component of (5) to (7) and stirred until uniform to obtain a hair lotion.
[0039]
<Prescription Example 15: Massage Gel>
(1) Dipropylene glycol 7.0, (2) Glycerin 8.0, (3) Polyoxyethylene (15E.O.) oleyl ether 0.5, (4) 1 wt% carboxyvinyl polymer aqueous solution 40.0, (5) 1 wt% methylcellulose aqueous solution 20.0, (6) Shiraneae extract (extract according to Production Example 1) 0.3, (7) 10% by weight aqueous potassium hydroxide solution 1.0, (8) Residual water 100 (process) (1), (2), (3) and (6) were uniformly dissolved, (4) and (5) were added, then (8) was added, and then (7) was added and thickened to obtain a massage gel.
[0040]
<Test 1>
Test 1 is a moisturizing effect with the cosmetic lotions of Formulation Examples 1 and 2 using the whole plant extract of Shiraneae in the above-described formulation examples for the external preparation for skin according to the present invention. Was determined by Kramer's assay. The test method and its evaluation criteria are as follows. As Comparative Example 1, a mixture of 50 wt% ethanol aqueous solution was prepared in place of the Shiraneae extract of Formulation Example 1.
[0041]
15 professional panelists applied two types of cosmetic lotions of Examples 1 and 2 and Comparative Example 1 to the face as blind samples, 2 points for the better moisturizing effect, 1 point for the poorer one An evaluation was attached. The number of each evaluation score and the total score are shown in Table 1. Since two types of examples were prepared, the above test was performed twice.
[0042]
[Table 1]

[0043]
As is clear from Table 1, the samples of each example showed an effect superior to the moisture retention than the sample of Comparative Example 1. In addition, there was a significant difference in these effects.
[0044]
<Test 2>
In Test 2, Examples 1 and 2 and Comparative Example 1 similar to Test 1 were used as samples, and the effect of preventing and improving rough skin was judged by Kramer's test method.
[0045]
15 professional panelists applied two types of cosmetic lotions of Example and Comparative Example 1 to the face as blind samples, and after 2 consecutive use for 10 days, 2 points, inferior to skin roughness prevention / improvement effect, 2 points A rating of 1 point was given to those who are. The number of each evaluation score and the total score are shown in Table 2. In addition, since two types of cosmetic lotions blended with different Shiraneae extract were prepared as examples, the above test was performed twice.
[0046]
[Table 2]

[0047]
As is clear from Table 2, the samples of each example showed an effect superior to the rough skin prevention / improvement than the sample of Comparative Example 1. In addition, there was a significant difference in these effects.
[0048]
<Test 3>
In Test 3, the skin lotion of Formulation Examples 9 and 10 was used as Examples 3 and 4 respectively in the formulation examples of the above-mentioned external preparation for skin according to the present invention, and the rough skin prevention / improvement effect was judged by Kramer's test method. . As Comparative Example 2, a mixture of 50 wt% 1,3-butylene glycol was prepared in place of the Shiraneae extract of Formulation Example 9.
[0049]
The test method and the evaluation method are the same as in Test 2.
[0050]
[Table 3]

[0051]
As is apparent from Table 3, the samples of each example showed an effect superior to the rough skin prevention / improvement than the sample of Comparative Example 2. In addition, there was a significant difference in these effects.
[0052]
<Test 4>
After the tests of Test 2 and Test 3 above, the samples of Examples were continuously used on the same panel for 20 days (total 30 days), and then the presence or absence of skin abnormality was confirmed. No abnormalities were found.
[0053]
【The invention's effect】
As described above in detail, according to the present invention, it is possible to provide a moisturizing agent that is highly safe and excellent in the moisturizing effect. In addition, there is an effect that it is possible to provide a skin external preparation that is highly safe and has a moisturizing effect and an excellent effect of preventing and improving rough skin.

Claims (3)

An external preparation for skin containing an extract of Shiraneae ( Glaucidium palmatum Sieb.et Zucc.). A moisturizer containing an extract of Shiraneae ( Glaucidium palmatum Sieb.et Zucc.). An external preparation for skin, comprising the moisturizer according to claim 2.