JP4338561B2 - Post form cosmetic - Google Patents
Post form cosmetic Download PDFInfo
- Publication number
- JP4338561B2 JP4338561B2 JP2004079780A JP2004079780A JP4338561B2 JP 4338561 B2 JP4338561 B2 JP 4338561B2 JP 2004079780 A JP2004079780 A JP 2004079780A JP 2004079780 A JP2004079780 A JP 2004079780A JP 4338561 B2 JP4338561 B2 JP 4338561B2
- Authority
- JP
- Japan
- Prior art keywords
- cosmetic
- parts
- acid
- weight
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002537 cosmetic Substances 0.000 title claims description 92
- 239000003094 microcapsule Substances 0.000 claims description 30
- 150000007524 organic acids Chemical class 0.000 claims description 23
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 20
- 239000006260 foam Substances 0.000 claims description 18
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 16
- 239000000194 fatty acid Substances 0.000 claims description 16
- 229930195729 fatty acid Natural products 0.000 claims description 16
- 238000005187 foaming Methods 0.000 claims description 16
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 10
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 7
- 150000004665 fatty acids Chemical class 0.000 claims description 7
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 6
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 6
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 6
- 239000005642 Oleic acid Substances 0.000 claims description 6
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 6
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 6
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 6
- 239000001569 carbon dioxide Substances 0.000 claims description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- 235000005985 organic acids Nutrition 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- -1 react Substances 0.000 description 35
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- 239000002775 capsule Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000011347 resin Substances 0.000 description 12
- 229920005989 resin Polymers 0.000 description 12
- 239000000203 mixture Substances 0.000 description 11
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 10
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 10
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 10
- 235000011187 glycerol Nutrition 0.000 description 9
- 229960005150 glycerol Drugs 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 8
- 239000002202 Polyethylene glycol Substances 0.000 description 7
- 239000006096 absorbing agent Substances 0.000 description 7
- 239000000443 aerosol Substances 0.000 description 7
- 239000004359 castor oil Substances 0.000 description 7
- 235000019438 castor oil Nutrition 0.000 description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 229920001296 polysiloxane Polymers 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 235000017788 Cydonia oblonga Nutrition 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 235000019437 butane-1,3-diol Nutrition 0.000 description 5
- 229960000541 cetyl alcohol Drugs 0.000 description 5
- 229960000735 docosanol Drugs 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 235000021313 oleic acid Nutrition 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- QIZPVNNYFKFJAD-UHFFFAOYSA-N 1-chloro-2-prop-1-ynylbenzene Chemical compound CC#CC1=CC=CC=C1Cl QIZPVNNYFKFJAD-UHFFFAOYSA-N 0.000 description 4
- JPPRXACMNPYJNK-UHFFFAOYSA-N 1-docosoxydocosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCCCCCC JPPRXACMNPYJNK-UHFFFAOYSA-N 0.000 description 4
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 229940035023 sucrose monostearate Drugs 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229920002907 Guar gum Polymers 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 235000010417 guar gum Nutrition 0.000 description 3
- 239000000665 guar gum Substances 0.000 description 3
- 229960002154 guar gum Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000008016 vaporization Effects 0.000 description 3
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004342 Benzoyl peroxide Substances 0.000 description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 238000007720 emulsion polymerization reaction Methods 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940094522 laponite Drugs 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 2
- 239000003949 liquefied natural gas Substances 0.000 description 2
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000003505 polymerization initiator Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- NCLNAHJFXIKYBY-UHFFFAOYSA-N 2-hexyldecyl 16-methylheptadecanoate Chemical compound CCCCCCCCC(CCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C NCLNAHJFXIKYBY-UHFFFAOYSA-N 0.000 description 1
- MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- MSPJNHHBNOLHOC-UHFFFAOYSA-N 3,3-dimethylcyclopropane-1,2-dicarboxylic acid Chemical compound CC1(C)C(C(O)=O)C1C(O)=O MSPJNHHBNOLHOC-UHFFFAOYSA-N 0.000 description 1
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 239000001879 Curdlan Substances 0.000 description 1
- 229920002558 Curdlan Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920000288 Keratan sulfate Polymers 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- RVSTWRHIGKXTLG-UHFFFAOYSA-N Pangamic acid Natural products CC(C)N(C(C)C)C(N(C(C)C)C(C)C)C(=O)OCC(O)C(O)C(O)C(O)C(O)=O RVSTWRHIGKXTLG-UHFFFAOYSA-N 0.000 description 1
- DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229920002359 Tetronic® Polymers 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 229930003756 Vitamin B7 Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- UDRYFKCHZFVZGJ-UHFFFAOYSA-N [5-hexadecanoyloxy-4-(hexadecanoyloxymethyl)-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(OC(=O)CCCCCCCCCCCCCCC)=C1COC(=O)CCCCCCCCCCCCCCC UDRYFKCHZFVZGJ-UHFFFAOYSA-N 0.000 description 1
- RJDOZRNNYVAULJ-UHFFFAOYSA-L [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[F-].[F-].[Mg++].[Mg++].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[K+] Chemical compound [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[F-].[F-].[Mg++].[Mg++].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[K+] RJDOZRNNYVAULJ-UHFFFAOYSA-L 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 239000010426 asphalt Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229940066595 beta tocopherol Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- HGKOWIQVWAQWDS-UHFFFAOYSA-N bis(16-methylheptadecyl) 2-hydroxybutanedioate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCCCCCCCCCC(C)C HGKOWIQVWAQWDS-UHFFFAOYSA-N 0.000 description 1
- 229940073609 bismuth oxychloride Drugs 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- JBTHDAVBDKKSRW-UHFFFAOYSA-N chembl1552233 Chemical compound CC1=CC(C)=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 JBTHDAVBDKKSRW-UHFFFAOYSA-N 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229910000428 cobalt oxide Inorganic materials 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 235000019316 curdlan Nutrition 0.000 description 1
- 229940078035 curdlan Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- VJHINFRRDQUWOJ-UHFFFAOYSA-N dioctyl sebacate Chemical compound CCCCC(CC)COC(=O)CCCCCCCCC(=O)OCC(CC)CCCC VJHINFRRDQUWOJ-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- VPWFPZBFBFHIIL-UHFFFAOYSA-L disodium 4-[(4-methyl-2-sulfophenyl)diazenyl]-3-oxidonaphthalene-2-carboxylate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC(C)=CC=C1N=NC1=C(O)C(C([O-])=O)=CC2=CC=CC=C12 VPWFPZBFBFHIIL-UHFFFAOYSA-L 0.000 description 1
- NDORGWUNFGHGKU-UHFFFAOYSA-N dodecanoic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(O)=O NDORGWUNFGHGKU-UHFFFAOYSA-N 0.000 description 1
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- TXGJTWACJNYNOJ-UHFFFAOYSA-N hexane-2,4-diol Chemical compound CCC(O)CC(C)O TXGJTWACJNYNOJ-UHFFFAOYSA-N 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical compound CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- ZQTHOIGMSJMBLM-BUJSFMDZSA-N pangamic acid Chemical compound CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O ZQTHOIGMSJMBLM-BUJSFMDZSA-N 0.000 description 1
- 108700024047 pangamic acid Proteins 0.000 description 1
- 235000008975 pantethine Nutrition 0.000 description 1
- 239000011581 pantethine Substances 0.000 description 1
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 description 1
- 229960000903 pantethine Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、化粧料に関し、更に詳細には、容器より取り出した時には発泡しておらず、使用時に遅れて発泡する、所謂「ポストフォーム」形態の化粧料に好適な化粧料に関する。 The present invention relates to a cosmetic, and more particularly, to a cosmetic suitable for a so-called “post-form” cosmetic that does not foam when taken out of a container and foams after use.
エアゾール化粧料の内、吐出時の形態は通常のクリーム乃至はゲルであり、擦過をして塗布することにより、発泡してフォームを形成する所謂「ポストフォーム化粧料」は、塗布延展時の発泡の肌触りが優しく、使用感に優れることと、適切な量を皮膚上に均一にのばせる特性から、毛髪化粧料、洗浄用の化粧料などの各種分野の化粧料に応用され、化粧料に於ける新しい剤形として注目を集めている。(例えば、特許文献1、特許文献2、特許文献3、特許文献4、特許文献5、特許文献6を参照)通常、この様なポストフォーム化粧料は、通常の発泡エアゾール化粧料に比して、フルオロカーボン類や液化天然ガスなどの気化成分の含有量を減じた構成で作成される。しかしながら、環境的配慮からエアゾール化粧料が使用しにくい現状に於いては、気化成分非含有形態のポストフォーム化粧料の開発が望まれている。 Among the aerosol cosmetics, the form at the time of discharge is a normal cream or gel, and the so-called “post foam cosmetic” that foams to form a foam by rubbing and applying is a foam at the time of spreading the coating. It is applied to cosmetics in various fields such as hair cosmetics and cleaning cosmetics because of its gentle touch, excellent usability and the ability to evenly apply an appropriate amount on the skin. It is attracting attention as a new dosage form. (For example, see Patent Document 1, Patent Document 2, Patent Document 3, Patent Document 4, Patent Document 5, and Patent Document 6) Usually, such a post-form cosmetic is compared with a normal foamed aerosol cosmetic. It is created with a configuration in which the content of vaporized components such as fluorocarbons and liquefied natural gas is reduced. However, in the present situation where aerosol cosmetics are difficult to use due to environmental considerations, it is desired to develop post-form cosmetics that do not contain vaporized components.
一方、炭酸塩乃至は重炭酸塩を用いた発泡化粧料としては、水に溶解することにより、固形の酸成分と炭酸塩乃至は重炭酸塩が反応して発泡する固形入浴剤、酸の水溶液と炭酸塩乃至は重炭酸塩を含有する粉体組成物を用時に混合、反応、発泡させるエアゾール化粧料などが知られているが、(例えば、特許文献7、特許文献8、特許文献9を参照)容器から取り出したときの状態が、クリーム状乃至はゲル状の化粧料に於いて、炭酸塩乃至は重炭酸塩を含有する、発泡性の化粧料は全く知られていない。更に、油性成分を含有するマイクロカプセルについては、化粧料原料としてその製造方法が既に知られているが(例えば、特許文献10、特許文献11、特許文献12を参照)、オレイン酸等の有機酸を内包するマイクロカプセルについては知られていない。 On the other hand, as foaming cosmetics using carbonates or bicarbonates, solid bathing agents in which solid acid components and carbonates or bicarbonates react to foam by dissolving in water, aqueous solutions of acids There are known aerosol cosmetics that mix, react, and foam a powder composition containing and carbonate or bicarbonate at the time of use (for example, Patent Document 7, Patent Document 8, and Patent Document 9). (Refer to) Cosmetics in the form of cream or gel when taken out from the container, and foaming cosmetics containing carbonate or bicarbonate are not known at all. Furthermore, for microcapsules containing an oily component, a production method thereof is already known as a cosmetic raw material (see, for example, Patent Document 10, Patent Document 11, and Patent Document 12), but organic acids such as oleic acid There is no known microcapsule that contains
本発明は、この様な状況下為されたものであり、気化成分非含有形態のポストフォーム化粧料を提供することを課題とする。 The present invention has been made under such circumstances, and an object of the present invention is to provide a post-form cosmetic that does not contain a vaporized component.
この様な状況に鑑みて、本発明者らは、気化成分非含有形態のポストフォーム化粧料を提供するべく、鋭意研究努力を重ねた結果、1)炭酸塩及び/又は重炭酸塩と2)有機酸包含圧縮崩壊性マイクロカプセルとを含有する化粧料を、使用時に擦過することにより、マイクロカプセルが崩壊し、有機酸が漏出し、炭酸塩、重炭酸塩と反応し、炭酸ガスを発生し、以て、フォームを形成することを見出し、発明を完成させるに至った。即ち、本発明は以下に示す技術に関するものである。
(1)1)炭酸塩及び/又は重炭酸塩と2)炭酸塩及び/又は重炭酸塩と混合した際に炭酸ガスを発生する有機酸を包含する有機酸包含圧縮崩壊性マイクロカプセルとを含有することを特徴とする、吐出時の形態は通常のクリーム乃至はゲルであり、擦過をして塗布することにより、発泡してフォームを形成する、B型粘度計での粘度が20000mパスカル秒以上であるクリーム状乃至はゲル状の、通常の非耐圧容器に充填された化粧料。
(2)前記炭酸塩及び/又は重炭酸塩が重炭酸ナトリウムであることを特徴とする、(1)に記載の化粧料。
(3)炭酸塩及び/又は重炭酸塩の含有量が1〜10質量%であることを特徴とする、(1)又は(2)に記載の化粧料。
(4)前記有機酸包含圧縮崩壊性マイクロカプセルが、脂肪酸包含圧縮崩壊性マイクロカプセルであることを特徴とする、(1)〜(3)何れか1項に記載の化粧料。
(5)前記脂肪酸包含圧縮崩壊性マイクロカプセルが、オレイン酸包含圧縮崩壊性マイクロカプセルであることを特徴とする、(4)に記載の化粧料。
(6)マイクロカプセル外殻が、ポリメタクリル酸メチルであることを特徴とする、(1)〜(5)何れか1項に記載の化粧料。
(7)有機酸包含圧縮崩壊性マイクロカプセルの含有量が、1〜20質量%であることを特徴とする、(1)〜(6)何れか1項に記載の化粧料。
(8)マッサージ化粧料であることを特徴とする、(1)〜(7)何れか1項に記載の化粧料。
In view of such a situation, the present inventors have made intensive research efforts to provide a post-form cosmetic that does not contain a vaporizing component. As a result, 1) carbonate and / or bicarbonate 2) When cosmetics containing organic acid-containing compression-disintegrating microcapsules are rubbed during use, the microcapsules disintegrate, organic acids leak, react with carbonates and bicarbonates, and generate carbon dioxide. Thus, the inventors have found that a foam can be formed and have completed the invention. That is, the present invention relates to the following technique.
(1) 1 ) Contains carbonates and / or bicarbonates and 2) organic acid-containing compression-disintegrating microcapsules including organic acids that generate carbon dioxide when mixed with carbonates and / or bicarbonates The form at the time of discharge is a normal cream or gel, and it is foamed to form a foam by rubbing and applying. The viscosity with a B-type viscometer is 20000 m Pascal second or more. Cosmetics filled in a normal non-pressure-resistant container in the form of cream or gel .
(2) The cosmetic according to (1), wherein the carbonate and / or bicarbonate is sodium bicarbonate.
(3) The cosmetic according to (1) or (2), wherein the content of carbonate and / or bicarbonate is 1 to 10% by mass.
(4) The cosmetic according to any one of (1) to (3), wherein the organic acid-containing compressible and disintegratable microcapsule is a fatty acid-containing compressible and disintegratable microcapsule.
(5) The cosmetic according to (4), wherein the fatty acid-containing compression-disintegrating microcapsule is an oleic acid-containing compression-disintegrating microcapsule.
(6) The cosmetic material according to any one of (1) to (5), wherein the outer shell of the microcapsule is polymethyl methacrylate.
(7) The cosmetic according to any one of (1) to (6), wherein the content of the organic acid-containing compression-disintegratable microcapsule is 1 to 20% by mass.
(8) The cosmetic according to any one of (1) to (7), which is a massage cosmetic.
本発明によれば、気化成分非含有形態のポストフォーム化粧料を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the post foam cosmetics of a vaporization component non-containing form can be provided.
(1)本発明の化粧料の必須成分である炭酸塩及び/又は重炭酸塩
本発明の化粧料は、ポストフォーム形態であって、炭酸塩及び/又は重炭酸塩を必須成分として含有する。炭酸塩乃至は重炭酸塩としては、炭酸乃至は重炭酸の、ナトリウム塩、カリウム塩等のアルカリ金属塩、カルシウム、マグネシウム等のアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩、トリエチルアミン塩等の有機アミン塩類、リジン塩、アルギニン塩等の塩基性アミノ酸塩等が好ましく例示できる。特に好ましいものは、炭酸ナトリウム乃至は重炭酸ナトリウムである。これは重さあたりの炭酸ガスの発生量が多く、しかも、有機酸との反応が速やかに起こるためである。本発明の化粧料では、かかる炭酸塩乃至は重炭酸塩を唯一種含有することも出来るし、二種以上組み合わせて含有することも出来る。本発明の化粧料に於ける、かかる炭酸塩、重炭酸塩の好ましい含有量は、総量で、化粧料全量に対して、1〜10質量%であり、より好ましくは3〜5質量%である。これは少なすぎると発泡が充分でない場合が存し、多すぎると泡の肌理が損なわれる場合が存するためである。
(1) Carbonate and / or bicarbonate which is an essential component of the cosmetic of the present invention The cosmetic of the present invention is in a post-foam form and contains carbonate and / or bicarbonate as an essential component. Examples of carbonates or bicarbonates include alkali metal salts such as sodium and potassium salts, alkaline earth metal salts such as calcium and magnesium, ammonium salts, triethanolamine salts, and triethylamine salts. Preferred examples include organic amino acid salts, basic amino acid salts such as lysine salts and arginine salts. Particularly preferred is sodium carbonate or sodium bicarbonate. This is because the amount of carbon dioxide generated per weight is large, and the reaction with the organic acid occurs quickly. In the cosmetic of the present invention, such carbonates or bicarbonates can be contained alone or in combination of two or more. The preferred content of such carbonates and bicarbonates in the cosmetics of the present invention is 1 to 10% by mass, more preferably 3 to 5% by mass, based on the total amount of the cosmetics. . This is because if the amount is too small, foaming may not be sufficient, and if the amount is too large, the foam texture may be impaired.
(2)本発明の化粧料の必須成分である有機酸包含マイクロカプセル
本発明の化粧料は、有機酸包含マイクロカプセルを必須成分として含有することを特徴とする。液状乃至は固形状の油脂原料や多価アルコールを、マイクロカプセルの内部に包含させて、化粧料に含有させる技術は既に知られており、(例えば、特許文献10、特許文献11、特許文献12を参照)この様な公知技術を応用して製造することが出来る。本発明の化粧料に利用できるマイクロカプセルとしては、通常使用されている原料であれば、特段の限定無く使用することが出来、例えば、ゼラチンなどの天然素材、或いは樹脂などの合成素材の何れもが使用できる。特に好ましくは基本構造が樹脂のものである。樹脂のカプセルとしては、そのカプセルの基本構造が、アクリル酸エステル、メタクリル酸エステル、酢酸ビニル、スチレンから選択される一種以上のモノマーから形成されるホモポリマー又はコポリマーからなる、もしくは前記モノマーとアクリル酸、メタクリル酸、ジビニルベンゼン、エチレングリコールジメタクリレートから選択されるモノマーとから形成されるコポリマーからなる樹脂カプセルが好ましく、中でも該樹脂カプセルには固体物或いは液体物である有機酸を内包し、前記カプセルに内包される有機酸の内包量がカプセル全体の50〜90質量%であり、前記カプセルの粒子径が2〜20μmであり、耐圧(破壊)強度が2〜40kg/cm2である、圧縮崩壊性球状樹脂カプセルであることが好ましい。この様なマイクロカプセルは、内容物とカプセルの外殻を構成するポリマーの構成モノマーとを乳化させて、これにアゾビスイソブチロニトリルや過酸化ベンゾイルなどの重合開始剤を加えて、乳化重合を行えばよい。かかる乳化に用いる界面活性成分としては、例えば、「ラポナイトXLG」の名称で販売されているヘクスライト等が好適に例示できる。かかる界面活性成分の好ましい含有量は0.01〜5質量%であり、より好ましくは0.05〜1質量%である。これは多すぎると却って内包率を低下させ、隔壁を弱くすることが存するからである。これらと隔壁成分1〜5質量%、包含する有機酸5〜9質量%、及び残余を水などの反応溶媒として、機械力により液滴が分散した乳化系を形成させ、これに重合開始剤を加えて乳化重合し、生じたマイクロカプセルを遠心分離などの手段で分離し、所望により、洗浄することにより、本発明の有機酸包含マイクロカプセルを製造することが出来る。又、内包させる液体又は固体の有機酸としては、例えば、アジピン酸、蓚酸、コハク酸等の二塩基酸、リンゴ酸、クエン酸、乳酸、グリコール酸等のヒドロキシカルボン酸、オレイン酸、リノール酸、リノレイン酸、リチノレイン酸、ステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ベヘン酸等の脂肪酸などが好適に例示でき、脂肪酸が特に好ましく例示でき、中でも1気圧、25℃で液体の脂肪酸が好ましく、具体的には、オレイン酸、リノール酸、リノレイン酸などが特に好ましい。これらは唯一種を含有することも出来るし、二種を組み合わせて含有することも出来る。本発明の化粧料に於ける、かかる有機酸包含マイクロカプセルの好ましい含有量は、1〜20質量%が好ましく、5〜15質量%がより好ましい。これは、少なすぎると発泡が充分でない場合が存し、多すぎると有機酸が過剰となり、未反応の有機酸によって、使用感が損なわれる場合が存するからである。
(2) Organic acid-containing microcapsules that are essential components of the cosmetic of the present invention The cosmetic of the present invention is characterized by containing organic acid-containing microcapsules as an essential component. Techniques in which liquid or solid oil raw materials and polyhydric alcohol are contained in microcapsules and contained in cosmetics are already known (for example, Patent Document 10, Patent Document 11, Patent Document 12). It can be manufactured by applying such a known technique. The microcapsules that can be used in the cosmetic of the present invention can be used without particular limitation as long as it is a commonly used raw material. For example, any of natural materials such as gelatin or synthetic materials such as resins can be used. Can be used. Particularly preferably, the basic structure is a resin. As the capsule of the resin, the basic structure of the capsule is a homopolymer or copolymer formed from one or more monomers selected from acrylic acid ester, methacrylic acid ester, vinyl acetate and styrene, or the monomer and acrylic acid , Methacrylic acid, divinylbenzene, and a resin capsule made of a copolymer selected from a monomer selected from ethylene glycol dimethacrylate are preferable. Among these, the resin capsule encapsulates a solid or liquid organic acid, and the capsule The amount of organic acid included in the capsule is 50 to 90% by mass of the whole capsule, the particle diameter of the capsule is 2 to 20 μm, and the pressure resistance (breaking) strength is 2 to 40 kg / cm 2. A spherical resin capsule is preferred. Such microcapsules emulsify the contents and the constituent monomers of the polymer that forms the outer shell of the capsule, and then add a polymerization initiator such as azobisisobutyronitrile or benzoyl peroxide to the emulsion polymerization. Just do. As a surface active component used for such emulsification, for example, hexlite sold under the name of “Laponite XLG” can be suitably exemplified. The preferable content of such a surfactant component is 0.01 to 5% by mass, and more preferably 0.05 to 1% by mass. This is because if it is too much, the inclusion rate is lowered and the partition walls are weakened. These and partition wall components 1 to 5% by mass, the included organic acid 5 to 9% by mass, and the remainder as a reaction solvent such as water, an emulsion system in which droplets are dispersed by mechanical force is formed, and a polymerization initiator is added thereto. In addition, emulsion polymerization is carried out, the resulting microcapsules are separated by means such as centrifugation, and washed if desired, whereby the organic acid-containing microcapsules of the present invention can be produced. Examples of the liquid or solid organic acid to be encapsulated include dibasic acids such as adipic acid, succinic acid, and succinic acid, hydroxycarboxylic acids such as malic acid, citric acid, lactic acid, and glycolic acid, oleic acid, linoleic acid, Fatty acids such as linolenic acid, lithinolic acid, stearic acid, lauric acid, myristic acid, palmitic acid, behenic acid and the like can be preferably exemplified, and fatty acids can be particularly preferred, among which a fatty acid which is liquid at 1 atm and 25 ° C is preferred, Specifically, oleic acid, linoleic acid, linolenic acid and the like are particularly preferable. These can contain only the seed | species, and can also contain them in combination of 2 types. The content of the organic acid-containing microcapsules in the cosmetic of the present invention is preferably 1 to 20% by mass, more preferably 5 to 15% by mass. This is because if the amount is too small, foaming may not be sufficient, and if the amount is too large, the organic acid becomes excessive, and the feeling of use may be impaired by the unreacted organic acid.
(3)本発明の化粧料
本発明の化粧料は、ポストフォーム形態の化粧料であって、1)前記炭酸塩及び/又は重炭酸塩と2)前記有機酸包含マイクロカプセルとを含有することを特徴とする。この様な構成を取ることにより、本発明の化粧料は、擦過行為に伴って徐々に発泡をし、それに伴い、擦過による刺激の強さが柔らかくなり、擦過行為によって喚起される心地よさが増加する特性を有する。これにより、マッサージなどに於いては、擦過行為により、摩擦による過剰な刺激付与を避けることが出来、マッサージの効果を更に高めることが出来る。又、発泡によって生じた泡の断熱効果により、マッサージによって得られた温感も長時間持続することが出来、これにより血流量の増加をより促すことが出来る。又、化粧料そのものには気化成分を含有しないことから、通常の非耐圧容器に充填し保存することが出来、これにより、エアゾール缶の廃棄のように、容器に穴をうがつ必要もない。又、液化したガス成分の溶媒効果が皮膚に及ぶことが無く、加えて、炭酸ガスによる、血流量の増加効果も得られる。この様な諸特徴から、本発明の化粧料は、マッサージ化粧料に適用することが好ましい。勿論、塗布延展時発泡による、使用感の心地よさは他の化粧料でも同様に発現し、他の化粧料でも好ましい特性であるので、本発明の化粧料がマッサージ化粧料以外の化粧料に応用されることも本発明の技術範囲に属する。
(3) Cosmetics of the present invention The cosmetics of the present invention are post-form cosmetics, and contain 1) the carbonate and / or bicarbonate and 2) the organic acid-containing microcapsules. It is characterized by. By taking such a configuration, the cosmetic of the present invention gradually foams with the rubbing action, and accordingly, the strength of the irritation due to the rubbing becomes soft and the comfort aroused by the rubbing action increases. Have the following characteristics: Thereby, in massage etc., it is possible to avoid excessive stimulation due to friction by rubbing and to further enhance the effect of massage. Moreover, the thermal sensation obtained by the massage can be maintained for a long time due to the heat insulating effect of the foam generated by the foaming, and thereby the blood flow can be further increased. Further, since the cosmetic itself does not contain a vaporizing component, it can be filled and stored in a normal non-pressure-resistant container, thereby eliminating the need to puncture the container as in the case of disposal of an aerosol can. Further, the solvent effect of the liquefied gas component does not reach the skin, and in addition, the effect of increasing the blood flow rate by carbon dioxide gas can be obtained. From such various features, the cosmetic of the present invention is preferably applied to massage cosmetics. Of course, the comfort of use due to foaming during application spreading is also manifested in other cosmetics as well, and is a desirable property in other cosmetics, so the cosmetic of the present invention is applied to cosmetics other than massage cosmetics. It is also within the technical scope of the present invention.
本発明の化粧料は、前記の成分以外に、通常化粧料で使用できる任意成分を含有することが出来る。この様な任意成分としては、例えば、マカデミアナッツ油、アボガド油、トウモロコシ油、オリーブ油、ナタネ油、ゴマ油、ヒマシ油、サフラワー油、綿実油、ホホバ油、ヤシ油、パーム油、液状ラノリン、硬化ヤシ油、硬化油、モクロウ、硬化ヒマシ油、ミツロウ、キャンデリラロウ、カルナウバロウ、イボタロウ、ラノリン、還元ラノリン、硬質ラノリン、ホホバロウ等のオイル、ワックス類、流動パラフィン、スクワラン、プリスタン、オゾケライト、パラフィン、セレシン、ワセリン、マイクロクリスタリンワックス等の炭化水素類、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、ベヘニルアルコール、オクチルドデカノール、ミリスチルアルコール、セトステアリルアルコール等の高級アルコール等、イソオクタン酸セチル、ミリスチン酸イソプロピル、イソステアリン酸ヘキシルデシル、アジピン酸ジイソプロピル、セバチン酸ジ−2−エチルヘキシル、乳酸セチル、リンゴ酸ジイソステアリル、ジ−2−エチルヘキサン酸エチレングリコール、ジカプリン酸ネオペンチルグリコール、ジ−2−ヘプチルウンデカン酸グリセリン、トリ−2−エチルヘキサン酸グリセリン、トリ−2−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−2−エチルヘキサン酸ペンタンエリトリット等の合成エステル油類、ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等の鎖状ポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン等の環状ポリシロキサン、アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等の変性ポリシロキサン等のシリコーン油等の油剤類、脂肪酸セッケン(ラウリン酸ナトリウム、パルミチン酸ナトリウム等)、ラウリル硫酸カリウム、アルキル硫酸トリエタノールアミンエーテル等のアニオン界面活性剤類、塩化ステアリルトリメチルアンモニウム、塩化ベンザルコニウム、ラウリルアミンオキサイド等のカチオン界面活性剤類、イミダゾリン系両性界面活性剤(2−ココイル−2−イミダゾリニウムヒドロキサイド−1−カルボキシエチロキシ2ナトリウム塩等)、ベタイン系界面活性剤(アルキルベタイン、アミドベタイン、スルホベタイン等)、アシルメチルタウリン等の両性界面活性剤類、ソルビタン脂肪酸エステル類(ソルビタンモノステアレート、セスキオレイン酸ソルビタン等)、グリセリン脂肪酸類(モノステアリン酸グリセリン等)、プロピレングリコール脂肪酸エステル類(モノステアリン酸プロピレングリコール等)、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、POEソルビタン脂肪酸エステル類(POEソルビタンモノオレエート、モノステアリン酸ポリオキエチレンソルビタン等)、POEソルビット脂肪酸エステル類(POE−ソルビットモノラウレート等)、POEグリセリン脂肪酸エステル類(POE−グリセリンモノイソステアレート等)、POE脂肪酸エステル類(ポリエチレングリコールモノオレート、POEジステアレート等)、POEアルキルエーテル類(POE2−オクチルドデシルエーテル等)、POEアルキルフェニルエーテル類(POEノニルフェニルエーテル等)、プルロニック型類、POE・POPアルキルエーテル類(POE・POP2−デシルテトラデシルエーテル等)、テトロニック類、POEヒマシ油・硬化ヒマシ油誘導体(POEヒマシ油、POE硬化ヒマシ油等)、ショ糖脂肪酸エステル、アルキルグルコシド等の非イオン界面活性剤類、ポリエチレングリコール、グリセリン、1,3−ブチレングリコール、エリスリトール、ソルビトール、キシリトール、マルチトール、プロピレングリコール、ジプロピレングリコール、ジグリセリン、イソプレングリコール、1,2−ペンタンジオール、2,4−ヘキシレングリコール、1,2−ヘキサンジオール、1,2−オクタンジオール等の多価アルコール類、グアガム、クインスシード、カラギーナン、ガラクタン、アラビアガム、ペクチン、マンナン、デンプン、キサンタンガム、カードラン、メチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルセルロース、メチルヒドロキシプロピルセルロース、コンドロイチン硫酸、デルマタン硫酸、グリコーゲン、ヘパラン硫酸、ヒアルロン酸、ヒアルロン酸ナトリウム、トラガントガム、ケラタン硫酸、コンドロイチン、ムコイチン硫酸、ヒドロキシエチルグアガム、カルボキシメチルグアガム、デキストラン、ケラト硫酸,ローカストビーンガム,サクシノグルカン,カロニン酸,キチン,キトサン、カルボキシメチルキチン、寒天、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、ポリアクリル酸ナトリウム、ポリエチレングリコール、ベントナイト等の増粘剤、表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸(シリカ)、酸化アルミニウム、硫酸バリウム等の粉体類、表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類、表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類、レーキ化されていても良い赤色202号、赤色228号、赤色226号、黄色4号、青色404号、黄色5号、赤色505号、赤色230号、赤色223号、橙色201号、赤色213号、黄色204号、黄色203号、青色1号、緑色201号、紫色201号、赤色204号等の有機色素類、ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類、パラアミノ安息香酸系紫外線吸収剤、アントラニル酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤、糖系紫外線吸収剤、2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール、4−メトキシ−4’−t−ブチルジベンゾイルメタン等の紫外線吸収剤類、エタノール、イソプロパノール等の低級アルコール類、ビタミンA又はその誘導体、ビタミンB6塩酸塩,ビタミンB6トリパルミテート,ビタミンB6ジオクタノエート,ビタミンB2又はその誘導体,ビタミンB12,ビタミンB15又はその誘導体等のビタミンB類、α−トコフェロール,β−トコフェロール,γ−トコフェロール,ビタミンEアセテート等のビタミンE類、ビタミンD類、ビタミンH、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類などが好ましく例示できる。但し、本発明の化粧料には、マイクロカプセル化されない形態では酸性成分は、実質的に含有しないことが好ましい。本発明の化粧料は、これらの成分を常法に従って処理することにより、製造することが出来る。本発明の化粧料の剤形としては、特段の限定はないが、発泡特性、泡特性を高めるために、クリーム状乃至はゲル状の、粘度或いは硬度の高い剤形にすることが好ましい。好ましい粘度或いは硬度値としては、例えば、B型粘度計での粘度が20000mパスカル秒以上が好ましく例示できる。 The cosmetics of this invention can contain the arbitrary components which can be normally used with cosmetics other than the said component. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils such as hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum Hydrocarbons such as microcrystalline wax, higher alcohols such as cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol, etc. Cetyl octoate, isopropyl myristate, hexyl decyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diisostearyl malate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, Synthetic esters such as glycerin di-2-heptylundecanoate, glyceryl tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentane erythritol tetra-2-ethylhexanoate Oils, linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxa , Oils such as silicone oil such as cyclic polysiloxane such as dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, and fluorine-modified polysiloxane, fatty acid soap (lauric acid) Sodium, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, alkylsulfuric triethanolamine ether, cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric Surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaines, amide betaines, Sulfobetaine etc.), amphoteric surfactants such as acylmethyl taurine, sorbitan fatty acid esters (sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg glyceryl monostearate), propylene glycol fatty acid esters ( Propylene glycol monostearate), hardened castor oil derivative, glycerin alkyl ether, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbit monolaur) POE glycerin fatty acid esters (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE diste) Rate), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.) ), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), nonionic surfactants such as sucrose fatty acid ester, alkyl glucoside, polyethylene glycol, glycerin, 1,3 -Butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol Polyhydric alcohols such as 1,2-hexanediol and 1,2-octanediol, guar gum, quince seed, carrageenan, galactan, arabic gum, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose , Methyl hydroxypropyl cellulose, chondroitin sulfate, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, kerato sulfate, locust bean gum , Succinoglucan, caronic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol , Polyvinylpyrrolidone, carboxyvinyl polymer, thickener such as sodium polyacrylate, polyethylene glycol, bentonite, surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silica Powders such as acid (silica), aluminum oxide, barium sulfate, inorganic pigments of which the surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide The surface may be treated, pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, red 202, red 228, red 226, yellow 4, which may be raked, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 20 No., yellow 203, blue 1, green 201, purple 201, red 204, organic dyes such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, and other organic powders, paraamino Benzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2'-hydroxy-5'- UV absorbers such as t-octylphenyl) benzotriazole, 4-methoxy-4'-t-butyldibenzoylmethane, lower alcohols such as ethanol and isopropanol, vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 Tripalmitate, vitamin B6 dioctanoate, vitamin B2 or its derivatives, Vitamin B such as Vitamin B12, Vitamin B15 or derivatives thereof, Vitamin E such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, pantethine, pyrroloquinoline quinone And the like are preferably exemplified. However, it is preferable that the cosmetic of the present invention contains substantially no acidic component in a form that is not microencapsulated. The cosmetic of the present invention can be produced by treating these components according to a conventional method. The dosage form of the cosmetic composition of the present invention is not particularly limited, but it is preferably a cream or gel-like dosage form with high viscosity or hardness in order to enhance foaming characteristics and foam characteristics. As a preferable viscosity or hardness value, for example, the viscosity with a B-type viscometer is preferably 20000 m Pascal second or more.
以下に、実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明が、かかる実施例にのみ限定されないことは言うまでもない。 Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.
(製造例1)
(A)「ラポナイトXLG」 3質量部
水 2750質量部
(B)塩化ナトリウム 6質量部
水 250質量部
(C)メタクリル酸メチル 320質量部
酢酸ビニル 40質量部
エチレングリコールジメタクリレート 40質量部
過酸化ベンゾイル 4質量部
(D)オレイン酸 600質量部
前記(A)、(B)、(C)を別々に分散、溶解した。つぎに(C)を(D)に加えて均一に溶解し、油相とした。(A)に(B)を添加し、系に曇りが生じたことを確認したのち油相(C+D)を加えて粗乳化し、ついで、ホモミキサーにて6000rpm、2分間乳化を行なった。この懸濁液を還流冷却器、撹拌器、温度計、窒素導入管のついた反応器に移し、65℃で12時間重合反応を行ない、ついで過硫酸カリウムの4wt%水溶液100ml、亜硫酸ナトリウムの2wt%水溶液100mlを加えて後重合を2時間行ない、マイクロカプセル化を完了した。反応液スラリーは吸引濾過、水洗、乾燥を行ない、目的とする樹脂カプセル1(平均粒径140μm、内包率59.4質量%)の乾燥物を得た。
(Production Example 1)
(A) "Laponite XLG" 3 parts by weight water 2750 parts by weight (B) sodium chloride 6 parts by weight water 250 parts by weight (C) methyl methacrylate 320 parts by weight vinyl acetate 40 parts by weight ethylene glycol dimethacrylate 40 parts by weight benzoyl peroxide 4 parts by mass (D) 600 parts by mass of oleic acid The above (A), (B) and (C) were dispersed and dissolved separately. Next, (C) was added to (D) and dissolved uniformly to obtain an oil phase. (B) was added to (A), and after confirming that the system was clouded, the oil phase (C + D) was added and coarsely emulsified, and then emulsified with a homomixer at 6000 rpm for 2 minutes. This suspension was transferred to a reactor equipped with a reflux condenser, a stirrer, a thermometer, and a nitrogen introduction tube, and subjected to a polymerization reaction at 65 ° C. for 12 hours, and then 100 ml of a 4 wt% aqueous solution of potassium persulfate and 2 wt% of sodium sulfite. After the polymerization was carried out for 2 hours by adding 100 ml of an aqueous solution of%, microencapsulation was completed. The reaction solution slurry was subjected to suction filtration, washed with water, and dried to obtain a dried product of the desired resin capsule 1 (average particle size 140 μm, encapsulation rate 59.4 mass%).
(製造例2)
(A)ポリメタクリル酸メチル 20質量部
塩化メチレン 200容量部
(B)グリコール酸 80質量部
(C)石油エーテル 1000容量部
前記(A)に(B)をゆつくり加え、ホモミキサー中10,000rpmで乳化した。つぎに系全体が均一となるように6,000rpmで攪拌しながら、Cをゆつくりと滴下して、グリコール酸を内包した球状樹脂カプセルを生成させた。得られたカプセルは濾過後、更に石油エーテルで洗浄して乾燥して、樹脂カプセル2を得た。このものは、平均粒子径が約15μm、グリコール酸の内包量は82.1質量%であった。
(Production Example 2)
(A) Polymethyl methacrylate 20 parts by mass Methylene chloride 200 parts by volume (B) Glycolic acid 80 parts by mass (C) Petroleum ether 1000 parts by volume Add (B) to (A) and add 10,000 rpm in a homomixer. Emulsified. Next, while stirring at 6,000 rpm so as to make the entire system uniform, C was slowly added dropwise to produce a spherical resin capsule containing glycolic acid. The obtained capsule was filtered, further washed with petroleum ether and dried to obtain a resin capsule 2. This product had an average particle size of about 15 μm and an encapsulated amount of glycolic acid of 82.1% by mass.
(配合例1)
以下に示す、処方に従って、本発明の化粧料である、マッサージ化粧料1を製造した。即ち、イ、ロの成分を80℃に加熱し、攪拌下イにロを徐々に加え、乳化し、攪拌しながら冷却し、本発明の化粧料であるマッサージ化粧料1を得た。このものの粘度はB型粘度計(4号ローター)で測定した場合、20℃において54000mパスカル・秒であった。
(イ)
モノステアリン酸ポリエチレングリコール 0.5質量部
デカグリセリンモノオレート 3.5質量部
セチルアルコール 3 質量部
ベヘニルアルコール 2 質量部
ショ糖モノステアリン酸エステル 5 質量部
POE(20)ベヘニルエーテル 1 質量部
実施例1の樹脂マイクロカプセル 10 質量部
(ロ)
1,3−ブタンジオール 8 質量部
グリセリン 18 質量部
ポリエチレングリコール1500 5 質量部
マルメロ水抽出物 2 質量部
重炭酸ナトリウム 4 質量部
水 38 質量部
(Formulation example 1)
According to the prescription shown below, massage cosmetic 1 which is the cosmetic of the present invention was produced. That is, ingredients (a) and (b) were heated to 80 ° C., and (b) was gradually added to the mixture under stirring, emulsified, and cooled with stirring to obtain a massage cosmetic 1 as the cosmetic of the present invention. The viscosity of this product was 54000 mPascal · second at 20 ° C. when measured with a B-type viscometer (No. 4 rotor).
(I)
Polyethylene glycol monostearate 0.5 parts by weight Decaglycerin monooleate 3.5 parts by weight cetyl alcohol 3 parts by weight behenyl alcohol 2 parts by weight sucrose monostearate 5 parts by weight POE (20) behenyl ether 1 part by weight Example 1 Resin microcapsule 10 parts by mass (b)
1,3-butanediol 8 parts by weight glycerin 18 parts by weight polyethylene glycol 1500 5 parts by weight quince water extract 2 parts by weight sodium bicarbonate 4 parts by weight water 38 parts by weight
<試験例1>
実施例3のマッサージ料1を用いて、ポストフォーム特性のテストを行った。即ち、マッサージ料1を2mlを標準白色板上に3カ所に取り、これらを、それぞれ手で軽く1回、3回、5回擦過し、3分後に体積を計測した。又、下記に処方を示す、従来のエアゾール形態のポストフォームマッサージ料を用いて同様に処理し、比較例とした。結果を表1に示す。本発明の化粧料に於いては、擦過行為の進行に伴って、発泡の度合いが進み、施術行為とマッチした形態変化が起こるが、従来のポストフォームでは擦過行為に関係なく、吐出後の時間によってしか発泡状態が規定されないことが判る。
<Test Example 1>
The massage material 1 of Example 3 was used to test the post foam characteristics. That is, 2 ml of massage material 1 was taken at three places on a standard white plate, and these were lightly rubbed once, three times, and five times by hand, and the volume was measured after 3 minutes. Moreover, it processed similarly using the conventional aerosol form post-form massage material which shows prescription below, and it was set as the comparative example. The results are shown in Table 1. In the cosmetic of the present invention, as the rubbing action progresses, the degree of foaming progresses, and a shape change that matches the treatment action occurs. It can be seen that the foaming state is defined only by.
(従来のポストフォーム)
イ、ロの成分を80℃に加熱し、攪拌下イにロを徐々に加え、乳化し、攪拌しながら冷却し、クリームを得た。これをハのガスとともにエアゾール缶に充填し、比較例のポストフォームとした。
(イ)
モノステアリン酸ポリエチレングリコール 0.5質量部
デカグリセリンモノオレート 3.5質量部
セチルアルコール 3 質量部
ベヘニルアルコール 2 質量部
ショ糖モノステアリン酸エステル 5 質量部
POE(20)ベヘニルエーテル 1 質量部
(ロ)
1,3−ブタンジオール 8 質量部
グリセリン 18 質量部
ポリエチレングリコール1500 5 質量部
マルメロ水抽出物 2 質量部
水 50 質量部
(ハ)
液化天然ガス 2 質量部
(Conventional post form)
The ingredients b) and b) were heated to 80 ° C., and b was gradually added to a under stirring, emulsified, and cooled with stirring to obtain a cream. This was filled in an aerosol can together with the gas C to obtain a post-form for a comparative example.
(I)
Polyethylene glycol monostearate 0.5 parts by mass Decaglycerin monooleate 3.5 parts by mass Cetyl alcohol 3 parts by mass Behenyl alcohol 2 parts by mass Sucrose monostearate 5 parts by mass POE (20) Behenyl ether 1 part by mass (b)
1,3-butanediol 8 parts by weight glycerin 18 parts by weight polyethylene glycol 1500 5 parts by weight quince water extract 2 parts by weight water 50 parts by weight (c)
Liquefied natural gas 2 parts by mass
<試験例2>
パネラー5名を用いて、試験例1で用いたマッサージ化粧料1、従来のポストフォーム化粧料でマッサージを行い、マッサージの前後での、唾液中のプラステロン硫酸を測定した。プラステロン硫酸濃度は、標識抗体を用いたサンドウィッチ抗体法により行った。結果を表2に、濃度の上昇率として示す。これより、本発明の化粧料によるマッサージの方が、プラステロン硫酸の濃度が上昇しており、より大きな心地よさを提供していることが判る。これは、前記の施術とマッチした発泡特性によるところが大きい。
<Test Example 2>
Using five panelists, massage was performed with the massage cosmetic 1 used in Test Example 1 and the conventional post-form cosmetic, and the plasterone sulfate in the saliva was measured before and after the massage. Plasterone sulfate concentration was determined by a sandwich antibody method using a labeled antibody. The results are shown in Table 2 as the rate of increase in concentration. From this, it can be seen that the massage with the cosmetic of the present invention has a higher concentration of plasterone sulfate and provides greater comfort. This is largely due to the foaming characteristics matched with the above treatment.
<試験例3>
マッサージ化粧料1を、無作為に選抜したパネラー10名に「ポストフォームタイプのパック化粧料」であると説明して渡し、パック化粧料としての使用性を問いただした。使用性は、良い、何とも言えない、悪いの三者択一の形で行った結果は、良いが8名、何とも言えないが2名であり、パック化粧料としても適していることが判った。これは擦過行為に従って発泡が進む、使用性の心地よさに起因するものと思われる。
<Test Example 3>
The massage cosmetics 1 were explained to the 10 panelists selected at random as “post-form pack cosmetics” and asked about their usability as pack cosmetics. Usability is good, can't say anything, bad, the result of three choices was good, 8 people can not say anything, but 2 people, it was found that it is suitable as a pack cosmetic . This seems to be due to the comfort of use, in which foaming proceeds according to the rubbing action.
実施例3と同様に、下記に示す処方に従って、本発明の化粧料である、マッサージ化粧料2を作成した。このものの発泡特性の評価結果は表3に示す。このものも優れた発泡特性を有していることが判る。 In the same manner as in Example 3, a massage cosmetic 2 as a cosmetic of the present invention was prepared according to the formulation shown below. The evaluation results of the foaming properties of this product are shown in Table 3. It can be seen that this also has excellent foaming properties.
(配合例2)
以下に示す、処方に従って、本発明の化粧料である、マッサージ化粧料2を製造した。即ち、イ、ロの成分を80℃に加熱し、攪拌下イにロを徐々に加え、乳化し、攪拌しながら冷却し、本発明の化粧料であるマッサージ化粧料2を得た。このものの粘度はB型粘度計(4号ローター)で測定した場合、20℃において49000mパスカル・秒であった。
(イ)
モノステアリン酸ポリエチレングリコール 0.5質量部
デカグリセリンモノオレート 3.5質量部
セチルアルコール 3 質量部
ベヘニルアルコール 2 質量部
ショ糖モノステアリン酸エステル 5 質量部
POE(20)ベヘニルエーテル 1 質量部
実施例2の樹脂マイクロカプセル 10 質量部
(ロ)
1,3−ブタンジオール 8 質量部
グリセリン 18 質量部
ポリエチレングリコール1500 5 質量部
マルメロ水抽出物 2 質量部
重炭酸ナトリウム 4 質量部
水 38 質量部
(Formulation example 2)
According to the prescription shown below, massage cosmetic 2 as a cosmetic of the present invention was produced. That is, the ingredients of (a) and (b) were heated to 80 ° C., and (b) was gradually added to the mixture under stirring, emulsified, and cooled with stirring to obtain a massage cosmetic 2 as the cosmetic of the present invention. The viscosity of this product was 49000 m Pascal · second at 20 ° C. when measured with a B-type viscometer (No. 4 rotor).
(I)
Polyethylene glycol monostearate 0.5 parts by weight Decaglycerin monooleate 3.5 parts by weight cetyl alcohol 3 parts by weight behenyl alcohol 2 parts by weight sucrose monostearate 5 parts by weight POE (20) behenyl ether 1 part by weight Example 2 Resin microcapsule 10 parts by mass (b)
1,3-butanediol 8 parts by weight glycerin 18 parts by weight polyethylene glycol 1500 5 parts by weight quince water extract 2 parts by weight sodium bicarbonate 4 parts by weight water 38 parts by weight
実施例3と同様に、下記に示す処方に従って、本発明の化粧料である、マッサージ化粧料3を作成した。このものの発泡特性の評価結果は表4に示す。このものも優れた発泡特性を有していることが判る。 In the same manner as in Example 3, a massage cosmetic 3 as a cosmetic of the present invention was prepared according to the formulation shown below. The evaluation results of the foaming properties of this product are shown in Table 4. It can be seen that this also has excellent foaming properties.
(配合例1)
以下に示す、処方に従って、本発明の化粧料である、マッサージ化粧料3を製造した。即ち、イ、ロの成分を80℃に加熱し、攪拌下イにロを徐々に加え、乳化し、攪拌しながら冷却し、本発明の化粧料であるマッサージ化粧料3を得た。このものの粘度はB型粘度計(4号ローター)で測定した場合、20℃において56000mパスカル・秒であった。
(イ)
モノステアリン酸ポリエチレングリコール 0.5質量部
デカグリセリンモノオレート 3.5質量部
セチルアルコール 3 質量部
ベヘニルアルコール 2 質量部
ショ糖モノステアリン酸エステル 5 質量部
POE(20)ベヘニルエーテル 1 質量部
実施例1の樹脂マイクロカプセル 10 質量部
(ロ)
1,3−ブタンジオール 8 質量部
グリセリン 18 質量部
ポリエチレングリコール1500 5 質量部
マルメロ水抽出物 2 質量部
炭酸ナトリウム 4 質量部
水 38 質量部
(Formulation example 1)
According to the prescription shown below, massage cosmetic 3 which is the cosmetic of the present invention was produced. That is, the ingredients (a) and (b) were heated to 80 ° C., and the ingredients (b) were gradually added to the mixture under stirring, emulsified, and cooled with stirring to obtain a massage cosmetic 3 as the cosmetic of the present invention. The viscosity of this product was 56000 mPascal · second at 20 ° C. when measured with a B-type viscometer (No. 4 rotor).
(I)
Polyethylene glycol monostearate 0.5 parts by weight Decaglycerin monooleate 3.5 parts by weight cetyl alcohol 3 parts by weight behenyl alcohol 2 parts by weight sucrose monostearate 5 parts by weight POE (20) behenyl ether 1 part by weight Example 1 Resin microcapsule 10 parts by mass (b)
1,3-butanediol 8 parts by weight glycerin 18 parts by weight polyethylene glycol 1500 5 parts by weight quince water extract 2 parts by weight sodium carbonate 4 parts by weight water 38 parts by weight
本発明は、パック機能を有するマッサージ化粧料に応用できる。 The present invention can be applied to massage cosmetics having a pack function.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004079780A JP4338561B2 (en) | 2004-03-19 | 2004-03-19 | Post form cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004079780A JP4338561B2 (en) | 2004-03-19 | 2004-03-19 | Post form cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005263703A JP2005263703A (en) | 2005-09-29 |
| JP4338561B2 true JP4338561B2 (en) | 2009-10-07 |
Family
ID=35088610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004079780A Expired - Lifetime JP4338561B2 (en) | 2004-03-19 | 2004-03-19 | Post form cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4338561B2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2706516C (en) * | 2008-02-08 | 2014-12-16 | Colgate-Palmolive Company | Cleaning compositions and methods |
| JP5146357B2 (en) * | 2009-02-25 | 2013-02-20 | 富士通株式会社 | DATA DIAGNOSIS DEVICE, DATA DIAGNOSIS SYSTEM, DATA DIAGNOSIS METHOD, AND DATA DIAGNOSIS PROGRAM |
| JP5935172B2 (en) * | 2013-01-22 | 2016-06-15 | 株式会社東洋新薬 | Effervescent skin external preparation |
| KR101420225B1 (en) * | 2014-04-09 | 2014-07-17 | (주) 제이앤케이사이언스 | Foaming composition for washing or cleansing aid and preparation method thereof |
| JP6209565B2 (en) * | 2015-07-28 | 2017-10-04 | 株式会社 ナチュラル | Method for producing solid cosmetic soap that generates carbon dioxide |
| CN116370319B (en) * | 2023-03-28 | 2025-05-30 | 苏州绿叶日用品有限公司 | A raspberry-shaped sunscreen nanocapsule and its preparation method and application |
-
2004
- 2004-03-19 JP JP2004079780A patent/JP4338561B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005263703A (en) | 2005-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4368250B2 (en) | Post-form dosage form of warm cosmetic | |
| JP4315909B2 (en) | Composition that does not require pressure and expands after application | |
| JP6256905B2 (en) | Fragrance-encapsulating capsule and cosmetics containing the same | |
| JP2006327952A (en) | Oil in water type emulsion composition and method for producing the same | |
| JP2009292740A (en) | Cosmetic for blood circulation promotion | |
| JP4338561B2 (en) | Post form cosmetic | |
| JP6180816B2 (en) | Topical skin preparation | |
| JP5180601B2 (en) | Aerosol composition | |
| JP2001097819A (en) | Microcapsule and its production | |
| JP2009191042A (en) | Skin external preparation in aerosol form | |
| JP2006290762A (en) | Oil-in-water emulsified composition | |
| JP6180817B2 (en) | Topical skin preparation | |
| JP4185900B2 (en) | Gel cosmetic | |
| JP2006022047A (en) | Skin care cosmetic high in closing effect | |
| JP4332468B2 (en) | Cosmetics | |
| JP2005187355A (en) | Cleansing cosmetic | |
| JP2009256254A (en) | Microsphere for cosmetic and cosmetic containing the microsphere | |
| JP2002370918A (en) | Non-emulsified and powder dispersed-in-oil type cosmetic | |
| JP2015229695A (en) | O/w emulsion composition | |
| JP2006298868A (en) | External preparation for skin, suitable for cleansing cosmetic | |
| JP4676730B2 (en) | Emulsifier type skin external preparation | |
| JP2005162703A (en) | Facial wash | |
| JP6013138B2 (en) | Foam aerosol type skin external composition | |
| JP2006001906A (en) | Cosmetic giving warm feeling | |
| JP2006063032A (en) | Skin external preparation suitable for sebum shine prevention |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070315 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20090305 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090326 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090522 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20090630 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20090630 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4338561 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150710 Year of fee payment: 6 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |