JP4300534B2 - Cell culture facility - Google Patents

Description

  The present invention relates to a cell culture facility, and more particularly to a cell culture facility that requires prevention of cross contamination.

In the field of regenerative medicine, specimen cells collected from individuals are increased by subculture and used in the medical field. Therefore, a cell culture facility for subculturing specimen cells is required. In this type of cell culture facility, it is necessary to reliably prevent foreign cells from entering the cell culture process and causing cross contamination. For this reason, in a conventional cell culture facility, one operator specified in a closed work room performs a cell culture operation under a strict management system in which only one specimen is handled in one operation.
On the other hand, Patent Document 1 describes a process monitoring control device that restricts plant operators by an ID card system and prevents operations by a third party.
Japanese Patent No. 2994107

However, in a cell culture facility that handles a large amount of various specimens, it is necessary to prepare a large number of working rooms for each specimen, resulting in an increase in equipment costs. In addition, work in a closed work room has a feeling of loneliness and blockage, which has been pointed out as a mental health hazard to workers. For this reason, a large-scale cell culture facility is conceivable in which a large number of work areas are arranged in a large common work room and individual cell culture operations are performed for each work area. In such a large room type, for example, the upper air-conditioned space can be shared, so that the equipment cost can be reduced. In addition, since the work area can be prevented from being closed, it is possible to suppress mental health problems that are caused to the worker. However, since a plurality of workers are engaged in a common work room, the workers go in and out frequently. For this reason, there arises a new problem that the risk of sample cell mix-up and cross contamination increases.

  In order to deal with such problems, it is conceivable to adopt a management method using an ID card system described in Patent Document 1. However, in an ID card system, the system does not function well unless an operator actively approaches the card reader of the ID card. For this reason, an operator's burden becomes large and is troublesome.

  The object of the present invention is to provide a cell culture facility that improves the above-mentioned problems of the prior art, makes use of the advantages of a large-room system, reduces the burden on the operator, and reduces the risk of sample cell mixing and cross contamination. It is to provide.

  In order to achieve the above object, the cell culture facility of the present invention according to claim 1 includes a work room, a plurality of work areas arranged in the work room, and a lock function arranged in each work area. A cell culture-related device, an area RF tag recognition device installed in each work area, and a management means for managing a lock function of the cell culture-related device. Has a function of recognizing the worker identification information given to the RF tag when the worker passes through the entrance / exit of each work area or moves in each work area, The management means has a function of managing a lock function of the cell culture-related device based on a recognition result of the area RF tag recognition device.

  In the cell culture facility of the present invention according to claim 2, a room RF tag recognition device is disposed at the entrance and exit of the work chamber, and the room RF tag recognition device is operated by an operator who possesses the RF tag. A function of recognizing the worker identification information given to the RF tag when passing through the entrance / exit of the room, and the management means combines the recognition result of the room RF tag recognition device It has a function of managing the lock function of cell culture-related equipment.

  The cell culture facility of the present invention according to claim 3 is provided with a human sensor at the entrance and exit of the work room and / or each work area, and the management means combines the detection results of the human sensor and It is characterized by managing the lock function of cell culture related equipment. In the present invention, the human sensor means a sensor having a function of detecting the presence of a human.

The cell culture facility of the present invention according to claim 4 allows the cell culture operation in the work area only when the management means specifies that only the worker registered in advance is in the work area. As described above, it has a function of managing a lock function of the cell culture-related device.
The cell culture facility of the present invention according to claim 5 is characterized in that the management means has a function of managing a lock function of the cell culture-related device so as to allow only an operation in the specified order. .

  According to the invention of claim 1, a plurality of work areas are arranged in a work room as a large room. For this reason, it is possible to reduce the equipment cost by sharing equipment such as air conditioning. Moreover, the feeling of blockage of each work area is eliminated, which contributes to the improvement of mental health for the workers engaged. Furthermore, the degree of freedom in forming a plurality of work areas is increased, and the layout of the work areas can be changed flexibly according to the actual situation by relocating the cell culture-related equipment.

  In addition, the area RF tag recognition device installed in each of the plurality of work areas recognizes the worker's identification information, and based on the recognition result, the management means provides a lock function for the cell culture-related equipment in each work area. Have been to manage. For this reason, the possibility that an unscheduled worker performs the cell culture operation is reduced, and it is possible to prevent the mistaken cell and cross contamination without imposing a special burden on the worker.

  According to the invention of claim 2, the room RF tag recognition device installed at the entrance / exit of the work room recognizes the identification information of the worker, and the management means combines the recognition results so that the management means It is designed to manage the lock function of culture-related equipment. For this reason, cell confusion and cross contamination can be prevented more strictly.

  According to the invention of claim 3, a human sensor is attached to the entrance / exit of the work room and each work area, and the management means manages the lock function of the cell culture-related device by combining the detection results of the human sensor. Has been. The RF tag recognition device is incapable of entering / exiting people who are not wearing an RF tag. The human sensor compensates for the weaknesses of the RF tag recognition device, and enables more precise management of the lock function of cell culture-related equipment, which in turn prevents high-level cell mixing and cross-contamination. it can.

  According to the invention of claim 4, the management means only allows the cell culture operation in the work area so as to allow the cell culture operation in the work area only when it is specified that only the pre-registered worker is in the work area. Manage device lock functions. When an unregistered worker enters the work area, the lock function of the cell culture-related device is managed so that the cell culture operation cannot be performed. For this reason, the possibility that an unregistered operator performs a cell culturing operation is extremely low, and it is possible to prevent cell mix-up and cross contamination.

  According to the invention of claim 5, the management means manages the lock function of the cell culture-related device so as to allow only the operation in the instructed order. For this reason, it is possible to prevent cells from being mixed up and cross-contaminated by operating errors more finely.

  FIG. 1 is a plan view showing a first embodiment of a cell culture facility according to the present invention, and FIG. 2 is a view taken along the line AA of FIG. In the work chamber 10, three work areas 18A, 18B, and 18C each having a series of a centrifuge 12, a safety cabinet 14, and an incubator 16 are arranged as cell culture-related devices. The cell culture operation is performed using the cell culture-related equipment in row A in the work area 18A, the cell culture-related equipment in row B in the work area 18B, and the cell culture-related equipment in row C in the work area 18C.

  The cell culture-related devices in the B row serve to partition the work area 18A and the work area 18B, and the cell culture-related devices in the C row serve to partition the work area 18B and the work area 18C. That is, the presence of the cell culture-related devices in the B and C rows prevents the operator from moving directly between the work areas.

  An entrance / exit 20 is provided at the left end of the work chamber 10, and an area of the work chamber 10 facing the entrance / exit 20 is a passage 22. Therefore, an operator entering / exiting the work chamber 10 for cell culture operation enters / exits the work areas 18A, 18B, 18C through the entrance / exit 24 through the entrance / exit 20 and the passage 22 respectively. An area RF tag recognition device 26 is installed at each of the entrances 24. These area RF tag recognition devices 26 recognize the worker identification information given to the RF tag when the worker who has the RF tag passes through the entrance / exit of each work area. The recognition result of each area RF tag recognition device 26 is transmitted to the management means 28.

  In the incubator 16 in each work area, a culture dish for cultured cells is stored. In storage, strict management is performed so that only one cell type is stored in one incubator 16 in order to prevent the mixing of cells.

The safety cabinet 14 is used for, for example, an operation for taking out the cells whose number has been increased by the culture from the culture dish and transferring them to a plurality of culture dishes. The centrifuge 12 is used to separate the cells in the culture dish from the medium. These cell culture-related devices are each provided with an opening / closing port for entering and exiting a culture dish and the like, and have a lock function. That is, it is possible to select either locking or unlocking of the opening and closing according to the management signal from the management means 28.

The entire work room 10 has a function as a clean room. That is, a high performance filter 32 is disposed in the front surface of the ceiling space 30 of the work chamber 10, and the clean air purified by the high performance filter 32 descends in a laminar flow in the work areas 18A, 18B, and 18C. The clean air that has passed through the air-permeable floor surface 34 is conditioned by the air conditioner 38 through the underfloor space 36 and then circulated into the ceiling space 30. By the circulation of this clean air, the work chamber 10 is placed in a clean state where there is almost no dust or airborne bacteria, thereby preventing contamination by airborne bacteria.

  In the management means 28, the work schedule of the day is registered for each of the work areas 18A, 18B, 18C. FIG. 3 is an explanatory diagram illustrating the registered contents of the work schedule. Work items are registered in advance for each work area by work time zone. As the work item, the contents of the work, the sample number to be worked, the incubator number that accommodates the cell of the sample number, the ID number of the worker in charge of the work, and the like are designated. Accordingly, each worker performs the designated work content in the work area of the designated area number in the designated work time zone based on the content designated in the work schedule.

  An operator wears an RF tag to which an ID number, which is identification information for identifying his / her name, is attached to a work clothes or a work cap. Then, in order to carry out the designated work content from the entrance / exit 20 of the work room 10 via the passage 22, one of the work areas 18A, 18B, 18C is entered. When the worker passes through the entrance / exit 20 of the work area, the area RF tag recognition device 26 recognizes the worker's ID number from the RF tag. The recognition result is immediately transmitted to the management means 28. The management means 28 collates the transmitted worker ID number with the worker ID number registered in the work schedule, and outputs a work permission signal to the entry / exit of the corresponding work area if they match. A lamp display or audio display is used as the permission signal. And the lock | rock of the opening / closing port of each cell culture related apparatus in the applicable work area is cancelled | released. As for the incubator 16, a plurality of incubators 16 having different sample numbers are installed in each work area. The management means 28 unlocks only the opening / closing port of the incubator 16 with the number registered in the work schedule in order to prevent the sample cells from being mixed up. Therefore, the operator can confirm the sample number of the incubator 16 that has been unlocked, and then perform the specified contents using the culture dish, the safety cabinet 14, the centrifuge 12, or the like.

On the other hand, when the worker ID number recognized by the area RF tag recognition device 26 does not match the worker ID number registered in the work schedule, the management means 28 sends a warning signal to the corresponding work area. Output to entry / exit. As the warning signal, lamp display or sound display is used. In addition to the warning signal, the management means 28 may automatically close the door provided at the entrance / exit. Further, the management means 28 searches the work schedule for the ID number of the worker recognized by the area RF tag recognition device 26, and another work area number or another work time zone that the worker of the ID number should enter. Can be guided by voice or the like. By outputting such a guide, it is possible to convey accurate work information to an operator who intends to enter the work area by mistake or misunderstanding. The management means 28 locks the opening / closing ports of all the cell culture related devices in the corresponding work area simultaneously with the output of the warning signal. For this reason, even if a person who is not aware of the warning signal or who is registered by ignoring the warning signal enters the work area, the work using the cell culture-related equipment cannot be performed.

  When the worker who entered the work area finishes the predetermined work by the permission signal and goes out of the work area through the entrance / exit 20, the area RF tag recognition device for the area works from the RF tag attached by the worker. Recognizes the ID number of the person. The recognition result is transmitted to the management unit 28. The management unit 28 determines that the worker with the ID number has left the work area, and resets the work area to a zero state without a worker. Even in the zero state without the operator, the management means 28 locks the opening / closing ports of all the cell culture-related devices in the work area. Therefore, even if a worker who has forgotten to wear the RF tag or a person who does not wear the RF tag enters the work area in the zero state, the work using the cell culture-related equipment cannot be performed. Further, even when an unregistered worker enters the work area while the worker who entered the work area by the permission signal is working, the management means 28 causes all cells in the work area to be displayed. Lock the opening and closing of the culture-related equipment.

  As described above, according to the cell culture facility 100 of the present embodiment, the area RF tag recognition device 26 is provided at each of the entrances / exits 24 of the plurality of work areas 18A, 18B, 18C arranged in the common work room 10. installed. The ID number of the worker who passes through each of the entrances / exits 24 is recognized by the area RF tag recognition device 26. The management means 20 collates the worker ID number recognized by the area RF tag recognition device 26 with a pre-registered work schedule, and only when the registered worker specifies that the work area is included, the cell The opening / closing port of the culture-related equipment was unlocked to allow cell culture operation. For this reason, the possibility that an unregistered worker performs a cell culturing operation is extremely low, the work schedule can be accurately performed, and therefore, the mistaken cell and cross contamination can be prevented in advance.

  Further, according to the cell culture facility 100 of the present embodiment, the work chamber 10 as a whole functions as a clean room, and a plurality of work areas 18A, 18B, and 18C are formed by using cell culture-related equipment as a partition. Yes. For this reason, it is possible to reduce the equipment cost by making the air conditioning and air cleaning system common. In addition, compared to a conventional cell culture facility in which each work area is completely a single room, the work area is not blocked and contributes to mental health improvement for the workers engaged. Furthermore, the degree of freedom in forming the plurality of work areas 18A, 18B, and 18C is increased, and the layout of the work area can be changed flexibly according to the actual situation by relocating the cell culture-related equipment. Can do.

  FIG. 4 is a plan view showing a second embodiment of the cell culture facility according to the present invention. 4, elements having the same reference numerals as those in FIG. 1 are elements having the same functions as those described in the first embodiment, and description thereof is omitted. In this embodiment, the area RF tag recognition device 26 is attached to the centrifuge 12, the safety cabinet 14, and the incubator 16 which are cell culture-related devices in the respective work areas 18A, 18B, and 18C. Therefore, when the worker wearing the RF tag moves within a certain work area, these area RF tag recognition devices 26 recognize the worker's ID number. The recognition result is transmitted to the management unit 28, and the management unit 28 manages the lock function of each cell culture-related device as in the first embodiment.

  According to the cell culture facility 110 of the present embodiment, the work is performed in each of the work areas 18A, 18B, and 18C as compared with the first embodiment in which the worker ID number is recognized only by the entrance and exit. Since the operator's ID number can always be collated at all times, more strict management can be performed.

  FIG. 5 is a plan view showing a third embodiment of the cell culture facility according to the present invention, and FIG. 6 is a perspective view taken along arrow BB in FIG. 5 and 6 are the elements having the same functions as those described in the first embodiment, and the description thereof is omitted. In the working chamber 10 of the present embodiment, a clothing room 40 dedicated to the entrance is provided on the left side, and a dressing room 42 dedicated to the exit is provided on the right side. A room RF tag recognition device 46 is disposed inside the door 44 of the dressing room 40, and a room RF tag recognition device 50 is disposed outside the door 48 of the dressing room 42. Further, the RF tag recognition device 26A for the room is provided at the entrance side of each work area 18A, 18B, 18C of the work chamber 10, the RF tag recognition device 26B for the area is provided for the centrifuge 12, and the RF tag recognition for the area is provided for the safety cabinet 14. The device 26C and the incubator 16 are provided with an area RF tag recognition device 26D, and a room RF tag recognition device 26E on the outlet side.

  The worker ID numbers recognized by the room RF tag recognition devices 46 and 50 and the area RF tag recognition devices 26A, 26B, 26C, 26D, and 26E are all transmitted to management means (not shown). The management means collates the transmitted worker ID number with the registered work schedule. And only when the management means specifies that only pre-registered workers are in each work area 18A, 18B, 18C, the centrifuge 12, so as to allow the cell culture operation in that work area, The lock function of the safety cabinet 14 and the incubator 16 is managed.

  According to the cell culture facility 120 of the present embodiment, the worker ID number recognized by the room RF tag recognition device 26A of the clothing room 40 is collated by the management means, and a warning is given when an unregistered person passes the door 44. A signal is output. Further, when an unregistered person who has received this warning signal enters the work room 10, the indoor movement status can be tracked one after another by a large number of area RF tag recognition devices arranged at each position. . Further, when an unregistered person who notices the warning signal returns from the dressing room 40, the ID number of the unregistered person is not recognized in any of the RF tag recognition devices for any area in the work room 10 thereafter. It turns out that the room 40 was turned back.

  When the worker ID number recognized by the room RF tag recognition device 46 in the clothing room 40 is registered in the work schedule, an entry permission signal is output. At the same time as the permission signal for entering the room, the management means can also instruct the work area number assigned to the worker.

  Each work area 18A, 18B, 18C is provided with an area RF tag recognition device 26A on the entrance side and an area RF tag recognition device 26E on the exit side, and the ID number of the worker entering and exiting the work area is provided. recognize. Therefore, the management means can manage the lock function of the cell culture-related device based on the recognition result. In addition, the area RF tag recognition devices 26B, 26C, and 26D arranged in each work area recognize the RF tag 52 attached to the worker, so that the movement status of the worker in the work area is determined one by one. Can track. For this reason, it becomes possible to carry out the management of the lock function of the cell culture-related equipment more precisely, and as a result, it is possible to surely prevent the mistaken cell and cross contamination.

  In addition, according to this embodiment, according to the cell culture facility 120, it becomes possible to manage the work procedure of the worker in each work area. FIG. 7 is an explanatory diagram illustrating work instructions registered in the management means. Among the instruction items shown in FIG. 7, the work area number, work time, work content, sample number, and worker ID number of items 1 to 5 are the same as the items shown in FIG. After these items are authenticated through the area RF tag recognition device 26A in the work area, the process proceeds to the specific work procedure of item 6. All cell culture equipment is locked before the start of work.

  In the first stage, after the area RF tag recognition device 26D recognizes the worker's ID number, the management unit unlocks only the incubator B among the plurality of incubators 16, and the remaining incubators are locked. To maintain. Then, in the management means, the work instruction in step (1) is given by voice, and the operator moves the front of the safety cabinet 14 after taking out the culture dish containing the cells B from the incubator B according to the instructions.

In the second stage, the area RF tag recognition device 26C recognizes the worker's ID number. The culture dish is affixed with an RF tag with an individual ID number that can identify cell B, and the area RF tag recognition device 26C also recognizes the ID number of the culture dish at the same time as the worker's ID number. To do. Then, after authenticating the operator's ID number and the culture dish ID number, the management means locks the incubator B and unlocks the safety cabinet 14. Thereafter, work instructions in steps (2) and (3) are given by voice from the management means, and the worker adds a predetermined medicine to the cells B placed in the safety cabinet 14 according to the instructions under predetermined conditions.

  In the third stage, the operator removes the culture dish containing the cells B from the safety cabinet 14 and then moves in front of the centrifuge 12. Then, the area RF tag recognition device 26B recognizes the operator's ID number and the culture dish ID number. After authenticating these ID numbers, the management means locks the safety cabinet 14 and unlocks the centrifuge 12. Thereafter, a work instruction in step (4) is given by voice from the management means, and the worker applies the cell B to the centrifuge 12 according to the instruction and centrifuges the cell B.

  In the fourth stage, the operator puts the cells B separated by the centrifuge 12 into a culture dish and moves them in front of the safety cabinet 14. Then, the area RF tag recognition device 26C recognizes the operator ID number and the culture dish ID number. After authenticating these ID numbers, the management means locks the centrifuge 12 and unlocks the safety cabinet 14. Thereafter, work instructions in steps (5) and (6) are given by voice from the management means, and the operator transfers the cells B placed inside to a new culture dish according to the instructions. And the ID label which recorded the new ID number is issued, and this ID label is stuck on a new culture dish.

  In the fifth stage, a work instruction in step (7) is first given by voice from the management means, and the operator takes out a new culture dish from the safety cabinet 14 and moves it in front of the incubator 16. Then, the area RF tag recognition device 26D recognizes the worker's ID number and the new ID number of the new culture dish. In the management means, after authenticating these ID numbers, the safety cabinet 14 is locked and the incubator C is unlocked. Next, according to the instruction from the management means, the operator stores a new culture dish in the incubator C, and the operation of step (8) is completed.

  In the sixth stage, the management means locks the incubator C. When the incubator C is locked, all the cell culture-related devices in the work area are returned to the state before the work is started.

  As described above, according to the cell culture facility 120 of the present embodiment, strict management that combines worker entry / exit management into the work room 10 and worker entry / exit management into each work area 18A, 18B, 18C is performed. Not only can it be realized, the management means also instructs the work order of cell culture operations performed by the operator by making full use of the area RF tag recognition device arranged in the cell culture-related equipment in each work area, and there is no mistake And can manage the lock function of cell culture related equipment.

  As described above, according to the cell culture facility 100, 110, 120 of each of the embodiments described above, the area RF tag recognition device installed in and / or in each work area 18A, 18B, 18C, In addition, the room RF tag recognition device installed at the entrance / exit of the work room 10 can strictly manage the entry / exit of the worker. However, the RF tag recognition device functions effectively on the assumption that the person entering and leaving the work room 10 and each of the work areas 18A, 18B, and 18C is always wearing the RF tag. It is powerless to the person. That is, even if the RF tag recognition device is provided in various places, there is a weak point that a person who does not wear the RF tag can enter and exit by free pass.

  As a method of complementing the weak points of this RF tag recognition device, a method of adding a human sensor in addition to the RF tag recognition device is effective. For example, in addition to the room RF tag recognition device 46, an infrared human sensor 60 is also provided at the door 44 of the clothing room 40 of FIG. Then, when a person who is not wearing the RF tag tries to enter the work room 10 through the door 44, the human sensor 60 detects it and the room RF tag recognition device 46 does not react. Therefore, the management means can know the entrance of the person who is not wearing the RF tag based on the detection signal of the human sensor 60, and can output a warning signal not only to the person entering the room but also to a necessary management department.

  If such a human sensor is also provided at the entrance / exit of each work area 18A, 18B, 18C in FIG. 1 or FIG. 5 or the area RF tag recognition device for the cell culture related equipment in FIG. 4 or FIG. In addition, the weak points of the RF tag recognition device can be complemented, and it becomes possible to more closely manage the lock function of the cell culture related equipment, which in turn can prevent the mix-up of cells and cross contamination at a high level. it can. As a human sensor, in addition to a direct sensor such as an infrared sensor, it is possible to employ means capable of indirectly detecting a human motion such as a surveillance camera or a photoelectric sensor.

  When the human sensor is also provided in the area RF tag recognition device of the cell culture-related device in FIG. 4 or FIG. 5, the management means only supports the corresponding area RF tag when the human sensor senses a person. It is desirable to function to emit radio waves from the recognition device. With such a function, it is possible to reduce interference caused by surplus radio waves that are constantly emitted from the area RF tag recognition device, reduce adverse effects on cells to be handled, and save power.

  In each of the above-described embodiments, the cell culture-related equipment in each work area plays a role of partitioning other work areas. However, the present invention is not limited to this, and includes a configuration in which a dedicated partition is arranged on the partition line of the work area, and various cell culture-related devices are arranged along the dedicated partition.

1 is a plan view showing a first embodiment of a cell culture facility according to the present invention. It is an AA arrow line view of FIG. It is explanatory drawing which illustrated the registration content of the work schedule. It is a top view which shows 2nd Embodiment of the cell culture facility which concerns on this invention. It is a top view which shows 3rd Embodiment of the cell culture facility which concerns on this invention. It is a BB arrow perspective view of FIG. It is explanatory drawing which illustrated the work instruction document registered into the management means.

Explanation of symbols

10 ......... Working room, 12 ......... Centrifuge, 14 ......... Safety cabinet, 16 ......... Incubator, 18A, 18B, 18C ......... Working area, 20 ......... Inlet / outlet, 22 ......... Aisle, 24 ......... entrance / exit, 26, 26A, 26B, 25C, 26D, 26E ......... RF tag recognition device for area, 28 ......... management means, 30 ......... ceiling space, 32 ......... high performance Filter, 34 ......... Floor surface, 36 ......... Underfloor space, 38 ......... Air conditioner, 40 ......... Clothing room, 42 ......... Undressing room, 44,48 ......... Door, 46,50 ... …… RF tag recognition device for room, 52 ……… RF tag, 60… Human motion sensor, 100, 110, 120… Cell culture facility.

Claims (5)

  Work chamber, a plurality of work areas arranged in the work chamber, a cell culture-related device having a lock function arranged in each work area, and an area RF tag recognition device installed in each work area And a management means for managing the lock function of the cell culture-related device, wherein the area RF tag recognition device is used when an operator carrying the RF tag passes through the entrance / exit of each work area or each work area. A function of recognizing worker identification information given to the RF tag when moving inside the device, and the management means is configured to use the cell culture-related device based on a recognition result of the area RF tag recognition device. A cell culture facility characterized by having a function of managing the lock function of the cell.   A room RF tag recognizing device is disposed at the entrance / exit of the working chamber, and the room RF tag recognizing device is attached to the RF tag when an operator carrying the RF tag passes through the entrance / exit of the working chamber. The management means has a function of managing the lock function of the cell culture-related equipment by combining the recognition results of the room RF tag recognition device. The cell culture facility according to claim 1, wherein   A human sensor is provided at the entrance / exit of the working room and / or each work area, and the management means manages the lock function of the cell culture-related device by combining the detection results of the human sensor. The cell culture facility according to claim 1 or 2, wherein the cell culture facility is characterized.   The management means manages the lock function of the cell culture-related device so as to allow the cell culture operation in the work area only when it is specified that only the pre-registered worker is in the work area. The cell culture facility according to any one of claims 1 to 3, wherein the cell culture facility has a function of:   The said management means has a function which manages the lock function of the said cell culture related apparatus so that only operation of the order instruct | indicated is permitted. Cell culture facility.

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